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Tropism of influenza B viruses in human respiratory tract explants and airway organoids.

Bui CHT, Chan RWY, Ng MMT, Cheung MC, Ng KC, Chan MPK, Chan LLY, Fong JHM, Nicholls JM, Peiris JSM, Chan MCW.

Eur Respir J. 2019 Aug 15;54(2). pii: 1900008. doi: 10.1183/13993003.00008-2019. Print 2019 Aug.


Risk assessment of the tropism & pathogenesis of the highly pathogenic avian influenza A/H7N9 virus using ex vivo & in vitro cultures of human respiratory tract.

Chan LLY, Hui KPY, Kuok DIT, Bui CHT, Ng KC, Mok CKP, Yang ZF, Guan W, Poon LLM, Zhong N, Peiris JSM, Nicholls JM, Chan MCW.

J Infect Dis. 2019 Apr 18. pii: jiz165. doi: 10.1093/infdis/jiz165. [Epub ahead of print]


Neuraminidase activity and specificity of influenza A virus are influenced by haemagglutinin-receptor binding.

Lai JCC, Karunarathna HMTK, Wong HH, Peiris JSM, Nicholls JM.

Emerg Microbes Infect. 2019;8(1):327-338. doi: 10.1080/22221751.2019.1581034.


Data Set for the Reporting of Carcinomas of the Nasopharynx and Oropharynx: Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting.

Lewis JS Jr, Adelstein DJ, Agaimy A, Carlson DL, Faquin WC, Helliwell T, Hille J, Ng T, Nicholls JM, O'Sullivan B, Thompson LDR.

Arch Pathol Lab Med. 2019 Apr;143(4):447-451. doi: 10.5858/arpa.2018-0405-SA. Epub 2018 Nov 30.


Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma.

Lin W, Yip YL, Jia L, Deng W, Zheng H, Dai W, Ko JMY, Lo KW, Chung GTY, Yip KY, Lee SD, Kwan JS, Zhang J, Liu T, Chan JY, Kwong DL, Lee VH, Nicholls JM, Busson P, Liu X, Chiang AKS, Hui KF, Kwok H, Cheung ST, Cheung YC, Chan CK, Li B, Cheung AL, Hau PM, Zhou Y, Tsang CM, Middeldorp J, Chen H, Lung ML, Tsao SW.

Nat Commun. 2018 Nov 7;9(1):4663. doi: 10.1038/s41467-018-06889-5.


Therapeutic Implications of Human Umbilical Cord Mesenchymal Stromal Cells in Attenuating Influenza A(H5N1) Virus-Associated Acute Lung Injury.

Loy H, Kuok DIT, Hui KPY, Choi MHL, Yuen W, Nicholls JM, Peiris JSM, Chan MCW.

J Infect Dis. 2019 Jan 7;219(2):186-196. doi: 10.1093/infdis/jiy478. Erratum in: J Infect Dis. 2019 Jan 7;219(2):339.


Tropism, replication competence, and innate immune responses of influenza virus: an analysis of human airway organoids and ex-vivo bronchus cultures.

Hui KPY, Ching RHH, Chan SKH, Nicholls JM, Sachs N, Clevers H, Peiris JSM, Chan MCW.

Lancet Respir Med. 2018 Nov;6(11):846-854. doi: 10.1016/S2213-2600(18)30236-4. Epub 2018 Jul 11.


Effect of interferon alpha and cyclosporine treatment separately and in combination on Middle East Respiratory Syndrome Coronavirus (MERS-CoV) replication in a human in-vitro and ex-vivo culture model.

Li HS, Kuok DIT, Cheung MC, Ng MMT, Ng KC, Hui KPY, Peiris JSM, Chan MCW, Nicholls JM.

Antiviral Res. 2018 Jul;155:89-96. doi: 10.1016/j.antiviral.2018.05.007. Epub 2018 May 17.


MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity.

Chu DKW, Hui KPY, Perera RAPM, Miguel E, Niemeyer D, Zhao J, Channappanavar R, Dudas G, Oladipo JO, Traoré A, Fassi-Fihri O, Ali A, Demissié GF, Muth D, Chan MCW, Nicholls JM, Meyerholz DK, Kuranga SA, Mamo G, Zhou Z, So RTY, Hemida MG, Webby RJ, Roger F, Rambaut A, Poon LLM, Perlman S, Drosten C, Chevalier V, Peiris M.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3144-3149. doi: 10.1073/pnas.1718769115. Epub 2018 Mar 5.


Characterization of influenza A viruses with polymorphism in PB2 residues 701 and 702.

Chin AWH, Leong NKC, Nicholls JM, Poon LLM.

Sci Rep. 2017 Sep 12;7(1):11361. doi: 10.1038/s41598-017-11625-y.


Replication of H9 influenza viruses in the human ex vivo respiratory tract, and the influence of neuraminidase on virus release.

Chan RWY, Chan LLY, Mok CKP, Lai J, Tao KP, Obadan A, Chan MCW, Perez DR, Peiris JSM, Nicholls JM.

Sci Rep. 2017 Jul 24;7(1):6208. doi: 10.1038/s41598-017-05853-5.


Tropism and innate host responses of influenza A/H5N6 virus: an analysis of ex vivo and in vitro cultures of the human respiratory tract.

Hui KP, Chan LL, Kuok DI, Mok CK, Yang ZF, Li RF, Luk GS, Lee EF, Lai JC, Yen HL, Zhu H, Guan Y, Nicholls JM, Peiris JS, Chan MC.

Eur Respir J. 2017 Mar 8;49(3). pii: 1601710. doi: 10.1183/13993003.01710-2016. Print 2017 Mar.


Prevention and treatment of swine-origin influenza virus with interferon: an in vivo and ex vivo study.

Nicholls JM, Chan RW, Fish E.

Hong Kong Med J. 2016 Dec;22 Suppl 7(6):10-14. No abstract available.


Evaluation of the human adaptation of influenza A/H7N9 virus in PB2 protein using human and swine respiratory tract explant cultures.

Chan LL, Bui CT, Mok CK, Ng MM, Nicholls JM, Peiris JS, Chan MC, Chan RW.

Sci Rep. 2016 Oct 14;6:35401. doi: 10.1038/srep35401.


Highly pathogenic avian influenza H5N1 virus delays apoptotic responses via activation of STAT3.

Hui KP, Li HS, Cheung MC, Chan RW, Yuen KM, Mok CK, Nicholls JM, Peiris JS, Chan MC.

Sci Rep. 2016 Jun 27;6:28593. doi: 10.1038/srep28593.


Pulmonary and central nervous system pathology in fatal cases of hand foot and mouth disease caused by enterovirus A71 infection.

Wang Z, Nicholls JM, Liu F, Wang J, Feng Z, Liu D, Sun Y, Zhou C, Li Y, Li H, Qi S, Huang X, Sui J, Liao Q, Peiris M, Yu H, Wang Y.

Pathology. 2016 Apr;48(3):267-74. doi: 10.1016/j.pathol.2015.12.450. Epub 2016 Mar 10.


Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo.

Chan MC, Kuok DI, Leung CY, Hui KP, Valkenburg SA, Lau EH, Nicholls JM, Fang X, Guan Y, Lee JW, Chan RW, Webster RG, Matthay MA, Peiris JS.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3621-6. doi: 10.1073/pnas.1601911113. Epub 2016 Mar 14.


Role of CD56-expressing immature biliary epithelial cells in biliary atresia.

Zhang RZ, Yu JK, Peng J, Wang FH, Liu HY, Lui VC, Nicholls JM, Tam PK, Lamb JR, Chen Y, Xia HM.

World J Gastroenterol. 2016 Feb 28;22(8):2545-57. doi: 10.3748/wjg.v22.i8.2545.


Generation of Live Attenuated Influenza Virus by Using Codon Usage Bias.

Fan RL, Valkenburg SA, Wong CK, Li OT, Nicholls JM, Rabadan R, Peiris JS, Poon LL.

J Virol. 2015 Nov;89(21):10762-73. doi: 10.1128/JVI.01443-15. Epub 2015 Aug 12.


Fatal H7N9 pneumonia complicated by viral infection of a prosthetic cardiac valve - an autopsy study.

Nicholls JM, Tsai PN, Chan RW, Hui KP, Chan MC, Malik Peiris JS, Chan KH, Yuen KY, To KK.

J Clin Virol. 2014 Nov;61(3):466-9. doi: 10.1016/j.jcv.2014.08.005. Epub 2014 Aug 15. No abstract available.


Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study.

Chan RW, Hemida MG, Kayali G, Chu DK, Poon LL, Alnaeem A, Ali MA, Tao KP, Ng HY, Chan MC, Guan Y, Nicholls JM, Peiris JS.

Lancet Respir Med. 2014 Oct;2(10):813-22. doi: 10.1016/S2213-2600(14)70158-4. Epub 2014 Aug 28.


Glycomic characterization of respiratory tract tissues of ferrets: implications for its use in influenza virus infection studies.

Jia N, Barclay WS, Roberts K, Yen HL, Chan RW, Lam AK, Air G, Peiris JS, Dell A, Nicholls JM, Haslam SM.

J Biol Chem. 2014 Oct 10;289(41):28489-504. doi: 10.1074/jbc.M114.588541. Epub 2014 Aug 18.


The R292K mutation that confers resistance to neuraminidase inhibitors leads to competitive fitness loss of A/Shanghai/1/2013 (H7N9) influenza virus in ferrets.

Yen HL, Zhou J, Choy KT, Sia SF, Teng O, Ng IH, Fang VJ, Hu Y, Wang W, Cowling BJ, Nicholls JM, Guan Y, Peiris JS.

J Infect Dis. 2014 Dec 15;210(12):1900-8. doi: 10.1093/infdis/jiu353. Epub 2014 Jun 20.


Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in Toll-like receptor 3 knockout mice.

Leung YH, Nicholls JM, Ho CK, Sia SF, Mok CK, Valkenburg SA, Cheung P, Hui KP, Chan RW, Guan Y, Akira S, Peiris JS.

J Gen Virol. 2014 Sep;95(Pt 9):1870-9. doi: 10.1099/vir.0.066258-0. Epub 2014 May 30.


IL-15 adjuvanted multivalent vaccinia-based universal influenza vaccine requires CD4+ T cells for heterosubtypic protection.

Valkenburg SA, Li OT, Mak PW, Mok CK, Nicholls JM, Guan Y, Waldmann TA, Peiris JS, Perera LP, Poon LL.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5676-81. doi: 10.1073/pnas.1403684111. Epub 2014 Mar 31.


Tropism and innate host responses of a novel avian influenza A H7N9 virus: an analysis of ex-vivo and in-vitro cultures of the human respiratory tract.

Chan MC, Chan RW, Chan LL, Mok CK, Hui KP, Fong JH, Tao KP, Poon LL, Nicholls JM, Guan Y, Peiris JS.

Lancet Respir Med. 2013 Sep;1(7):534-42. doi: 10.1016/S2213-2600(13)70138-3. Epub 2013 Jul 25.


Amino acid substitutions in polymerase basic protein 2 gene contribute to the pathogenicity of the novel A/H7N9 influenza virus in mammalian hosts.

Mok CK, Lee HH, Lestra M, Nicholls JM, Chan MC, Sia SF, Zhu H, Poon LL, Guan Y, Peiris JS.

J Virol. 2014 Mar;88(6):3568-76. doi: 10.1128/JVI.02740-13. Epub 2014 Jan 8.


The battle between influenza and the innate immune response in the human respiratory tract.

Nicholls JM.

Infect Chemother. 2013 Mar;45(1):11-21. doi: 10.3947/ic.2013.45.1.11. Epub 2013 Mar 29. Review.


Effect of clinical context on simulator-based assessment of blood pressure taking - a pilot randomized study.

Leung GK, Nicholls JM.

Med Teach. 2014 Feb;36(2):177-9. doi: 10.3109/0142159X.2013.849328. Epub 2013 Oct 24.


Investigation of the binding and cleavage characteristics of N1 neuraminidases from avian, seasonal, and pandemic influenza viruses using saturation transfer difference nuclear magnetic resonance.

Garcia JM, Lai JC, Haselhorst T, Choy KT, Yen HL, Peiris JS, von Itzstein M, Nicholls JM.

Influenza Other Respir Viruses. 2014 Mar;8(2):235-42. doi: 10.1111/irv.12184. Epub 2013 Sep 30.


Infection of swine ex vivo tissues with avian viruses including H7N9 and correlation with glycomic analysis.

Chan RW, Karamanska R, Van Poucke S, Van Reeth K, Chan IW, Chan MC, Dell A, Peiris JS, Haslam SM, Guan Y, Nicholls JM.

Influenza Other Respir Viruses. 2013 Nov;7(6):1269-82. doi: 10.1111/irv.12144. Epub 2013 Aug 27.


Pathogenicity of the novel A/H7N9 influenza virus in mice.

Mok CK, Lee HH, Chan MC, Sia SF, Lestra M, Nicholls JM, Zhu H, Guan Y, Peiris JM.

MBio. 2013 Jul 2;4(4). pii: e00362-13. doi: 10.1128/mBio.00362-13.


Use of ex vivo and in vitro cultures of the human respiratory tract to study the tropism and host responses of highly pathogenic avian influenza A (H5N1) and other influenza viruses.

Chan RW, Chan MC, Nicholls JM, Malik Peiris JS.

Virus Res. 2013 Dec 5;178(1):133-45. doi: 10.1016/j.virusres.2013.03.003. Epub 2013 May 15. Review.


The use of sialidase therapy for respiratory viral infections.

Nicholls JM, Moss RB, Haslam SM.

Antiviral Res. 2013 Jun;98(3):401-9. doi: 10.1016/j.antiviral.2013.04.012. Epub 2013 Apr 17. Review.


Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures.

Chan RW, Chan MC, Agnihothram S, Chan LL, Kuok DI, Fong JH, Guan Y, Poon LL, Baric RS, Nicholls JM, Peiris JS.

J Virol. 2013 Jun;87(12):6604-14. doi: 10.1128/JVI.00009-13. Epub 2013 Apr 3.


Glycomic analysis of human respiratory tract tissues and correlation with influenza virus infection.

Walther T, Karamanska R, Chan RW, Chan MC, Jia N, Air G, Hopton C, Wong MP, Dell A, Malik Peiris JS, Haslam SM, Nicholls JM.

PLoS Pathog. 2013 Mar;9(3):e1003223. doi: 10.1371/journal.ppat.1003223. Epub 2013 Mar 14.


Patient-specific induced-pluripotent stem cells-derived cardiomyocytes recapitulate the pathogenic phenotypes of dilated cardiomyopathy due to a novel DES mutation identified by whole exome sequencing.

Tse HF, Ho JC, Choi SW, Lee YK, Butler AW, Ng KM, Siu CW, Simpson MA, Lai WH, Chan YC, Au KW, Zhang J, Lay KW, Esteban MA, Nicholls JM, Colman A, Sham PC.

Hum Mol Genet. 2013 Apr 1;22(7):1395-403. doi: 10.1093/hmg/dds556. Epub 2013 Jan 8. Erratum in: Hum Mol Genet. 2014 Apr 15;23(8):2332-3.


Proinflammatory cytokine response and viral replication in mouse bone marrow derived macrophages infected with influenza H1N1 and H5N1 viruses.

Chan RW, Leung CY, Nicholls JM, Peiris JS, Chan MC.

PLoS One. 2012;7(11):e51057. doi: 10.1371/journal.pone.0051057. Epub 2012 Nov 30.


Studies on the sialylation of galactoses with different C-5 modified sialyl donors.

Gong J, Liu H, Nicholls JM, Li X.

Carbohydr Res. 2012 Nov 1;361:91-9. doi: 10.1016/j.carres.2012.08.007. Epub 2012 Aug 20.


Entry of influenza A Virus with a α2,6-linked sialic acid binding preference requires host fibronectin.

Leung HS, Li OT, Chan RW, Chan MC, Nicholls JM, Poon LL.

J Virol. 2012 Oct;86(19):10704-13. doi: 10.1128/JVI.01166-12. Epub 2012 Jul 25.


A global view of the oncogenic landscape in nasopharyngeal carcinoma: an integrated analysis at the genetic and expression levels.

Hu C, Wei W, Chen X, Woodman CB, Yao Y, Nicholls JM, Joab I, Sihota SK, Shao JY, Derkaoui KD, Amari A, Maloney SL, Bell AI, Murray PG, Dawson CW, Young LS, Arrand JR.

PLoS One. 2012;7(7):e41055. doi: 10.1371/journal.pone.0041055. Epub 2012 Jul 17.


LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma.

Chen H, Ko JM, Wong VC, Hyytiainen M, Keski-Oja J, Chua D, Nicholls JM, Cheung FM, Lee AW, Kwong DL, Chiu PM, Zabarovsky ER, Tsao SW, Tao Q, Kan R, Chan SH, Stanbridge EJ, Lung ML.

Cancer Lett. 2012 Dec 1;325(1):89-98. doi: 10.1016/j.canlet.2012.06.005. Epub 2012 Jun 26.


Highly pathogenic influenza A(H5N1) virus survival in complex artificial aquatic biotopes.

Horm VS, Gutiérrez RA, Nicholls JM, Buchy P.

PLoS One. 2012;7(4):e34160. doi: 10.1371/journal.pone.0034160. Epub 2012 Apr 13.


A secondary sialic acid binding site on influenza virus neuraminidase: fact or fiction?

Lai JC, Garcia JM, Dyason JC, Böhm R, Madge PD, Rose FJ, Nicholls JM, Peiris JS, Haselhorst T, von Itzstein M.

Angew Chem Int Ed Engl. 2012 Feb 27;51(9):2221-4. doi: 10.1002/anie.201108245. Epub 2012 Jan 26. No abstract available.


Eurasian Tree Sparrows, risk for H5N1 virus spread and human contamination through Buddhist ritual: an experimental approach.

Gutiérrez RA, Sorn S, Nicholls JM, Buchy P.

PLoS One. 2011;6(12):e28609. doi: 10.1371/journal.pone.0028609. Epub 2011 Dec 2.


Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties.

Huang Z, Cheng Y, Chiu PM, Cheung FM, Nicholls JM, Kwong DL, Lee AW, Zabarovsky ER, Stanbridge EJ, Lung HL, Lung ML.

Oncogene. 2012 Aug 9;31(32):3709-20. doi: 10.1038/onc.2011.529. Epub 2011 Dec 12.


Detection of highly pathogenic influenza and pandemic influenza virus in formalin fixed tissues by immunohistochemical methods.

Nicholls JM, Wong LP, Chan RW, Poon LL, So LK, Yen HL, Fung K, van Poucke S, Peiris JS.

J Virol Methods. 2012 Feb;179(2):409-13. doi: 10.1016/j.jviromet.2011.11.006. Epub 2011 Nov 18.


Tissue tropism of swine influenza viruses and reassortants in ex vivo cultures of the human respiratory tract and conjunctiva.

Chan RW, Kang SS, Yen HL, Li AC, Tang LL, Yu WC, Yuen KM, Chan IW, Wong DD, Lai WW, Kwong DL, Sihoe AD, Poon LL, Guan Y, Nicholls JM, Peiris JS, Chan MC.

J Virol. 2011 Nov;85(22):11581-7. doi: 10.1128/JVI.05662-11. Epub 2011 Aug 31.


Anatomical pathology is dead? Long live anatomical pathology.

Nicholls JM, Francis GD.

Pathology. 2011 Oct;43(6):635-41. doi: 10.1097/PAT.0b013e32834a404f.


Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets.

Yen HL, Liang CH, Wu CY, Forrest HL, Ferguson A, Choy KT, Jones J, Wong DD, Cheung PP, Hsu CH, Li OT, Yuen KM, Chan RW, Poon LL, Chan MC, Nicholls JM, Krauss S, Wong CH, Guan Y, Webster RG, Webby RJ, Peiris M.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14264-9. doi: 10.1073/pnas.1111000108. Epub 2011 Aug 8.

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