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Items: 14


BET Inhibition as a Rational Therapeutic Strategy for Invasive Lobular Breast Cancer.

Walsh L, Haley KE, Moran B, Mooney B, Tarrant F, Madden SF, Di Grande A, Fan Y, Das S, Rueda OM, Dowling CM, Varešlija D, Chin SF, Linn S, Young LS, Jirström K, Crown JP, Bernards R, Caldas C, Gallagher WM, O'Connor DP, Ní Chonghaile T.

Clin Cancer Res. 2019 Dec 1;25(23):7139-7150. doi: 10.1158/1078-0432.CCR-19-0713. Epub 2019 Aug 13.


The Anti-inflammatory Compound Candesartan Cilexetil Improves Neurological Outcomes in a Mouse Model of Neonatal Hypoxia.

Quinlan S, Merino-Serrais P, Di Grande A, Dussmann H, Prehn JHM, Ní Chonghaile T, Henshall DC, Jimenez-Mateos EM.

Front Immunol. 2019 Jul 24;10:1752. doi: 10.3389/fimmu.2019.01752. eCollection 2019.


Therapeutic Rationale to Target Highly Expressed CDK7 Conferring Poor Outcomes in Triple-Negative Breast Cancer.

Li B, Ni Chonghaile T, Fan Y, Madden SF, Klinger R, O'Connor AE, Walsh L, O'Hurley G, Mallya Udupi G, Joseph J, Tarrant F, Conroy E, Gaber A, Chin SF, Bardwell HA, Provenzano E, Crown J, Dubois T, Linn S, Jirstrom K, Caldas C, O'Connor DP, Gallagher WM.

Cancer Res. 2017 Jul 15;77(14):3834-3845. doi: 10.1158/0008-5472.CAN-16-2546. Epub 2017 Apr 28.


The Emerging Role of Non-traditional Ubiquitination in Oncogenic Pathways.

Dwane L, Gallagher WM, Ní Chonghaile T, O'Connor DP.

J Biol Chem. 2017 Mar 3;292(9):3543-3551. doi: 10.1074/jbc.R116.755694. Epub 2017 Feb 1. Review.


Big Data-Led Cancer Research, Application, and Insights.

Brown JA, Ni Chonghaile T, Matchett KB, Lynam-Lennon N, Kiely PA.

Cancer Res. 2016 Nov 1;76(21):6167-6170. Epub 2016 Oct 20.


Diagnostic and Therapeutic Implications of Histone Epigenetic Modulators in Breast Cancer.

Walsh L, Gallagher WM, O'Connor DP, Ní Chonghaile T.

Expert Rev Mol Diagn. 2016;16(5):541-51. doi: 10.1586/14737159.2016.1156534. Epub 2016 Mar 16. Review.


Targeting the miR-221-222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma.

Zhao JJ, Chu ZB, Hu Y, Lin J, Wang Z, Jiang M, Chen M, Wang X, Kang Y, Zhou Y, Ni Chonghaile T, Johncilla ME, Tai YT, Cheng JQ, Letai A, Munshi NC, Anderson KC, Carrasco RD.

Cancer Res. 2015 Oct 15;75(20):4384-4397. doi: 10.1158/0008-5472.CAN-15-0457. Epub 2015 Aug 6.


Mitochondria: gatekeepers of response to chemotherapy.

Sarosiek KA, Ni Chonghaile T, Letai A.

Trends Cell Biol. 2013 Dec;23(12):612-9. doi: 10.1016/j.tcb.2013.08.003. Epub 2013 Sep 21. Review.


Who put the "A" in Atg12: autophagy or apoptosis?

Ni Chonghaile T, Letai A.

Mol Cell. 2011 Dec 23;44(6):844-5. doi: 10.1016/j.molcel.2011.12.007.


Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy.

Ni Chonghaile T, Sarosiek KA, Vo TT, Ryan JA, Tammareddi A, Moore Vdel G, Deng J, Anderson KC, Richardson P, Tai YT, Mitsiades CS, Matulonis UA, Drapkin R, Stone R, Deangelo DJ, McConkey DJ, Sallan SE, Silverman L, Hirsch MS, Carrasco DR, Letai A.

Science. 2011 Nov 25;334(6059):1129-33. doi: 10.1126/science.1206727. Epub 2011 Oct 27.


Mimicking the BH3 domain to kill cancer cells.

Ni Chonghaile T, Letai A.

Oncogene. 2008 Dec;27 Suppl 1:S149-57. doi: 10.1038/onc.2009.52. Review.


Bcl-2 family on guard at the ER.

Szegezdi E, Macdonald DC, Ní Chonghaile T, Gupta S, Samali A.

Am J Physiol Cell Physiol. 2009 May;296(5):C941-53. doi: 10.1152/ajpcell.00612.2008. Epub 2009 Mar 11. Review.


Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL.

Reeve JL, Szegezdi E, Logue SE, Ní Chonghaile T, O'Brien T, Ritter T, Samali A.

J Cell Mol Med. 2007 May-Jun;11(3):509-20.


Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL.

Ní Chonghaile T, Concannon CG, Szegezdi E, Gorman AM, Samali A.

Apoptosis. 2006 Jul;11(7):1247-55.


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