Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 143

1.

Delineation of Human Carotid Plaque Features In Vivo by Exploiting Displacement Variance.

Torres G, Czernuszewicz TJ, Homeister JW, Caughey MC, Huang BY, Lee ER, Zamora CA, Farber MA, Marston WA, Huang DY, Nichols TC, Gallippi CM.

IEEE Trans Ultrason Ferroelectr Freq Control. 2019 Mar;66(3):481-492. doi: 10.1109/TUFFC.2019.2898628. Epub 2019 Feb 11.

PMID:
30762544
2.

Combining CDK4/6 inhibition with taxanes enhances anti-tumor efficacy by sustained impairment of pRB-E2F pathways in squamous cell lung cancer.

Cao J, Zhu Z, Wang H, Nichols TC, Lui GYL, Deng S, Rejto PA, VanArsdale T, Hardwick JS, Weinrich SL, Wei P.

Oncogene. 2019 May;38(21):4125-4141. doi: 10.1038/s41388-019-0708-7. Epub 2019 Jan 30.

PMID:
30700828
3.

An Observational Study from Long-Term AAV Re-administration in Two Hemophilia Dogs.

Sun J, Shao W, Chen X, Merricks EP, Wimsey L, Abajas YL, Niemeyer GP, Lothrop CD, Monahan PE, Samulski RJ, Nichols TC, Li C.

Mol Ther Methods Clin Dev. 2018 Aug 4;10:257-267. doi: 10.1016/j.omtm.2018.07.011. eCollection 2018 Sep 21.

4.

Mechanical Anisotropy Assessment in Kidney Cortex Using ARFI Peak Displacement: Preclinical Validation and Pilot In Vivo Clinical Results in Kidney Allografts.

Hossain MM, Detwiler RK, Chang EH, Caughey MC, Fisher MW, Nichols TC, Merricks EP, Raymer RA, Whitford M, Bellinger DA, Wimsey LE, Gallippi CM.

IEEE Trans Ultrason Ferroelectr Freq Control. 2019 Mar;66(3):551-562. doi: 10.1109/TUFFC.2018.2865203. Epub 2018 Aug 13.

PMID:
30106723
5.

Complete correction of hemophilia B phenotype by FIX-Padua skeletal muscle gene therapy in an inhibitor-prone dog model.

French RA, Samelson-Jones BJ, Niemeyer GP, Lothrop CD Jr, Merricks EP, Nichols TC, Arruda VR.

Blood Adv. 2018 Mar 13;2(5):505-508. doi: 10.1182/bloodadvances.2017015313. No abstract available.

6.

Influence of diabetes on the foreign body response to nitric oxide-releasing implants.

Soto RJ, Merricks EP, Bellinger DA, Nichols TC, Schoenfisch MH.

Biomaterials. 2018 Mar;157:76-85. doi: 10.1016/j.biomaterials.2017.11.044. Epub 2017 Nov 30.

7.

Performance of acoustic radiation force impulse ultrasound imaging for carotid plaque characterization with histologic validation.

Czernuszewicz TJ, Homeister JW, Caughey MC, Wang Y, Zhu H, Huang BY, Lee ER, Zamora CA, Farber MA, Fulton JJ, Ford PF, Marston WA, Vallabhaneni R, Nichols TC, Gallippi CM.

J Vasc Surg. 2017 Dec;66(6):1749-1757.e3. doi: 10.1016/j.jvs.2017.04.043. Epub 2017 Jul 13.

8.

Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models.

Markusic DM, Nichols TC, Merricks EP, Palaschak B, Zolotukhin I, Marsic D, Zolotukhin S, Srivastava A, Herzog RW.

J Transl Med. 2017 May 1;15(1):94. doi: 10.1186/s12967-017-1200-1.

9.

Global measurement of coagulation in plasma from normal and haemophilia dogs using a novel modified thrombin generation test - Demonstrated in vitro and ex vivo.

Madsen DE, Nichols TC, Merricks EP, Waters EK, Wiinberg B.

PLoS One. 2017 Apr 6;12(4):e0175030. doi: 10.1371/journal.pone.0175030. eCollection 2017.

10.

An anti-αVβ3 antibody inhibits coronary artery atherosclerosis in diabetic pigs.

Maile LA, Busby WH, Xi G, Gollahan KP, Flowers W, Gafbacik N, Gafbacik S, Stewart K, Merricks EP, Nichols TC, Bellinger DA, Clemmons DR.

Atherosclerosis. 2017 Mar;258:40-50. doi: 10.1016/j.atherosclerosis.2017.01.030. Epub 2017 Jan 27.

PMID:
28189040
11.

Oral Tolerance Induction in Hemophilia B Dogs Fed with Transplastomic Lettuce.

Herzog RW, Nichols TC, Su J, Zhang B, Sherman A, Merricks EP, Raymer R, Perrin GQ, Häger M, Wiinberg B, Daniell H.

Mol Ther. 2017 Feb 1;25(2):512-522. doi: 10.1016/j.ymthe.2016.11.009.

12.

Severe Hemophilia A in a Male Old English Sheep Dog with a C→T Transition that Created a Premature Stop Codon in Factor VIII.

Lozier JN, Kloos MT, Merricks EP, Lemoine N, Whitford MH, Raymer RA, Bellinger DA, Nichols TC.

Comp Med. 2016;66(5):405-411.

13.

Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models.

Siner JI, Samelson-Jones BJ, Crudele JM, French RA, Lee BJ, Zhou S, Merricks E, Raymer R, Nichols TC, Camire RM, Arruda VR.

JCI Insight. 2016 Oct 6;1(16):e89371. doi: 10.1172/jci.insight.89371.

14.

Soy Phosphatidylinositol-Containing Lipid Nanoparticle Prolongs the Plasma Survival and Hemostatic Efficacy of B-domain-Deleted Recombinant Canine Factor VIII in Hemophilia A Dogs.

Shetty KA, Merricks EP, Raymer R, Rigsbee N, Nichols TC, Balu-Iyer SV.

J Pharm Sci. 2016 Aug;105(8):2459-64. doi: 10.1016/j.xphs.2016.05.023. Epub 2016 Jun 30.

15.

Ex Vivo Porcine Arterial and Chorioallantoic Membrane Acoustic Angiography Using Dual-Frequency Intravascular Ultrasound Probes.

Martin KH, Lindsey BD, Ma J, Nichols TC, Jiang X, Dayton PA.

Ultrasound Med Biol. 2016 Sep;42(9):2294-307. doi: 10.1016/j.ultrasmedbio.2016.04.008. Epub 2016 May 31.

16.

Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies.

Nichols TC, Hough C, Agersø H, Ezban M, Lillicrap D.

J Thromb Haemost. 2016 May;14(5):894-905. doi: 10.1111/jth.13301. Epub 2016 Apr 5. Review.

17.

Sustained correction of FVII deficiency in dogs using AAV-mediated expression of zymogen FVII.

Marcos-Contreras OA, Smith SM, Bellinger DA, Raymer RA, Merricks E, Faella A, Pavani G, Zhou S, Nichols TC, High KA, Margaritis P.

Blood. 2016 Feb 4;127(5):565-71. doi: 10.1182/blood-2015-09-671420. Epub 2015 Dec 23.

18.

Experimental Validation of ARFI Surveillance of Subcutaneous Hemorrhage (ASSH) Using Calibrated Infusions in a Tissue-Mimicking Model and Dogs.

Geist RE, DuBois CH, Nichols TC, Caughey MC, Merricks EP, Raymer R, Gallippi CM.

Ultrason Imaging. 2016 Sep;38(5):346-58. doi: 10.1177/0161734615617940. Epub 2015 Nov 27.

19.

Oxidized LDL and Fructosamine Associated with Severity of Coronary Artery Atherosclerosis in Insulin Resistant Pigs Fed a High Fat/High NaCl Diet.

Nichols TC, Merricks EP, Bellinger DA, Raymer RA, Yu J, Lam D, Koch GG, Busby WH Jr, Clemmons DR.

PLoS One. 2015 Jul 6;10(7):e0132302. doi: 10.1371/journal.pone.0132302. eCollection 2015.

20.
21.

Translational data from adeno-associated virus-mediated gene therapy of hemophilia B in dogs.

Nichols TC, Whitford MH, Arruda VR, Stedman HH, Kay MA, High KA.

Hum Gene Ther Clin Dev. 2015 Mar;26(1):5-14. doi: 10.1089/humc.2014.153. Epub 2015 Feb 12. Review.

22.

Non-invasive in vivo characterization of human carotid plaques with acoustic radiation force impulse ultrasound: comparison with histology after endarterectomy.

Czernuszewicz TJ, Homeister JW, Caughey MC, Farber MA, Fulton JJ, Ford PF, Marston WA, Vallabhaneni R, Nichols TC, Gallippi CM.

Ultrasound Med Biol. 2015 Mar;41(3):685-97. doi: 10.1016/j.ultrasmedbio.2014.09.016. Epub 2015 Jan 22.

23.

Targeted disruption of LDLR causes hypercholesterolemia and atherosclerosis in Yucatan miniature pigs.

Davis BT, Wang XJ, Rohret JA, Struzynski JT, Merricks EP, Bellinger DA, Rohret FA, Nichols TC, Rogers CS.

PLoS One. 2014 Apr 1;9(4):e93457. doi: 10.1371/journal.pone.0093457. eCollection 2014.

24.

Portal vein delivery of viral vectors for gene therapy for hemophilia.

Sherman A, Schlachterman A, Cooper M, Merricks EP, Raymer RA, Bellinger DA, Herzog RW, Nichols TC.

Methods Mol Biol. 2014;1114:413-26. doi: 10.1007/978-1-62703-761-7_27.

25.

Acoustic radiation force beam sequence performance for detection and material characterization of atherosclerotic plaques: preclinical, ex vivo results.

Behler RH, Czernuszewicz TJ, Wu CD, Nichols TC, Zhu H, Homeister JW, Merricks EP, Gallippi CM.

IEEE Trans Ultrason Ferroelectr Freq Control. 2013 Dec;60(12):2471-87. doi: 10.1109/TUFFC.2013.2847.

26.

Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging.

O'Brien PJ, Lee M, Spilker ME, Zhang CC, Yan Z, Nichols TC, Li W, Johnson CH, Patti GJ, Siuzdak G.

Cancer Metab. 2013 Jan 23;1(1):4. doi: 10.1186/2049-3002-1-4.

27.

Bad cholesterol breaking really bad.

Nichols TC.

Blood. 2013 Nov 21;122(22):3551-3. doi: 10.1182/blood-2013-09-527697.

28.

Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A.

Du LM, Nurden P, Nurden AT, Nichols TC, Bellinger DA, Jensen ES, Haberichter SL, Merricks E, Raymer RA, Fang J, Koukouritaki SB, Jacobi PM, Hawkins TB, Cornetta K, Shi Q, Wilcox DA.

Nat Commun. 2013;4:2773. doi: 10.1038/ncomms3773.

29.

Contrast-enhanced imaging of SPIO-labeled platelets using magnetomotive ultrasound.

Pope AG, Wu G, McWhorter FY, Merricks EP, Nichols TC, Czernuszewicz TJ, Gallippi CM, Oldenburg AL.

Phys Med Biol. 2013 Oct 21;58(20):7277-90. doi: 10.1088/0031-9155/58/20/7277. Epub 2013 Sep 27.

30.

Animal models of hemophilia and related bleeding disorders.

Lozier JN, Nichols TC.

Semin Hematol. 2013 Apr;50(2):175-84. Review.

31.

Phase II prospective open-label trial of recombinant interleukin-11 in desmopressin-unresponsive von Willebrand disease and mild or moderate haemophilia A.

Ragni MV, Novelli EM, Murshed A, Merricks EP, Kloos MT, Nichols TC.

Thromb Haemost. 2013 Feb;109(2):248-54. doi: 10.1160/TH12-06-0447. Epub 2012 Dec 13.

32.

The efficacy and the risk of immunogenicity of FIX Padua (R338L) in hemophilia B dogs treated by AAV muscle gene therapy.

Finn JD, Nichols TC, Svoronos N, Merricks EP, Bellenger DA, Zhou S, Simioni P, High KA, Arruda VR.

Blood. 2012 Nov 29;120(23):4521-3. doi: 10.1182/blood-2012-06-440123. Epub 2012 Aug 23.

33.

Pharmacokinetics and pharmacodynamics of turoctocog alfa and N8-GP in haemophilia A dogs.

Agersø H, Stennicke HR, Pelzer H, Olsen EN, Merricks EP, Defriess NA, Nichols TC, Ezban M.

Haemophilia. 2012 Nov;18(6):941-7. doi: 10.1111/j.1365-2516.2012.02896.x. Epub 2012 Jul 20.

34.

Improved kinetics of rIX-FP, a recombinant fusion protein linking factor IX with albumin, in cynomolgus monkeys and hemophilia B dogs.

Nolte MW, Nichols TC, Mueller-Cohrs J, Merricks EP, Pragst I, Zollner S, Dickneite G.

J Thromb Haemost. 2012 Aug;10(8):1591-9. doi: 10.1111/j.1538-7836.2012.04826.x.

35.
36.

A review of current methods for assessing hemostasis in vivo and introduction to a potential alternative approach.

Scola MR, Baggesen LM, Nichols TC, Key NS, Gallippi CM.

Thromb Res. 2012 May;129 Suppl 2:S57-61. doi: 10.1016/j.thromres.2012.02.035. Epub 2012 Mar 8. Review.

37.

Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs.

Dumont JA, Liu T, Low SC, Zhang X, Kamphaus G, Sakorafas P, Fraley C, Drager D, Reidy T, McCue J, Franck HW, Merricks EP, Nichols TC, Bitonti AJ, Pierce GF, Jiang H.

Blood. 2012 Mar 29;119(13):3024-30. doi: 10.1182/blood-2011-08-367813. Epub 2012 Jan 13.

38.

Animal models of hemophilia.

Sabatino DE, Nichols TC, Merricks E, Bellinger DA, Herzog RW, Monahan PE.

Prog Mol Biol Transl Sci. 2012;105:151-209. doi: 10.1016/B978-0-12-394596-9.00006-8. Review.

39.

ARFI ultrasound monitoring of hemorrhage and hemostasis in vivo in canine von Willebrand disease and hemophilia.

Scola MR, Nichols TC, Zhu H, Caughey MC, Merricks EP, Raymer RA, Margaritis P, High KA, Gallippi CM.

Ultrasound Med Biol. 2011 Dec;37(12):2126-32. doi: 10.1016/j.ultrasmedbio.2011.09.006. Epub 2011 Oct 26.

40.

Phase II prospective open-label trial of recombinant interleukin-11 in women with mild von Willebrand disease and refractory menorrhagia.

Ragni MV, Jankowitz RC, Jaworski K, Merricks EP, Kloos MT, Nichols TC.

Thromb Haemost. 2011 Oct;106(4):641-5. doi: 10.1160/TH11-04-0274. Epub 2011 Aug 11.

41.

Poly-N-acetylglucosamine fibers amplify the effectiveness of recombinant factor VIIA on clot formation in hemophilia B canine blood.

Fischer TH, Nichols TC, Scull CM, Smith CJ, Demcheva M.

J Trauma. 2011 Aug;71(2 Suppl 1):S171-5. doi: 10.1097/TA.0b013e31822556f4.

42.

Development of a flow cytometric assay for detection of coated platelets in dogs and evaluation of binding of coated platelets to recombinant human coagulation factor VIIa.

Knudsen T, Kjalke M, Tranholm M, Nichols TC, Jensen AL, Kristensen AT.

Am J Vet Res. 2011 Aug;72(8):1007-14. doi: 10.2460/ajvr.72.8.1007.

PMID:
21801056
43.

Prolonged half-life and preserved enzymatic properties of factor IX selectively PEGylated on native N-glycans in the activation peptide.

Østergaard H, Bjelke JR, Hansen L, Petersen LC, Pedersen AA, Elm T, Møller F, Hermit MB, Holm PK, Krogh TN, Petersen JM, Ezban M, Sørensen BB, Andersen MD, Agersø H, Ahmadian H, Balling KW, Christiansen ML, Knobe K, Nichols TC, Bjørn SE, Tranholm M.

Blood. 2011 Aug 25;118(8):2333-41. doi: 10.1182/blood-2011-02-336172. Epub 2011 Jun 23.

44.

Pharmacokinetics and ex vivo whole blood clot formation of a new recombinant FVIII (N8) in haemophilia A dogs.

Karpf DM, Kjalke M, Thim L, Agersø H, Merricks EP, Defriess N, Nichols TC, Ezban M.

Haemophilia. 2011 Sep;17(5):e963-8. doi: 10.1111/j.1365-2516.2011.02580.x. Epub 2011 Jun 20.

45.

Pharmacokinetics, pharmacodynamics and safety of recombinant canine FVIIa in a study dosing one haemophilia A and one haemostatically normal dog.

Knudsen T, Kristensen AT, Nichols TC, Agersø H, Jensen AL, Kjalke M, Ezban M, Tranholm M.

Haemophilia. 2011 Nov;17(6):962-70. doi: 10.1111/j.1365-2516.2011.02536.x. Epub 2011 Jun 6.

46.

Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk.

Mátrai J, Cantore A, Bartholomae CC, Annoni A, Wang W, Acosta-Sanchez A, Samara-Kuko E, De Waele L, Ma L, Genovese P, Damo M, Arens A, Goudy K, Nichols TC, von Kalle C, L Chuah MK, Roncarolo MG, Schmidt M, Vandendriessche T, Naldini L.

Hepatology. 2011 May;53(5):1696-707. doi: 10.1002/hep.24230.

47.

Canine specific ELISA for coagulation factor VII.

Knudsen T, Kjelgaard-Hansen M, Tranholm M, Wiinberg B, Clausen JT, Hansen JJ, Nichols TC, Kjalke M, Jensen AL, Kristensen AT.

Vet J. 2011 Dec;190(3):352-8. doi: 10.1016/j.tvjl.2010.11.010. Epub 2011 Jan 8.

48.

Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin.

Petersen LC, Karpf DM, Agersø H, Hermit MB, Pelzer H, Persson E, Nichols TC, Ezban M.

Br J Haematol. 2011 Jan;152(1):99-107. doi: 10.1111/j.1365-2141.2010.08432.x. Epub 2010 Nov 18.

49.

Efficacy and safety of long-term prophylaxis in severe hemophilia A dogs following liver gene therapy using AAV vectors.

Sabatino DE, Lange AM, Altynova ES, Sarkar R, Zhou S, Merricks EP, Franck HG, Nichols TC, Arruda VR, Kazazian HH Jr.

Mol Ther. 2011 Mar;19(3):442-9. doi: 10.1038/mt.2010.240. Epub 2010 Nov 16.

50.

Magnetic and contrast properties of labeled platelets for magnetomotive optical coherence tomography.

Oldenburg AL, Gallippi CM, Tsui F, Nichols TC, Beicker KN, Chhetri RK, Spivak D, Richardson A, Fischer TH.

Biophys J. 2010 Oct 6;99(7):2374-83. doi: 10.1016/j.bpj.2010.08.007.

Supplemental Content

Loading ...
Support Center