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Items: 1 to 50 of 140

1.

Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women.

Lum FM, Narang V, Hue S, Chen J, McGovern N, Rajarethinam R, Tan JJ, Amrun SN, Chan YH, Lee CY, Chua TK, Yee WX, Yeo NK, Tan TC, Liu X, Haldenby S, Leo YS, Ginhoux F, Chan JK, Hiscox J, Chong CY, Ng LF.

Clin Transl Immunology. 2019 Nov 5;8(11):e01082. doi: 10.1002/cti2.1082. eCollection 2019.

PMID:
31709049
2.

VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses.

Carissimo G, Chan YH, Utt A, Chua TK, Bakar FA, Merits A, Ng LFP.

Front Microbiol. 2019 Sep 24;10:2236. doi: 10.3389/fmicb.2019.02236. eCollection 2019.

3.

WNT Signaling in Disease.

Ng LF, Kaur P, Bunnag N, Suresh J, Sung ICH, Tan QH, Gruber J, Tolwinski NS.

Cells. 2019 Aug 3;8(8). pii: E826. doi: 10.3390/cells8080826. Review.

4.

Novel differential linear B-cell epitopes to identify Zika and dengue virus infections in patients.

Amrun SN, Yee WX, Abu Bakar F, Lee B, Kam YW, Lum FM, Tan JJ, Lim VW, Watthanaworawit W, Ling C, Nosten F, Renia L, Leo YS, Ng LF.

Clin Transl Immunology. 2019 Jul 26;8(7):e1066. doi: 10.1002/cti2.1066. eCollection 2019.

5.

Inhibition of amyloid-induced toxicity by ergothioneine in a transgenic Caenorhabditis elegans model.

Cheah IK, Ng LT, Ng LF, Lam VY, Gruber J, Huang CYW, Goh FQ, Lim KHC, Halliwell B.

FEBS Lett. 2019 Aug;593(16):2139-2150. doi: 10.1002/1873-3468.13497. Epub 2019 Jun 30.

PMID:
31211853
6.

Chikungunya virus drug discovery: still a long way to go?

Pérez-Pérez MJ, Delang L, Ng LFP, Priego EM.

Expert Opin Drug Discov. 2019 Sep;14(9):855-866. doi: 10.1080/17460441.2019.1629413. Epub 2019 Jun 14.

PMID:
31177861
7.

Mitochondrial DNA Damage Does Not Determine C. elegans Lifespan.

Ng LF, Ng LT, van Breugel M, Halliwell B, Gruber J.

Front Genet. 2019 Apr 12;10:311. doi: 10.3389/fgene.2019.00311. eCollection 2019.

8.

Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate.

Chan YH, Teo TH, Utt A, Tan JJ, Amrun SN, Abu Bakar F, Yee WX, Becht E, Lee CY, Lee B, Rajarethinam R, Newell E, Merits A, Carissimo G, Lum FM, Ng LF.

EMBO Mol Med. 2019 Jun;11(6). pii: e10092. doi: 10.15252/emmm.201810092.

9.

GloPID-R report on Chikungunya, O'nyong-nyong and Mayaro virus, part I: Biological diagnostics.

Pezzi L, Reusken CB, Weaver SC, Drexler JF, Busch M, LaBeaud AD, Diamond MS, Vasilakis N, Drebot MA, Siqueira AM, Ribeiro GS, Kohl A, Lecuit M, Ng LFP, Gallian P, de Lamballerie X; GloPID-R Chikungunya, O'nyong-nyong and Mayaro virus Working Group.

Antiviral Res. 2019 Jun;166:66-81. doi: 10.1016/j.antiviral.2019.03.009. Epub 2019 Mar 21. Review.

10.

ZIKV-Specific NS1 Epitopes as Serological Markers of Acute Zika Virus Infection.

Kam YW, Leite JA, Amrun SN, Lum FM, Yee WX, Bakar FA, Eng KE, Lye DC, Leo YS, Chong CY, Freitas ARR, Milanez GP, Proença-Modena JL, Rénia L, Costa FTM, Ng LFP; Zika-Unicamp Network .

J Infect Dis. 2019 Jun 19;220(2):203-212. doi: 10.1093/infdis/jiz092.

PMID:
30901054
11.

Understanding Molecular Pathogenesis with Chikungunya Virus Research Tools.

Carissimo G, Ng LFP.

Curr Top Microbiol Immunol. 2019 Mar 20. doi: 10.1007/82_2019_158. [Epub ahead of print]

PMID:
30888547
12.

Viperin controls chikungunya virus-specific pathogenic T cell IFNγ Th1 stimulation in mice.

Carissimo G, Teo TH, Chan YH, Lee CY, Lee B, Torres-Ruesta A, Tan JJ, Chua TK, Fong SW, Lum FM, Ng LF.

Life Sci Alliance. 2019 Jan 21;2(1). pii: e201900298. doi: 10.26508/lsa.201900298. Print 2019 Feb.

13.

Fast Tracks and Roadblocks for Zika Vaccines.

Ghaffar KA, Ng LFP, Renia L.

Vaccines (Basel). 2018 Nov 21;6(4). pii: E77. doi: 10.3390/vaccines6040077. Review.

14.

Multimodal assessments of Zika virus immune pathophysiological responses in marmosets.

Lum FM, Zhang W, Lim KC, Malleret B, Teo TH, Koh JJ, Lee KJ, Chua TK, Kam YW, Yee WX, Huen I, Tan JJL, Amrun SN, Prakash Kn B, Cozzone PJ, Renia L, Lee PTH, Ng LFP.

Sci Rep. 2018 Nov 20;8(1):17125. doi: 10.1038/s41598-018-35481-6.

15.

Lipid profiling of C. elegans strains administered pro-longevity drugs and drug combinations.

Admasu TD, Batchu KC, Ng LF, Cazenave-Gassiot A, Wenk MR, Gruber J.

Sci Data. 2018 Oct 23;5:180231. doi: 10.1038/sdata.2018.231.

16.

Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling.

Admasu TD, Chaithanya Batchu K, Barardo D, Ng LF, Lam VYM, Xiao L, Cazenave-Gassiot A, Wenk MR, Tolwinski NS, Gruber J.

Dev Cell. 2018 Oct 8;47(1):67-79.e5. doi: 10.1016/j.devcel.2018.09.001. Epub 2018 Sep 27.

17.

Plasmodium co-infection protects against chikungunya virus-induced pathologies.

Teo TH, Lum FM, Ghaffar K, Chan YH, Amrun SN, Tan JJL, Lee CYP, Chua TK, Carissimo G, Lee WWL, Claser C, Rajarethinam R, Rénia L, Ng LFP.

Nat Commun. 2018 Sep 25;9(1):3905. doi: 10.1038/s41467-018-06227-9.

18.

Viperin Poisons Viral Replication.

Ng LFP, Hiscox JA.

Cell Host Microbe. 2018 Aug 8;24(2):181-183. doi: 10.1016/j.chom.2018.07.014.

19.

The 2016 Singapore Zika virus outbreak did not cause a surge in Guillain-Barré syndrome.

Umapathi T, Kam YW, Ohnmar O, Ng BCJ, Ng Y, Premikha M, Leo YS, Ng LFP.

J Peripher Nerv Syst. 2018 Sep;23(3):197-201. doi: 10.1111/jns.12284. Epub 2018 Aug 21.

PMID:
30070025
20.

Clonal expansion of mitochondrial DNA deletions is a private mechanism of aging in long-lived animals.

Lakshmanan LN, Yee Z, Ng LF, Gunawan R, Halliwell B, Gruber J.

Aging Cell. 2018 Oct;17(5):e12814. doi: 10.1111/acel.12814. Epub 2018 Jul 24.

21.

Paradoxical Effect of Chloroquine Treatment in Enhancing Chikungunya Virus Infection.

Roques P, Thiberville SD, Dupuis-Maguiraga L, Lum FM, Labadie K, Martinon F, Gras G, Lebon P, Ng LFP, de Lamballerie X, Le Grand R.

Viruses. 2018 May 17;10(5). pii: E268. doi: 10.3390/v10050268.

22.

Longitudinal Study of Cellular and Systemic Cytokine Signatures to Define the Dynamics of a Balanced Immune Environment During Disease Manifestation in Zika Virus-Infected Patients.

Lum FM, Lye DCB, Tan JJL, Lee B, Chia PY, Chua TK, Amrun SN, Kam YW, Yee WX, Ling WP, Lim VWX, Pang VJX, Lee LK, Mok EWH, Chong CY, Leo YS, Ng LFP.

J Infect Dis. 2018 Jul 24;218(5):814-824. doi: 10.1093/infdis/jiy225.

23.

Zika Virus Infection Preferentially Counterbalances Human Peripheral Monocyte and/or NK Cell Activity.

Lum FM, Lee D, Chua TK, Tan JJL, Lee CYP, Liu X, Fang Y, Lee B, Yee WX, Rickett NY, Chia PY, Lim V, Leo YS, Matthews DA, Hiscox JA, Ng LFP.

mSphere. 2018 Mar 28;3(2). pii: e00120-18. doi: 10.1128/mSphereDirect.00120-18. eCollection 2018 Mar-Apr.

24.

Mosquito Saliva Reshapes Alphavirus Infection and Immunopathogenesis.

Fong SW, Kini RM, Ng LFP.

J Virol. 2018 May 29;92(12). pii: e01004-17. doi: 10.1128/JVI.01004-17. Print 2018 Jun 15. Review.

25.

Zika virus: from an obscurity to a priority.

Lee CY, Ng LFP.

Microbes Infect. 2018 Dec;20(11-12):635-645. doi: 10.1016/j.micinf.2018.02.009. Epub 2018 Mar 9. Review.

26.

Efficient detection of Zika virus RNA in patients' blood from the 2016 outbreak in Campinas, Brazil.

Judice CC, Tan JJL, Parise PL, Kam YW, Milanez GP, Leite JA, Caserta LC, Arns CW, Resende MR, Angerami R, Amaral E, Junior RP, Freitas ARR, Costa FTM, Proenca-Modena JL, Ng LFP; Zika-Unicamp Network.

Sci Rep. 2018 Mar 5;8(1):4012. doi: 10.1038/s41598-018-22159-2.

27.

Therapeutic modulation of the bile acid pool by Cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice.

Chevre R, Trigueros-Motos L, Castaño D, Chua T, Corlianò M, Patankar JV, Sng L, Sim L, Juin TL, Carissimo G, Ng LFP, Yi CNJ, Eliathamby CC, Groen AK, Hayden MR, Singaraja RR.

FASEB J. 2018 Jul;32(7):3792-3802. doi: 10.1096/fj.201701084RR. Epub 2018 Feb 26.

PMID:
29481310
28.

Nonstructural Proteins of Alphavirus-Potential Targets for Drug Development.

Abu Bakar F, Ng LFP.

Viruses. 2018 Feb 9;10(2). pii: E71. doi: 10.3390/v10020071. Review.

29.

Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5- d]pyrimidin-7(6 H)-ones.

Gómez-SanJuan A, Gamo AM, Delang L, Pérez-Sánchez A, Amrun SN, Abdelnabi R, Jacobs S, Priego EM, Camarasa MJ, Jochmans D, Leyssen P, Ng LFP, Querat G, Neyts J, Pérez-Pérez MJ.

ACS Infect Dis. 2018 Apr 13;4(4):605-619. doi: 10.1021/acsinfecdis.7b00219. Epub 2018 Feb 14.

PMID:
29406692
30.

Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity.

Lum FM, Couderc T, Chia BS, Ong RY, Her Z, Chow A, Leo YS, Kam YW, Rénia L, Lecuit M, Ng LFP.

Sci Rep. 2018 Jan 30;8(1):1860. doi: 10.1038/s41598-018-20305-4.

31.

Interferon regulatory factor 1 is essential for pathogenic CD8+ T cell migration and retention in the brain during experimental cerebral malaria.

Gun SY, Claser C, Teo TH, Howland SW, Poh CM, Chye RRY, Ng LFP, Rénia L.

Cell Microbiol. 2018 May;20(5):e12819. doi: 10.1111/cmi.12819. Epub 2018 Jan 18.

PMID:
29281764
32.

Seroprevalence of antibodies against chikungunya virus in Singapore resident adult population.

Ang LW, Kam YW, Lin C, Krishnan PU, Tay J, Ng LC, James L, Lee VJM, Goh KT, Ng LFP, Lin RTP.

PLoS Negl Trop Dis. 2017 Dec 27;11(12):e0006163. doi: 10.1371/journal.pntd.0006163. eCollection 2017 Dec.

33.

Immunopathogenesis and Virus-Host Interactions of Enterovirus 71 in Patients with Hand, Foot and Mouth Disease.

Cox JA, Hiscox JA, Solomon T, Ooi MH, Ng LFP.

Front Microbiol. 2017 Nov 28;8:2249. doi: 10.3389/fmicb.2017.02249. eCollection 2017. Review.

34.

Co-infection with Chikungunya virus alters trafficking of pathogenic CD8+ T cells into the brain and prevents Plasmodium-induced neuropathology.

Teo TH, Howland SW, Claser C, Gun SY, Poh CM, Lee WW, Lum FM, Ng LF, Rénia L.

EMBO Mol Med. 2018 Jan;10(1):121-138. doi: 10.15252/emmm.201707885.

35.

Persistence of Zika virus in conjunctival fluid of convalescence patients.

Tan JJL, Balne PK, Leo YS, Tong L, Ng LFP, Agrawal R.

Sci Rep. 2017 Sep 11;7(1):11194. doi: 10.1038/s41598-017-09479-5.

36.

Deep Sequencing of RNA from Blood and Oral Swab Samples Reveals the Presence of Nucleic Acid from a Number of Pathogens in Patients with Acute Ebola Virus Disease and Is Consistent with Bacterial Translocation across the Gut.

Carroll MW, Haldenby S, Rickett NY, Pályi B, Garcia-Dorival I, Liu X, Barker G, Bore JA, Koundouno FR, Williamson ED, Laws TR, Kerber R, Sissoko D, Magyar N, Di Caro A, Biava M, Fletcher TE, Sprecher A, Ng LFP, Rénia L, Magassouba N, Günther S, Wölfel R, Stoecker K, Matthews DA, Hiscox JA.

mSphere. 2017 Aug 23;2(4). pii: e00325-17. doi: 10.1128/mSphereDirect.00325-17. eCollection 2017 Jul-Aug.

37.

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.

Chen W, Foo SS, Zaid A, Teng TS, Herrero LJ, Wolf S, Tharmarajah K, Vu LD, van Vreden C, Taylor A, Freitas JR, Li RW, Woodruff TM, Gordon R, Ojcius DM, Nakaya HI, Kanneganti TD, O'Neill LAJ, Robertson AAB, King NJ, Suhrbier A, Cooper MA, Ng LFP, Mahalingam S.

Nat Microbiol. 2017 Oct;2(10):1435-1445. doi: 10.1038/s41564-017-0015-4. Epub 2017 Aug 28.

PMID:
28848230
38.

Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus-Infected Patients in Brazil.

Kam YW, Leite JA, Lum FM, Tan JJL, Lee B, Judice CC, Teixeira DAT, Andreata-Santos R, Vinolo MA, Angerami R, Resende MR, Freitas ARR, Amaral E, Junior RP, Costa ML, Guida JP, Arns CW, Ferreira LCS, Rénia L, Proença-Modena JL, Ng LFP, Costa FTM; Zika-Unicamp Network.

J Infect Dis. 2017 Jul 15;216(2):172-181. doi: 10.1093/infdis/jix261.

39.

Age has a role in driving host immunopathological response to alphavirus infection.

Chan YH, Ng LFP.

Immunology. 2017 Dec;152(4):545-555. doi: 10.1111/imm.12799. Epub 2017 Aug 23. Review.

40.

Immunopathology of Chikungunya Virus Infection: Lessons Learned from Patients and Animal Models.

Ng LFP.

Annu Rev Virol. 2017 Sep 29;4(1):413-427. doi: 10.1146/annurev-virology-101416-041808. Epub 2017 Jun 21. Review.

PMID:
28637387
41.

Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network.

Aliota MT, Bassit L, Bradrick SS, Cox B, Garcia-Blanco MA, Gavegnano C, Friedrich TC, Golos TG, Griffin DE, Haddow AD, Kallas EG, Kitron U, Lecuit M, Magnani DM, Marrs C, Mercer N, McSweegan E, Ng LFP, O'Connor DH, Osorio JE, Ribeiro GS, Ricciardi M, Rossi SL, Saade G, Schinazi RF, Schott-Lerner GO, Shan C, Shi PY, Watkins DI, Vasilakis N, Weaver SC.

Antiviral Res. 2017 Aug;144:223-246. doi: 10.1016/j.antiviral.2017.06.001. Epub 2017 Jun 6. Review.

42.

A Sensitive Method for Detecting Zika Virus Antigen in Patients' Whole-Blood Specimens as an Alternative Diagnostic Approach.

Lum FM, Lin C, Susova OY, Teo TH, Fong SW, Mak TM, Lee LK, Chong CY, Lye DCB, Lin RTP, Merits A, Leo YS, Ng LFP.

J Infect Dis. 2017 Jul 15;216(2):182-190. doi: 10.1093/infdis/jix276.

43.

Cross-reactive dengue human monoclonal antibody prevents severe pathologies and death from Zika virus infections.

Kam YW, Lee CY, Teo TH, Howland SW, Amrun SN, Lum FM, See P, Kng NQ, Huber RG, Xu MH, Tan HL, Choo A, Maurer-Stroh S, Ginhoux F, Fink K, Wang CI, Ng LF, Rénia L.

JCI Insight. 2017 Apr 20;2(8). pii: 92428. doi: 10.1172/jci.insight.92428. eCollection 2017 Apr 20.

44.

Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity.

Tang TH, Alonso S, Ng LF, Thein TL, Pang VJ, Leo YS, Lye DC, Yeo TW.

Sci Rep. 2017 Apr 10;7:46191. doi: 10.1038/srep46191.

45.

Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays detergent-sensitive primer extension and terminal adenylyltransferase activities.

Chen MW, Tan YB, Zheng J, Zhao Y, Lim BT, Cornvik T, Lescar J, Ng LFP, Luo D.

Antiviral Res. 2017 Jul;143:38-47. doi: 10.1016/j.antiviral.2017.04.001. Epub 2017 Apr 5.

PMID:
28390873
46.

Zika Virus Infects Human Fetal Brain Microglia and Induces Inflammation.

Lum FM, Low DK, Fan Y, Tan JJ, Lee B, Chan JK, Rénia L, Ginhoux F, Ng LF.

Clin Infect Dis. 2017 Apr 1;64(7):914-920. doi: 10.1093/cid/ciw878.

PMID:
28362944
47.

Structural Optimizations of Thieno[3,2-b]pyrrole Derivatives for the Development of Metabolically Stable Inhibitors of Chikungunya Virus.

Ching KC, Tran TN, Amrun SN, Kam YW, Ng LF, Chai CL.

J Med Chem. 2017 Apr 13;60(7):3165-3186. doi: 10.1021/acs.jmedchem.7b00180. Epub 2017 Apr 4.

PMID:
28350454
48.

Clinical features of patients with Zika and dengue virus co-infection in Singapore.

Chia PY, Yew HS, Ho H, Chow A, Sadarangani SP, Chan M, Kam YW, Chong CY, Thoon KC, Yung CF, Li JH, Lye DC, De PP, Ng LFP, Yeo TW, Leo YS.

J Infect. 2017 Jun;74(6):611-615. doi: 10.1016/j.jinf.2017.03.007. Epub 2017 Mar 23. No abstract available.

PMID:
28344113
49.

Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen.

Burt FJ, Chen W, Miner JJ, Lenschow DJ, Merits A, Schnettler E, Kohl A, Rudd PA, Taylor A, Herrero LJ, Zaid A, Ng LFP, Mahalingam S.

Lancet Infect Dis. 2017 Apr;17(4):e107-e117. doi: 10.1016/S1473-3099(16)30385-1. Epub 2017 Feb 1. Review.

PMID:
28159534
50.

Fingolimod treatment abrogates chikungunya virus-induced arthralgia.

Teo TH, Chan YH, Lee WW, Lum FM, Amrun SN, Her Z, Rajarethinam R, Merits A, Rötzschke O, Rénia L, Ng LF.

Sci Transl Med. 2017 Feb 1;9(375). pii: eaal1333. doi: 10.1126/scitranslmed.aal1333.

PMID:
28148838

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