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Items: 1 to 50 of 90


The IκB-protein BCL-3 controls Toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus.

Collins PE, Somma D, Kerrigan D, Herrington F, Keeshan K, Nibbs RJB, Carmody RJ.

Proc Natl Acad Sci U S A. 2019 Nov 26. pii: 201900408. doi: 10.1073/pnas.1900408116. [Epub ahead of print]


Can molecular stratification improve the treatment of inflammatory bowel disease?

Wang C, Baer HM, Gaya DR, Nibbs RJB, Milling S.

Pharmacol Res. 2019 Oct;148:104442. doi: 10.1016/j.phrs.2019.104442. Epub 2019 Sep 3. Review.


A Comprehensive Profile of Chemokine Gene Expression in the Tissues of the Female Reproductive Tract in Mice.

Menzies FM, Oldham RS, Waddell C, Nelson SM, Nibbs RJB.

Immunol Invest. 2019 Aug 20:1-23. doi: 10.1080/08820139.2019.1655573. [Epub ahead of print]


Understanding and overcoming the resistance of cancer to PD-1/PD-L1 blockade.

Shergold AL, Millar R, Nibbs RJB.

Pharmacol Res. 2019 Jul;145:104258. doi: 10.1016/j.phrs.2019.104258. Epub 2019 May 4. Review.


Chemokine Transport Dynamics and Emerging Recognition of Their Role in Immune Function.

Moore JE Jr, Brook BS, Nibbs RJB.

Curr Opin Biomed Eng. 2018 Mar;5:90-95. doi: 10.1016/j.cobme.2018.03.001. Epub 2018 Mar 20.


The Atypical Chemokine Receptor Ackr2 Constrains NK Cell Migratory Activity and Promotes Metastasis.

Hansell CAH, Fraser AR, Hayes AJ, Pingen M, Burt CL, Lee KM, Medina-Ruiz L, Brownlie D, Macleod MKL, Burgoyne P, Wilson GJ, Nibbs RJB, Graham GJ.

J Immunol. 2018 Oct 15;201(8):2510-2519. doi: 10.4049/jimmunol.1800131. Epub 2018 Aug 29.


TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.

Bird TG, Müller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu WY, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, Hedley A, Clarke M, Gentaz P, Nixon C, Bryce S, Kiourtis C, Sprangers J, Nibbs RJB, Van Rooijen N, Bartholin L, McGreal SR, Apte U, Barry ST, Iredale JP, Clarke AR, Serrano M, Roskams TA, Sansom OJ, Forbes SJ.

Sci Transl Med. 2018 Aug 15;10(454). pii: eaan1230. doi: 10.1126/scitranslmed.aan1230.


Expression of the Atypical Chemokine Receptor ACKR4 Identifies a Novel Population of Intestinal Submucosal Fibroblasts That Preferentially Expresses Endothelial Cell Regulators.

Thomson CA, van de Pavert SA, Stakenborg M, Labeeuw E, Matteoli G, Mowat AM, Nibbs RJB.

J Immunol. 2018 Jul 1;201(1):215-229. doi: 10.4049/jimmunol.1700967. Epub 2018 May 14.


A guide to chemokines and their receptors.

Hughes CE, Nibbs RJB.

FEBS J. 2018 Aug;285(16):2944-2971. doi: 10.1111/febs.14466. Epub 2018 Apr 24. Review.


Atypical chemokine receptor 4 shapes activated B cell fate.

Kara EE, Bastow CR, McKenzie DR, Gregor CE, Fenix KA, Babb R, Norton TS, Zotos D, Rodda LB, Hermes JR, Bourne K, Gilchrist DS, Nibbs RJ, Alsharifi M, Vinuesa CG, Tarlinton DM, Brink R, Hill GR, Cyster JG, Comerford I, McColl SR.

J Exp Med. 2018 Mar 5;215(3):801-813. doi: 10.1084/jem.20171067. Epub 2018 Jan 31.


Pre-conception maternal erythrocyte saturated to unsaturated fatty acid ratio predicts pregnancy after natural cycle frozen embryo transfer.

Onyiaodike CC, Murray HM, Zhang R, Meyer BJ, Jordan F, Brown EA, Nibbs RJB, Lyall H, Sattar N, Nelson SM, Freeman DJ.

Sci Rep. 2018 Jan 19;8(1):1216. doi: 10.1038/s41598-018-19500-0.


Immune checkpoint inhibitors: new strategies to checkmate cancer.

Wilson RAM, Evans TRJ, Fraser AR, Nibbs RJB.

Clin Exp Immunol. 2018 Feb;191(2):133-148. doi: 10.1111/cei.13081. Epub 2017 Dec 27. Review.


A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4.

Jafarnejad M, Zawieja DC, Brook BS, Nibbs RJB, Moore JE Jr.

J Immunol. 2017 Oct 1;199(7):2291-2304. doi: 10.4049/jimmunol.1700377. Epub 2017 Aug 14.


Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection.

Hulme HE, Meikle LM, Wessel H, Strittmatter N, Swales J, Thomson C, Nilsson A, Nibbs RJB, Milling S, Andren PE, Mackay CL, Dexter A, Bunch J, Goodwin RJA, Burchmore R, Wall DM.

Sci Rep. 2017 Jun 5;7(1):2786. doi: 10.1038/s41598-017-03100-5.


CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma.

Steele CW, Karim SA, Leach JDG, Bailey P, Upstill-Goddard R, Rishi L, Foth M, Bryson S, McDaid K, Wilson Z, Eberlein C, Candido JB, Clarke M, Nixon C, Connelly J, Jamieson N, Carter CR, Balkwill F, Chang DK, Evans TRJ, Strathdee D, Biankin AV, Nibbs RJB, Barry ST, Sansom OJ, Morton JP.

Cancer Cell. 2016 Jun 13;29(6):832-845. doi: 10.1016/j.ccell.2016.04.014. Epub 2016 Jun 2.


Regulation of the Adaptive Immune Response by the IκB Family Protein Bcl-3.

Herrington FD, Nibbs RJ.

Cells. 2016 Mar 24;5(2). pii: E14. doi: 10.3390/cells5020014. Review.


ACKR4 on Stromal Cells Scavenges CCL19 To Enable CCR7-Dependent Trafficking of APCs from Inflamed Skin to Lymph Nodes.

Bryce SA, Wilson RA, Tiplady EM, Asquith DL, Bromley SK, Luster AD, Graham GJ, Nibbs RJ.

J Immunol. 2016 Apr 15;196(8):3341-53. doi: 10.4049/jimmunol.1501542. Epub 2016 Mar 14.


Maternal Plasma DHA Levels Increase Prior to 29 Days Post-LH Surge in Women Undergoing Frozen Embryo Transfer: A Prospective, Observational Study of Human Pregnancy.

Meyer BJ, Onyiaodike CC, Brown EA, Jordan F, Murray H, Nibbs RJ, Sattar N, Lyall H, Nelson SM, Freeman DJ.

J Clin Endocrinol Metab. 2016 Apr;101(4):1745-53. doi: 10.1210/jc.2015-3089. Epub 2016 Feb 19.


Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.

Serrels A, Lund T, Serrels B, Byron A, McPherson RC, von Kriegsheim A, Gómez-Cuadrado L, Canel M, Muir M, Ring JE, Maniati E, Sims AH, Pachter JA, Brunton VG, Gilbert N, Anderton SM, Nibbs RJ, Frame MC.

Cell. 2015 Sep 24;163(1):160-73. doi: 10.1016/j.cell.2015.09.001.


CXCR2 inhibition suppresses acute and chronic pancreatic inflammation.

Steele CW, Karim SA, Foth M, Rishi L, Leach JD, Porter RJ, Nixon C, Jeffry Evans TR, Carter CR, Nibbs RJ, Sansom OJ, Morton JP.

J Pathol. 2015 Sep;237(1):85-97. doi: 10.1002/path.4555. Epub 2015 Jun 4.


Targeting cell migration in rheumatoid arthritis.

Asquith DL, Bryce SA, Nibbs RJ.

Curr Opin Rheumatol. 2015 Mar;27(2):204-11. doi: 10.1097/BOR.0000000000000150. Review.


CCRL1/ACKR4 is expressed in key thymic microenvironments but is dispensable for T lymphopoiesis at steady state in adult mice.

Lucas B, White AJ, Ulvmar MH, Nibbs RJ, Sitnik KM, Agace WW, Jenkinson WE, Anderson G, Rot A.

Eur J Immunol. 2015 Feb;45(2):574-83. doi: 10.1002/eji.201445015. Epub 2015 Jan 16.


The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens.

Hansell CA, MacLellan LM, Oldham RS, Doonan J, Chapple KJ, Anderson EJ, Linington C, McInnes IB, Nibbs RJ, Goodyear CS.

Immunol Cell Biol. 2015 Feb;93(2):167-76. doi: 10.1038/icb.2014.90. Epub 2014 Oct 28.


Atypical chemokine receptor ACKR2 mediates chemokine scavenging by primary human trophoblasts and can regulate fetal growth, placental structure, and neonatal mortality in mice.

Teoh PJ, Menzies FM, Hansell CA, Clarke M, Waddell C, Burton GJ, Nelson SM, Nibbs RJ.

J Immunol. 2014 Nov 15;193(10):5218-28. doi: 10.4049/jimmunol.1401096. Epub 2014 Oct 8.


The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density.

Lee KM, Danuser R, Stein JV, Graham D, Nibbs RJ, Graham GJ.

EMBO J. 2014 Nov 3;33(21):2564-80. doi: 10.15252/embj.201488887. Epub 2014 Sep 30.


Periodontitis in the absence of B cells and specific anti-bacterial antibody.

Oliver-Bell J, Butcher JP, Malcolm J, MacLeod MK, Adrados Planell A, Campbell L, Nibbs RJ, Garside P, McInnes IB, Culshaw S.

Mol Oral Microbiol. 2015 Apr;30(2):160-9. doi: 10.1111/omi.12082. Epub 2014 Oct 28.


Characterization of conventional and atypical receptors for the chemokine CCL2 on mouse leukocytes.

Ford LB, Cerovic V, Milling SW, Graham GJ, Hansell CA, Nibbs RJ.

J Immunol. 2014 Jul 1;193(1):400-11. doi: 10.4049/jimmunol.1303236. Epub 2014 Jun 2.


Chemokines as novel and versatile reagents for flow cytometry and cell sorting.

Le Brocq ML, Fraser AR, Cotton G, Woznica K, McCulloch CV, Hewitt KD, McKimmie CS, Nibbs RJB, Campbell JDM, Graham GJ.

J Immunol. 2014 Jun 15;192(12):6120-6130. doi: 10.4049/jimmunol.1303371. Epub 2014 May 21.


The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes.

Ulvmar MH, Werth K, Braun A, Kelay P, Hub E, Eller K, Chan L, Lucas B, Novitzky-Basso I, Nakamura K, Rülicke T, Nibbs RJ, Worbs T, Förster R, Rot A.

Nat Immunol. 2014 Jul;15(7):623-30. doi: 10.1038/ni.2889. Epub 2014 May 11.


The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding.

Hewit KD, Fraser A, Nibbs RJ, Graham GJ.

J Biol Chem. 2014 May 2;289(18):12330-42. doi: 10.1074/jbc.M113.534545. Epub 2014 Mar 18.


Immune regulation by atypical chemokine receptors.

Nibbs RJ, Graham GJ.

Nat Rev Immunol. 2013 Nov;13(11):815-29. Review.


Microarray analyses demonstrate the involvement of type I interferons in psoriasiform pathology development in D6-deficient mice.

Baldwin HM, Pallas K, King V, Jamieson T, McKimmie CS, Nibbs RJ, Carballido JM, Jaritz M, Rot A, Graham GJ.

J Biol Chem. 2013 Dec 20;288(51):36473-83. doi: 10.1074/jbc.M113.491563. Epub 2013 Nov 5.


Cell-autonomous regulation of neutrophil migration by the D6 chemokine decoy receptor.

Rot A, McKimmie C, Burt CL, Pallas KJ, Jamieson T, Pruenster M, Horuk R, Nibbs RJB, Graham GJ.

J Immunol. 2013 Jun 15;190(12):6450-6456. doi: 10.4049/jimmunol.1201429. Epub 2013 May 13.


Using fluorescent chemokine uptake to detect chemokine receptors by fluorescent activated cell sorting.

Ford LB, Hansell CA, Nibbs RJ.

Methods Mol Biol. 2013;1013:203-14. doi: 10.1007/978-1-62703-426-5_13.


Bcl-3 deficiency protects against dextran-sodium sulphate-induced colitis in the mouse.

O'Carroll C, Moloney G, Hurley G, Melgar S, Brint E, Nally K, Nibbs RJ, Shanahan F, Carmody RJ.

Clin Exp Immunol. 2013 Aug;173(2):332-42. doi: 10.1111/cei.12119.


An analysis of the function and expression of D6 on lymphatic endothelial cells.

McKimmie CS, Singh MD, Hewit K, Lopez-Franco O, Le Brocq M, Rose-John S, Lee KM, Baker AH, Wheat R, Blackbourn DJ, Nibbs RJ, Graham GJ.

Blood. 2013 May 2;121(18):3768-77. doi: 10.1182/blood-2012-04-425314. Epub 2013 Mar 11.


Suppression, subversion and escape: the role of regulatory T cells in cancer progression.

Oleinika K, Nibbs RJ, Graham GJ, Fraser AR.

Clin Exp Immunol. 2013 Jan;171(1):36-45. doi: 10.1111/j.1365-2249.2012.04657.x. Review.


CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity.

Bunting MD, Comerford I, Seach N, Hammett MV, Asquith DL, Körner H, Boyd RL, Nibbs RJ, McColl SR.

Blood. 2013 Jan 3;121(1):118-28. doi: 10.1182/blood-2012-06-434886. Epub 2012 Nov 14.


Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.

Jamieson T, Clarke M, Steele CW, Samuel MS, Neumann J, Jung A, Huels D, Olson MF, Das S, Nibbs RJ, Sansom OJ.

J Clin Invest. 2012 Sep;122(9):3127-44. doi: 10.1172/JCI61067. Epub 2012 Aug 27.


D6: the 'crowd controller' at the immune gateway.

Lee KM, Nibbs RJ, Graham GJ.

Trends Immunol. 2013 Jan;34(1):7-12. doi: 10.1016/ Epub 2012 Aug 24.


The chemokine receptor CCR2 is not required for successful initiation of labor in mice.

Menzies FM, Khan AH, Higgins CA, Nelson SM, Nibbs RJ.

Biol Reprod. 2012 Apr 19;86(4):118. doi: 10.1095/biolreprod.111.094631. Print 2012 Apr.


Co-opting endogenous immunoglobulin for the regulation of inflammation and osteoclastogenesis in humans and mice.

MacLellan LM, Montgomery J, Sugiyama F, Kitson SM, Thümmler K, Silverman GJ, Beers SA, Nibbs RJ, McInnes IB, Goodyear CS.

Arthritis Rheum. 2011 Dec;63(12):3897-907. doi: 10.1002/art.30629.


The odd couple: innate-like B cells and the chemokine scavenger D6.

Hansell CA, Nibbs RJ.

Cell Cycle. 2011 Nov 1;10(21):3619-20. doi: 10.4161/cc.10.21.17851. Epub 2011 Nov 1. No abstract available.


D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion.

Lee KM, McKimmie CS, Gilchrist DS, Pallas KJ, Nibbs RJ, Garside P, McDonald V, Jenkins C, Ransohoff R, Liu L, Milling S, Cerovic V, Graham GJ.

Blood. 2011 Dec 1;118(23):6220-9. doi: 10.1182/blood-2011-03-344044. Epub 2011 Oct 6.


Mast cells reside in myometrium and cervix, but are dispensable in mice for successful pregnancy and labor.

Menzies FM, Higgins CA, Shepherd MC, Nibbs RJ, Nelson SM.

Immunol Cell Biol. 2012 Mar;90(3):321-9. doi: 10.1038/icb.2011.40. Epub 2011 May 17.


Universal expression and dual function of the atypical chemokine receptor D6 on innate-like B cells in mice.

Hansell CA, Schiering C, Kinstrie R, Ford L, Bordon Y, McInnes IB, Goodyear CS, Nibbs RJ.

Blood. 2011 May 19;117(20):5413-24. doi: 10.1182/blood-2010-11-317115. Epub 2011 Mar 30.


DARC and D6: silent partners in chemokine regulation?

Hansell CA, Hurson CE, Nibbs RJ.

Immunol Cell Biol. 2011 Feb;89(2):197-206. doi: 10.1038/icb.2010.147. Epub 2010 Dec 14. Review.


The role of mast cells and their mediators in reproduction, pregnancy and labour.

Menzies FM, Shepherd MC, Nibbs RJ, Nelson SM.

Hum Reprod Update. 2011 May-Jun;17(3):383-96. doi: 10.1093/humupd/dmq053. Epub 2010 Oct 19. Review.


The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses.

Comerford I, Nibbs RJ, Litchfield W, Bunting M, Harata-Lee Y, Haylock-Jacobs S, Forrow S, Korner H, McColl SR.

Blood. 2010 Nov 18;116(20):4130-40. doi: 10.1182/blood-2010-01-264390. Epub 2010 Jun 18.


IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells.

Henriques CM, Rino J, Nibbs RJ, Graham GJ, Barata JT.

Blood. 2010 Apr 22;115(16):3269-77. doi: 10.1182/blood-2009-10-246876. Epub 2010 Feb 26.

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