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Binding and structural asymmetry governs ligand sensitivity in a cyclic nucleotide-gated ion channel.

Ng LCT, Zhuang M, Van Petegem F, Li YX, Accili EA.

J Gen Physiol. 2019 Sep 3. pii: jgp.201812162. doi: 10.1085/jgp.201812162. [Epub ahead of print]


Conjugative IncX 1 plasmid harboring colistin resistance gene mcr-5.1 in E. coli isolated from chicken rice retailed in Singapore.

Guo S, Tay MYF, Thu AK, Seow KLG, Zhong Y, Ng LC, Schlundt J.

Antimicrob Agents Chemother. 2019 Sep 3. pii: AAC.01043-19. doi: 10.1128/AAC.01043-19. [Epub ahead of print]


Detection and characterization of a novel bat-borne coronavirus in Singapore using multiple molecular approaches.

Lim XF, Lee CB, Pascoe SM, How CB, Chan S, Tan JH, Yang X, Zhou P, Shi Z, Sessions OM, Wang LF, Ng LC, Anderson DE, Yap G.

J Gen Virol. 2019 Aug 16. doi: 10.1099/jgv.0.001307. [Epub ahead of print]


Pre-vaccination screening strategies for the use of the CYD-TDV dengue vaccine: A meeting report.

Wilder-Smith A, Smith PG, Luo R, Kelly-Cirino C, Curry D, Larson H, Durbin A, Chu M, Tharmaphornpilas P, Ng LC, Sartori AMC, Luna EJA, Gubler DJ, España G, Yoon IK, Flasche S.

Vaccine. 2019 Aug 23;37(36):5137-5146. doi: 10.1016/j.vaccine.2019.07.016. Epub 2019 Jul 31.


Opening TRPP2 (PKD2L1) requires the transfer of gating charges.

Ng LCT, Vien TN, Yarov-Yarovoy V, DeCaen PG.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15540-15549. doi: 10.1073/pnas.1902917116. Epub 2019 Jul 17.


Second WIN International Conference on "Integrated approaches and innovative tools for combating insecticide resistance in vectors of arboviruses", October 2018, Singapore.

Corbel V, Durot C, Achee NL, Chandre F, Coulibaly MB, David JP, Devine GJ, Dusfour I, Fonseca DM, Griego J, Juntarajumnong W, Lenhart A, Kasai S, Martins AJ, Moyes C, Ng LC, Pinto J, Pompon JF, Muller P, Raghavendra K, Roiz D, Vatandoost H, Vontas J, Weetman D.

Parasit Vectors. 2019 Jul 3;12(1):331. doi: 10.1186/s13071-019-3591-8.


One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia.

Barkham T, Zadoks RN, Azmai MNA, Baker S, Bich VTN, Chalker V, Chau ML, Dance D, Deepak RN, van Doorn HR, Gutierrez RA, Holmes MA, Huong LNP, Koh TH, Martins E, Mehershahi K, Newton P, Ng LC, Phuoc NN, Sangwichian O, Sawatwong P, Surin U, Tan TY, Tang WY, Thuy NV, Turner P, Vongsouvath M, Zhang D, Whistler T, Chen SL.

PLoS Negl Trop Dis. 2019 Jun 27;13(6):e0007421. doi: 10.1371/journal.pntd.0007421. eCollection 2019 Jun.


The effectiveness of inspections on reported mosquito larval habitats in households: A case-control study.

Aik J, Neo ZW, Rajarethinam J, Chio K, Lam WM, Ng LC.

PLoS Negl Trop Dis. 2019 Jun 26;13(6):e0007492. doi: 10.1371/journal.pntd.0007492. eCollection 2019 Jun.


Locating "gold standard" evidence for simulation as a substitute for clinical practice in prelicensure health professional education: A systematic review.

Bogossian FE, Cant RP, Ballard EL, Cooper SJ, Levett-Jones TL, McKenna LG, Ng LC, Seaton PC.

J Clin Nurs. 2019 Jun 19. doi: 10.1111/jocn.14965. [Epub ahead of print] Review.


Inferring who-infected-whom-where in the 2016 Zika outbreak in Singapore-a spatio-temporal model.

Prem K, Lau MSY, Tam CC, Ho MZJ, Ng LC, Cook AR.

J R Soc Interface. 2019 Jun 28;16(155):20180604. doi: 10.1098/rsif.2018.0604. Epub 2019 Jun 19.


Serological evidence of continued Japanese encephalitis virus transmission in Singapore nearly three decades after end of pig farming.

Yap G, Lim XF, Chan S, How CB, Humaidi M, Yeo G, Mailepessov D, Kong M, Lai YL, Okumura C, Ng LC.

Parasit Vectors. 2019 May 17;12(1):244. doi: 10.1186/s13071-019-3501-0.


Force-of-infection and True Infection Rate of Dengue in Singapore - its implication on dengue control and management.

Tan LK, Low SL, Sun H, Shi Y, Liu L, Lam S, Tan HH, Ang LW, Wong WY, Chua R, Teo D, Ng LC, Cook AR.

Am J Epidemiol. 2019 May 7. pii: kwz110. doi: 10.1093/aje/kwz110. [Epub ahead of print]


Application of a targeted-enrichment methodology for full-genome sequencing of Dengue 1-4, Chikungunya and Zika viruses directly from patient samples.

Kamaraj US, Tan JH, Xin Mei O, Pan L, Chawla T, Uehara A, Wang LF, Ooi EE, Gubler DJ, Tissera H, Ng LC, Wilder-Smith A, de Sessions PF, Barkham T, Anderson DE, Sessions OM.

PLoS Negl Trop Dis. 2019 Apr 25;13(4):e0007184. doi: 10.1371/journal.pntd.0007184. eCollection 2019 Apr.


Augmented Adsorptive Blood Purification during Continuous Veno-Venous Haemodiafiltration in a Severe Septic, Acute Kidney Injury Patient: Use of oXiris®: A Single Centre Case Report.

Tan HK, Kaushik M, Tan CW, Liew ZH, Teo SH, Loo CM, Ng LC, Choong LHL, Foo MWY.

Blood Purif. 2019;47 Suppl 3:1-6. doi: 10.1159/000499633. Epub 2019 Apr 12.


Microbial Quality and Safety of Sushi Prepared with Gloved or Bare Hands: Food Handlers' Impact on Retail Food Hygiene and Safety.

Yap M, Chau ML, Hartantyo SHP, Oh JQ, Aung KT, Gutiérrez RA, Ng LC.

J Food Prot. 2019 Apr;82(4):615-622. doi: 10.4315/0362-028X.JFP-18-349.


Multiplex targeted mass spectrometry assay for one-shot flavivirus diagnosis.

Wee S, Alli-Shaik A, Kek R, Swa HLF, Tien WP, Lim VW, Leo YS, Ng LC, Hapuarachchi HC, Gunaratne J.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6754-6759. doi: 10.1073/pnas.1817867116. Epub 2019 Mar 18.


Utility of Spatial Point-Pattern Analysis Using Residential and Workplace Geospatial Information to Localize Potential Outbreak Sources.

Chua JL, Ng LC, Lee VJ, Ong MEH, Lim EL, Lim HCS, Ooi CK, Tyebally A, Seow E, Chen MI.

Am J Epidemiol. 2019 May 1;188(5):940-949. doi: 10.1093/aje/kwy290.


Using Human Movement Data to Identify Potential Areas of Zika Transmission: Case Study of the Largest Zika Cluster in Singapore.

Rajarethinam J, Ong J, Lim SH, Tay YH, Bounliphone W, Chong CS, Yap G, Ng LC.

Int J Environ Res Public Health. 2019 Mar 5;16(5). pii: E808. doi: 10.3390/ijerph16050808.


Exposure and risk assessment of volatile organic compounds and airborne phthalates in Singapore's Child Care Centers.

Jia S, Sankaran G, Wang B, Shang H, Tan ST, Yap HM, Shen J, Gutiérrez RA, Fang W, Liu M, Chang VW, Ng LC, Fang M.

Chemosphere. 2019 Jun;224:85-92. doi: 10.1016/j.chemosphere.2019.02.120. Epub 2019 Feb 21.


Trauma exposure, depression, suicidal ideation, and alcohol use in people with severe mental disorder in Ethiopia.

Ng LC, Medhin G, Hanlon C, Fekadu A.

Soc Psychiatry Psychiatr Epidemiol. 2019 Jul;54(7):835-842. doi: 10.1007/s00127-019-01673-2. Epub 2019 Feb 20.


First detection of a Vssc allele V1016G conferring a high level of insecticide resistance in Aedes albopictus collected from Europe (Italy) and Asia (Vietnam), 2016: a new emerging threat to controlling arboviral diseases.

Kasai S, Caputo B, Tsunoda T, Cuong TC, Maekawa Y, Lam-Phua SG, Pichler V, Itokawa K, Murota K, Komagata O, Yoshida C, Chung HH, Bellini R, Tsuda Y, Teng HJ, Filho JLL, Alves LC, Ng LC, Minakawa N, Yen NT, Phong TV, Sawabe K, Tomita T.

Euro Surveill. 2019 Jan;24(5). doi: 10.2807/1560-7917.ES.2019.24.5.1700847.


Highly Selective Transmission Success of Dengue Virus Type 1 Lineages in a Dynamic Virus Population: An Evolutionary and Fitness Perspective.

Koo C, Tien WP, Xu H, Ong J, Rajarethinam J, Lai YL, Ng LC, Hapuarachchi HC.

iScience. 2018 Aug 31;6:38-51. doi: 10.1016/j.isci.2018.07.008. Epub 2018 Jul 18.


Deliberations of the Strategic Advisory Group of Experts on Immunization on the use of CYD-TDV dengue vaccine.

Wilder-Smith A, Hombach J, Ferguson N, Selgelid M, O'Brien K, Vannice K, Barrett A, Ferdinand E, Flasche S, Guzman M, Novaes HM, Ng LC, Smith PG, Tharmaphornpilas P, Yoon IK, Cravioto A, Farrar J, Nolan TM.

Lancet Infect Dis. 2019 Jan;19(1):e31-e38. doi: 10.1016/S1473-3099(18)30494-8. Epub 2018 Sep 5. Review.


Mosquitoes (Diptera: Culicidae) of Singapore: Updated Checklist and New Records.

Lam-Phua SG, Yeo H, Lee RM, Chong CS, Png AB, Foo SY, Liew C, Ng LC, Tang CS, Rueda LM, Pecor JE, Harrison BA.

J Med Entomol. 2019 Jan 8;56(1):103-119. doi: 10.1093/jme/tjy154.


Construction sites as an important driver of dengue transmission: implications for disease control.

Liang S, Hapuarachchi HC, Rajarethinam J, Koo C, Tang CS, Chong CS, Ng LC, Yap G.

BMC Infect Dis. 2018 Aug 8;18(1):382. doi: 10.1186/s12879-018-3311-6.


Neighbourhood level real-time forecasting of dengue cases in tropical urban Singapore.

Chen Y, Ong JHY, Rajarethinam J, Yap G, Ng LC, Cook AR.

BMC Med. 2018 Aug 6;16(1):129. doi: 10.1186/s12916-018-1108-5.


Climate variability and salmonellosis in Singapore - A time series analysis.

Aik J, Heywood AE, Newall AT, Ng LC, Kirk MD, Turner R.

Sci Total Environ. 2018 Oct 15;639:1261-1267. doi: 10.1016/j.scitotenv.2018.05.254. Epub 2018 May 26.


Mapping dengue risk in Singapore using Random Forest.

Ong J, Liu X, Rajarethinam J, Kok SY, Liang S, Tang CS, Cook AR, Ng LC, Yap G.

PLoS Negl Trop Dis. 2018 Jun 18;12(6):e0006587. doi: 10.1371/journal.pntd.0006587. eCollection 2018 Jun.


Dengue in Singapore from 2004 to 2016: Cyclical Epidemic Patterns Dominated by Serotypes 1 and 2.

Rajarethinam J, Ang LW, Ong J, Ycasas J, Hapuarachchi HC, Yap G, Chong CS, Lai YL, Cutter J, Ho D, Lee V, Ng LC.

Am J Trop Med Hyg. 2018 Jul;99(1):204-210. doi: 10.4269/ajtmh.17-0819. Epub 2018 May 24.


A Sense of Obligation: Cultural Differences in the Experience of Obligation.

Buchtel EE, Ng LCY, Norenzayan A, Heine SJ, Biesanz JC, Chen SX, Bond MH, Peng Q, Su Y.

Pers Soc Psychol Bull. 2018 Nov;44(11):1545-1566. doi: 10.1177/0146167218769610. Epub 2018 May 9.


Viral and Antibody Kinetics, and Mosquito Infectivity of an Imported Case of Zika Fever Due to Asian Genotype (American Strain) in Singapore.

Tan CH, Tan LK, Hapuarachchi HC, Lai YL, Wong PSJ, Yap G, Mak KW, Wong WY, Leo YS, Wong MC, Ng LC.

Viruses. 2018 Jan 18;10(1). pii: E44. doi: 10.3390/v10010044.


Weather Correlations to Calculate Infiltration Rates for U. S. Commercial Building Energy Models.

Ng LC, Quiles NO, Dols WS, Emmerich SJ.

Build Environ. 2018 Jan;127:47-57. doi: 10.1016/j.buildenv.2017.10.029. Epub 2017 Oct 28.


Seroprevalence of antibodies against chikungunya virus in Singapore resident adult population.

Ang LW, Kam YW, Lin C, Krishnan PU, Tay J, Ng LC, James L, Lee VJM, Goh KT, Ng LFP, Lin RTP.

PLoS Negl Trop Dis. 2017 Dec 27;11(12):e0006163. doi: 10.1371/journal.pntd.0006163. eCollection 2017 Dec.


Group B Streptococcus Infections Caused by Improper Sourcing and Handling of Fish for Raw Consumption, Singapore, 2015-2016.

Chau ML, Chen SL, Yap M, Hartantyo SHP, Chiew PKT, Fernandez CJ, Wong WK, Fong RK, Tan WL, Tan BZY, Ng Y, Aung KT, Mehershahi KS, Goh C, Kang JSL, Barkham T, Leong AOK, Gutiérrez RA, Ng LC.

Emerg Infect Dis. 2017 Dec;23(12). doi: 10.3201/eid2312.170596.


Singapore's Anopheles sinensis Form A is susceptible to Plasmodium vivax isolates from the western Thailand-Myanmar border.

Pang SC, Andolina C, Malleret B, Christensen PR, Lam-Phua SG, Razak MABA, Chong CS, Li D, Chu CS, Russell B, Rénia L, Ng LC, Nosten F.

Malar J. 2017 Nov 16;16(1):465. doi: 10.1186/s12936-017-2114-3.


SYBR green-based one step quantitative real-time polymerase chain reaction assay for the detection of Zika virus in field-caught mosquitoes.

Tien WP, Lim G, Yeo G, Chiang SN, Chong CS, Ng LC, Hapuarachchi HC.

Parasit Vectors. 2017 Sep 19;10(1):427. doi: 10.1186/s13071-017-2373-4.


Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in retail food in Singapore.

Aung KT, Hsu LY, Koh TH, Hapuarachchi HC, Chau ML, Gutiérrez RA, Ng LC.

Antimicrob Resist Infect Control. 2017 Sep 8;6:94. doi: 10.1186/s13756-017-0255-3. eCollection 2017.


Erratum to: International workshop on insecticide resistance in vectors of arboviruses, December 2016, Rio de Janeiro, Brazil.

Corbel V, Fonseca DM, Weetman D, Pinto J, Achee NL, Chandre F, Coulibaly MB, Dusfour I, Grieco J, Juntarajumnong W, Lenhart A, Martins AJ, Moyes C, Ng LC, Raghavendra K, Vatandoost H, Vontas J, Muller P, Kasai S, Fouque F, Velayudhan R, Durot C, David JP.

Parasit Vectors. 2017 Aug 21;10(1):391. doi: 10.1186/s13071-017-2327-x. No abstract available.


Reducing tunneled catheter-related infection in hemodialysis patients with nationwide standardization of catheter care protocol.

Lee KG, Ng LC, Yeon W, Silva Thore S, Rahman MA, Rofi SNM, Lim WW, Ling ML, Choong HL.

J Vasc Access. 2018 Jan;19(1):110-111. doi: 10.5301/jva.5000752. No abstract available.


Contemporary status of insecticide resistance in the major Aedes vectors of arboviruses infecting humans.

Moyes CL, Vontas J, Martins AJ, Ng LC, Koou SY, Dusfour I, Raghavendra K, Pinto J, Corbel V, David JP, Weetman D.

PLoS Negl Trop Dis. 2017 Jul 20;11(7):e0005625. doi: 10.1371/journal.pntd.0005625. eCollection 2017 Jul. Review.


International workshop on insecticide resistance in vectors of arboviruses, December 2016, Rio de Janeiro, Brazil.

Corbel V, Fonseca DM, Weetman D, Pinto J, Achee NL, Chandre F, Coulibaly MB, Dusfour I, Grieco J, Juntarajumnong W, Lenhart A, Martins AJ, Moyes C, Ng LC, Raghavendra K, Vatandoost H, Vontas J, Muller P, Kasai S, Fouque F, Velayudhan R, Durot C, David JP.

Parasit Vectors. 2017 Jun 2;10(1):278. doi: 10.1186/s13071-017-2224-3. Erratum in: Parasit Vectors. 2017 Aug 21;10 (1):391.


wMel limits zika and chikungunya virus infection in a Singapore Wolbachia-introgressed Ae. aegypti strain, wMel-Sg.

Tan CH, Wong PJ, Li MI, Yang H, Ng LC, O'Neill SL.

PLoS Negl Trop Dis. 2017 May 19;11(5):e0005496. doi: 10.1371/journal.pntd.0005496. eCollection 2017 May.


Family-based promotion of mental health in children affected by HIV: a pilot randomized controlled trial.

Betancourt TS, Ng LC, Kirk CM, Brennan RT, Beardslee WR, Stulac S, Mushashi C, Nduwimana E, Mukunzi S, Nyirandagijimana B, Kalisa G, Rwabukwisi CF, Sezibera V.

J Child Psychol Psychiatry. 2017 Aug;58(8):922-930. doi: 10.1111/jcpp.12729. Epub 2017 May 15.


2015 Epidemic of Severe Streptococcus agalactiae Sequence Type 283 Infections in Singapore Associated With the Consumption of Raw Freshwater Fish: A Detailed Analysis of Clinical, Epidemiological, and Bacterial Sequencing Data.

Kalimuddin S, Chen SL, Lim CTK, Koh TH, Tan TY, Kam M, Wong CW, Mehershahi KS, Chau ML, Ng LC, Tang WY, Badaruddin H, Teo J, Apisarnthanarak A, Suwantarat N, Ip M, Holden MTG, Hsu LY, Barkham T; Singapore Group B Streptococcus Consortium.

Clin Infect Dis. 2017 May 15;64(suppl_2):S145-S152. doi: 10.1093/cid/cix021.


A Zika virus from America is more efficiently transmitted than an Asian virus by Aedes aegypti mosquitoes from Asia.

Pompon J, Morales-Vargas R, Manuel M, Huat Tan C, Vial T, Hao Tan J, Sessions OM, Vasconcelos PDC, Ng LC, Missé D.

Sci Rep. 2017 Apr 27;7(1):1215. doi: 10.1038/s41598-017-01282-6.


Posttraumatic stress disorder, trauma, and reconciliation in South Sudan.

Ng LC, López B, Pritchard M, Deng D.

Soc Psychiatry Psychiatr Epidemiol. 2017 Jun;52(6):705-714. doi: 10.1007/s00127-017-1376-y. Epub 2017 Apr 11.


Microbial survey of ready-to-eat salad ingredients sold at retail reveals the occurrence and the persistence of Listeria monocytogenes Sequence Types 2 and 87 in pre-packed smoked salmon.

Chau ML, Aung KT, Hapuarachchi HC, Lee PS, Lim PY, Kang JS, Ng Y, Yap HM, Yuk HG, Gutiérrez RA, Ng LC.

BMC Microbiol. 2017 Feb 28;17(1):46. doi: 10.1186/s12866-017-0956-z.


The complete structure of an activated open sodium channel.

Sula A, Booker J, Ng LC, Naylor CE, DeCaen PG, Wallace BA.

Nat Commun. 2017 Feb 16;8:14205. doi: 10.1038/ncomms14205.


Tracking Insecticide Resistance in Mosquito Vectors of Arboviruses: The Worldwide Insecticide resistance Network (WIN).

Corbel V, Achee NL, Chandre F, Coulibaly MB, Dusfour I, Fonseca DM, Grieco J, Juntarajumnong W, Lenhart A, Martins AJ, Moyes C, Ng LC, Pinto J, Raghavendra K, Vatandoost H, Vontas J, Weetman D, Fouque F, Velayudhan R, David JP.

PLoS Negl Trop Dis. 2016 Dec 1;10(12):e0005054. doi: 10.1371/journal.pntd.0005054. eCollection 2016 Dec. No abstract available.

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