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Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells.

Chen RR, Yung MMH, Xuan Y, Zhan S, Leung LL, Liang RR, Leung THY, Yang H, Xu D, Sharma R, Chan KKL, Ngu SF, Ngan HYS, Chan DW.

Commun Biol. 2019 Jul 31;2(1):281. doi: 10.1038/s42003-019-0508-1.


Aberrant upregulation of PDK1 in ovarian cancer cells impairs CD8+ T cell function and survival through elevation of PD-L1.

Wang JJ, Siu MK, Jiang YX, Leung TH, Chan DW, Cheng RR, Cheung AN, Ngan HY, Chan KK.

Oncoimmunology. 2019 Sep 5;8(11):e1659092. doi: 10.1080/2162402X.2019.1659092. eCollection 2019.


The Value of Contrast-Enhanced CT in the Detection of Residual Disease After Neo-Adjuvant Chemotherapy in Ovarian Cancer.

An H, Chiu KWH, Tse KY, Ngan HYS, Khong PL, Lee EYP.

Acad Radiol. 2019 Oct 16. pii: S1076-6332(19)30452-0. doi: 10.1016/j.acra.2019.09.019. [Epub ahead of print]


Overexpression of iASPP is required for autophagy in response to oxidative stress in choriocarcinoma.

Chan KK, Wong ES, Wong IT, Cheung CL, Wong OG, Ngan HY, Cheung AN.

BMC Cancer. 2019 Oct 15;19(1):953. doi: 10.1186/s12885-019-6206-z.


Placental biology of Down syndrome in relation to increased gene dosage.

Wong OGW, Ngan HYS, Cheung ANY.

Hong Kong Med J. 2019 Aug;25 Suppl 5(4):33-35. No abstract available.


Predictive biomarkers and tumor microenvironment in female genital melanomas: a multi-institutional study of 55 cases.

Yu Y, Tse KY, Lee HHY, Chow KL, Tsang HW, Wong RWC, Cheung ETY, Cheuk W, Lee VWK, Chan WK, Wong AST, Loong HHF, Chan KKL, Ngan HYS, Cheung ANY, Ip PPC.

Mod Pathol. 2020 Jan;33(1):138-152. doi: 10.1038/s41379-019-0345-2. Epub 2019 Aug 5.


Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells.

Chen RR, Yung MMH, Xuan Y, Zhan S, Leung LL, Liang RR, Leung THY, Yang H, Xu D, Sharma R, Chan KKL, Ngu SF, Ngan HYS, Chan DW.

Commun Biol. 2019 Jul 31;2:281. doi: 10.1038/s42003-019-0508-1. eCollection 2019.


ERK Regulates HIF1α-Mediated Platinum Resistance by Directly Targeting PHD2 in Ovarian Cancer.

Li Z, Zhou W, Zhang Y, Sun W, Yung MMH, Sun J, Li J, Chen CW, Li Z, Meng Y, Chai J, Zhou Y, Liu SS, Cheung ANY, Ngan HYS, Chan DW, Zheng W, Zhu W.

Clin Cancer Res. 2019 Oct 1;25(19):5947-5960. doi: 10.1158/1078-0432.CCR-18-4145. Epub 2019 Jul 8.


CD71+ Population Enriched by HPV-E6 Protein Promotes Cancer Aggressiveness and Radioresistance in Cervical Cancer Cells.

Leung TH, Tang HW, Siu MK, Chan DW, Chan KK, Cheung AN, Ngan HY.

Mol Cancer Res. 2019 Sep;17(9):1867-1880. doi: 10.1158/1541-7786.MCR-19-0068. Epub 2019 Jun 24.


Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasion and Stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 Signaling Cascades.

Siu MKY, Jiang YX, Wang JJ, Leung THY, Han CY, Tsang BK, Cheung ANY, Ngan HYS, Chan KKL.

Cancers (Basel). 2019 Jun 12;11(6). pii: E813. doi: 10.3390/cancers11060813.


Update on the diagnosis and management of gestational trophoblastic disease.

Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L.

Int J Gynaecol Obstet. 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615.


Maternal transfer of anti HPV 6 and 11 antibodies upon immunization with the 9-valent HPV vaccine.

Guevara AM, Suarez E, Victoria A, Ngan HY, Hirschberg AL, Fedrizzi E, Bautista O, Shields C, Joshi A, Luxembourg A.

Hum Vaccin Immunother. 2019;15(1):141-145. doi: 10.1080/21645515.2018.1514227. Epub 2018 Sep 27.


Oncogenic microRNA signature for early diagnosis of cervical intraepithelial neoplasia and cancer.

Liu SS, Chan KKL, Chu DKH, Wei TN, Lau LSK, Ngu SF, Chu MMY, Tse KY, Ip PPC, Ng EKO, Cheung ANY, Ngan HYS.

Mol Oncol. 2018 Dec;12(12):2009-2022. doi: 10.1002/1878-0261.12383. Epub 2018 Sep 27.


miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer.

Sun J, Cai X, Yung MM, Zhou W, Li J, Zhang Y, Li Z, Liu SS, Cheung ANY, Ngan HYS, Li Y, Dai Z, Kai Y, Tzatsos A, Peng W, Chan DW, Zhu W.

Oncogene. 2019 Jan;38(4):564-580. doi: 10.1038/s41388-018-0459-x. Epub 2018 Aug 30.


Amyloid Precursor Protein Overexpression in Down Syndrome Trophoblast Reduces Cell Invasiveness and Interferes with Syncytialization.

Wong OGW, Cheung CLY, Ip PPC, Ngan HYS, Cheung ANY.

Am J Pathol. 2018 Oct;188(10):2307-2317. doi: 10.1016/j.ajpath.2018.07.004. Epub 2018 Jul 20.


A Case Series of Five Patients With Pure or Mixed Gestational Epithelioid Trophoblastic Tumors and a Literature Review on Mixed Tumors.

Tse KY, Chiu KWH, Chan KKL, Chu MMY, Ngu SF, Cheung ANY, Ngan HYS, Ip PPC.

Am J Clin Pathol. 2018 Aug 30;150(4):318-332. doi: 10.1093/ajcp/aqy039. Review.


Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface.

Tang MKS, Yue PYK, Ip PP, Huang RL, Lai HC, Cheung ANY, Tse KY, Ngan HYS, Wong AST.

Nat Commun. 2018 Jun 11;9(1):2270. doi: 10.1038/s41467-018-04695-7.


The first pilot study of expanded newborn screening for inborn errors of metabolism and survey of related knowledge and opinions of health care professionals in Hong Kong.

Mak CM, Law EC, Lee HH, Siu WK, Chow KM, Au Yeung SK, Ngan HY, Tse NK, Kwong NS, Chan GC, Lee KW, Chan WP, Wong SF, Tang MH, Kan AS, Hui AP, So PL, Shek CC, Lee RS, Wong KY, Yau EK, Poon KH, Siu S, Poon GW, Kwok AM, Ng JW, Yim VC, Ma GG, Chu CH, Tong TY, Chong YK, Chen SP, Ching CK, Chan AO, Tam S, Lau RL, Ng WF, Lee KC, Chan AY, Lam CW.

Hong Kong Med J. 2018 Jun;24(3):226-237. doi: 10.12809/hkmj176939. Epub 2018 Jun 4.


Efficacy, Immunogenicity, and Safety of a 9-Valent Human Papillomavirus Vaccine: Subgroup Analysis of Participants From Asian Countries.

Garland SM, Pitisuttithum P, Ngan HYS, Cho CH, Lee CY, Chen CA, Yang YC, Chu TY, Twu NF, Samakoses R, Takeuchi Y, Cheung TH, Kim SC, Huang LM, Kim BG, Kim YT, Kim KH, Song YS, Lalwani S, Kang JH, Sakamoto M, Ryu HS, Bhatla N, Yoshikawa H, Ellison MC, Han SR, Moeller E, Murata S, Ritter M, Sawata M, Shields C, Walia A, Perez G, Luxembourg A.

J Infect Dis. 2018 Jun 5;218(1):95-108. doi: 10.1093/infdis/jiy133.


Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer.

Chan KKL, Siu MKY, Jiang YX, Wang JJ, Leung THY, Ngan HYS.

Cancer Cell Int. 2018 May 1;18:65. doi: 10.1186/s12935-018-0559-2. eCollection 2018.


DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer.

Meng Y, Chen CW, Yung MMH, Sun W, Sun J, Li Z, Li J, Li Z, Zhou W, Liu SS, Cheung ANY, Ngan HYS, Braisted JC, Kai Y, Peng W, Tzatsos A, Li Y, Dai Z, Zheng W, Chan DW, Zhu W.

Cancer Lett. 2018 Aug 1;428:104-116. doi: 10.1016/j.canlet.2018.04.029. Epub 2018 Apr 26.


Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance.

Zhou W, Sun W, Yung MMH, Dai S, Cai Y, Chen CW, Meng Y, Lee JB, Braisted JC, Xu Y, Southall NT, Shinn P, Huang X, Song Z, Chen X, Kai Y, Cai X, Li Z, Hao Q, Cheung ANY, Ngan HYS, Liu SS, Barak S, Hao J, Dai Z, Tzatsos A, Peng W, Pei H, Han Z, Chan DW, Zheng W, Zhu W.

Oncogene. 2018 Jul;37(29):3981-3997. doi: 10.1038/s41388-018-0238-8. Epub 2018 Apr 17.


Identification of nonsynonymous TP53 mutations in hydatidiform moles.

Chan KK, Wong ES, Wong OG, Ngan HY, Cheung AN.

Mutat Res. 2018 May;809:20-23. doi: 10.1016/j.mrfmmm.2018.03.006. Epub 2018 Mar 29.


GRO-α and IL-8 enhance ovarian cancer metastatic potential via the CXCR2-mediated TAK1/NFκB signaling cascade.

Yung MM, Tang HW, Cai PC, Leung TH, Ngu SF, Chan KK, Xu D, Yang H, Ngan HY, Chan DW.

Theranostics. 2018 Feb 2;8(5):1270-1285. doi: 10.7150/thno.22536. eCollection 2018.


Rapid detection of BRCA1/2 recurrent mutations in Chinese breast and ovarian cancer patients with multiplex SNaPshot genotyping panels.

Kwong A, Ho JCW, Shin VY, Kurian AW, Tai E, Esserman LJ, Weitzel JN, Lin PH, Field M, Domchek SM, Lo J, Ngan HYS, Ma ESK, Chan TL, Ford JM.

Oncotarget. 2017 Dec 20;9(8):7832-7843. doi: 10.18632/oncotarget.23471. eCollection 2018 Jan 30.


Combined electroacupuncture and auricular acupuncture for postoperative pain after abdominal surgery for gynecological diseases: study protocol for a randomized controlled trial.

Lam WL, Yeung WF, Wong MK, Cheung CW, Chan KKL, Ngan HYS, Wong CKH, Chen HY, Lao L.

Trials. 2018 Jan 4;19(1):8. doi: 10.1186/s13063-017-2359-8.


Methylation-associated silencing of miR-193a-3p promotes ovarian cancer aggressiveness by targeting GRB7 and MAPK/ERK pathways.

Chen K, Liu MX, Mak CS, Yung MM, Leung TH, Xu D, Ngu SF, Chan KK, Yang H, Ngan HY, Chan DW.

Theranostics. 2018 Jan 1;8(2):423-436. doi: 10.7150/thno.22377. eCollection 2018.


ERBB2 mutation: A promising target in non-squamous cervical cancer.

Xiang L, Jiang W, Ye S, He T, Pei X, Li J, Chan DW, Ngan HYS, Li F, Tao P, Shen X, Zhou X, Wu X, Yang G, Yang H.

Gynecol Oncol. 2018 Feb;148(2):311-316. doi: 10.1016/j.ygyno.2017.12.023. Epub 2017 Dec 24.


Human papillomavirus E6 protein enriches the CD55(+) population in cervical cancer cells, promoting radioresistance and cancer aggressiveness.

Leung TH, Tang HW, Siu MK, Chan DW, Chan KK, Cheung AN, Ngan HY.

J Pathol. 2018 Feb;244(2):151-163. doi: 10.1002/path.4991. Epub 2017 Dec 19.


Differential expression of estrogen receptor subtypes and variants in ovarian cancer: effects on cell invasion, proliferation and prognosis.

Chan KKL, Siu MKY, Jiang YX, Wang JJ, Wang Y, Leung THY, Liu SS, Cheung ANY, Ngan HYS.

BMC Cancer. 2017 Aug 31;17(1):606. doi: 10.1186/s12885-017-3601-1.


Apoptosis and Anti-cancer Drug Discovery: The Power of Medicinal Fungi and Plants.

Wong JH, Sze SCW, Ng TB, Cheung RCF, Tam C, Zhang KY, Dan X, Chan YS, Shing Cho WC, Ng CCW, Waye MMY, Liang W, Zhang J, Yang J, Ye X, Lin J, Ye X, Wang H, Liu F, Chan DW, Ngan HYS, Sha O, Li G, Tse R, Tse TF, Chan H.

Curr Med Chem. 2018;25(40):5613-5630. doi: 10.2174/0929867324666170720165005. Review.


Robot-assisted gynaecological cancer surgery-complications and prevention.

Tse KY, Ngan HYS, Lim PC.

Best Pract Res Clin Obstet Gynaecol. 2017 Nov;45:94-106. doi: 10.1016/j.bpobgyn.2017.04.005. Epub 2017 Apr 23. Review.


Impact of different educational interventions on psychosocial well-being of women with a positive high-risk human papillomavirus and normal cervical cytology: a randomised trial.

Ngu SF, Wei N, Kwan TTC, Chu MMY, Tse KY, Chan KKL, Ngan HYS.

J Psychosom Obstet Gynaecol. 2018 Jun;39(2):146-155. doi: 10.1080/0167482X.2017.1312335. Epub 2017 Apr 10.


Hidrosadénite suppurée vulvaire : la masse est-elle maligne?

Ngu SF, Chu MMY, Ip PPC, Ngan HYS.

J Obstet Gynaecol Can. 2018 Jan;40(1):2. doi: 10.1016/j.jogc.2017.03.103. Epub 2017 Mar 31. French. No abstract available.


Vulvar Hidradenitis Suppurativa: Is the Mass Malignant?

Ngu SF, Chu MMY, Ip PPC, Ngan HYS.

J Obstet Gynaecol Can. 2018 Jan;40(1):1. doi: 10.1016/j.jogc.2016.10.015. Epub 2017 Mar 31. No abstract available.


MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis.

Mak CS, Yung MM, Hui LM, Leung LL, Liang R, Chen K, Liu SS, Qin Y, Leung TH, Lee KF, Chan KK, Ngan HY, Chan DW.

Mol Cancer. 2017 Jan 17;16(1):11. doi: 10.1186/s12943-017-0582-2.


The mitosis-specific marker phosphohistone-H3 (PHH3) is an independent prognosticator in uterine smooth muscle tumours: an outcome-based study.

Chow KL, Tse KY, Cheung CL, Wong KW, Cheung AN, Wong RW, Chan AN, Yuen NW, Ngan HY, Ip PP.

Histopathology. 2017 Apr;70(5):746-755. doi: 10.1111/his.13124. Epub 2017 Jan 24.


Successful Treatment of a Pararenal Pregnancy Using High-Dose Methotrexate Regimen: A Case Report.

Tse KY, Cheung VYT, Lam C, Lee EYP, Khong PL, Ngan HYS.

J Reprod Med. 2016 Nov-Dec;61(11-12):592-4.


DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-β/SMAD4 signaling.

Chan DW, Hui WW, Wang JJ, Yung MM, Hui LM, Qin Y, Liang RR, Leung TH, Xu D, Chan KK, Yao KM, Tsang BK, Ngan HY.

Oncogene. 2017 Mar;36(10):1404-1416. doi: 10.1038/onc.2016.307. Epub 2016 Sep 5.


Patient compliance with cervical smear surveillance in a shared-care setting.

Tse KY, Lau SK, Lui MW, Ip PP, Cheung AN, Ngan HY.

Int J Gynaecol Obstet. 2016 Nov;135(2):177-181. doi: 10.1016/j.ijgo.2016.04.012. Epub 2016 Jul 7.


Extremely stringent activation of p16INK4a prevents immortalization of uterine cervical epithelial cells without human papillomavirus oncogene expression.

Hang S, Tiwari AF, Ngan HY, Yip YL, Cheung AL, Tsao SW, Deng W.

Oncotarget. 2016 Jul 19;7(29):45656-45670. doi: 10.18632/oncotarget.10120.


Management and Care of Women With Invasive Cervical Cancer: American Society of Clinical Oncology Resource-Stratified Clinical Practice Guideline.

Chuang LT, Temin S, Camacho R, Dueñas-Gonzalez A, Feldman S, Gultekin M, Gupta V, Horton S, Jacob G, Kidd EA, Lishimpi K, Nakisige C, Nam JH, Ngan HYS, Small W, Thomas G, Berek JS.

J Glob Oncol. 2016 May 25;2(5):311-340. doi: 10.1200/JGO.2016.003954. eCollection 2016 Oct.


Targeting AMPK signaling in combating ovarian cancers: opportunities and challenges.

Yung MM, Ngan HY, Chan DW.

Acta Biochim Biophys Sin (Shanghai). 2016 Apr;48(4):301-17. doi: 10.1093/abbs/gmv128. Epub 2016 Jan 12. Review.


Pazopanib Maintenance Therapy in East Asian Women With Advanced Epithelial Ovarian Cancer: Results From AGO-OVAR16 and an East Asian Study.

Kim JW, Mahner S, Wu LY, Shoji T, Kim BG, Zhu JQ, Takano T, Park SY, Kong BH, Wu Q, Wang KL, Ngan HY, Liu JH, Wei LH, Mitrica I, Zhang P, Crescenzo R, Wang Q, Cox CJ, Harter P, du Bois A.

Int J Gynecol Cancer. 2018 Jan;28(1):2-10. doi: 10.1097/IGC.0000000000000602.


Chemotherapy in pregnancy.

Ngu SF, Ngan HY.

Best Pract Res Clin Obstet Gynaecol. 2016 May;33:86-101. doi: 10.1016/j.bpobgyn.2015.10.007. Epub 2015 Oct 19. Review.


Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade.

Yung MM, Ross FA, Hardie DG, Leung TH, Zhan J, Ngan HY, Chan DW.

Integr Cancer Ther. 2016 Sep;15(3):376-89. doi: 10.1177/1534735415611747. Epub 2015 Oct 19.


Update on the diagnosis and management of gestational trophoblastic disease.

Ngan HY, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR.

Int J Gynaecol Obstet. 2015 Oct;131 Suppl 2:S123-6. doi: 10.1016/j.ijgo.2015.06.008. No abstract available.


The Significance of Mismatch Repair Deficiency in Young Patients With Endometrial Cancer.

Chu MM, Liu SS, Tam KF, Ip PP, Cheung AN, Ngan HY.

Int J Gynecol Pathol. 2015 Sep;34(5):403-10. doi: 10.1097/PGP.0000000000000174.


p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation.

Siu MK, Kong DS, Ngai SY, Chan HY, Jiang L, Wong ES, Liu SS, Chan KK, Ngan HY, Cheung AN.

PLoS One. 2015 Jul 28;10(7):e0133467. doi: 10.1371/journal.pone.0133467. eCollection 2015.

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