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Items: 1 to 50 of 128

1.

Fast Tracks and Roadblocks for Zika Vaccines.

Ghaffar KA, Ng LFP, Renia L.

Vaccines (Basel). 2018 Nov 21;6(4). pii: E77. doi: 10.3390/vaccines6040077. Review.

2.

Multimodal assessments of Zika virus immune pathophysiological responses in marmosets.

Lum FM, Zhang W, Lim KC, Malleret B, Teo TH, Koh JJ, Lee KJ, Chua TK, Kam YW, Yee WX, Huen I, Tan JJL, Amrun SN, Prakash Kn B, Cozzone PJ, Renia L, Lee PTH, Ng LFP.

Sci Rep. 2018 Nov 20;8(1):17125. doi: 10.1038/s41598-018-35481-6.

3.

Lipid profiling of C. elegans strains administered pro-longevity drugs and drug combinations.

Admasu TD, Batchu KC, Ng LF, Cazenave-Gassiot A, Wenk MR, Gruber J.

Sci Data. 2018 Oct 23;5:180231. doi: 10.1038/sdata.2018.231.

4.

Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling.

Admasu TD, Chaithanya Batchu K, Barardo D, Ng LF, Lam VYM, Xiao L, Cazenave-Gassiot A, Wenk MR, Tolwinski NS, Gruber J.

Dev Cell. 2018 Oct 8;47(1):67-79.e5. doi: 10.1016/j.devcel.2018.09.001. Epub 2018 Sep 27.

PMID:
30269951
5.

Plasmodium co-infection protects against chikungunya virus-induced pathologies.

Teo TH, Lum FM, Ghaffar K, Chan YH, Amrun SN, Tan JJL, Lee CYP, Chua TK, Carissimo G, Lee WWL, Claser C, Rajarethinam R, Rénia L, Ng LFP.

Nat Commun. 2018 Sep 25;9(1):3905. doi: 10.1038/s41467-018-06227-9.

6.

Viperin Poisons Viral Replication.

Ng LFP, Hiscox JA.

Cell Host Microbe. 2018 Aug 8;24(2):181-183. doi: 10.1016/j.chom.2018.07.014.

PMID:
30092190
7.

The 2016 Singapore Zika virus outbreak did not cause a surge in Guillain-Barré syndrome.

Umapathi T, Kam YW, Ohnmar O, Ng BCJ, Ng Y, Premikha M, Leo YS, Ng LFP.

J Peripher Nerv Syst. 2018 Sep;23(3):197-201. doi: 10.1111/jns.12284. Epub 2018 Aug 21.

PMID:
30070025
8.

Clonal expansion of mitochondrial DNA deletions is a private mechanism of aging in long-lived animals.

Lakshmanan LN, Yee Z, Ng LF, Gunawan R, Halliwell B, Gruber J.

Aging Cell. 2018 Oct;17(5):e12814. doi: 10.1111/acel.12814. Epub 2018 Jul 24.

9.

Paradoxical Effect of Chloroquine Treatment in Enhancing Chikungunya Virus Infection.

Roques P, Thiberville SD, Dupuis-Maguiraga L, Lum FM, Labadie K, Martinon F, Gras G, Lebon P, Ng LFP, de Lamballerie X, Le Grand R.

Viruses. 2018 May 17;10(5). pii: E268. doi: 10.3390/v10050268.

10.

Longitudinal Study of Cellular and Systemic Cytokine Signatures to Define the Dynamics of a Balanced Immune Environment During Disease Manifestation in Zika Virus-Infected Patients.

Lum FM, Lye DCB, Tan JJL, Lee B, Chia PY, Chua TK, Amrun SN, Kam YW, Yee WX, Ling WP, Lim VWX, Pang VJX, Lee LK, Mok EWH, Chong CY, Leo YS, Ng LFP.

J Infect Dis. 2018 Jul 24;218(5):814-824. doi: 10.1093/infdis/jiy225.

11.

Zika Virus Infection Preferentially Counterbalances Human Peripheral Monocyte and/or NK Cell Activity.

Lum FM, Lee D, Chua TK, Tan JJL, Lee CYP, Liu X, Fang Y, Lee B, Yee WX, Rickett NY, Chia PY, Lim V, Leo YS, Matthews DA, Hiscox JA, Ng LFP.

mSphere. 2018 Mar 28;3(2). pii: e00120-18. doi: 10.1128/mSphereDirect.00120-18. eCollection 2018 Mar-Apr.

12.

Mosquito Saliva Reshapes Alphavirus Infection and Immunopathogenesis.

Fong SW, Kini RM, Ng LFP.

J Virol. 2018 May 29;92(12). pii: e01004-17. doi: 10.1128/JVI.01004-17. Print 2018 Jun 15. Review.

13.

Zika virus: from an obscurity to a priority.

Lee CY, Ng LFP.

Microbes Infect. 2018 Dec;20(11-12):635-645. doi: 10.1016/j.micinf.2018.02.009. Epub 2018 Mar 9.

14.

Efficient detection of Zika virus RNA in patients' blood from the 2016 outbreak in Campinas, Brazil.

Judice CC, Tan JJL, Parise PL, Kam YW, Milanez GP, Leite JA, Caserta LC, Arns CW, Resende MR, Angerami R, Amaral E, Junior RP, Freitas ARR, Costa FTM, Proenca-Modena JL, Ng LFP; Zika-Unicamp Network.

Sci Rep. 2018 Mar 5;8(1):4012. doi: 10.1038/s41598-018-22159-2.

15.

Therapeutic modulation of the bile acid pool by Cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice.

Chevre R, Trigueros-Motos L, Castaño D, Chua T, Corlianò M, Patankar JV, Sng L, Sim L, Juin TL, Carissimo G, Ng LFP, Yi CNJ, Eliathamby CC, Groen AK, Hayden MR, Singaraja RR.

FASEB J. 2018 Jul;32(7):3792-3802. doi: 10.1096/fj.201701084RR. Epub 2018 Feb 26.

PMID:
29481310
16.

Nonstructural Proteins of Alphavirus-Potential Targets for Drug Development.

Abu Bakar F, Ng LFP.

Viruses. 2018 Feb 9;10(2). pii: E71. doi: 10.3390/v10020071. Review.

17.

Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5- d]pyrimidin-7(6 H)-ones.

Gómez-SanJuan A, Gamo AM, Delang L, Pérez-Sánchez A, Amrun SN, Abdelnabi R, Jacobs S, Priego EM, Camarasa MJ, Jochmans D, Leyssen P, Ng LFP, Querat G, Neyts J, Pérez-Pérez MJ.

ACS Infect Dis. 2018 Apr 13;4(4):605-619. doi: 10.1021/acsinfecdis.7b00219. Epub 2018 Feb 14.

PMID:
29406692
18.

Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity.

Lum FM, Couderc T, Chia BS, Ong RY, Her Z, Chow A, Leo YS, Kam YW, Rénia L, Lecuit M, Ng LFP.

Sci Rep. 2018 Jan 30;8(1):1860. doi: 10.1038/s41598-018-20305-4.

19.

Interferon regulatory factor 1 is essential for pathogenic CD8+ T cell migration and retention in the brain during experimental cerebral malaria.

Gun SY, Claser C, Teo TH, Howland SW, Poh CM, Chye RRY, Ng LFP, Rénia L.

Cell Microbiol. 2018 May;20(5):e12819. doi: 10.1111/cmi.12819. Epub 2018 Jan 18.

PMID:
29281764
20.

Seroprevalence of antibodies against chikungunya virus in Singapore resident adult population.

Ang LW, Kam YW, Lin C, Krishnan PU, Tay J, Ng LC, James L, Lee VJM, Goh KT, Ng LFP, Lin RTP.

PLoS Negl Trop Dis. 2017 Dec 27;11(12):e0006163. doi: 10.1371/journal.pntd.0006163. eCollection 2017 Dec.

21.

Immunopathogenesis and Virus-Host Interactions of Enterovirus 71 in Patients with Hand, Foot and Mouth Disease.

Cox JA, Hiscox JA, Solomon T, Ooi MH, Ng LFP.

Front Microbiol. 2017 Nov 28;8:2249. doi: 10.3389/fmicb.2017.02249. eCollection 2017. Review.

22.

Co-infection with Chikungunya virus alters trafficking of pathogenic CD8+ T cells into the brain and prevents Plasmodium-induced neuropathology.

Teo TH, Howland SW, Claser C, Gun SY, Poh CM, Lee WW, Lum FM, Ng LF, Rénia L.

EMBO Mol Med. 2018 Jan;10(1):121-138. doi: 10.15252/emmm.201707885.

23.

Persistence of Zika virus in conjunctival fluid of convalescence patients.

Tan JJL, Balne PK, Leo YS, Tong L, Ng LFP, Agrawal R.

Sci Rep. 2017 Sep 11;7(1):11194. doi: 10.1038/s41598-017-09479-5.

24.

Deep Sequencing of RNA from Blood and Oral Swab Samples Reveals the Presence of Nucleic Acid from a Number of Pathogens in Patients with Acute Ebola Virus Disease and Is Consistent with Bacterial Translocation across the Gut.

Carroll MW, Haldenby S, Rickett NY, Pályi B, Garcia-Dorival I, Liu X, Barker G, Bore JA, Koundouno FR, Williamson ED, Laws TR, Kerber R, Sissoko D, Magyar N, Di Caro A, Biava M, Fletcher TE, Sprecher A, Ng LFP, Rénia L, Magassouba N, Günther S, Wölfel R, Stoecker K, Matthews DA, Hiscox JA.

mSphere. 2017 Aug 23;2(4). pii: e00325-17. doi: 10.1128/mSphereDirect.00325-17. eCollection 2017 Jul-Aug.

25.

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.

Chen W, Foo SS, Zaid A, Teng TS, Herrero LJ, Wolf S, Tharmarajah K, Vu LD, van Vreden C, Taylor A, Freitas JR, Li RW, Woodruff TM, Gordon R, Ojcius DM, Nakaya HI, Kanneganti TD, O'Neill LAJ, Robertson AAB, King NJ, Suhrbier A, Cooper MA, Ng LFP, Mahalingam S.

Nat Microbiol. 2017 Oct;2(10):1435-1445. doi: 10.1038/s41564-017-0015-4. Epub 2017 Aug 28.

PMID:
28848230
26.

Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus-Infected Patients in Brazil.

Kam YW, Leite JA, Lum FM, Tan JJL, Lee B, Judice CC, Teixeira DAT, Andreata-Santos R, Vinolo MA, Angerami R, Resende MR, Freitas ARR, Amaral E, Junior RP, Costa ML, Guida JP, Arns CW, Ferreira LCS, Rénia L, Proença-Modena JL, Ng LFP, Costa FTM; Zika-Unicamp Network.

J Infect Dis. 2017 Jul 15;216(2):172-181. doi: 10.1093/infdis/jix261.

27.

Age has a role in driving host immunopathological response to alphavirus infection.

Chan YH, Ng LFP.

Immunology. 2017 Dec;152(4):545-555. doi: 10.1111/imm.12799. Epub 2017 Aug 23. Review.

28.

Immunopathology of Chikungunya Virus Infection: Lessons Learned from Patients and Animal Models.

Ng LFP.

Annu Rev Virol. 2017 Sep 29;4(1):413-427. doi: 10.1146/annurev-virology-101416-041808. Epub 2017 Jun 21. Review.

PMID:
28637387
29.

Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network.

Aliota MT, Bassit L, Bradrick SS, Cox B, Garcia-Blanco MA, Gavegnano C, Friedrich TC, Golos TG, Griffin DE, Haddow AD, Kallas EG, Kitron U, Lecuit M, Magnani DM, Marrs C, Mercer N, McSweegan E, Ng LFP, O'Connor DH, Osorio JE, Ribeiro GS, Ricciardi M, Rossi SL, Saade G, Schinazi RF, Schott-Lerner GO, Shan C, Shi PY, Watkins DI, Vasilakis N, Weaver SC.

Antiviral Res. 2017 Aug;144:223-246. doi: 10.1016/j.antiviral.2017.06.001. Epub 2017 Jun 6. Review.

30.

A Sensitive Method for Detecting Zika Virus Antigen in Patients' Whole-Blood Specimens as an Alternative Diagnostic Approach.

Lum FM, Lin C, Susova OY, Teo TH, Fong SW, Mak TM, Lee LK, Chong CY, Lye DCB, Lin RTP, Merits A, Leo YS, Ng LFP.

J Infect Dis. 2017 Jul 15;216(2):182-190. doi: 10.1093/infdis/jix276.

31.

Cross-reactive dengue human monoclonal antibody prevents severe pathologies and death from Zika virus infections.

Kam YW, Lee CY, Teo TH, Howland SW, Amrun SN, Lum FM, See P, Kng NQ, Huber RG, Xu MH, Tan HL, Choo A, Maurer-Stroh S, Ginhoux F, Fink K, Wang CI, Ng LFP, Rénia L.

JCI Insight. 2017 Apr 20;2(8). pii: 92428. doi: 10.1172/jci.insight.92428. [Epub ahead of print]

32.

Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity.

Tang TH, Alonso S, Ng LF, Thein TL, Pang VJ, Leo YS, Lye DC, Yeo TW.

Sci Rep. 2017 Apr 10;7:46191. doi: 10.1038/srep46191.

33.

Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays detergent-sensitive primer extension and terminal adenylyltransferase activities.

Chen MW, Tan YB, Zheng J, Zhao Y, Lim BT, Cornvik T, Lescar J, Ng LFP, Luo D.

Antiviral Res. 2017 Jul;143:38-47. doi: 10.1016/j.antiviral.2017.04.001. Epub 2017 Apr 5.

PMID:
28390873
34.

Zika Virus Infects Human Fetal Brain Microglia and Induces Inflammation.

Lum FM, Low DK, Fan Y, Tan JJ, Lee B, Chan JK, Rénia L, Ginhoux F, Ng LF.

Clin Infect Dis. 2017 Apr 1;64(7):914-920. doi: 10.1093/cid/ciw878.

PMID:
28362944
35.

Structural Optimizations of Thieno[3,2-b]pyrrole Derivatives for the Development of Metabolically Stable Inhibitors of Chikungunya Virus.

Ching KC, Tran TN, Amrun SN, Kam YW, Ng LF, Chai CL.

J Med Chem. 2017 Apr 13;60(7):3165-3186. doi: 10.1021/acs.jmedchem.7b00180. Epub 2017 Apr 4.

PMID:
28350454
36.

Clinical features of patients with Zika and dengue virus co-infection in Singapore.

Chia PY, Yew HS, Ho H, Chow A, Sadarangani SP, Chan M, Kam YW, Chong CY, Thoon KC, Yung CF, Li JH, Lye DC, De PP, Ng LFP, Yeo TW, Leo YS.

J Infect. 2017 Jun;74(6):611-615. doi: 10.1016/j.jinf.2017.03.007. Epub 2017 Mar 23. No abstract available.

PMID:
28344113
37.

Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen.

Burt FJ, Chen W, Miner JJ, Lenschow DJ, Merits A, Schnettler E, Kohl A, Rudd PA, Taylor A, Herrero LJ, Zaid A, Ng LFP, Mahalingam S.

Lancet Infect Dis. 2017 Apr;17(4):e107-e117. doi: 10.1016/S1473-3099(16)30385-1. Epub 2017 Feb 1. Review.

PMID:
28159534
38.

Fingolimod treatment abrogates chikungunya virus-induced arthralgia.

Teo TH, Chan YH, Lee WW, Lum FM, Amrun SN, Her Z, Rajarethinam R, Merits A, Rötzschke O, Rénia L, Ng LF.

Sci Transl Med. 2017 Feb 1;9(375). pii: eaal1333. doi: 10.1126/scitranslmed.aal1333.

PMID:
28148838
39.

Severity of Plasma Leakage Is Associated With High Levels of Interferon γ-Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection.

Her Z, Kam YW, Gan VC, Lee B, Thein TL, Tan JJ; SIgN Immunomonitoring Platform, Lee LK, Fink K, Lye DC, Rénia L, Leo YS, Ng LF.

J Infect Dis. 2017 Jan 1;215(1):42-51. doi: 10.1093/infdis/jiw494. Epub 2016 Oct 17.

PMID:
28077582
40.

Identification of a previously undetected metabolic defect in the Complex II Caenorhabditis elegans mev-1 mutant strain using respiratory control analysis.

Fong S, Ng LF, Ng LT, Moore PK, Halliwell B, Gruber J.

Biogerontology. 2017 Apr;18(2):189-200. doi: 10.1007/s10522-016-9672-6. Epub 2016 Dec 30.

PMID:
28039571
41.

Protein kinases C as potential host targets for the inhibition of chikungunya virus replication.

Abdelnabi R, Amrun SN, Ng LF, Leyssen P, Neyts J, Delang L.

Antiviral Res. 2017 Mar;139:79-87. doi: 10.1016/j.antiviral.2016.12.020. Epub 2016 Dec 27.

PMID:
28039020
42.

The Role of Mitochondrial Non-Enzymatic Protein Acylation in Ageing.

Hong SY, Ng LT, Ng LF, Inoue T, Tolwinski NS, Hagen T, Gruber J.

PLoS One. 2016 Dec 29;11(12):e0168752. doi: 10.1371/journal.pone.0168752. eCollection 2016.

43.

Virus infection drives IL-2 antibody complexes into pro-inflammatory agonists in mice.

Lee WW, Teo TH, Lum FM, Andiappan AK, Amrun SN, Rénia L, Rötzschke O, Ng LF.

Sci Rep. 2016 Nov 25;6:37603. doi: 10.1038/srep37603.

44.

Post biopsy Liver Hemorrhage Successfully Controlled by Ultrasound-guided Percutaneous Microwave Ablation.

Wai OK, Ng LF, Yu PS, Chan JC.

J Clin Imaging Sci. 2016 Sep 19;6:34. eCollection 2016.

45.

Energy crisis precedes global metabolic failure in a novel Caenorhabditis elegans Alzheimer Disease model.

Fong S, Teo E, Ng LF, Chen CB, Lakshmanan LN, Tsoi SY, Moore PK, Inoue T, Halliwell B, Gruber J.

Sci Rep. 2016 Sep 22;6:33781. doi: 10.1038/srep33781.

46.

Ruptured Renal Pelvis Due to Obstruction by Ureterosciatic Hernia: A Rare Condition With a Rare Complication.

Wai OK, Ng LF, Yu PS.

Urology. 2016 Nov;97:e13-e14. doi: 10.1016/j.urology.2016.08.014. Epub 2016 Aug 16.

PMID:
27542861
47.

The Antiviral Alkaloid Berberine Reduces Chikungunya Virus-Induced Mitogen-Activated Protein Kinase Signaling.

Varghese FS, Thaa B, Amrun SN, Simarmata D, Rausalu K, Nyman TA, Merits A, McInerney GM, Ng LF, Ahola T.

J Virol. 2016 Oct 14;90(21):9743-9757. Print 2016 Nov 1.

48.

Early clearance of Chikungunya virus in children is associated with a strong innate immune response.

Simarmata D, Ng DC, Kam YW, Lee B, Sum MS, Her Z, Chow A, Leo YS, Cardosa J, Perera D, Ooi MH, Ng LF.

Sci Rep. 2016 May 16;6:26097. doi: 10.1038/srep26097.

49.

C. elegans miro-1 Mutation Reduces the Amount of Mitochondria and Extends Life Span.

Shen Y, Ng LF, Low NP, Hagen T, Gruber J, Inoue T.

PLoS One. 2016 Apr 11;11(4):e0153233. doi: 10.1371/journal.pone.0153233. eCollection 2016.

50.

Trisubstituted Thieno[3,2-b]pyrrole 5-Carboxamides as Potent Inhibitors of Alphaviruses.

Ching KC, Kam YW, Merits A, Ng LF, Chai CL.

J Med Chem. 2015 Dec 10;58(23):9196-213. doi: 10.1021/acs.jmedchem.5b01047. Epub 2015 Nov 19.

PMID:
26540338

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