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Items: 1 to 50 of 99

1.

Oncoprotein AEG-1 is an endoplasmic reticulum RNA-binding protein whose interactome is enriched in organelle resident protein-encoding mRNAs.

Hsu JC, Reid DW, Hoffman AM, Sarkar D, Nicchitta CV.

RNA. 2018 May;24(5):688-703. doi: 10.1261/rna.063313.117. Epub 2018 Feb 7.

PMID:
29438049
2.

Dengue Virus Selectively Annexes Endoplasmic Reticulum-Associated Translation Machinery as a Strategy for Co-opting Host Cell Protein Synthesis.

Reid DW, Campos RK, Child JR, Zheng T, Chan KWK, Bradrick SS, Vasudevan SG, Garcia-Blanco MA, Nicchitta CV.

J Virol. 2018 Mar 14;92(7). pii: e01766-17. doi: 10.1128/JVI.01766-17. Print 2018 Apr 1.

PMID:
29321322
3.

Complementary Roles of GADD34- and CReP-Containing Eukaryotic Initiation Factor 2α Phosphatases during the Unfolded Protein Response.

Reid DW, Tay AS, Sundaram JR, Lee IC, Chen Q, George SE, Nicchitta CV, Shenolikar S.

Mol Cell Biol. 2016 Jun 15;36(13):1868-80. doi: 10.1128/MCB.00190-16. Print 2016 Jul 1.

4.

Simple and inexpensive ribosome profiling analysis of mRNA translation.

Reid DW, Shenolikar S, Nicchitta CV.

Methods. 2015 Dec;91:69-74. doi: 10.1016/j.ymeth.2015.07.003. Epub 2015 Jul 8.

5.

LOCAL TRANSLATION. Comment on "Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling".

Reid DW, Nicchitta CV.

Science. 2015 Jun 12;348(6240):1217. doi: 10.1126/science.aaa7257. Epub 2015 Jun 11.

6.

Diversity and selectivity in mRNA translation on the endoplasmic reticulum.

Reid DW, Nicchitta CV.

Nat Rev Mol Cell Biol. 2015 Apr;16(4):221-31. doi: 10.1038/nrm3958. Epub 2015 Mar 4. Review.

7.

A novel ribosomopathy caused by dysfunction of RPL10 disrupts neurodevelopment and causes X-linked microcephaly in humans.

Brooks SS, Wall AL, Golzio C, Reid DW, Kondyles A, Willer JR, Botti C, Nicchitta CV, Katsanis N, Davis EE.

Genetics. 2014 Oct;198(2):723-33. doi: 10.1534/genetics.114.168211.

8.

The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum.

Reid DW, Chen Q, Tay AS, Shenolikar S, Nicchitta CV.

Cell. 2014 Sep 11;158(6):1362-1374. doi: 10.1016/j.cell.2014.08.012.

9.

De novo translation initiation on membrane-bound ribosomes as a mechanism for localization of cytosolic protein mRNAs to the endoplasmic reticulum.

Jagannathan S, Reid DW, Cox AH, Nicchitta CV.

RNA. 2014 Oct;20(10):1489-98. doi: 10.1261/rna.045526.114. Epub 2014 Aug 20.

10.

Multifunctional roles for the protein translocation machinery in RNA anchoring to the endoplasmic reticulum.

Jagannathan S, Hsu JC, Reid DW, Chen Q, Thompson WJ, Moseley AM, Nicchitta CV.

J Biol Chem. 2014 Sep 12;289(37):25907-24. doi: 10.1074/jbc.M114.580688. Epub 2014 Jul 25.

11.

Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells.

Epple LM, Dodd RD, Merz AL, Dechkovskaia AM, Herring M, Winston BA, Lencioni AM, Russell RL, Madsen H, Nega M, Dusto NL, White J, Bigner DD, Nicchitta CV, Serkova NJ, Graner MW.

PLoS One. 2013 Aug 15;8(8):e73267. doi: 10.1371/journal.pone.0073267. eCollection 2013.

12.

Premature translational termination products are rapidly degraded substrates for MHC class I presentation.

Lacsina JR, Marks OA, Liu X, Reid DW, Jagannathan S, Nicchitta CV.

PLoS One. 2012;7(12):e51968. doi: 10.1371/journal.pone.0051968. Epub 2012 Dec 14.

13.

Rare codons regulate KRas oncogenesis.

Lampson BL, Pershing NL, Prinz JA, Lacsina JR, Marzluff WF, Nicchitta CV, MacAlpine DM, Counter CM.

Curr Biol. 2013 Jan 7;23(1):70-5. doi: 10.1016/j.cub.2012.11.031. Epub 2012 Dec 13.

14.

Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance.

LaMonte G, Philip N, Reardon J, Lacsina JR, Majoros W, Chapman L, Thornburg CD, Telen MJ, Ohler U, Nicchitta CV, Haystead T, Chi JT.

Cell Host Microbe. 2012 Aug 16;12(2):187-99. doi: 10.1016/j.chom.2012.06.007.

15.

Glycoprotein 96 perpetuates the persistent inflammation of rheumatoid arthritis.

Huang QQ, Koessler RE, Birkett R, Dorfleutner A, Perlman H, Haines GK 3rd, Stehlik C, Nicchitta CV, Pope RM.

Arthritis Rheum. 2012 Nov;64(11):3638-48. doi: 10.1002/art.34610.

16.

Development of a Grp94 inhibitor.

Duerfeldt AS, Peterson LB, Maynard JC, Ng CL, Eletto D, Ostrovsky O, Shinogle HE, Moore DS, Argon Y, Nicchitta CV, Blagg BS.

J Am Chem Soc. 2012 Jun 13;134(23):9796-804. doi: 10.1021/ja303477g. Epub 2012 May 29.

17.

The enduring enigma of nuclear translation.

Reid DW, Nicchitta CV.

J Cell Biol. 2012 Apr 2;197(1):7-9. doi: 10.1083/jcb.201202140.

18.

Primary role for endoplasmic reticulum-bound ribosomes in cellular translation identified by ribosome profiling.

Reid DW, Nicchitta CV.

J Biol Chem. 2012 Feb 17;287(8):5518-27. doi: 10.1074/jbc.M111.312280. Epub 2011 Dec 23.

19.

Hierarchical regulation of mRNA partitioning between the cytoplasm and the endoplasmic reticulum of mammalian cells.

Chen Q, Jagannathan S, Reid DW, Zheng T, Nicchitta CV.

Mol Biol Cell. 2011 Jul 15;22(14):2646-58. doi: 10.1091/mbc.E11-03-0239. Epub 2011 May 25.

20.

Polysome profiling of the malaria parasite Plasmodium falciparum.

Lacsina JR, LaMonte G, Nicchitta CV, Chi JT.

Mol Biochem Parasitol. 2011 Sep;179(1):42-6. doi: 10.1016/j.molbiopara.2011.05.003. Epub 2011 May 13.

21.

Out with the old, in with the new? Comparing methods for measuring protein degradation.

Yewdell JW, Lacsina JR, Rechsteiner MC, Nicchitta CV.

Cell Biol Int. 2011 May;35(5):457-62. doi: 10.1042/CBI20110055. Review.

22.

Analyzing mRNA localization to the endoplasmic reticulum via cell fractionation.

Jagannathan S, Nwosu C, Nicchitta CV.

Methods Mol Biol. 2011;714:301-21. doi: 10.1007/978-1-61779-005-8_19.

23.

Re-examination of CD91 function in GRP94 (glycoprotein 96) surface binding, uptake, and peptide cross-presentation.

Jockheck-Clark AR, Bowers EV, Totonchy MB, Neubauer J, Pizzo SV, Nicchitta CV.

J Immunol. 2010 Dec 1;185(11):6819-30. doi: 10.4049/jimmunol.1000448. Epub 2010 Nov 3.

24.

Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control.

Maynard JC, Pham T, Zheng T, Jockheck-Clark A, Rankin HB, Newgard CB, Spana EP, Nicchitta CV.

Dev Biol. 2010 Mar 15;339(2):295-306. doi: 10.1016/j.ydbio.2009.12.023. Epub 2010 Jan 4.

25.

Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent.

Lev A, Dimberu P, Das SR, Maynard JC, Nicchitta CV, Bennink JR, Yewdell JW.

J Immunol. 2009 Oct 1;183(7):4205-10. doi: 10.4049/jimmunol.0901828. Epub 2009 Sep 14. Erratum in: J Immunol. 2010 Jul 1;185(1):770.

26.

Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling.

Huang QQ, Sobkoviak R, Jockheck-Clark AR, Shi B, Mandelin AM 2nd, Tak PP, Haines GK 3rd, Nicchitta CV, Pope RM.

J Immunol. 2009 Apr 15;182(8):4965-73. doi: 10.4049/jimmunol.0801563.

27.

Cell biology: How to combat stress.

Nicchitta CV.

Nature. 2009 Feb 5;457(7230):668-9. doi: 10.1038/457668a. No abstract available.

PMID:
19194438
28.

The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation.

Lev A, Takeda K, Zanker D, Maynard JC, Dimberu P, Waffarn E, Gibbs J, Netzer N, Princiotta MF, Neckers L, Picard D, Nicchitta CV, Chen W, Reiter Y, Bennink JR, Yewdell JW.

Immunity. 2008 Jun;28(6):787-98. doi: 10.1016/j.immuni.2008.04.015.

29.

Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo.

Tewalt EF, Maynard JC, Walters JJ, Schell AM, Berwin BL, Nicchitta CV, Norbury CC.

Immunology. 2008 Dec;125(4):480-91. doi: 10.1111/j.1365-2567.2008.02861.x. Epub 2008 May 15.

30.

Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells.

Stephens SB, Dodd RD, Lerner RS, Pyhtila BM, Nicchitta CV.

Methods Mol Biol. 2008;419:197-214. doi: 10.1007/978-1-59745-033-1_14.

PMID:
18369985
31.

Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum.

Pyhtila B, Zheng T, Lager PJ, Keene JD, Reedy MC, Nicchitta CV.

RNA. 2008 Mar;14(3):445-53. doi: 10.1261/rna.721108. Epub 2008 Jan 11.

32.
33.

In vitro and tissue culture methods for analysis of translation initiation on the endoplasmic reticulum.

Stephens SB, Nicchitta CV.

Methods Enzymol. 2007;431:47-60. Review.

PMID:
17923230
34.

The DRiP hypothesis decennial: support, controversy, refinement and extension.

Yewdell JW, Nicchitta CV.

Trends Immunol. 2006 Aug;27(8):368-73. Epub 2006 Jul 11.

PMID:
16815756
35.

Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses.

Warger T, Hilf N, Rechtsteiner G, Haselmayer P, Carrick DM, Jonuleit H, von Landenberg P, Rammensee HG, Nicchitta CV, Radsak MP, Schild H.

J Biol Chem. 2006 Aug 11;281(32):22545-53. Epub 2006 Jun 5.

36.

Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94.

Chu F, Maynard JC, Chiosis G, Nicchitta CV, Burlingame AL.

Protein Sci. 2006 Jun;15(6):1260-9.

37.

Synthesis of Hsp90 dimerization modulators.

Chiosis G, Aguirre J, Nicchitta CV.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3529-32. Epub 2006 Apr 18.

PMID:
16621545
39.

Pathways for compartmentalizing protein synthesis in eukaryotic cells: the template-partitioning model.

Nicchitta CV, Lerner RS, Stephens SB, Dodd RD, Pyhtila B.

Biochem Cell Biol. 2005 Dec;83(6):687-95. Review.

PMID:
16333319
40.

Enhancement of cancer radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94/gp96 expression.

Liu S, Wang H, Yang Z, Kon T, Zhu J, Cao Y, Li F, Kirkpatrick J, Nicchitta CV, Li CY.

Cancer Res. 2005 Oct 15;65(20):9126-31.

41.

Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translation.

Stephens SB, Dodd RD, Brewer JW, Lager PJ, Keene JD, Nicchitta CV.

Mol Biol Cell. 2005 Dec;16(12):5819-31. Epub 2005 Oct 12.

42.

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor.

Kovacs JJ, Murphy PJ, Gaillard S, Zhao X, Wu JT, Nicchitta CV, Yoshida M, Toft DO, Pratt WB, Yao TP.

Mol Cell. 2005 May 27;18(5):601-7.

43.

Catheter-mediated subselective intracoronary gene delivery to the rabbit heart: introduction of a novel method.

Parsa CJ, Reed RC, Walton GB, Pascal LS, Thompson RB, Petrofski JA, Emani SM, Folgar F, Riel RU, Nicchitta CV, Koch WJ.

J Gene Med. 2005 May;7(5):595-603.

PMID:
15651066
44.

The messenger and the message: gp96 (GRP94)-peptide interactions in cellular immunity.

Nicchitta CV, Carrick DM, Baker-Lepain JC.

Cell Stress Chaperones. 2004 Winter;9(4):325-31. Review.

45.

Adenosine nucleotides and the regulation of GRP94-client protein interactions.

Rosser MF, Trotta BM, Marshall MR, Berwin B, Nicchitta CV.

Biochemistry. 2004 Jul 13;43(27):8835-45.

PMID:
15236592
46.
47.

Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells.

Berwin B, Hart JP, Rice S, Gass C, Pizzo SV, Post SR, Nicchitta CV.

EMBO J. 2003 Nov 17;22(22):6127-36.

48.

Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation.

Soldano KL, Jivan A, Nicchitta CV, Gewirth DT.

J Biol Chem. 2003 Nov 28;278(48):48330-8. Epub 2003 Sep 11.

49.
50.

Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes.

Lerner RS, Seiser RM, Zheng T, Lager PJ, Reedy MC, Keene JD, Nicchitta CV.

RNA. 2003 Sep;9(9):1123-37.

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