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Items: 1 to 50 of 99

1.

Radiotherapy versus transoral robotic surgery and neck dissection for oropharyngeal squamous cell carcinoma (ORATOR): an open-label, phase 2, randomised trial.

Nichols AC, Theurer J, Prisman E, Read N, Berthelet E, Tran E, Fung K, de Almeida JR, Bayley A, Goldstein DP, Hier M, Sultanem K, Richardson K, Mlynarek A, Krishnan S, Le H, Yoo J, MacNeil SD, Winquist E, Hammond JA, Venkatesan V, Kuruvilla S, Warner A, Mitchell S, Chen J, Corsten M, Johnson-Obaseki S, Eapen L, Odell M, Parker C, Wehrli B, Kwan K, Palma DA.

Lancet Oncol. 2019 Oct;20(10):1349-1359. doi: 10.1016/S1470-2045(19)30410-3. Epub 2019 Aug 12.

PMID:
31416685
2.

High Level Expression of MHC-II in HPV+ Head and Neck Cancers Suggests that Tumor Epithelial Cells Serve an Important Role as Accessory Antigen Presenting Cells.

Gameiro SF, Ghasemi F, Barrett JW, Nichols AC, Mymryk JS.

Cancers (Basel). 2019 Aug 7;11(8). pii: E1129. doi: 10.3390/cancers11081129.

3.

Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition.

Ruicci KM, Plantinga P, Pinto N, Khan MI, Stecho W, Dhaliwal SS, Yoo J, Fung K, MacNeil D, Mymryk JS, Barrett JW, Howlett CJ, Nichols AC.

Mol Oncol. 2019 Oct;13(10):2160-2177. doi: 10.1002/1878-0261.12558. Epub 2019 Aug 28.

4.

Closure of tracheocutaneous fistula using prefabricated conchal bowl cartilage and a supraclavicular flap.

Mundi N, Patel KB, Yeh DH, Nichols AC.

J Laryngol Otol. 2019 Aug;133(8):727-729. doi: 10.1017/S0022215119001427. Epub 2019 Jul 9.

PMID:
31284887
5.

Looking Back, Moving Forward: A Retrospective Review of Care Trends in an Academic Palliative and Supportive Care Program from 2004 to 2016.

Bagcivan G, Bakitas M, Palmore J, Kvale E, Nichols AC, Howell SL, Dionne-Odom JN, Mancarella GA, Osisami O, Hicks J, Huang CS, Tucker R.

J Palliat Med. 2019 Aug;22(8):970-976. doi: 10.1089/jpm.2018.0410. Epub 2019 Mar 11.

PMID:
30855204
6.

Predictors of cisplatin-induced ototoxicity and survival in chemoradiation treated head and neck cancer patients.

Teft WA, Winquist E, Nichols AC, Kuruvilla S, Richter S, Parker C, Francis P, Trinnear M, Lukovic J, Bukhari N, Choi YH, Welch S, Palma DA, Yoo J, Kim RB.

Oral Oncol. 2019 Feb;89:72-78. doi: 10.1016/j.oraloncology.2018.12.010. Epub 2018 Dec 21.

PMID:
30732962
7.

Novel minimally invasive transoral surgery bleeding model implemented in a nationwide otolaryngology emergencies bootcamp.

Sahovaler A, Eibling DE, Bruni I, Duvvuri U, MacNeil SD, Nichols AC, Yoo J, Fung K, Roth K.

J Robot Surg. 2019 Jan 23. doi: 10.1007/s11701-019-00920-7. [Epub ahead of print]

PMID:
30673979
8.

Mutational analysis of head and neck squamous cell carcinoma stratified by smoking status.

Ghasemi F, Prokopec SD, MacNeil D, Mundi N, Gameiro SF, Howlett C, Stecho W, Plantinga P, Pinto N, Ruicci KM, Khan MI, Yoo J, Fung K, Sahovaler A, Palma DA, Winquist E, Mymryk JS, Barrett JW, Boutros PC, Nichols AC.

JCI Insight. 2019 Jan 10;4(1). pii: 123443. doi: 10.1172/jci.insight.123443. [Epub ahead of print]

9.

Functional outcomes in early (T1/T2) supraglottic cancer: a systematic review.

van der Woerd B, Patel KB, Nichols AC, Fung K, Yoo J, MacNeil SD.

J Otolaryngol Head Neck Surg. 2018 Dec 18;47(1):76. doi: 10.1186/s40463-018-0321-8.

10.

Shouldering the load of mandible reconstruction: 81 cases of oromandibular reconstruction with the scapular tip free flap.

Yeh DH, Lee DJ, Sahovaler A, Fung K, MacNeil D, Nichols AC, Yoo J.

Head Neck. 2019 Jan;41(1):30-36. doi: 10.1002/hed.25342. Epub 2018 Dec 4.

PMID:
30511790
11.

A controlled trial of HNSCC patient-derived xenografts reveals broad efficacy of PI3Kα inhibition in controlling tumor growth.

Ruicci KM, Meens J, Sun RX, Rizzo G, Pinto N, Yoo J, Fung K, MacNeil D, Mymryk JS, Barrett JW, Boutros PC, Ailles L, Nichols AC.

Int J Cancer. 2019 Oct 15;145(8):2100-2106. doi: 10.1002/ijc.32009. Epub 2018 Dec 18.

PMID:
30468243
12.

Lestaurtinib is a potent inhibitor of anaplastic thyroid cancer cell line models.

Pinto N, Prokopec SD, Vizeacoumar F, Searle K, Lowerison M, Ruicci KM, Yoo J, Fung K, MacNeil D, Lacefield JC, Leong HS, Mymryk JS, Barrett JW, Datti A, Boutros PC, Nichols AC.

PLoS One. 2018 Nov 12;13(11):e0207152. doi: 10.1371/journal.pone.0207152. eCollection 2018.

13.

Treatment-naïve HPV+ head and neck cancers display a T-cell-inflamed phenotype distinct from their HPV- counterparts that has implications for immunotherapy.

Gameiro SF, Ghasemi F, Barrett JW, Koropatnick J, Nichols AC, Mymryk JS, Maleki Vareki S.

Oncoimmunology. 2018 Jul 30;7(10):e1498439. doi: 10.1080/2162402X.2018.1498439. eCollection 2018.

14.

The use of standardized order sets to improve adherence to evidence-based postoperative management in major head and neck surgery.

Ansari S, Fung K, MacNeil SD, Nichols AC, Yoo J, Sowerby LJ.

Eur Ann Otorhinolaryngol Head Neck Dis. 2018 Sep;135(5S):S107-S111. doi: 10.1016/j.anorl.2018.08.009. Epub 2018 Aug 28.

15.

ERK-TSC2 signalling in constitutively-active HRAS mutant HNSCC cells promotes resistance to PI3K inhibition.

Ruicci KM, Pinto N, Khan MI, Yoo J, Fung K, MacNeil D, Mymryk JS, Barrett JW, Nichols AC.

Oral Oncol. 2018 Sep;84:95-103. doi: 10.1016/j.oraloncology.2018.07.010. Epub 2018 Jul 27.

PMID:
30115483
16.

Moving Career Development Upstream: Evaluation of a Course for Internal Medicine Trainees Contemplating Career Pathways in Academic Medicine.

Kraemer RR, Wakelee JF, Hites L, Frank SJ, Saag K, Rogers DA, Nellore A, Erdmann N, Nichols AC, Merlin JS.

South Med J. 2018 Aug;111(8):471-475. doi: 10.14423/SMJ.0000000000000844.

17.

Predictors of plate extrusion in oromandibular free flap reconstruction.

Prasad J, Sahovaler A, Theurer J, Yeh DH, Fung K, MacNeil SD, Yoo J, Nichols AC.

Microsurgery. 2018 Sep;38(6):682-689. doi: 10.1002/micr.30349. Epub 2018 Jun 29.

PMID:
29956850
18.

High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines.

Ghasemi F, Black M, Sun RX, Vizeacoumar F, Pinto N, Ruicci KM, Yoo J, Fung K, MacNeil D, Palma DA, Winquist E, Mymryk JS, Ailles LA, Datti A, Barrett JW, Boutros PC, Nichols AC.

Oncotarget. 2018 May 25;9(40):26064-26071. doi: 10.18632/oncotarget.25436. eCollection 2018 May 25.

19.

The impact of seasonal operating room closures on wait times for oral cancer surgery.

Mundi N, Theurer J, Warner A, Yoo J, Fung K, MacNeil D, Dhaliwal S, Winquist E, Palma DA, Nichols AC.

Curr Oncol. 2018 Feb;25(1):67-72. doi: 10.3747/co.25.3726. Epub 2018 Feb 28.

20.

Treatment of early stage Supraglottic squamous cell carcinoma: meta-analysis comparing primary surgery versus primary radiotherapy.

Patel KB, Nichols AC, Fung K, Yoo J, MacNeil SD.

J Otolaryngol Head Neck Surg. 2018 Mar 5;47(1):19. doi: 10.1186/s40463-018-0262-2. Review.

21.

The prevalence of human papillomavirus in pediatric tonsils: a systematic review of the literature.

Wojtera M, Paradis J, Husein M, Nichols AC, Barrett JW, Salvadori MI, Strychowsky JE.

J Otolaryngol Head Neck Surg. 2018 Jan 30;47(1):8. doi: 10.1186/s40463-018-0255-1. Review.

22.

The incidence and management of non-head and neck incidentalomas for the head and neck surgeon.

Sahovaler A, Yeh DH, Morrison D, de Ribaupierre S, Izawa J, Power A, Inculet R, Parry N, Palma DA, Landis M, Leung A, Fung K, MacNeil SD, Yoo J, Nichols AC.

Oral Oncol. 2017 Nov;74:98-104. doi: 10.1016/j.oraloncology.2017.09.004. Epub 2017 Oct 2. Review. No abstract available.

PMID:
29103759
23.

Human papillomavirus dysregulates the cellular apparatus controlling the methylation status of H3K27 in different human cancers to consistently alter gene expression regardless of tissue of origin.

Gameiro SF, Kolendowski B, Zhang A, Barrett JW, Nichols AC, Torchia J, Mymryk JS.

Oncotarget. 2017 Aug 3;8(42):72564-72576. doi: 10.18632/oncotarget.19885. eCollection 2017 Sep 22.

24.

Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer.

Ghasemi F, Black M, Vizeacoumar F, Pinto N, Ruicci KM, Le CCSH, Lowerison MR, Leong HS, Yoo J, Fung K, MacNeil D, Palma DA, Winquist E, Mymryk JS, Boutros PC, Datti A, Barrett JW, Nichols AC.

Oncotarget. 2017 Apr 20;8(42):71512-71519. doi: 10.18632/oncotarget.17292. eCollection 2017 Sep 22.

25.

Analysis of Class I Major Histocompatibility Complex Gene Transcription in Human Tumors Caused by Human Papillomavirus Infection.

Gameiro SF, Zhang A, Ghasemi F, Barrett JW, Nichols AC, Mymryk JS.

Viruses. 2017 Sep 10;9(9). pii: E252. doi: 10.3390/v9090252.

26.

Estimating Survival After Salvage Surgery for Recurrent Oral Cavity Cancer.

Tam S, Araslanova R, Low TH, Warner A, Yoo J, Fung K, MacNeil SD, Palma DA, Nichols AC.

JAMA Otolaryngol Head Neck Surg. 2017 Jul 1;143(7):685-690. doi: 10.1001/jamaoto.2017.0001.

27.

Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas.

Papillon-Cavanagh S, Lu C, Gayden T, Mikael LG, Bechet D, Karamboulas C, Ailles L, Karamchandani J, Marchione DM, Garcia BA, Weinreb I, Goldstein D, Lewis PW, Dancu OM, Dhaliwal S, Stecho W, Howlett CJ, Mymryk JS, Barrett JW, Nichols AC, Allis CD, Majewski J, Jabado N.

Nat Genet. 2017 Feb;49(2):180-185. doi: 10.1038/ng.3757. Epub 2017 Jan 9.

28.

Cytokine and Growth Factor Concentrations in Canine Autologous Conditioned Serum.

Sawyere DM, Lanz OI, Dahlgren LA, Barry SL, Nichols AC, Werre SR.

Vet Surg. 2016 Jul;45(5):582-6. doi: 10.1111/vsu.12506.

PMID:
27357270
29.

Pedicled adipofascial infraclavicular flap: Elevation technique and its use for maintaining neck contour and vessel coverage after radical and modified radical neck dissection.

Yoo J, Low TH, Tam S, Partridge A, MacNeil SD, Nichols AC, Fung K.

Head Neck. 2016 Oct;38(10):1579-82. doi: 10.1002/hed.24472. Epub 2016 Apr 29.

PMID:
27126378
30.

Transoral robotic surgery vs. radiotherapy for management of oropharyngeal squamous cell carcinoma - A systematic review of the literature.

Yeh DH, Tam S, Fung K, MacNeil SD, Yoo J, Winquist E, Palma DA, Nichols AC.

Eur J Surg Oncol. 2015 Dec;41(12):1603-14. doi: 10.1016/j.ejso.2015.09.007. Epub 2015 Sep 26. Review.

PMID:
26461255
31.

Feasibility of Targeting PIK3CA Mutations in Head and Neck Squamous Cell Carcinoma.

Theurer JA, Stecho W, Yoo J, Kwan K, Wehrli B, Harry V, Black M, Pinto N, Winquist E, Palma D, Richter S, Barrett JW, Danielle MacNeil S, Fung K, Howlett CJ, Nichols AC.

Pathol Oncol Res. 2016 Jan;22(1):35-40. doi: 10.1007/s12253-015-9970-3. Epub 2015 Aug 14.

PMID:
26271341
32.

Exploiting high-throughput cell line drug screening studies to identify candidate therapeutic agents in head and neck cancer.

Nichols AC, Black M, Yoo J, Pinto N, Fernandes A, Haibe-Kains B, Boutros PC, Barrett JW.

BMC Pharmacol Toxicol. 2014 Nov 27;15:66. doi: 10.1186/2050-6511-15-66.

33.

Genomically driven precision medicine to improve outcomes in anaplastic thyroid cancer.

Pinto N, Black M, Patel K, Yoo J, Mymryk JS, Barrett JW, Nichols AC.

J Oncol. 2014;2014:936285. doi: 10.1155/2014/936285. Epub 2014 Sep 7. Review.

34.

Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands.

Weinreb I, Piscuoglio S, Martelotto LG, Waggott D, Ng CK, Perez-Ordonez B, Harding NJ, Alfaro J, Chu KC, Viale A, Fusco N, da Cruz Paula A, Marchio C, Sakr RA, Lim R, Thompson LD, Chiosea SI, Seethala RR, Skalova A, Stelow EB, Fonseca I, Assaad A, How C, Wang J, de Borja R, Chan-Seng-Yue M, Howlett CJ, Nichols AC, Wen YH, Katabi N, Buchner N, Mullen L, Kislinger T, Wouters BG, Liu FF, Norton L, McPherson JD, Rubin BP, Clarke BA, Weigelt B, Boutros PC, Reis-Filho JS.

Nat Genet. 2014 Nov;46(11):1166-9. doi: 10.1038/ng.3096. Epub 2014 Sep 21.

35.

Temporal changes in the efficacy of chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck: a systematic review and meta-analysis.

Winquist E, Al-Rasheedy I, Nichols AC, Palma DA, Stitt L.

Cancer Treat Rev. 2014 Oct;40(9):1073-9. doi: 10.1016/j.ctrv.2014.08.002. Epub 2014 Aug 27.

PMID:
25200522
36.

The control of anaplastic thyroid carcinoma cell lines by oncolytic poxviruses.

Mundi N, Um S, Yoo J, Rizzo G, Black M, Pinto N, Palma DA, Fung K, MacNeil D, Mymryk JS, Barrett JW, Nichols AC.

Virus Res. 2014 Sep 22;190:53-9. doi: 10.1016/j.virusres.2014.07.009. Epub 2014 Jul 16.

PMID:
25038405
37.

Variable expression of the forgotten oncogene E5 in HPV-positive oropharyngeal cancer.

Um SH, Mundi N, Yoo J, Palma DA, Fung K, MacNeil D, Wehrli B, Mymryk JS, Barrett JW, Nichols AC.

J Clin Virol. 2014 Sep;61(1):94-100. doi: 10.1016/j.jcv.2014.06.019. Epub 2014 Jun 30.

PMID:
25027574
38.

Defining the genomic landscape of head and neck cancers through next-generation sequencing.

Rizzo G, Black M, Mymryk JS, Barrett JW, Nichols AC.

Oral Dis. 2015 Jan;21(1):e11-24. doi: 10.1111/odi.12246. Epub 2014 Apr 30. Review.

PMID:
24725020
39.

The human papillomavirus E7 proteins associate with p190RhoGAP and alter its function.

Todorovic B, Nichols AC, Chitilian JM, Myers MP, Shepherd TG, Parsons SJ, Barrett JW, Banks L, Mymryk JS.

J Virol. 2014 Apr;88(7):3653-63. doi: 10.1128/JVI.03263-13. Epub 2014 Jan 8.

40.

Human papillomavirus in head and neck cancer.

Palma DA, Nichols AC.

CMAJ. 2014 Mar 18;186(5):370. doi: 10.1503/cmaj.130849. Epub 2013 Dec 2. Review. No abstract available.

41.

Vaccinia virus outperforms a panel of other poxviruses as a potent oncolytic agent for the control of head and neck squamous cell carcinoma cell lines.

Nichols AC, Yoo J, Um S, Mundi N, Palma DA, Fung K, Macneil SD, Koropatnick J, Mymryk JS, Barrett JW.

Intervirology. 2014;57(1):17-22. doi: 10.1159/000353854. Epub 2013 Aug 13.

42.

The epidemic of human papillomavirus and oropharyngeal cancer in a Canadian population.

Nichols AC, Palma DA, Dhaliwal SS, Tan S, Theuer J, Chow W, Rajakumar C, Um S, Mundi N, Berk S, Zhou R, Basmaji J, Rizzo G, Franklin JH, Fung K, Kwan K, Wehrli B, Salvadori MI, Winquist E, Ernst S, Kuruvilla S, Read N, Venkatesan V, Todorovic B, Hammond JA, Koropatnick J, Mymryk JS, Yoo J, Barrett JW.

Curr Oncol. 2013 Aug;20(4):212-9. doi: 10.3747/co.20.1375.

43.

High frequency of activating PIK3CA mutations in human papillomavirus-positive oropharyngeal cancer.

Nichols AC, Palma DA, Chow W, Tan S, Rajakumar C, Rizzo G, Fung K, Kwan K, Wehrli B, Winquist E, Koropatnick J, Mymryk JS, Yoo J, Barrett JW.

JAMA Otolaryngol Head Neck Surg. 2013 Jun;139(6):617-22. doi: 10.1001/jamaoto.2013.3210.

PMID:
23787421
44.

Viral retasking of hBre1/RNF20 to recruit hPaf1 for transcriptional activation.

Fonseca GJ, Cohen MJ, Nichols AC, Barrett JW, Mymryk JS.

PLoS Pathog. 2013;9(6):e1003411. doi: 10.1371/journal.ppat.1003411. Epub 2013 Jun 13.

45.

Does HPV type affect outcome in oropharyngeal cancer?

Nichols AC, Dhaliwal SS, Palma DA, Basmaji J, Chapeskie C, Dowthwaite S, Franklin JH, Fung K, Kwan K, Wehrli B, Howlett C, Siddiqui I, Salvadori MI, Winquist E, Ernst S, Kuruvilla S, Read N, Venkatesan V, Todorovic B, Hammond JA, Koropatnick J, Mymryk JS, Yoo J, Barrett JW.

J Otolaryngol Head Neck Surg. 2013 Feb 1;42:9. doi: 10.1186/1916-0216-42-9.

46.

Development of a transoral robotic surgery program in Canada.

Nichols AC, Fung K, Chapeskie C, Dowthwaite SA, Basmaji J, Dhaliwal S, Szeto CC, Palma DA, Theurer JA, Corsten MA, Odell M, Barrett JW, Franklin JH, Yoo J.

J Otolaryngol Head Neck Surg. 2013 Feb 1;42:8. doi: 10.1186/1916-0216-42-8.

47.

A case report and genetic characterization of a massive acinic cell carcinoma of the parotid with delayed distant metastases.

Nichols AC, Chan-Seng-Yue M, Yoo J, Agrawal SK, Starmans MH, Waggott D, Harding NJ, Dowthwaite SA, Palma DA, Fung K, Wehrli B, Macneil SD, Lambin P, Winquist E, Koropatnick J, Mymryk JS, Boutros PC, Barrett JW.

Case Rep Oncol Med. 2013;2013:270362. doi: 10.1155/2013/270362. Epub 2013 Apr 3.

48.

The use of autologous platelet and plasma products in salvage neck dissections: a prospective clinical study evaluating early and late wound healing.

Yoo J, Chandarana S, Fung K, Franklin JH, Nichols AC, Doyle PC.

J Biol Regul Homeost Agents. 2012 Apr-Jun;26(2 Suppl 1):63S-69S.

PMID:
23648200
49.

Early-stage squamous cell carcinoma of the oropharynx: radiotherapy vs. trans-oral robotic surgery (ORATOR)--study protocol for a randomized phase II trial.

Nichols AC, Yoo J, Hammond JA, Fung K, Winquist E, Read N, Venkatesan V, MacNeil SD, Ernst DS, Kuruvilla S, Chen J, Corsten M, Odell M, Eapen L, Theurer J, Doyle PC, Wehrli B, Kwan K, Palma DA.

BMC Cancer. 2013 Mar 20;13:133. doi: 10.1186/1471-2407-13-133.

50.

Transoral robotic total laryngectomy: report of 3 cases.

Dowthwaite S, Nichols AC, Yoo J, Smith RV, Dhaliwal S, Basmaji J, Franklin JH, Fung K.

Head Neck. 2013 Nov;35(11):E338-42. doi: 10.1002/hed.23226. Epub 2013 Mar 8.

PMID:
23471833

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