Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 31

1.

Using dissolved organic matter fluorescence to identify the provenance of nutrients in a lowland catchment; the River Thames, England.

Old GH, Naden PS, Harman M, Bowes MJ, Roberts C, Scarlett PM, Nicholls DJE, Armstrong LK, Wickham HD, Read DS.

Sci Total Environ. 2019 Feb 25;653:1240-1252. doi: 10.1016/j.scitotenv.2018.10.421. Epub 2018 Nov 2.

PMID:
30759564
2.

Impact of a five-dimensional framework on R&D productivity at AstraZeneca.

Morgan P, Brown DG, Lennard S, Anderton MJ, Barrett JC, Eriksson U, Fidock M, Hamrén B, Johnson A, March RE, Matcham J, Mettetal J, Nicholls DJ, Platz S, Rees S, Snowden MA, Pangalos MN.

Nat Rev Drug Discov. 2018 Mar;17(3):167-181. doi: 10.1038/nrd.2017.244. Epub 2018 Jan 19. Review.

PMID:
29348681
3.

Characterisation of a major phytoplankton bloom in the River Thames (UK) using flow cytometry and high performance liquid chromatography.

Moorhouse HL, Read DS, McGowan S, Wagner M, Roberts C, Armstrong LK, Nicholls DJE, Wickham HD, Hutchins MG, Bowes MJ.

Sci Total Environ. 2018 May 15;624:366-376. doi: 10.1016/j.scitotenv.2017.12.128. Epub 2017 Dec 16.

PMID:
29258037
4.

Pharmacological characterization of AZD5069, a slowly reversible CXC chemokine receptor 2 antagonist.

Nicholls DJ, Wiley K, Dainty I, MacIntosh F, Phillips C, Gaw A, Mårdh CK.

J Pharmacol Exp Ther. 2015 May;353(2):340-50. doi: 10.1124/jpet.114.221358. Epub 2015 Mar 3.

PMID:
25736418
5.

Micronucleus induction in the bone marrow of rats by pharmacological mechanisms. II: long-acting beta-2 agonism.

Pontén I, Mutch P, Nicholls DJ, Saad A, Pohl CD, Young A, Fred C, O'Donovan MR, Åberg P.

Mutagenesis. 2013 Mar;28(2):233-9. doi: 10.1093/mutage/ges078.

PMID:
23408845
6.

Characteristics of AZD9708, a novel, selective β2-adrenoceptor agonist with rapid onset and long duration of action.

Nicholls DJ, Jordan S, Cadogan E, Lawson M, Austin RP, Paine SW, Gardiner P, Bonnert R, Connolly S, Young A.

Pulm Pharmacol Ther. 2012 Aug;25(4):293-302. doi: 10.1016/j.pupt.2012.05.008. Epub 2012 May 29.

PMID:
22659538
7.

The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).

Cheshire DR, Åberg A, Andersson GM, Andrews G, Beaton HG, Birkinshaw TN, Boughton-Smith N, Connolly S, Cook TR, Cooper A, Cooper SL, Cox D, Dixon J, Gensmantel N, Hamley PJ, Harrison R, Hartopp P, Käck H, Leeson PD, Luker T, Mete A, Millichip I, Nicholls DJ, Pimm AD, St-Gallay SA, Wallace AV.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2468-71. doi: 10.1016/j.bmcl.2011.02.061. Epub 2011 Feb 18.

PMID:
21398123
8.

Formoterol and salmeterol induce a similar degree of β2-adrenoceptor tolerance in human small airways but via different mechanisms.

Cooper PR, Kurten RC, Zhang J, Nicholls DJ, Dainty IA, Panettieri RA.

Br J Pharmacol. 2011 Jun;163(3):521-32. doi: 10.1111/j.1476-5381.2011.01257.x.

9.

Agonist-specific patterns of beta 2-adrenoceptor responses in human airway cells during prolonged exposure.

Düringer C, Grundström G, Gürcan E, Dainty IA, Lawson M, Korn SH, Jerre A, Håkansson HF, Wieslander E, Fredriksson K, Sköld CM, Löfdahl M, Löfdahl CG, Nicholls DJ, Silberstein DS.

Br J Pharmacol. 2009 Sep;158(1):169-79. doi: 10.1111/j.1476-5381.2009.00262.x. Epub 2009 Jun 22.

10.

Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.

Garcin ED, Arvai AS, Rosenfeld RJ, Kroeger MD, Crane BR, Andersson G, Andrews G, Hamley PJ, Mallinder PR, Nicholls DJ, St-Gallay SA, Tinker AC, Gensmantel NP, Mete A, Cheshire DR, Connolly S, Stuehr DJ, Aberg A, Wallace AV, Tainer JA, Getzoff ED.

Nat Chem Biol. 2008 Nov;4(11):700-7. doi: 10.1038/nchembio.115. Epub 2008 Oct 12.

11.

Identification of a putative intracellular allosteric antagonist binding-site in the CXC chemokine receptors 1 and 2.

Nicholls DJ, Tomkinson NP, Wiley KE, Brammall A, Bowers L, Grahames C, Gaw A, Meghani P, Shelton P, Wright TJ, Mallinder PR.

Mol Pharmacol. 2008 Nov;74(5):1193-202. doi: 10.1124/mol.107.044610. Epub 2008 Aug 1.

PMID:
18676678
12.

2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.

Connolly S, Aberg A, Arvai A, Beaton HG, Cheshire DR, Cook AR, Cooper S, Cox D, Hamley P, Mallinder P, Millichip I, Nicholls DJ, Rosenfeld RJ, St-Gallay SA, Tainer J, Tinker AC, Wallace AV.

J Med Chem. 2004 Jun 3;47(12):3320-3.

PMID:
15163211
13.

1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.

Tinker AC, Beaton HG, Boughton-Smith N, Cook TR, Cooper SL, Fraser-Rae L, Hallam K, Hamley P, McInally T, Nicholls DJ, Pimm AD, Wallace AV.

J Med Chem. 2003 Mar 13;46(6):913-6.

PMID:
12620067
14.

Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity.

Beaton H, Boughton-Smith N, Hamley P, Ghelani A, Nicholls DJ, Tinker AC, Wallace AV.

Bioorg Med Chem Lett. 2001 Apr 23;11(8):1027-30.

PMID:
11327581
15.

3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.

Beaton H, Hamley P, Nicholls DJ, Tinker AC, Wallace AV.

Bioorg Med Chem Lett. 2001 Apr 23;11(8):1023-6.

PMID:
11327580
17.

Reversibility of inhibition of human type II nitric oxide synthase.

Nicholls DJ, Kirk A, Wallace AV.

Biochem Soc Trans. 1996 Feb;24(1):20S. No abstract available.

PMID:
8674663
18.

Nurses' attitudes about floating.

Nicholls DJ, Duplaga EA, Meyer LM.

Nurs Manage. 1996 Jan;27(1):56-8. No abstract available.

PMID:
8552363
19.

Catalytic-rate improvement of a thermostable malate dehydrogenase by a subtle alteration in cofactor binding.

Alldread RM, Halsall DM, Clarke AR, Sundaram TK, Atkinson T, Scawen MD, Nicholls DJ.

Biochem J. 1995 Jan 15;305 ( Pt 2):539-48.

20.

Malate dehydrogenase: a model for structure, evolution, and catalysis.

Goward CR, Nicholls DJ.

Protein Sci. 1994 Oct;3(10):1883-8. Review.

21.

Erwinia chrysanthemi L-asparaginase: epitope mapping and production of antigenically modified enzymes.

Moola ZB, Scawen MD, Atkinson T, Nicholls DJ.

Biochem J. 1994 Sep 15;302 ( Pt 3):921-7.

22.

A single amino acid mutation enhances the thermal stability of Escherichia coli malate dehydrogenase.

Goward CR, Miller J, Nicholls DJ, Irons LI, Scawen MD, O'Brien R, Chowdhry BZ.

Eur J Biochem. 1994 Aug 15;224(1):249-55.

23.

Contribution of a buried aspartate residue towards the catalytic efficiency and structural stability of Bacillus stearothermophilus lactate dehydrogenase.

Nobbs TJ, Cortés A, Gelpi JL, Holbrook JJ, Atkinson T, Scawen MD, Nicholls DJ.

Biochem J. 1994 Jun 1;300 ( Pt 2):491-9.

24.

An investigation of the thermal stabilities of two malate dehydrogenases by comparison of their three-dimensional structures.

Duffield ML, Nicholls DJ, Atkinson T, Scawen MD.

J Mol Graph. 1994 Mar;12(1):14-21, 34.

PMID:
8011596
25.

Substitution of the amino acid at position 102 with polar and aromatic residues influences substrate specificity of lactate dehydrogenase.

Nicholls DJ, Davey M, Jones SE, Miller J, Holbrook JJ, Clarke AR, Scawen MD, Atkinson T, Goward CR.

J Protein Chem. 1994 Jan;13(1):129-33.

PMID:
8011065
26.

Dissecting the contributions of a specific side-chain interaction to folding and catalysis of Bacillus stearothermophilus lactate dehydrogenase.

Nicholls DJ, Wood IS, Nobbs TJ, Clarke AR, Holbrook JJ, Atkinson T, Scawen MD.

Eur J Biochem. 1993 Mar 1;212(2):447-55.

27.

The importance of arginine 102 for the substrate specificity of Escherichia coli malate dehydrogenase.

Nicholls DJ, Miller J, Scawen MD, Clarke AR, Holbrook JJ, Atkinson T, Goward CR.

Biochem Biophys Res Commun. 1992 Dec 15;189(2):1057-62.

PMID:
1472016
28.

Cloning and overexpression of Lactobacillus helveticus D-lactate dehydrogenase gene in Escherichia coli.

Kochhar S, Hottinger H, Chuard N, Taylor PG, Atkinson T, Scawen MD, Nicholls DJ.

Eur J Biochem. 1992 Sep 15;208(3):799-805.

29.

Overexpression of the Thermus aquaticus B malate dehydrogenase-encoding gene in Escherichia coli.

Alldread RM, Nicholls DJ, Sundaram TK, Scawen MD, Atkinson T.

Gene. 1992 May 1;114(1):139-43.

PMID:
1587476
30.

Cloning and nucleotide sequences of the mdh and sucD genes from Thermus aquaticus B.

Nicholls DJ, Sundaram TK, Atkinson T, Minton NP.

FEMS Microbiol Lett. 1990 Jun 15;58(1):7-14.

PMID:
2204576
31.

Nucleotide sequence of the succinyl-CoA synthetase alpha-subunit from Thermus aquaticus B.

Nicholls DJ, Sundaram TK, Atkinson T, Minton NP.

Nucleic Acids Res. 1988 Oct 25;16(20):9858. No abstract available.

Supplemental Content

Loading ...
Support Center