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The prevalence of sarcopenic obesity and its association with cognitive performance in type 2 diabetes in Singapore.

Low S, Goh KS, Ng TP, Ang SF, Moh A, Wang J, Ang K, Subramaniam T, Sum CF, Lim SC.

Clin Nutr. 2019 Nov 4. pii: S0261-5614(19)33106-1. doi: 10.1016/j.clnu.2019.10.019. [Epub ahead of print]


Assessment of Sarcopenia Among Community-Dwelling At-Risk Frail Adults Aged 65 Years and Older Who Received Multidomain Lifestyle Interventions: A Secondary Analysis of a Randomized Clinical Trial.

Lu Y, Niti M, Yap KB, Tan CTY, Zin Nyunt MS, Feng L, Tan BY, Chan G, Khoo SA, Chan SM, Yap P, Larbi A, Ng TP.

JAMA Netw Open. 2019 Oct 2;2(10):e1913346. doi: 10.1001/jamanetworkopen.2019.13346.


The Association of Sedentary Behaviour and Cognitive Function in People Without Dementia: A Coordinated Analysis Across Five Cohort Studies from COSMIC.

Maasakkers CM, Claassen JAHR, Gardiner PA, Olde Rikkert MGM, Lipnicki DM, Scarmeas N, Dardiotis E, Yannakoulia M, Anstey KJ, Cherbuin N, Haan MN, Kumagai S, Narazaki K, Chen T, Ng TP, Gao Q, Nyunt MSZ, Crawford JD, Kochan NA, Makkar SR, Sachdev PS; COSMIC Collaborators, Thijssen DHJ, Melis RJF.

Sports Med. 2019 Sep 16. doi: 10.1007/s40279-019-01186-7. [Epub ahead of print]


Determinants of cognitive performance and decline in 20 diverse ethno-regional groups: A COSMIC collaboration cohort study.

Lipnicki DM, Makkar SR, Crawford JD, Thalamuthu A, Kochan NA, Lima-Costa MF, Castro-Costa E, Ferri CP, Brayne C, Stephan B, Llibre-Rodriguez JJ, Llibre-Guerra JJ, Valhuerdi-Cepero AJ, Lipton RB, Katz MJ, Derby CA, Ritchie K, Ancelin ML, Carrière I, Scarmeas N, Yannakoulia M, Hadjigeorgiou GM, Lam L, Chan WC, Fung A, Guaita A, Vaccaro R, Davin A, Kim KW, Han JW, Suh SW, Riedel-Heller SG, Roehr S, Pabst A, van Boxtel M, Köhler S, Deckers K, Ganguli M, Jacobsen EP, Hughes TF, Anstey KJ, Cherbuin N, Haan MN, Aiello AE, Dang K, Kumagai S, Chen T, Narazaki K, Ng TP, Gao Q, Nyunt MSZ, Scazufca M, Brodaty H, Numbers K, Trollor JN, Meguro K, Yamaguchi S, Ishii H, Lobo A, Lopez-Anton R, Santabárbara J, Leung Y, Lo JW, Popovic G, Sachdev PS; for Cohort Studies of Memory in an International Consortium (COSMIC).

PLoS Med. 2019 Jul 23;16(7):e1002853. doi: 10.1371/journal.pmed.1002853. eCollection 2019 Jul.


Circulating microRNAs as Potential Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma.

Jin Y, Wong YS, Goh BKP, Chan CY, Cheow PC, Chow PKH, Lim TKH, Goh GBB, Krishnamoorthy TL, Kumar R, Ng TP, Chong SS, Tan HH, Chung AYF, Ooi LLPJ, Chang JPE, Tan CK, Lee CGL.

Sci Rep. 2019 Jul 18;9(1):10464. doi: 10.1038/s41598-019-46872-8.


Degree and centrality-based approaches in network-based variable selection: Insights from the Singapore Longitudinal Aging Study.

Valenzuela JFB, Monterola C, Tong VJC, Fülöp T, Ng TP, Larbi A.

PLoS One. 2019 Jul 18;14(7):e0219186. doi: 10.1371/journal.pone.0219186. eCollection 2019.


Long-term changes in nutritional status are associated with functional and mortality outcomes among community-living older adults.

Wei K, Nyunt MSZ, Gao Q, Wee SL, Ng TP.

Nutrition. 2019 Oct;66:180-186. doi: 10.1016/j.nut.2019.05.006. Epub 2019 May 29.


Cornell product is an ECG marker of heart failure with preserved ejection fraction.

Tan ES, Chan SP, Xu CF, Yap J, Richards AM, Ling LH, Sim D, Jaufeerally F, Yeo D, Loh SY, Ong HY, Leong KTG, Ng TP, Nyunt SZ, Feng L, Okin P, Lam CS, Lim TW.

Heart Asia. 2019 May 28;11(1):e011108. doi: 10.1136/heartasia-2018-011108. eCollection 2019.


Estimating Biological Age in the Singapore Longitudinal Aging Study.

Zhong X, Lu Y, Gao Q, Nyunt MSZ, Fulop T, Monterola CP, Tong JC, Larbi A, Ng TP.

J Gerontol A Biol Sci Med Sci. 2019 Jun 8. pii: glz146. doi: 10.1093/gerona/glz146. [Epub ahead of print]


Metformin Monotherapy Downregulates Diabetes-Associated Inflammatory Status and Impacts on Mortality.

Tizazu AM, Nyunt MSZ, Cexus O, Suku K, Mok E, Xian CH, Chong J, Tan C, How W, Hubert S, Combet E, Fulop T, Ng TP, Larbi A.

Front Physiol. 2019 May 21;10:572. doi: 10.3389/fphys.2019.00572. eCollection 2019.


Symptom clusters of subjective cognitive decline amongst cognitively normal older persons and their utilities in predicting objective cognitive performance: structural equation modelling.

Liew TM, Yap P, Ng TP, Mahendran R, Kua EH, Feng L.

Eur J Neurol. 2019 Sep;26(9):1153-1160. doi: 10.1111/ene.13958. Epub 2019 Apr 30.


Combining Circulating MicroRNA and NT-proBNP to Detect and Categorize Heart Failure Subtypes.

Wong LL, Zou R, Zhou L, Lim JY, Phua DCY, Liu C, Chong JPC, Ng JYX, Liew OW, Chan SP, Chen YT, Chan MMY, Yeo PSD, Ng TP, Ling LH, Sim D, Leong KTG, Ong HY, Jaufeerally F, Wong R, Chai P, Low AF, Lund M, Devlin G, Troughton R, Cameron VA, Doughty RN, Lam CSP, Too HP, Richards AM.

J Am Coll Cardiol. 2019 Mar 26;73(11):1300-1313. doi: 10.1016/j.jacc.2018.11.060.


Super-cognition in aging: Cognitive profiles and associated lifestyle factors.

Yu J, Collinson SL, Liew TM, Ng TP, Mahendran R, Kua EH, Feng L.

Appl Neuropsychol Adult. 2019 Feb 22:1-7. doi: 10.1080/23279095.2019.1570928. [Epub ahead of print]


Hallmarks of improved immunological responses in the vaccination of more physically active elderly females.

Wong GCL, Narang V, Lu Y, Camous X, Nyunt MSZ, Carre C, Tan C, Xian CH, Chong J, Chua M, How W, Mok E, Tambyah P, Poidinger M, Abel B, Burdin N, Quemeneur L, Bosco N, Ng TP, Larbi A.

Exerc Immunol Rev. 2019;25:20-33.


Successful aging, cognitive function, socioeconomic status, and leukocyte telomere length.

Huang Y, Yim OS, Lai PS, Yu R, Chew SH, Gwee X, Nyunt MSZ, Gao Q, Ng TP, Ebstein RP, Gouin JP.

Psychoneuroendocrinology. 2019 May;103:180-187. doi: 10.1016/j.psyneuen.2019.01.015. Epub 2019 Jan 17.


Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific.

Tan ESJ, Tay WT, Teng TK, Sim D, Leong KTG, Yeo PSD, Ong HY, Jaufeerally F, Ng TP, Poppe K, Lund M, Devlin G, Troughton RW, Ling LH, Richards AM, Doughty RN, Lam CSP.

Heart. 2019 Jun;105(11):842-847. doi: 10.1136/heartjnl-2018-314077. Epub 2019 Jan 19.


Systemic and Metabolic Signature of Sarcopenia in Community-Dwelling Older Adults.

Lu Y, Karagounis LG, Ng TP, Carre C, Narang V, Wong G, Ying Tan CT, Zin Nyunt MS, Gao Q, Abel B, Poidinger M, Fulop T, Bosco N, Larbi A.

J Gerontol A Biol Sci Med Sci. 2019 Jan 8. doi: 10.1093/gerona/glz001. [Epub ahead of print]


Heart Failure With Preserved Ejection Fraction in the Young.

Tromp J, MacDonald MR, Tay WT, Teng TK, Hung CL, Narasimhan C, Shimizu W, Ling LH, Ng TP, Yap J, McMurray JJV, Zile MR, Richards AM, Anand IS, Lam CSP.

Circulation. 2018 Dec 11;138(24):2763-2773. doi: 10.1161/CIRCULATIONAHA.118.034720.


Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence.

Xu W, Monaco G, Wong EH, Tan WLW, Kared H, Simoni Y, Tan SW, How WZY, Tan CTY, Lee BTK, Carbajo D, K G S, Low ICH, Mok EWH, Foo S, Lum J, Tey HL, Tan WP, Poidinger M, Newell E, Ng TP, Foo R, Akbar AN, Fülöp T, Larbi A.

EBioMedicine. 2019 Jan;39:44-58. doi: 10.1016/j.ebiom.2018.11.053. Epub 2018 Dec 7.


Nutritional and Frailty State Transitions in the Singapore Longitudinal Aging Study.

Wei K, Thein FS, Nyunt MSZ, Gao Q, Wee SL, Ng TP.

J Nutr Health Aging. 2018;22(10):1221-1227. doi: 10.1007/s12603-018-1096-3.


Influenza Vaccine-Induced Antibody Responses Are Not Impaired by Frailty in the Community-Dwelling Elderly With Natural Influenza Exposure.

Narang V, Lu Y, Tan C, Camous XFN, Nyunt SZ, Carre C, Mok EWH, Wong G, Maurer-Stroh S, Abel B, Burdin N, Poidinger M, Tambyah PA, Bosco N, Visan L, Ng TP, Larbi A.

Front Immunol. 2018 Oct 24;9:2465. doi: 10.3389/fimmu.2018.02465. eCollection 2018.


Dysregulated homeostatic pathways in sarcopenia among frail older adults.

Ng TP, Lu Y, Choo RWM, Tan CTY, Nyunt MSZ, Gao Q, Mok EWH, Larbi A.

Aging Cell. 2018 Dec;17(6):e12842. doi: 10.1111/acel.12842. Epub 2018 Oct 9.


Effectiveness of a Personalized Brain-Computer Interface System for Cognitive Training in Healthy Elderly: A Randomized Controlled Trial.

Yeo SN, Lee TS, Sng WT, Heo MQ, Bautista D, Cheung YB, Zhang HH, Wang C, Chin ZY, Feng L, Zhou J, Chong MS, Ng TP, Krishnan KR, Guan C.

J Alzheimers Dis. 2018;66(1):127-138. doi: 10.3233/JAD-180450.


Modified Criteria for Diagnosing "Cognitive Frailty".

Won CW, Lee Y, Kim S, Yoo J, Kim M, Ng TP, Kim H, Son SJ.

Psychiatry Investig. 2018 Sep;15(9):839-842. doi: 10.30773/pi.2018.05.22. Epub 2018 Sep 17.


Dynamics of helper CD4 T cells during acute and stable allergic asthma.

Lu Y, Kared H, Tan SW, Becht E, Newell EW, Van Bever HPS, Ng TP, Larbi A.

Mucosal Immunol. 2018 Nov;11(6):1640-1652. doi: 10.1038/s41385-018-0057-9. Epub 2018 Aug 7.


Biomarker Signatures Predicting 10-Year All-Cause and Disease-Specific Mortality.

Lu Y, Monaco G, Camous X, Andiappan AK, Rotzschke O, Ng TP, Larbi A.

J Gerontol A Biol Sci Med Sci. 2019 Mar 14;74(4):469-479. doi: 10.1093/gerona/gly138.


Mild Cognitive Impairment Reversion and Progression: Rates and Predictors in Community-Living Older Persons in the Singapore Longitudinal Ageing Studies Cohort.

Gao Q, Gwee X, Feng L, Nyunt MSZ, Feng L, Collinson SL, Chong MS, Lim WS, Lee TS, Yap P, Yap KB, Ng TP.

Dement Geriatr Cogn Dis Extra. 2018 Jun 19;8(2):226-237. doi: 10.1159/000488936. eCollection 2018 May-Aug.


Physical frailty and cognitive impairment is associated with diabetes and adversely impact functional status and mortality.

Thein FS, Li Y, Nyunt MSZ, Gao Q, Wee SL, Ng TP.

Postgrad Med. 2018 Aug;130(6):561-567. doi: 10.1080/00325481.2018.1491779. Epub 2018 Jul 26.


Old age depression: worse clinical course, brighter treatment prospects?

Ng TP.

Lancet Psychiatry. 2018 Jul;5(7):533-534. doi: 10.1016/S2215-0366(18)30186-X. Epub 2018 Jun 7. No abstract available.


Strong Relationship between Malnutrition and Cognitive Frailty in the Singapore Longitudinal Ageing Studies (SLAS-1 and SLAS-2).

Chye L, Wei K, Nyunt MSZ, Gao Q, Wee SL, Ng TP.

J Prev Alzheimers Dis. 2018;5(2):142-148. doi: 10.14283/jpad.2017.46.


Ministry of Health Clinical Practice Guidelines: Chronic Obstructive Pulmonary Disease.

Lim TK, Chee CB, Chow P, Chua GSW, Eng SK, Goh SK, Kng KK, Lim WH, Ng TP, Ong TH, Seah STA, Tan HY, Tee KH, Palanichamy V, Yeung MT.

Singapore Med J. 2018 Feb;59(2):76-86. doi: 10.11622/smedj.2018015.


Feasibility of a community-based Functional Power Training program for older adults.

Tan QLL, Chye LMY, Ng DHM, Chong MS, Ng TP, Wee SL.

Clin Interv Aging. 2018 Feb 22;13:309-316. doi: 10.2147/CIA.S157911. eCollection 2018.


Neuropsychiatric and Cognitive Subtypes among Community-Dwelling Older Persons and the Association with DSM-5 Mild Neurocognitive Disorder: Latent Class Analysis.

Liew TM, Yu J, Mahendran R, Ng TP, Kua EH, Feng L.

J Alzheimers Dis. 2018;62(2):675-686. doi: 10.3233/JAD-170947.


The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence.

Ong SM, Hadadi E, Dang TM, Yeap WH, Tan CT, Ng TP, Larbi A, Wong SC.

Cell Death Dis. 2018 Feb 15;9(3):266. doi: 10.1038/s41419-018-0327-1.


Elderly Nutritional Indicators for Geriatric Malnutrition Assessment (ENIGMA): Development and validation of a nutritional prognostic index.

Ng TP, Nyunt MSZ, Gao Q, Wee SL, Yap P, Yap KB.

Clin Nutr ESPEN. 2017 Dec;22:54-63. doi: 10.1016/j.clnesp.2017.08.012. Epub 2017 Sep 18.


Associations of Long-Term Tea Consumption with Depressive and Anxiety Symptoms in Community-Living Elderly: Findings from the Diet and Healthy Aging Study.

Chan SP, Yong PZ, Sun Y, Mahendran R, Wong JCM, Qiu C, Ng TP, Kua EH, Feng L.

J Prev Alzheimers Dis. 2018;5(1):21-25. doi: 10.14283/jpad.2017.20.


Mortality associated with heart failure with preserved vs. reduced ejection fraction in a prospective international multi-ethnic cohort study.

Lam CSP, Gamble GD, Ling LH, Sim D, Leong KTG, Yeo PSD, Ong HY, Jaufeerally F, Ng TP, Cameron VA, Poppe K, Lund M, Devlin G, Troughton R, Richards AM, Doughty RN.

Eur Heart J. 2018 May 21;39(20):1770-1780. doi: 10.1093/eurheartj/ehy005.


A novel language-neutral Visual Cognitive Assessment Test (VCAT): validation in four Southeast Asian countries.

Lim L, Ng TP, Ong AP, Tan MP, Cenina AR, Gao Q, Ng A, Kandiah N.

Alzheimers Res Ther. 2018 Jan 22;10(1):6. doi: 10.1186/s13195-017-0333-z.


Characterisation of Physical Frailty and Associated Physical and Functional Impairments in Mild Cognitive Impairment.

Nyunt MSZ, Soh CY, Gao Q, Gwee X, Ling ASL, Lim WS, Lee TS, Yap PLK, Yap KB, Ng TP.

Front Med (Lausanne). 2017 Dec 18;4:230. doi: 10.3389/fmed.2017.00230. eCollection 2017.


Vitamin B12 deficiency and impaired expression of amnionless during aging.

Pannérec A, Migliavacca E, De Castro A, Michaud J, Karaz S, Goulet L, Rezzi S, Ng TP, Bosco N, Larbi A, Feige JN.

J Cachexia Sarcopenia Muscle. 2018 Feb;9(1):41-52. doi: 10.1002/jcsm.12260. Epub 2017 Nov 21.


Health and disease phenotyping in old age using a cluster network analysis.

Valenzuela JF, Monterola C, Tong VJC, Ng TP, Larbi A.

Sci Rep. 2017 Nov 15;7(1):15608. doi: 10.1038/s41598-017-15753-3.


Cognitive Effects of Multi-Domain Interventions Among Pre-Frail and Frail Community-Living Older Persons: Randomized Controlled Trial.

Ng TP, Ling LHA, Feng L, Nyunt MSZ, Feng L, Niti M, Tan BY, Chan G, Khoo SA, Chan SM, Yap P, Yap KB.

J Gerontol A Biol Sci Med Sci. 2018 May 9;73(6):806-812. doi: 10.1093/gerona/glx207.


Multi-Domains Lifestyle Interventions Reduces Depressive Symptoms among Frail and Pre-Frail Older Persons: Randomized Controlled Trial.

Ng TP, Nyunt MSZ, Feng L, Feng L, Niti M, Tan BY, Chan G, Khoo SA, Chan SM, Yap P, Yap KB.

J Nutr Health Aging. 2017;21(8):918-926. doi: 10.1007/s12603-016-0867-y.


The Neighborhood Built Environment and Cognitive Function of Older Persons: Results from the Singapore Longitudinal Ageing Study.

Ng TP, Nyunt MSZ, Shuvo FK, Eng JY, Yap KB, Hee LM, Chan SP, Scherer S.

Gerontology. 2018;64(2):149-156. doi: 10.1159/000480080. Epub 2017 Sep 15.


Frailty and Malnutrition: Related and Distinct Syndrome Prevalence and Association among Community-Dwelling Older Adults: Singapore Longitudinal Ageing Studies.

Wei K, Nyunt MSZ, Gao Q, Wee SL, Ng TP.

J Am Med Dir Assoc. 2017 Dec 1;18(12):1019-1028. doi: 10.1016/j.jamda.2017.06.017. Epub 2017 Aug 10.


Age-dependent relationships between body mass index and mortality: Singapore longitudinal ageing study.

Ng TP, Jin A, Chow KY, Feng L, Nyunt MSZ, Yap KB.

PLoS One. 2017 Jul 24;12(7):e0180818. doi: 10.1371/journal.pone.0180818. eCollection 2017.


Social Frailty and Functional Disability: Findings From the Singapore Longitudinal Ageing Studies.

Teo N, Gao Q, Nyunt MSZ, Wee SL, Ng TP.

J Am Med Dir Assoc. 2017 Jul 1;18(7):637.e13-637.e19. doi: 10.1016/j.jamda.2017.04.015.


The Asia-Pacific Clinical Practice Guidelines for the Management of Frailty.

Dent E, Lien C, Lim WS, Wong WC, Wong CH, Ng TP, Woo J, Dong B, de la Vega S, Hua Poi PJ, Kamaruzzaman SBB, Won C, Chen LK, Rockwood K, Arai H, Rodriguez-Mañas L, Cao L, Cesari M, Chan P, Leung E, Landi F, Fried LP, Morley JE, Vellas B, Flicker L.

J Am Med Dir Assoc. 2017 Jul 1;18(7):564-575. doi: 10.1016/j.jamda.2017.04.018. Erratum in: J Am Med Dir Assoc. 2018 Jan;19(1):94.


Thymosin Beta-4 Is Elevated in Women With Heart Failure With Preserved Ejection Fraction.

Drum CL, Tan WKY, Chan SP, Pakkiri LS, Chong JPC, Liew OW, Ng TP, Ling LH, Sim D, Leong KG, Yeo DPS, Ong HY, Jaufeerally F, Wong RCC, Chai P, Low AF, Davidsson P, Liljeblad M, Söderling AS, Gan LM, Bhat RV, Purnamawati K, Lam CSP, Richards AM.

J Am Heart Assoc. 2017 Jun 13;6(6). pii: e005586. doi: 10.1161/JAHA.117.005586.

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