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In Reply.

Dang VQ, Nguyen LK, Mol BW.

Obstet Gynecol. 2019 Jun;133(6):1283-1284. doi: 10.1097/AOG.0000000000003298. No abstract available.


Pessary Compared With Vaginal Progesterone for the Prevention of Preterm Birth in Women With Twin Pregnancies and Cervical Length Less Than 38 mm: A Randomized Controlled Trial.

Dang VQ, Nguyen LK, Pham TD, He YTN, Vu KN, Phan MTN, Le TQ, Le CH, Vuong LN, Mol BW.

Obstet Gynecol. 2019 Mar;133(3):459-467. doi: 10.1097/AOG.0000000000003136.


LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy.

Padman BS, Nguyen TN, Uoselis L, Skulsuppaisarn M, Nguyen LK, Lazarou M.

Nat Commun. 2019 Jan 24;10(1):408. doi: 10.1038/s41467-019-08335-6.


Metastatic Urachus Neoplasia: A Case Report and Review of the Current Literature.

Maish WN, Nguyen LK, Ngu C, Bennett G, Pranavan G.

Clin Genitourin Cancer. 2019 Apr;17(2):e377-e382. doi: 10.1016/j.clgc.2018.11.017. Epub 2018 Dec 4. No abstract available.


Uncovering Bistability in the Rac1/RhoA Signaling Network Through Integrating Computational Modeling and Experimentation.

von Kriegsheim A, Nguyen LK.

Methods Mol Biol. 2018;1821:21-36. doi: 10.1007/978-1-4939-8612-5_2.


Computational Modeling of the Dynamics of Spatiotemporal Rho GTPase Signaling: A Systematic Review.

Khatibi S, Rios KI, Nguyen LK.

Methods Mol Biol. 2018;1821:3-20. doi: 10.1007/978-1-4939-8612-5_1.


Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer.

Shin SY, Müller AK, Verma N, Lev S, Nguyen LK.

PLoS Comput Biol. 2018 Jun 19;14(6):e1006192. doi: 10.1371/journal.pcbi.1006192. eCollection 2018 Jun.


Dynamic modelling of the mTOR signalling network reveals complex emergent behaviours conferred by DEPTOR.

Varusai TM, Nguyen LK.

Sci Rep. 2018 Jan 12;8(1):643. doi: 10.1038/s41598-017-18400-z.


IVF Transfer of Fresh or Frozen Embryos in Women without Polycystic Ovaries.

Vuong LN, Dang VQ, Ho TM, Huynh BG, Ha DT, Pham TD, Nguyen LK, Norman RJ, Mol BW.

N Engl J Med. 2018 Jan 11;378(2):137-147. doi: 10.1056/NEJMoa1703768.


Factors associated with nicotine dependence during methadone maintenance treatment: findings from a multisite survey in Vietnam.

Do HP, Nguyen LH, Thi Nguyen NP, Ngo C, Thi Nguyen HL, Le GT, Nguyen LK, Nguyen CT, Tran BX, Le HT, Vu TMT, Phan HTT, Tran TD, Latkin CA, Dunne MP.

BMJ Open. 2017 Jul 17;7(7):e015889. doi: 10.1136/bmjopen-2017-015889.


Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis.

Verma N, Müller AK, Kothari C, Panayotopoulou E, Kedan A, Selitrennik M, Mills GB, Nguyen LK, Shin S, Karn T, Holtrich U, Lev S.

Cancer Res. 2017 Jan 1;77(1):86-99. doi: 10.1158/0008-5472.CAN-16-1797. Epub 2016 Oct 28.


SARAH Domain-Mediated MST2-RASSF Dimeric Interactions.

Sánchez-Sanz G, Tywoniuk B, Matallanas D, Romano D, Nguyen LK, Kholodenko BN, Rosta E, Kolch W, Buchete NV.

PLoS Comput Biol. 2016 Oct 7;12(10):e1005051. doi: 10.1371/journal.pcbi.1005051. eCollection 2016 Oct.


HER2-HER3 dimer quantification by FLIM-FRET predicts breast cancer metastatic relapse independently of HER2 IHC status.

Weitsman G, Barber PR, Nguyen LK, Lawler K, Patel G, Woodman N, Kelleher MT, Pinder SE, Rowley M, Ellis PA, Purushotham AD, Coolen AC, Kholodenko BN, Vojnovic B, Gillett C, Ng T.

Oncotarget. 2016 Aug 9;7(32):51012-51026. doi: 10.18632/oncotarget.9963.


Rac1 and RhoA: Networks, loops and bistability.

Nguyen LK, Kholodenko BN, von Kriegsheim A.

Small GTPases. 2018 Jul 4;9(4):316-321. doi: 10.1080/21541248.2016.1224399. Epub 2016 Sep 10. Review.


Unveiling Hidden Dynamics of Hippo Signalling: A Systems Analysis.

Shin SY, Nguyen LK.

Genes (Basel). 2016 Aug 5;7(8). pii: E44. doi: 10.3390/genes7080044.


Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity.

Zhang Y, Shen K, Bai Y, Lv X, Huang R, Zhang W, Chao J, Nguyen LK, Hua J, Gan G, Hu G, Yao H.

Autophagy. 2016 Sep;12(9):1538-59. doi: 10.1080/15548627.2016.1191723. Epub 2016 Jul 27.


Molecular Mechanisms Involving Sigma-1 Receptor in Cell Apoptosis of BV-2 Microglial Cells Induced by Methamphetamine.

Shen K, Zhang Y, Lv X, Chen X, Zhou R, Nguyen LK, Wu X, Yao H.

CNS Neurol Disord Drug Targets. 2016;15(7):857-65.


Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches.

Byrne KM, Monsefi N, Dawson JC, Degasperi A, Bukowski-Wills JC, Volinsky N, Dobrzyński M, Birtwistle MR, Tsyganov MA, Kiyatkin A, Kida K, Finch AJ, Carragher NO, Kolch W, Nguyen LK, von Kriegsheim A, Kholodenko BN.

Cell Syst. 2016 Jan 27;2(1):38-48. doi: 10.1016/j.cels.2016.01.003. Epub 2016 Jan 27.


Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways.

Rodriguez J, Pilkington R, Garcia Munoz A, Nguyen LK, Rauch N, Kennedy S, Monsefi N, Herrero A, Taylor CT, von Kriegsheim A.

Cell Rep. 2016 Mar 22;14(11):2745-60. doi: 10.1016/j.celrep.2016.02.043. Epub 2016 Mar 10.


Understanding complexity in the HIF signaling pathway using systems biology and mathematical modeling.

Fábián Z, Taylor CT, Nguyen LK.

J Mol Med (Berl). 2016 Apr;94(4):377-90. doi: 10.1007/s00109-016-1383-6. Epub 2016 Jan 29. Review.


Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation.

Jambrina PG, Rauch N, Pilkington R, Rybakova K, Nguyen LK, Kholodenko BN, Buchete NV, Kolch W, Rosta E.

Angew Chem Int Ed Engl. 2016 Jan 18;55(3):983-6. doi: 10.1002/anie.201509272. Epub 2015 Dec 8.


Feedback regulation in cell signalling: Lessons for cancer therapeutics.

Nguyen LK, Kholodenko BN.

Semin Cell Dev Biol. 2016 Feb;50:85-94. doi: 10.1016/j.semcdb.2015.09.024. Epub 2015 Oct 19. Review.


MST2-RASSF protein-protein interactions through SARAH domains.

Sánchez-Sanz G, Matallanas D, Nguyen LK, Kholodenko BN, Rosta E, Kolch W, Buchete NV.

Brief Bioinform. 2016 Jul;17(4):593-602. doi: 10.1093/bib/bbv070. Epub 2015 Oct 5.


Preference of methadone maintenance patients for the integrative and decentralized service delivery models in Vietnam.

Tran BX, Nguyen LH, Phan HT, Nguyen LK, Latkin CA.

Harm Reduct J. 2015 Sep 17;12:29. doi: 10.1186/s12954-015-0063-0.


Ossifying Fibroma of the Mandible: A Case Report Using Vascularized Free Fibula Flap Reconstruction.

Hoang MP, Nguyen TT, Nguyen LK, Jeng SF.

Plast Reconstr Surg Glob Open. 2015 Aug 10;3(7):e470. doi: 10.1097/GOX.0000000000000450. eCollection 2015 Jul.


Protein-protein interactions generate hidden feedback and feed-forward loops to trigger bistable switches, oscillations and biphasic dose-responses.

Varusai TM, Kolch W, Kholodenko BN, Nguyen LK.

Mol Biosyst. 2015 Oct;11(10):2750-62. doi: 10.1039/c5mb00385g.


Relationship between serum response factor and androgen receptor in prostate cancer.

Prencipe M, O'Neill A, O'Hurley G, Nguyen LK, Fabre A, Bjartell A, Gallagher WM, Morrissey C, Kay EW, Watson RW.

Prostate. 2015 Nov;75(15):1704-17. doi: 10.1002/pros.23051. Epub 2015 Aug 7.


DYVIPAC: an integrated analysis and visualisation framework to probe multi-dimensional biological networks.

Nguyen LK, Degasperi A, Cotter P, Kholodenko BN.

Sci Rep. 2015 Jul 29;5:12569. doi: 10.1038/srep12569.


Dynamics of ubiquitin-mediated signalling: insights from mathematical modelling and experimental studies.

Nguyen LK.

Brief Bioinform. 2016 May;17(3):479-93. doi: 10.1093/bib/bbv052. Epub 2015 Jul 25.


A statewide analysis of specialized care for pediatric appendicitis.

Putnam LR, Nguyen LK, Lally KP, Franzini L, Tsao K, Austin MT.

Surgery. 2015 Sep;158(3):787-92. doi: 10.1016/j.surg.2015.05.010. Epub 2015 Jun 24.


Species differential regulation of COX2 can be described by an NFκB-dependent logic AND gate.

Nguyen LK, Cavadas MA, Kholodenko BN, Frank TD, Cheong A.

Cell Mol Life Sci. 2015 Jun;72(12):2431-43. doi: 10.1007/s00018-015-1850-1. Epub 2015 Feb 20.


Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device.

Nguyen LK, Matallanas DG, Romano D, Kholodenko BN, Kolch W.

Cell Cycle. 2015;14(2):189-99. doi: 10.4161/15384101.2014.973743.


A dynamic model of the hypoxia-inducible factor 1a (HIF-1a) network.

Nguyen LK, Cavadas MA, Scholz CC, Fitzpatrick SF, Bruning U, Cummins EP, Tambuwala MM, Manresa MC, Kholodenko BN, Taylor CT, Cheong A.

J Cell Sci. 2015 Jan 15;128(2):422. doi: 10.1242/jcs.167304. No abstract available.


Ubiquitin chain specific auto-ubiquitination triggers sustained oscillation, bistable switches and excitable firing.

Nguyen LK, Zhao Q, Varusai TM, Kholodenko BN.

IET Syst Biol. 2014 Dec;8(6):282-92. doi: 10.1049/iet-syb.2014.0024.


Integrated signaling pathway and gene expression regulatory model to dissect dynamics of Escherichia coli challenged mammary epithelial cells.

den Breems NY, Nguyen LK, Kulasiri D.

Biosystems. 2014 Dec;126:27-40. doi: 10.1016/j.biosystems.2014.09.011. Epub 2014 Oct 5.


The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility.

Kiuchi T, Ortiz-Zapater E, Monypenny J, Matthews DR, Nguyen LK, Barbeau J, Coban O, Lawler K, Burford B, Rolfe DJ, de Rinaldis E, Dafou D, Simpson MA, Woodman N, Pinder S, Gillett CE, Devauges V, Poland SP, Fruhwirth G, Marra P, Boersma YL, Plückthun A, Gullick WJ, Yarden Y, Santis G, Winn M, Kholodenko BN, Martin-Fernandez ML, Parker P, Tutt A, Ameer-Beg SM, Ng T.

Sci Signal. 2014 Aug 19;7(339):ra78. doi: 10.1126/scisignal.2005157.


Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses.

Dobrzyński M, Nguyen LK, Birtwistle MR, von Kriegsheim A, Blanco Fernández A, Cheong A, Kolch W, Kholodenko BN.

J R Soc Interface. 2014 Sep 6;11(98):20140383. doi: 10.1098/rsif.2014.0383.


Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling.

Romano D, Nguyen LK, Matallanas D, Halasz M, Doherty C, Kholodenko BN, Kolch W.

Nat Cell Biol. 2014 Jul;16(7):673-84. doi: 10.1038/ncb2986. Epub 2014 Jun 15.


Polyubiquitin chain assembly and organization determine the dynamics of protein activation and degradation.

Nguyen LK, Dobrzyński M, Fey D, Kholodenko BN.

Front Physiol. 2014 Jan 24;5:4. doi: 10.3389/fphys.2014.00004. eCollection 2014.


When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling.

Nguyen LK, Kolch W, Kholodenko BN.

Cell Commun Signal. 2013 Jul 31;11:52. doi: 10.1186/1478-811X-11-52. Review.


Hypoxia-inducible factor (HIF) network: insights from mathematical models.

Cavadas MA, Nguyen LK, Cheong A.

Cell Commun Signal. 2013 Jun 10;11(1):42. doi: 10.1186/1478-811X-11-42.


A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network.

Nguyen LK, Cavadas MA, Scholz CC, Fitzpatrick SF, Bruning U, Cummins EP, Tambuwala MM, Manresa MC, Kholodenko BN, Taylor CT, Cheong A.

J Cell Sci. 2013 Mar 15;126(Pt 6):1454-63. doi: 10.1242/jcs.119974. Epub 2013 Feb 6. Erratum in: J Cell Sci. 2015 Jan 15;128(2):422.


Low-dose computed tomography versus plain abdominal radiography in the investigation of an acute abdomen.

Nguyen LK, Wong DD, Fatovich DM, Yeung JM, Persaud J, Wood CJ, de Vos D, Mendelson RM.

ANZ J Surg. 2012 Jan-Feb;82(1-2):36-41. doi: 10.1111/j.1445-2197.2010.05632.x. Epub 2011 Jan 26.


Regulation of oscillation dynamics in biochemical systems with dual negative feedback loops.

Nguyen LK.

J R Soc Interface. 2012 Aug 7;9(73):1998-2010. doi: 10.1098/rsif.2012.0028. Epub 2012 Mar 14.


Signalling by protein phosphatases and drug development: a systems-centred view.

Nguyen LK, Matallanas D, Croucher DR, von Kriegsheim A, Kholodenko BN.

FEBS J. 2013 Jan;280(2):751-65. doi: 10.1111/j.1742-4658.2012.08522.x. Epub 2012 Mar 14. Review.


Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system.

Nguyen LK, Muñoz-García J, Maccario H, Ciechanover A, Kolch W, Kholodenko BN.

PLoS Comput Biol. 2011 Dec;7(12):e1002317. doi: 10.1371/journal.pcbi.1002317. Epub 2011 Dec 15.


Distinct noise-controlling roles of multiple negative feedback mechanisms in a prokaryotic operon system.

Nguyen LK, Kulasiri D.

IET Syst Biol. 2011 Mar;5(2):145-56. doi: 10.1049/iet-syb.2010.0020.


Healthy colon, healthy life: a novel colorectal cancer screening intervention.

Walsh JM, Salazar R, Nguyen TT, Kaplan C, Nguyen LK, Hwang J, McPhee SJ, Pasick RJ.

Am J Prev Med. 2010 Jul;39(1):1-14. doi: 10.1016/j.amepre.2010.02.020.

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