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Items: 1 to 50 of 251

1.

Cardiovascular consequences of KATP overactivity in Cantu syndrome.

Huang Y, McClenaghan C, Harter TM, Hinman K, Halabi CM, Matkovich SJ, Zhang H, Brown GS, Mecham RP, England SK, Kovacs A, Remedi MS, Nichols CG.

JCI Insight. 2018 Aug 9;3(15). pii: 121153. doi: 10.1172/jci.insight.121153. [Epub ahead of print]

2.

Novel drug targets for ductus arteriosus manipulation: Looking beyond prostaglandins.

Shelton EL, Singh GK, Nichols CG.

Semin Perinatol. 2018 Jun;42(4):221-227. doi: 10.1053/j.semperi.2018.05.004. Epub 2018 May 10. Review.

PMID:
29880312
3.

Superior diastolic function with KATP channel opener diazoxide in a novel mouse Langendorff model.

Makepeace CM, Suarez-Pierre A, Kanter EM, Schuessler RB, Nichols CG, Lawton JS.

J Surg Res. 2018 Jul;227:186-193. doi: 10.1016/j.jss.2018.02.024. Epub 2018 Mar 22.

PMID:
29804852
4.

Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms.

Deng Z, Paknejad N, Maksaev G, Sala-Rabanal M, Nichols CG, Hite RK, Yuan P.

Nat Struct Mol Biol. 2018 Mar;25(3):252-260. doi: 10.1038/s41594-018-0037-5. Epub 2018 Feb 26.

PMID:
29483651
5.

Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms.

McClenaghan C, Hanson A, Sala-Rabanal M, Roessler HI, Josifova D, Grange DK, van Haaften G, Nichols CG.

J Biol Chem. 2018 Feb 9;293(6):2041-2052. doi: 10.1074/jbc.RA117.000351. Epub 2017 Dec 22.

PMID:
29275331
6.

Studying Structural Dynamics of Potassium Channels by Single-Molecule FRET.

Wang S, Brettmann JB, Nichols CG.

Methods Mol Biol. 2018;1684:163-180. doi: 10.1007/978-1-4939-7362-0_13.

PMID:
29058191
7.

Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.

Cooper PE, McClenaghan C, Chen X, Stary-Weinzinger A, Nichols CG.

J Biol Chem. 2017 Oct 20;292(42):17387-17398. doi: 10.1074/jbc.M117.804971. Epub 2017 Aug 23.

PMID:
28842488
8.

Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice.

Qiao Y, Lipovsky C, Hicks S, Bhatnagar S, Li G, Khandekar A, Guzy R, Woo KV, Nichols CG, Efimov IR, Rentschler S.

Circ Res. 2017 Aug 18;121(5):549-563. doi: 10.1161/CIRCRESAHA.116.310396. Epub 2017 Jul 3.

9.

Conformational changes at cytoplasmic intersubunit interactions control Kir channel gating.

Wang S, Borschel WF, Heyman S, Hsu P, Nichols CG.

J Biol Chem. 2017 Jun 16;292(24):10087-10096. doi: 10.1074/jbc.M117.785154. Epub 2017 Apr 26.

10.

Modulation of TMEM16A channel activity by the von Willebrand factor type A (VWA) domain of the calcium-activated chloride channel regulator 1 (CLCA1).

Sala-Rabanal M, Yurtsever Z, Berry KN, Nichols CG, Brett TJ.

J Biol Chem. 2017 Jun 2;292(22):9164-9174. doi: 10.1074/jbc.M117.788232. Epub 2017 Apr 18.

11.

Control of Kir channel gating by cytoplasmic domain interface interactions.

Borschel WF, Wang S, Lee S, Nichols CG.

J Gen Physiol. 2017 May 1;149(5):561-576. doi: 10.1085/jgp.201611719. Epub 2017 Apr 7.

12.

Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells.

Emfinger CH, Welscher A, Yan Z, Wang Y, Conway H, Moss JB, Moss LG, Remedi MS, Nichols CG.

R Soc Open Sci. 2017 Feb 8;4(2):160808. doi: 10.1098/rsos.160808. eCollection 2017 Feb.

13.

Sulfonylurea challenge test in subjects diagnosed with type 1 diabetes mellitus.

Remedi MS, Thomas M, Nichols CG, Marshall BA.

Pediatr Diabetes. 2017 Dec;18(8):777-784. doi: 10.1111/pedi.12489. Epub 2017 Jan 23.

PMID:
28111849
14.

Clinical utility gene card for: Cantú syndrome.

Kirk EP, Scurr I, van Haaften G, van Haelst MM, Nichols CG, Williams M, Smithson SF, Grange DK.

Eur J Hum Genet. 2017 Apr;25(4). doi: 10.1038/ejhg.2016.185. Epub 2017 Jan 4. No abstract available.

15.

Diabetes induced by gain-of-function mutations in the Kir6.1 subunit of the KATP channel.

Remedi MS, Friedman JB, Nichols CG.

J Gen Physiol. 2017 Jan;149(1):75-84. doi: 10.1085/jgp.201611653. Epub 2016 Dec 12.

16.

Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption.

Jimah JR, Salinas ND, Sala-Rabanal M, Jones NG, Sibley LD, Nichols CG, Schlesinger PH, Tolia NH.

Elife. 2016 Dec 1;5. pii: e20621. doi: 10.7554/eLife.20621.

17.

Increased tolerance to stress in cardiac expressed gain-of-function of adenosine triphosphate-sensitive potassium channel subunit Kir6.1.

Henn MC, Janjua MB, Zhang H, Kanter EM, Makepeace CM, Schuessler RB, Nichols CG, Lawton JS.

J Surg Res. 2016 Dec;206(2):460-465. doi: 10.1016/j.jss.2016.08.043. Epub 2016 Aug 12.

PMID:
27884343
18.

Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids.

Lee SJ, Ren F, Zangerl-Plessl EM, Heyman S, Stary-Weinzinger A, Yuan P, Nichols CG.

J Gen Physiol. 2016 Sep;148(3):227-37. doi: 10.1085/jgp.201611616. Epub 2016 Aug 15.

19.

Neurologic and neuroimaging manifestations of Cantú syndrome: A case series.

Leon Guerrero CR, Pathak S, Grange DK, Singh GK, Nichols CG, Lee JM, Vo KD.

Neurology. 2016 Jul 19;87(3):270-6. doi: 10.1212/WNL.0000000000002861. Epub 2016 Jun 17.

20.

Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection.

Nichols CG.

Card Electrophysiol Clin. 2016 Jun;8(2):323-35. doi: 10.1016/j.ccep.2016.01.005. Epub 2016 Mar 19. Review.

21.

K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome.

Levin MD, Singh GK, Zhang HX, Uchida K, Kozel BA, Stein PK, Kovacs A, Westenbroek RE, Catterall WA, Grange DK, Nichols CG.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):6773-8. doi: 10.1073/pnas.1606465113. Epub 2016 May 31.

22.

Novel KCNJ10 Gene Variations Compromise Function of Inwardly Rectifying Potassium Channel 4.1.

Méndez-González MP, Kucheryavykh YV, Zayas-Santiago A, Vélez-Carrasco W, Maldonado-Martínez G, Cubano LA, Nichols CG, Skatchkov SN, Eaton MJ.

J Biol Chem. 2016 Apr 1;291(14):7716-26. doi: 10.1074/jbc.M115.679910. Epub 2016 Feb 11.

23.

Structural dynamics of potassium-channel gating revealed by single-molecule FRET.

Wang S, Vafabakhsh R, Borschel WF, Ha T, Nichols CG.

Nat Struct Mol Biol. 2016 Jan;23(1):31-36. doi: 10.1038/nsmb.3138. Epub 2015 Dec 7.

24.

Differential mechanisms of Cantú syndrome-associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel.

Cooper PE, Sala-Rabanal M, Lee SJ, Nichols CG.

J Gen Physiol. 2015 Dec;146(6):527-40. doi: 10.1085/jgp.201511495.

25.

Modular Design of the Selectivity Filter Pore Loop in a Novel Family of Prokaryotic 'Inward Rectifier' (NirBac) channels.

Zubcevic L, Wang S, Bavro VN, Lee SJ, Nichols CG, Tucker SJ.

Sci Rep. 2015 Oct 16;5:15305. doi: 10.1038/srep15305.

26.

Role of a Hydrophobic Pocket in Polyamine Interactions with the Polyspecific Organic Cation Transporter OCT3.

Li DC, Nichols CG, Sala-Rabanal M.

J Biol Chem. 2015 Nov 13;290(46):27633-43. doi: 10.1074/jbc.M115.668913. Epub 2015 Sep 24.

27.

Adenosine Triphosphate-Sensitive Potassium Channel Kir Subunits Implicated in Cardioprotection by Diazoxide.

Henn MC, Janjua MB, Kanter EM, Makepeace CM, Schuessler RB, Nichols CG, Lawton JS.

J Am Heart Assoc. 2015 Aug 24;4(8):e002016. doi: 10.1161/JAHA.115.002016.

28.

ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes.

Baier LJ, Muller YL, Remedi MS, Traurig M, Piaggi P, Wiessner G, Huang K, Stacy A, Kobes S, Krakoff J, Bennett PH, Nelson RG, Knowler WC, Hanson RL, Nichols CG, Bogardus C.

Diabetes. 2015 Dec;64(12):4322-32. doi: 10.2337/db15-0459. Epub 2015 Aug 5.

29.

ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target.

Nelson PT, Jicha GA, Wang WX, Ighodaro E, Artiushin S, Nichols CG, Fardo DW.

Ageing Res Rev. 2015 Nov;24(Pt B):111-25. doi: 10.1016/j.arr.2015.07.007. Epub 2015 Jul 28. Review.

30.

Electrophysiologic consequences of KATP gain of function in the heart: Conduction abnormalities in Cantu syndrome.

Levin MD, Zhang H, Uchida K, Grange DK, Singh GK, Nichols CG.

Heart Rhythm. 2015 Nov;12(11):2316-24. doi: 10.1016/j.hrthm.2015.06.042. Epub 2015 Jun 30.

31.

Diazoxide Cardioprotection Is Independent of Adenosine Triphosphate-Sensitive Potassium Channel Kir6.1 Subunit in Response to Stress.

Henn MC, Janjua MB, Zhang H, Kanter EM, Makepeace CM, Schuessler RB, Nichols CG, Lawton JS.

J Am Coll Surg. 2015 Aug;221(2):319-25. doi: 10.1016/j.jamcollsurg.2015.02.014. Epub 2015 Feb 21.

32.

Molecular Dynamics Simulations of KirBac1.1 Mutants Reveal Global Gating Changes of Kir Channels.

Linder T, Wang S, Zangerl-Plessl EM, Nichols CG, Stary-Weinzinger A.

J Chem Inf Model. 2015 Apr 27;55(4):814-22. doi: 10.1021/acs.jcim.5b00010. Epub 2015 Apr 3.

33.

Secreted CLCA1 modulates TMEM16A to activate Ca(2+)-dependent chloride currents in human cells.

Sala-Rabanal M, Yurtsever Z, Nichols CG, Brett TJ.

Elife. 2015 Mar 17;4. doi: 10.7554/eLife.05875.

34.

Remission of severe neonatal diabetes with very early sulfonylurea treatment.

Marshall BA, Green RP, Wambach J, White NH, Remedi MS, Nichols CG.

Diabetes Care. 2015 Mar;38(3):e38-9. doi: 10.2337/dc14-2124. No abstract available.

35.

Identification of a cholesterol-binding pocket in inward rectifier K(+) (Kir) channels.

Fürst O, Nichols CG, Lamoureux G, D'Avanzo N.

Biophys J. 2014 Dec 16;107(12):2786-2796. doi: 10.1016/j.bpj.2014.10.066.

36.

Modeling K,ATP--dependent excitability in pancreatic islets.

Silva JR, Cooper P, Nichols CG.

Biophys J. 2014 Nov 4;107(9):2016-26. doi: 10.1016/j.bpj.2014.09.037.

37.

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart.

Lavine KJ, Epelman S, Uchida K, Weber KJ, Nichols CG, Schilling JD, Ornitz DM, Randolph GJ, Mann DL.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16029-34. doi: 10.1073/pnas.1406508111. Epub 2014 Oct 27. Erratum in: Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):E1414. Dosage error in article text.

38.

Cantú Syndrome and Related Disorders.

Grange DK, Nichols CG, Singh GK.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018.
2014 Oct 2.

39.

Cardioprotective benefits of adenosine triphosphate-sensitive potassium channel opener diazoxide are lost with administration after the onset of stress in mouse and human myocytes.

Janjua MB, Makepeace CM, Anastacio MM, Schuessler RB, Nichols CG, Lawton JS.

J Am Coll Surg. 2014 Oct;219(4):803-13. doi: 10.1016/j.jamcollsurg.2014.05.010. Epub 2014 Jun 3.

40.

Pancreatic β cell dedifferentiation in diabetes and redifferentiation following insulin therapy.

Wang Z, York NW, Nichols CG, Remedi MS.

Cell Metab. 2014 May 6;19(5):872-82. doi: 10.1016/j.cmet.2014.03.010. Epub 2014 Apr 17.

41.

Cantú syndrome resulting from activating mutation in the KCNJ8 gene.

Cooper PE, Reutter H, Woelfle J, Engels H, Grange DK, van Haaften G, van Bon BW, Hoischen A, Nichols CG.

Hum Mutat. 2014 Jul;35(7):809-13. doi: 10.1002/humu.22555. Epub 2014 May 6.

42.

Direct activation of β-cell KATP channels with a novel xanthine derivative.

Raphemot R, Swale DR, Dadi PK, Jacobson DA, Cooper P, Wojtovich AP, Banerjee S, Nichols CG, Denton JS.

Mol Pharmacol. 2014 Jun;85(6):858-65. doi: 10.1124/mol.114.091884. Epub 2014 Mar 19.

43.

Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes.

Arakel EC, Brandenburg S, Uchida K, Zhang H, Lin YW, Kohl T, Schrul B, Sulkin MS, Efimov IR, Nichols CG, Lehnart SE, Schwappach B.

J Cell Sci. 2014 May 1;127(Pt 9):2106-19. doi: 10.1242/jcs.141440. Epub 2014 Feb 25.

44.

Focal congenital hyperinsulinism managed by medical treatment: a diagnostic algorithm based on molecular genetic screening.

Maiorana A, Barbetti F, Boiani A, Rufini V, Pizzoferro M, Francalanci P, Faletra F, Nichols CG, Grimaldi C, de Ville de Goyet J, Rahier J, Henquin JC, Dionisi-Vici C.

Clin Endocrinol (Oxf). 2014 Nov;81(5):679-88. doi: 10.1111/cen.12400. Epub 2014 Jan 30.

PMID:
24383515
45.

Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathy.

Cilvik SN, Wang JI, Lavine KJ, Uchida K, Castro A, Gierasch CM, Weinheimer CJ, House SL, Kovacs A, Nichols CG, Ornitz DM.

PLoS One. 2013 Dec 11;8(12):e82979. doi: 10.1371/journal.pone.0082979. eCollection 2013.

46.

Secondary anionic phospholipid binding site and gating mechanism in Kir2.1 inward rectifier channels.

Lee SJ, Wang S, Borschel W, Heyman S, Gyore J, Nichols CG.

Nat Commun. 2013;4:2786. doi: 10.1038/ncomms3786.

47.

Control of KirBac3.1 potassium channel gating at the interface between cytoplasmic domains.

Zubcevic L, Bavro VN, Muniz JR, Schmidt MR, Wang S, De Zorzi R, Venien-Bryan C, Sansom MS, Nichols CG, Tucker SJ.

J Biol Chem. 2014 Jan 3;289(1):143-51. doi: 10.1074/jbc.M113.501833. Epub 2013 Nov 20.

48.

Relationship between mitochondrial matrix volume and cellular volume in response to stress and the role of ATP-sensitive potassium channel.

Anastacio MM, Kanter EM, Makepeace CM, Keith AD, Zhang H, Schuessler RB, Nichols CG, Lawton JS.

Circulation. 2013 Sep 10;128(11 Suppl 1):S130-5. doi: 10.1161/CIRCULATIONAHA.112.000128.

49.

Effect of diaminopropionic acid (Dap) on the biophysical properties of a modified synthetic channel-forming peptide.

Bukovnik U, Sala-Rabanal M, Francis S, Frazier SJ, Schultz BD, Nichols CG, Tomich JM.

Mol Pharm. 2013 Oct 7;10(10):3959-66. doi: 10.1021/mp4002377. Epub 2013 Sep 23.

50.

Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle.

Li A, Knutsen RH, Zhang H, Osei-Owusu P, Moreno-Dominguez A, Harter TM, Uchida K, Remedi MS, Dietrich HH, Bernal-Mizrachi C, Blumer KJ, Mecham RP, Koster JC, Nichols CG.

J Am Heart Assoc. 2013 Aug 23;2(4):e000365. doi: 10.1161/JAHA.113.000365.

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