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PACRG and FAP20 form the inner junction of axonemal doublet microtubules and regulate ciliary motility.

Dymek EE, Lin J, Fu G, Porter ME, Nicastro D, Smith EF.

Mol Biol Cell. 2019 Jul 15;30(15):1805-1816. doi: 10.1091/mbc.E19-01-0063. Epub 2019 May 22.


Morphological Plasticity in a Sulfur-Oxidizing Marine Bacterium from the SUP05 Clade Enhances Dark Carbon Fixation.

Shah V, Zhao X, Lundeen RA, Ingalls AE, Nicastro D, Morris RM.

MBio. 2019 May 7;10(3). pii: e00216-19. doi: 10.1128/mBio.00216-19.


Heterotrophic carbon metabolism and energy acquisition in Candidatus Thioglobus singularis strain PS1, a member of the SUP05 clade of marine Gammaproteobacteria.

Spietz RL, Lundeen RA, Zhao X, Nicastro D, Ingalls AE, Morris RM.

Environ Microbiol. 2019 Jul;21(7):2391-2401. doi: 10.1111/1462-2920.14623. Epub 2019 Apr 24.


Membrane bridging by Munc13-1 is crucial for neurotransmitter release.

Quade B, Camacho M, Zhao X, Orlando M, Trimbuch T, Xu J, Li W, Nicastro D, Rosenmund C, Rizo J.

Elife. 2019 Feb 28;8. pii: e42806. doi: 10.7554/eLife.42806.


Mdm1 maintains endoplasmic reticulum homeostasis by spatially regulating lipid droplet biogenesis.

Hariri H, Speer N, Bowerman J, Rogers S, Fu G, Reetz E, Datta S, Feathers JR, Ugrankar R, Nicastro D, Henne WM.

J Cell Biol. 2019 Apr 1;218(4):1319-1334. doi: 10.1083/jcb.201808119. Epub 2019 Feb 26.


Ionotropic Receptors Specify the Morphogenesis of Phasic Sensors Controlling Rapid Thermal Preference in Drosophila.

Budelli G, Ni L, Berciu C, van Giesen L, Knecht ZA, Chang EC, Kaminski B, Silbering AF, Samuel A, Klein M, Benton R, Nicastro D, Garrity PA.

Neuron. 2019 Feb 20;101(4):738-747.e3. doi: 10.1016/j.neuron.2018.12.022. Epub 2019 Jan 14.


Tetrahymena RIB72A and RIB72B are microtubule inner proteins in the ciliary doublet microtubules.

Stoddard D, Zhao Y, Bayless BA, Gui L, Louka P, Dave D, Suryawanshi S, Tomasi RF, Dupuis-Williams P, Baroud CN, Gaertig J, Winey M, Nicastro D.

Mol Biol Cell. 2018 Oct 15;29(21):2566-2577. doi: 10.1091/mbc.E18-06-0405. Epub 2018 Aug 22.


Asymmetric distribution and spatial switching of dynein activity generates ciliary motility.

Lin J, Nicastro D.

Science. 2018 Apr 27;360(6387). pii: eaar1968. doi: 10.1126/science.aar1968.


Ciliary proteins Fap43 and Fap44 interact with each other and are essential for proper cilia and flagella beating.

Urbanska P, Joachimiak E, Bazan R, Fu G, Poprzeczko M, Fabczak H, Nicastro D, Wloga D.

Cell Mol Life Sci. 2018 Dec;75(24):4479-4493. doi: 10.1007/s00018-018-2819-7. Epub 2018 Apr 23.


The I1 dynein-associated tether and tether head complex is a conserved regulator of ciliary motility.

Fu G, Wang Q, Phan N, Urbanska P, Joachimiak E, Lin J, Wloga D, Nicastro D.

Mol Biol Cell. 2018 May 1;29(9):1048-1059. doi: 10.1091/mbc.E18-02-0142. Epub 2018 Mar 22.


The IDA3 adapter, required for intraflagellar transport of I1 dynein, is regulated by ciliary length.

Hunter EL, Lechtreck K, Fu G, Hwang J, Lin H, Gokhale A, Alford LM, Lewis B, Yamamoto R, Kamiya R, Yang F, Nicastro D, Dutcher SK, Wirschell M, Sale WS.

Mol Biol Cell. 2018 Apr 15;29(8):886-896. doi: 10.1091/mbc.E17-12-0729. Epub 2018 Mar 29.


Cellular Uptake of A Taurine-Modified, Ester Bond-Decorated D-Peptide Derivative via Dynamin-Based Endocytosis and Macropinocytosis.

Zhou J, Du X, Berciu C, Del Signore SJ, Chen X, Yamagata N, Rodal AA, Nicastro D, Xu B.

Mol Ther. 2018 Feb 7;26(2):648-658. doi: 10.1016/j.ymthe.2017.11.020. Epub 2018 Jan 6.


DRC2/CCDC65 is a central hub for assembly of the nexin-dynein regulatory complex and other regulators of ciliary and flagellar motility.

Bower R, Tritschler D, Mills KV, Heuser T, Nicastro D, Porter ME.

Mol Biol Cell. 2018 Jan 15;29(2):137-153. doi: 10.1091/mbc.E17-08-0510. Epub 2017 Nov 22.


Centriolar remodeling underlies basal body maturation during ciliogenesis in Caenorhabditis elegans.

Nechipurenko IV, Berciu C, Sengupta P, Nicastro D.

Elife. 2017 Apr 15;6. pii: e25686. doi: 10.7554/eLife.25686.


Enzyme-Instructed Self-Assembly for Spatiotemporal Profiling of the Activities of Alkaline Phosphatases on Live Cells.

Zhou J, Du X, Berciu C, He H, Shi J, Nicastro D, Xu B.

Chem. 2016 Aug 11;1(2):246-263. doi: 10.1016/j.chempr.2016.07.003.


Three-Dimensional Structure of the Ultraoligotrophic Marine Bacterium "Candidatus Pelagibacter ubique".

Zhao X, Schwartz CL, Pierson J, Giovannoni SJ, McIntosh JR, Nicastro D.

Appl Environ Microbiol. 2017 Jan 17;83(3). pii: e02807-16. doi: 10.1128/AEM.02807-16. Print 2017 Feb 1.


The nexin link and B-tubule glutamylation maintain the alignment of outer doublets in the ciliary axoneme.

Alford LM, Stoddard D, Li JH, Hunter EL, Tritschler D, Bower R, Nicastro D, Porter ME, Sale WS.

Cytoskeleton (Hoboken). 2016 Jun;73(7):331-40. doi: 10.1002/cm.21301. Epub 2016 Jun 13.


Membrane Charge Directs the Outcome of F-BAR Domain Lipid Binding and Autoregulation.

Kelley CF, Messelaar EM, Eskin TL, Wang S, Song K, Vishnia K, Becalska AN, Shupliakov O, Hagan MF, Danino D, Sokolova OS, Nicastro D, Rodal AA.

Cell Rep. 2015 Dec 22;13(11):2597-2609. doi: 10.1016/j.celrep.2015.11.044. Epub 2015 Dec 10.


ATP Consumption of Eukaryotic Flagella Measured at a Single-Cell Level.

Chen DTN, Heymann M, Fraden S, Nicastro D, Dogic Z.

Biophys J. 2015 Dec 15;109(12):2562-2573. doi: 10.1016/j.bpj.2015.11.003.


Assembly of actin filaments and microtubules in Nwk F-BAR-induced membrane deformations.

Kelley CF, Becalska AN, Berciu C, Nicastro D, Rodal AA.

Commun Integr Biol. 2015 Apr 29;8(2):e1000703. doi: 10.1080/19420889.2014.1000703. eCollection 2015 Mar-Apr.


DRC3 connects the N-DRC to dynein g to regulate flagellar waveform.

Awata J, Song K, Lin J, King SM, Sanderson MJ, Nicastro D, Witman GB.

Mol Biol Cell. 2015 Aug 1;26(15):2788-800. doi: 10.1091/mbc.E15-01-0018. Epub 2015 Jun 10.


The CSC proteins FAP61 and FAP251 build the basal substructures of radial spoke 3 in cilia.

Urbanska P, Song K, Joachimiak E, Krzemien-Ojak L, Koprowski P, Hennessey T, Jerka-Dziadosz M, Fabczak H, Gaertig J, Nicastro D, Wloga D.

Mol Biol Cell. 2015 Apr 15;26(8):1463-75. doi: 10.1091/mbc.E14-11-1545. Epub 2015 Feb 18.


In situ localization of N and C termini of subunits of the flagellar nexin-dynein regulatory complex (N-DRC) using SNAP tag and cryo-electron tomography.

Song K, Awata J, Tritschler D, Bower R, Witman GB, Porter ME, Nicastro D.

J Biol Chem. 2015 Feb 27;290(9):5341-53. doi: 10.1074/jbc.M114.626556. Epub 2015 Jan 6.


FAP206 is a microtubule-docking adapter for ciliary radial spoke 2 and dynein c.

Vasudevan KK, Song K, Alford LM, Sale WS, Dymek EE, Smith EF, Hennessey T, Joachimiak E, Urbanska P, Wloga D, Dentler W, Nicastro D, Gaertig J.

Mol Biol Cell. 2015 Feb 15;26(4):696-710. doi: 10.1091/mbc.E14-11-1506. Epub 2014 Dec 24.


Cryo-electron tomography reveals ciliary defects underlying human RSPH1 primary ciliary dyskinesia.

Lin J, Yin W, Smith MC, Song K, Leigh MW, Zariwala MA, Knowles MR, Ostrowski LE, Nicastro D.

Nat Commun. 2014 Dec 4;5:5727. doi: 10.1038/ncomms6727.


Structural correlates of rotavirus cell entry.

Abdelhakim AH, Salgado EN, Fu X, Pasham M, Nicastro D, Kirchhausen T, Harrison SC.

PLoS Pathog. 2014 Sep 11;10(9):e1004355. doi: 10.1371/journal.ppat.1004355. eCollection 2014 Sep.


Robust excitons inhabit soft supramolecular nanotubes.

Eisele DM, Arias DH, Fu X, Bloemsma EA, Steiner CP, Jensen RA, Rebentrost P, Eisele H, Tokmakoff A, Lloyd S, Nelson KA, Nicastro D, Knoester J, Bawendi MG.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):E3367-75. doi: 10.1073/pnas.1408342111. Epub 2014 Aug 4.


Membrane deformation and scission by the HSV-1 nuclear egress complex.

Bigalke JM, Heuser T, Nicastro D, Heldwein EE.

Nat Commun. 2014 Jun 11;5:4131. doi: 10.1038/ncomms5131.


Insights into the structure and function of ciliary and flagellar doublet microtubules: tektins, Ca2+-binding proteins, and stable protofilaments.

Linck R, Fu X, Lin J, Ouch C, Schefter A, Steffen W, Warren P, Nicastro D.

J Biol Chem. 2014 Jun 20;289(25):17427-44. doi: 10.1074/jbc.M114.568949. Epub 2014 May 2.


Structural mechanism of the dynein power stroke.

Lin J, Okada K, Raytchev M, Smith MC, Nicastro D.

Nat Cell Biol. 2014 May;16(5):479-85. doi: 10.1038/ncb2939. Epub 2014 Apr 13.


A high-resolution morphological and ultrastructural map of anterior sensory cilia and glia in Caenorhabditis elegans.

Doroquez DB, Berciu C, Anderson JR, Sengupta P, Nicastro D.

Elife. 2014 Mar 25;3:e01948. doi: 10.7554/eLife.01948.


Critical roles for multiple formins during cardiac myofibril development and repair.

Rosado M, Barber CF, Berciu C, Feldman S, Birren SJ, Nicastro D, Goode BL.

Mol Biol Cell. 2014 Mar;25(6):811-27. doi: 10.1091/mbc.E13-08-0443. Epub 2014 Jan 15.


Probing nanoscale self-assembly of nonfluorescent small molecules inside live mammalian cells.

Gao Y, Berciu C, Kuang Y, Shi J, Nicastro D, Xu B.

ACS Nano. 2013 Oct 22;7(10):9055-63. doi: 10.1021/nn403664n. Epub 2013 Sep 25.


Formation of membrane ridges and scallops by the F-BAR protein Nervous Wreck.

Becalska AN, Kelley CF, Berciu C, Stanishneva-Konovalova TB, Fu X, Wang S, Sokolova OS, Nicastro D, Rodal AA.

Mol Biol Cell. 2013 Aug;24(15):2406-18. doi: 10.1091/mbc.E13-05-0271. Epub 2013 Jun 12.


The MIA complex is a conserved and novel dynein regulator essential for normal ciliary motility.

Yamamoto R, Song K, Yanagisawa HA, Fox L, Yagi T, Wirschell M, Hirono M, Kamiya R, Nicastro D, Sale WS.

J Cell Biol. 2013 Apr 15;201(2):263-78. doi: 10.1083/jcb.201211048. Epub 2013 Apr 8.


Conserved structural motifs in the central pair complex of eukaryotic flagella.

Carbajal-González BI, Heuser T, Fu X, Lin J, Smith BW, Mitchell DR, Nicastro D.

Cytoskeleton (Hoboken). 2013 Feb;70(2):101-120. doi: 10.1002/cm.21094. Epub 2012 Dec 26.


One of the nine doublet microtubules of eukaryotic flagella exhibits unique and partially conserved structures.

Lin J, Heuser T, Song K, Fu X, Nicastro D.

PLoS One. 2012;7(10):e46494. doi: 10.1371/journal.pone.0046494. Epub 2012 Oct 10.


The CSC connects three major axonemal complexes involved in dynein regulation.

Heuser T, Dymek EE, Lin J, Smith EF, Nicastro D.

Mol Biol Cell. 2012 Aug;23(16):3143-55. doi: 10.1091/mbc.E12-05-0357. Epub 2012 Jun 27.


Cryoelectron tomography reveals doublet-specific structures and unique interactions in the I1 dynein.

Heuser T, Barber CF, Lin J, Krell J, Rebesco M, Porter ME, Nicastro D.

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):E2067-76. doi: 10.1073/pnas.1120690109. Epub 2012 Jun 25.


Reconfigurable self-assembly through chiral control of interfacial tension.

Gibaud T, Barry E, Zakhary MJ, Henglin M, Ward A, Yang Y, Berciu C, Oldenbourg R, Hagan MF, Nicastro D, Meyer RB, Dogic Z.

Nature. 2012 Jan 4;481(7381):348-51. doi: 10.1038/nature10769.


The structural heterogeneity of radial spokes in cilia and flagella is conserved.

Lin J, Heuser T, Carbajal-González BI, Song K, Nicastro D.

Cytoskeleton (Hoboken). 2012 Feb;69(2):88-100. doi: 10.1002/cm.21000. Epub 2012 Jan 12.


Three-dimensional structure of the radial spokes reveals heterogeneity and interactions with dyneins in Chlamydomonas flagella.

Barber CF, Heuser T, Carbajal-González BI, Botchkarev VV Jr, Nicastro D.

Mol Biol Cell. 2012 Jan;23(1):111-20. doi: 10.1091/mbc.E11-08-0692. Epub 2011 Nov 9.


Cryo-electron tomography reveals conserved features of doublet microtubules in flagella.

Nicastro D, Fu X, Heuser T, Tso A, Porter ME, Linck RW.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):E845-53. doi: 10.1073/pnas.1106178108. Epub 2011 Sep 19.


Cilia-like beating of active microtubule bundles.

Sanchez T, Welch D, Nicastro D, Dogic Z.

Science. 2011 Jul 22;333(6041):456-9. doi: 10.1126/science.1203963.


Building blocks of the nexin-dynein regulatory complex in Chlamydomonas flagella.

Lin J, Tritschler D, Song K, Barber CF, Cobb JS, Porter ME, Nicastro D.

J Biol Chem. 2011 Aug 19;286(33):29175-91. doi: 10.1074/jbc.M111.241760. Epub 2011 Jun 23.


Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome.

Gopalakrishnan J, Mennella V, Blachon S, Zhai B, Smith AH, Megraw TL, Nicastro D, Gygi SP, Agard DA, Avidor-Reiss T.

Nat Commun. 2011 Jun 21;2:359. doi: 10.1038/ncomms1367.


The CSC is required for complete radial spoke assembly and wild-type ciliary motility.

Dymek EE, Heuser T, Nicastro D, Smith EF.

Mol Biol Cell. 2011 Jul 15;22(14):2520-31. doi: 10.1091/mbc.E11-03-0271. Epub 2011 May 25.


Improved electrical wiring of microbes: anthraquinone-modified electrodes for biosensing of chlorinated hydrocarbons.

Aulenta F, Ferri T, Nicastro D, Majone M, Papini MP.

N Biotechnol. 2011 Dec 15;29(1):126-31. doi: 10.1016/j.nbt.2011.04.001. Epub 2011 Apr 15.


Arrangement of photosystem II and ATP synthase in chloroplast membranes of spinach and pea.

Daum B, Nicastro D, Austin J 2nd, McIntosh JR, Kühlbrandt W.

Plant Cell. 2010 Apr;22(4):1299-312. doi: 10.1105/tpc.109.071431. Epub 2010 Apr 13.


The dynein regulatory complex is the nexin link and a major regulatory node in cilia and flagella.

Heuser T, Raytchev M, Krell J, Porter ME, Nicastro D.

J Cell Biol. 2009 Dec 14;187(6):921-33. doi: 10.1083/jcb.200908067.

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