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Neutrophils instruct homeostatic and pathological states in naive tissues.

Casanova-Acebes M, Nicolás-Ávila JA, Li JL, García-Silva S, Balachander A, Rubio-Ponce A, Weiss LA, Adrover JM, Burrows K, A-González N, Ballesteros I, Devi S, Quintana JA, Crainiciuc G, Leiva M, Gunzer M, Weber C, Nagasawa T, Soehnlein O, Merad M, Mortha A, Ng LG, Peinado H, Hidalgo A.

J Exp Med. 2018 Nov 5;215(11):2778-2795. doi: 10.1084/jem.20181468. Epub 2018 Oct 3.


Streamlining volumetric multi-channel image cytometry using hue-saturation-brightness-based surface creation.

Tan Y, Li JLY, Goh CC, Lee BTK, Kwok IWH, Ng WJ, Evrard M, Poidinger M, Tey HL, Ng LG.

Commun Biol. 2018 Sep 6;1:136. doi: 10.1038/s42003-018-0139-y. eCollection 2018.


Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.

Lim HY, Lim SY, Tan CK, Thiam CH, Goh CC, Carbajo D, Chew SHS, See P, Chakarov S, Wang XN, Lim LH, Johnson LA, Lum J, Fong CY, Bongso A, Biswas A, Goh C, Evrard M, Yeo KP, Basu R, Wang JK, Tan Y, Jain R, Tikoo S, Choong C, Weninger W, Poidinger M, Stanley RE, Collin M, Tan NS, Ng LG, Jackson DG, Ginhoux F, Angeli V.

Immunity. 2018 Aug 21;49(2):326-341.e7. doi: 10.1016/j.immuni.2018.06.008. Epub 2018 Jul 24.


Anti-Allergic Inflammatory Activity of Interleukin-37 Is Mediated by Novel Signaling Cascades in Human Eosinophils.

Zhu J, Dong J, Ji L, Jiang P, Leung TF, Liu D, Ng LG, Tsang MS, Jiao D, Lam CW, Wong CK.

Front Immunol. 2018 Jun 22;9:1445. doi: 10.3389/fimmu.2018.01445. eCollection 2018.


Reverse-engineering flow-cytometry gating strategies for phenotypic labelling and high-performance cell sorting.

Becht E, Simoni Y, Coustan-Smith E, Maximilien E, Cheng Y, Ng LG, Campana D, Newell E.

Bioinformatics. 2018 Jun 21. doi: 10.1093/bioinformatics/bty491. [Epub ahead of print]


Intermediate Outcomes of Image-Guided Radiofrequency Ablation of Renal Tumours.

Chua JM, Rasheed S, Gogna A, Yuen JS, Lo RH, Ng LG, Chong TW, Irani FG, Too CW, Tan BS.

Ann Acad Med Singapore. 2018 Mar;47(3):119-122. No abstract available.


Polymeric nanorods with aggregation-induced emission characteristics for enhanced cancer targeting and imaging.

Feng G, Mao D, Liu J, Goh CC, Ng LG, Kong D, Tang BZ, Liu B.

Nanoscale. 2018 Mar 29;10(13):5869-5874. doi: 10.1039/C7NR09196F.


The impact of ischemia-reperfusion injuries on skin resident murine dendritic cells.

Goh CC, Evrard M, Chong SZ, Tan Y, Tan LL, Teng KWW, Weninger W, Becker DL, Tey HL, Newell EW, Liu B, Ng LG.

Eur J Immunol. 2018 Jun;48(6):1014-1019. doi: 10.1002/eji.201747347. Epub 2018 Mar 23.


Nanostring Analysis of Skin Biopsies from Patients with Henoch-Schönlein Purpura Reveals Genes Associated with Pathology and Heterogeneity in the Disease Process.

Tan Y, Li JLY, Lee BTK, Lum J, Pramono ZAD, Evrard M, Poidinger M, Tey HL, Ng LG.

Acta Derm Venereol. 2018 Oct 10;98(9):896-897. doi: 10.2340/00015555-2914. No abstract available.


Imaging of Inflammatory Responses in the Mouse Ear Skin.

Li JL, Goh CC, Ng LG.

Methods Mol Biol. 2018;1763:87-107. doi: 10.1007/978-1-4939-7762-8_9.


Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions.

Evrard M, Kwok IWH, Chong SZ, Teng KWW, Becht E, Chen J, Sieow JL, Penny HL, Ching GC, Devi S, Adrover JM, Li JLY, Liong KH, Tan L, Poon Z, Foo S, Chua JW, Su IH, Balabanian K, Bachelerie F, Biswas SK, Larbi A, Hwang WYK, Madan V, Koeffler HP, Wong SC, Newell EW, Hidalgo A, Ginhoux F, Ng LG.

Immunity. 2018 Feb 20;48(2):364-379.e8. doi: 10.1016/j.immuni.2018.02.002.


Botulinum toxin and benign prostatic hyperplasia.

Ng LG.

Asian J Urol. 2018 Jan;5(1):33-36. doi: 10.1016/j.ajur.2017.11.003. Epub 2017 Nov 22. Review.


Illuminating the covert mission of mononuclear phagocytes in their regional niches.

Chong SZ, Evrard M, Goh CC, Ng LG.

Curr Opin Immunol. 2018 Feb;50:94-101. doi: 10.1016/j.coi.2017.12.004. Epub 2017 Dec 21. Review.


A 3D Printed Implantable Device for Voiding the Bladder Using Shape Memory Alloy (SMA) Actuators.

Hassani FA, Peh WYX, Gammad GGL, Mogan RP, Ng TK, Kuo TLC, Ng LG, Luu P, Yen SC, Lee C.

Adv Sci (Weinh). 2017 Jul 26;4(11):1700143. doi: 10.1002/advs.201700143. eCollection 2017 Nov.


Dual modal ultra-bright nanodots with aggregation-induced emission and gadolinium-chelation for vascular integrity and leakage detection.

Feng G, Li JLY, Claser C, Balachander A, Tan Y, Goh CC, Kwok IWH, Rénia L, Tang BZ, Ng LG, Liu B.

Biomaterials. 2018 Jan;152:77-85. doi: 10.1016/j.biomaterials.2017.10.031. Epub 2017 Oct 20.


A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment.

Sierro F, Evrard M, Rizzetto S, Melino M, Mitchell AJ, Florido M, Beattie L, Walters SB, Tay SS, Lu B, Holz LE, Roediger B, Wong YC, Warren A, Ritchie W, McGuffog C, Weninger W, Le Couteur DG, Ginhoux F, Britton WJ, Heath WR, Saunders BM, McCaughan GW, Luciani F, MacDonald KPA, Ng LG, Bowen DG, Bertolino P.

Immunity. 2017 Aug 15;47(2):374-388.e6. doi: 10.1016/j.immuni.2017.07.018.


Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function.

Takata K, Kozaki T, Lee CZW, Thion MS, Otsuka M, Lim S, Utami KH, Fidan K, Park DS, Malleret B, Chakarov S, See P, Low D, Low G, Garcia-Miralles M, Zeng R, Zhang J, Goh CC, Gul A, Hubert S, Lee B, Chen J, Low I, Shadan NB, Lum J, Wei TS, Mok E, Kawanishi S, Kitamura Y, Larbi A, Poidinger M, Renia L, Ng LG, Wolf Y, Jung S, Önder T, Newell E, Huber T, Ashihara E, Garel S, Pouladi MA, Ginhoux F.

Immunity. 2017 Jul 18;47(1):183-198.e6. doi: 10.1016/j.immuni.2017.06.017.


Intravital multiphoton imaging of mouse tibialis anterior muscle.

Lau J, Goh CC, Devi S, Keeble J, See P, Ginhoux F, Ng LG.

Intravital. 2016 Apr 8;5(2):e1156272. doi: 10.1080/21659087.2016.1156272. eCollection 2016.


Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2.

Ler LD, Ghosh S, Chai X, Thike AA, Heng HL, Siew EY, Dey S, Koh LK, Lim JQ, Lim WK, Myint SS, Loh JL, Ong P, Sam XX, Huang D, Lim T, Tan PH, Nagarajan S, Cheng CW, Ho H, Ng LG, Yuen J, Lin PH, Chuang CK, Chang YH, Weng WH, Rozen SG, Tan P, Creasy CL, Pang ST, McCabe MT, Poon SL, Teh BT.

Sci Transl Med. 2017 Feb 22;9(378). pii: eaai8312. doi: 10.1126/scitranslmed.aai8312.


Inducing Ischemia-reperfusion Injury in the Mouse Ear Skin for Intravital Multiphoton Imaging of Immune Responses.

Goh CC, Li JL, Becker D, Weninger W, Angeli V, Ng LG.

J Vis Exp. 2016 Dec 22;(118). doi: 10.3791/54956.


CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses.

Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, Weber C, Duchene J, Lum J, Poidinger M, Chen Q, Rénia L, Wang CI, Larbi A, Randolph GJ, Weninger W, Looney MR, Krummel MF, Biswas SK, Ginhoux F, Hidalgo A, Bachelerie F, Ng LG.

J Exp Med. 2016 Oct 17;213(11):2293-2314. Epub 2016 Oct 10.


Nanocrystallization: A Unique Approach to Yield Bright Organic Nanocrystals for Biological Applications.

Fateminia SM, Wang Z, Goh CC, Manghnani PN, Wu W, Mao D, Ng LG, Zhao Z, Tang BZ, Liu B.

Adv Mater. 2017 Jan;29(1). doi: 10.1002/adma.201604100. Epub 2016 Nov 2.


Tumor size and Fuhrman grade further enhance the prognostic impact of perinephric fat invasion and renal vein extension in T3a staging of renal cell carcinoma.

Chen K, Lee BL, Huang HH, Tan BY, Lee LS, Ng LG, Lau W, Yuen JS.

Int J Urol. 2017 Jan;24(1):51-58. doi: 10.1111/iju.13237. Epub 2016 Oct 18.


Glycopeptide antibiotic analogs for selective inactivation and two-photon imaging of vancomycin-resistant strains.

Ariyasu S, Too PC, Mu J, Goh CC, Ding Y, Tnay YL, Yeow EK, Yang L, Ng LG, Chiba S, Xing B.

Chem Commun (Camb). 2016 Mar 28;52(25):4667-70. doi: 10.1039/c5cc10230h.


Neutrophils Self-Regulate Immune Complex-Mediated Cutaneous Inflammation through CXCL2.

Li JL, Lim CH, Tay FW, Goh CC, Devi S, Malleret B, Lee B, Bakocevic N, Chong SZ, Evrard M, Tanizaki H, Lim HY, Russell B, Renia L, Zolezzi F, Poidinger M, Angeli V, St John AL, Harris JE, Tey HL, Tan SM, Kabashima K, Weninger W, Larbi A, Ng LG.

J Invest Dermatol. 2016 Feb;136(2):416-24. doi: 10.1038/JID.2015.410.


Metformin Use in Relation With Survival Outcomes of Patients With Renal Cell Carcinoma.

Cheng JJ, Li H, Tan HS, Tan PH, Ng LG, Ng QS, Toh CK, Kanesvaran R, Tan MH.

Clin Genitourin Cancer. 2016 Apr;14(2):168-75. doi: 10.1016/j.clgc.2015.12.012. Epub 2015 Dec 21.


The clinical presentation and diagnosis of ketamine-associated urinary tract dysfunction in Singapore.

Yek J, Sundaram P, Aydin H, Kuo T, Ng LG.

Singapore Med J. 2015 Dec;56(12):660-4; quiz 665. doi: 10.11622/smedj.2015185.


Identification of a novel lymphoid population in the murine epidermis.

Almeida FF, Tenno M, Brzostek J, Li JL, Allies G, Hoeffel G, See P, Ng LG, Fehling HJ, Gascoigne NR, Taniuchi I, Ginhoux F.

Sci Rep. 2015 Jul 30;5:12554. doi: 10.1038/srep12554.


Silica shelled and block copolymer encapsulated red-emissive AIE nanoparticles with 50% quantum yield for two-photon excited vascular imaging.

Geng J, Goh CC, Qin W, Liu R, Tomczak N, Ng LG, Tang BZ, Liu B.

Chem Commun (Camb). 2015 Sep 7;51(69):13416-9. doi: 10.1039/c5cc03603h.


Biocompatible Green and Red Fluorescent Organic Dots with Remarkably Large Two-Photon Action Cross Sections for Targeted Cellular Imaging and Real-Time Intravital Blood Vascular Visualization.

Xiang J, Cai X, Lou X, Feng G, Min X, Luo W, He B, Goh CC, Ng LG, Zhou J, Zhao Z, Liu B, Tang BZ.

ACS Appl Mater Interfaces. 2015 Jul 15;7(27):14965-74. doi: 10.1021/acsami.5b03766. Epub 2015 Jul 2.


Pelvic floor spasm as a cause of voiding dysfunction.

Kuo TL, Ng LG, Chapple CR.

Curr Opin Urol. 2015 Jul;25(4):311-6. doi: 10.1097/MOU.0000000000000174. Review.


Mutation signatures implicate aristolochic acid in bladder cancer development.

Poon SL, Huang MN, Choo Y, McPherson JR, Yu W, Heng HL, Gan A, Myint SS, Siew EY, Ler LD, Ng LG, Weng WH, Chuang CK, Yuen JS, Pang ST, Tan P, Teh BT, Rozen SG.

Genome Med. 2015 Apr 28;7(1):38. doi: 10.1186/s13073-015-0161-3. eCollection 2015.


Tumor stroma and chemokines control T-cell migration into melanoma following Temozolomide treatment.

Tan KW, Evrard M, Tham M, Hong M, Huang C, Kato M, Prevost-Blondel A, Donnadieu E, Ng LG, Abastado JP.

Oncoimmunology. 2015 Feb 25;4(2):e978709. eCollection 2015 Feb.


C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages.

Hoeffel G, Chen J, Lavin Y, Low D, Almeida FF, See P, Beaudin AE, Lum J, Low I, Forsberg EC, Poidinger M, Zolezzi F, Larbi A, Ng LG, Chan JK, Greter M, Becher B, Samokhvalov IM, Merad M, Ginhoux F.

Immunity. 2015 Apr 21;42(4):665-78. doi: 10.1016/j.immuni.2015.03.011.


The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin.

Gunawan M, Venkatesan N, Loh JT, Wong JF, Berger H, Neo WH, Li LY, La Win MK, Yau YH, Guo T, See PC, Yamazaki S, Chin KC, Gingras AR, Shochat SG, Ng LG, Sze SK, Ginhoux F, Su IH.

Nat Immunol. 2015 May;16(5):505-16. doi: 10.1038/ni.3125. Epub 2015 Mar 9.


Heart failure as the first manifestation of renal cell carcinoma.

Lee CM, Sim A, Kurugulasigamoney G, Ng LG.

Korean J Urol. 2015 Jan;56(1):82-5. doi: 10.4111/kju.2015.56.1.82. Epub 2015 Jan 6.


Visualization of bone marrow monocyte mobilization using Cx3cr1gfp/+Flt3L-/- reporter mouse by multiphoton intravital microscopy.

Evrard M, Chong SZ, Devi S, Chew WK, Lee B, Poidinger M, Ginhoux F, Tan SM, Ng LG.

J Leukoc Biol. 2015 Mar;97(3):611-9. doi: 10.1189/jlb.1TA0514-274R. Epub 2014 Dec 16.


Real-time imaging of dendritic cell responses to sterile tissue injury.

Goh CC, Li JL, Devi S, Bakocevic N, See P, Larbi A, Weninger W, Ginhoux F, Angeli V, Ng LG.

J Invest Dermatol. 2015 Apr;135(4):1181-1184. doi: 10.1038/jid.2014.506. Epub 2014 Nov 28. No abstract available.


Plasmodium vivax: restricted tropism and rapid remodeling of CD71-positive reticulocytes.

Malleret B, Li A, Zhang R, Tan KS, Suwanarusk R, Claser C, Cho JS, Koh EG, Chu CS, Pukrittayakamee S, Ng ML, Ginhoux F, Ng LG, Lim CT, Nosten F, Snounou G, Rénia L, Russell B.

Blood. 2015 Feb 19;125(8):1314-24. doi: 10.1182/blood-2014-08-596015. Epub 2014 Nov 20.


The gut microbiota influences blood-brain barrier permeability in mice.

Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A, Tóth M, Korecka A, Bakocevic N, Ng LG, Kundu P, Gulyás B, Halldin C, Hultenby K, Nilsson H, Hebert H, Volpe BT, Diamond B, Pettersson S.

Sci Transl Med. 2014 Nov 19;6(263):263ra158. doi: 10.1126/scitranslmed.3009759. Erratum in: Sci Transl Med. 2014 Dec 10;6(266):266er7. Guan, Ng Lai [corrected to Ng, Lai Guan].


A small-molecule FRET reporter for the real-time visualization of cell-surface proteolytic enzyme functions.

Mu J, Liu F, Rajab MS, Shi M, Li S, Goh C, Lu L, Xu QH, Liu B, Ng LG, Xing B.

Angew Chem Int Ed Engl. 2014 Dec 22;53(52):14357-62. doi: 10.1002/anie.201407182. Epub 2014 Oct 27.


Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin.

Natsuaki Y, Egawa G, Nakamizo S, Ono S, Hanakawa S, Okada T, Kusuba N, Otsuka A, Kitoh A, Honda T, Nakajima S, Tsuchiya S, Sugimoto Y, Ishii KJ, Tsutsui H, Yagita H, Iwakura Y, Kubo M, Ng Lg, Hashimoto T, Fuentes J, Guttman-Yassky E, Miyachi Y, Kabashima K.

Nat Immunol. 2014 Nov;15(11):1064-9. doi: 10.1038/ni.2992. Epub 2014 Sep 21.


A multigene assay identifying distinct prognostic subtypes of clear cell renal cell carcinoma with differential response to tyrosine kinase inhibition.

Choudhury Y, Wei X, Chu YH, Ng LG, Tan HS, Koh V, Thike AA, Poon E, Ng QS, Toh CK, Kanesvaran R, Tan PH, Tan MH.

Eur Urol. 2015 Jan;67(1):17-20. doi: 10.1016/j.eururo.2014.06.041. Epub 2014 Jul 10.


CD41 is a reliable identification and activation marker for murine basophils in the steady state and during helminth and malarial infections.

Bakocevic N, Claser C, Yoshikawa S, Jones LA, Chew S, Goh CC, Malleret B, Larbi A, Ginhoux F, de Lafaille MC, Karasuyama H, Renia L, Ng LG.

Eur J Immunol. 2014 Jun;44(6):1823-34. doi: 10.1002/eji.201344254. Epub 2014 Apr 10.


Congenital renal arteriovenous malformation presenting with gross hematuria after a routine jog: a case report.

Dames EL, Ng LG, Tay KH.

J Med Case Rep. 2014 Feb 20;8:65. doi: 10.1186/1752-1947-8-65.


A three-dimensional atlas of human dermal leukocytes, lymphatics, and blood vessels.

Wang XN, McGovern N, Gunawan M, Richardson C, Windebank M, Siah TW, Lim HY, Fink K, Yao Li JL, Ng LG, Ginhoux F, Angeli V, Collin M, Haniffa M.

J Invest Dermatol. 2014 Apr;134(4):965-974. doi: 10.1038/jid.2013.481. Epub 2013 Nov 11.


Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection.

Abtin A, Jain R, Mitchell AJ, Roediger B, Brzoska AJ, Tikoo S, Cheng Q, Ng LG, Cavanagh LL, von Andrian UH, Hickey MJ, Firth N, Weninger W.

Nat Immunol. 2014 Jan;15(1):45-53. doi: 10.1038/ni.2769. Epub 2013 Nov 24.


Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D.

Tan KW, Chong SZ, Wong FH, Evrard M, Tan SM, Keeble J, Kemeny DM, Ng LG, Abastado JP, Angeli V.

Blood. 2013 Nov 21;122(22):3666-77. doi: 10.1182/blood-2012-11-466532. Epub 2013 Oct 10.


Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow.

Devi S, Wang Y, Chew WK, Lima R, A-González N, Mattar CN, Chong SZ, Schlitzer A, Bakocevic N, Chew S, Keeble JL, Goh CC, Li JL, Evrard M, Malleret B, Larbi A, Renia L, Haniffa M, Tan SM, Chan JK, Balabanian K, Nagasawa T, Bachelerie F, Hidalgo A, Ginhoux F, Kubes P, Ng LG.

J Exp Med. 2013 Oct 21;210(11):2321-36. doi: 10.1084/jem.20130056. Epub 2013 Sep 30.


Lights, camera, and action: vertebrate skin sets the stage for immune cell interaction with arthropod-vectored pathogens.

Chong SZ, Evrard M, Ng LG.

Front Immunol. 2013 Sep 17;4:286. doi: 10.3389/fimmu.2013.00286. Review.

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