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Novel endotypes in heart failure: effects on guideline-directed medical therapy.

Tromp J, Ouwerkerk W, Demissei BG, Anker SD, Cleland JG, Dickstein K, Filippatos G, van der Harst P, Hillege HL, Lang CC, Metra M, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zannad F, Zwinderman AH, Voors AA, van der Meer P.

Eur Heart J. 2018 Dec 13. doi: 10.1093/eurheartj/ehy712. [Epub ahead of print]


Dimensionality reduction for visualizing single-cell data using UMAP.

Becht E, McInnes L, Healy J, Dutertre CA, Kwok IWH, Ng LG, Ginhoux F, Newell EW.

Nat Biotechnol. 2018 Dec 3. doi: 10.1038/nbt.4314. [Epub ahead of print]


Ketamine and selective activation of parvalbumin interneurons inhibit stress-induced dendritic spine elimination.

Ng LHL, Huang Y, Han L, Chang RC, Chan YS, Lai CSW.

Transl Psychiatry. 2018 Dec 10;8(1):272. doi: 10.1038/s41398-018-0321-5.


Ezh2 Controls Skin Tolerance through Distinct Mechanisms in Different Subsets of Skin Dendritic Cells.

Loh JT, Lim TJF, Ikumi K, Matoba T, Janela B, Gunawan M, Toyama T, Bunjamin M, Ng LG, Poidinger M, Morita A, Ginhoux F, Yamazaki S, Lam KP, Su IH.

iScience. 2018 Nov 14;10:23-39. doi: 10.1016/j.isci.2018.11.019. [Epub ahead of print]

Free PMC Article

Non-cardiac comorbidities in heart failure with reduced, mid-range and preserved ejection fraction.

Streng KW, Nauta JF, Hillege HL, Anker SD, Cleland JG, Dickstein K, Filippatos G, Lang CC, Metra M, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zwinderman AH, Zannad F, Damman K, van der Meer P, Voors AA.

Int J Cardiol. 2018 Nov 15;271:132-139. doi: 10.1016/j.ijcard.2018.04.001. Epub 2018 Jul 7.


Early life factors are associated with trajectories of consistent organized sport participation over childhood and adolescence: Longitudinal analysis from the Raine Study.

Howie EK, Ng L, Beales D, McVeigh JA, Straker LM.

J Sci Med Sport. 2018 Nov 16. pii: S1440-2440(18)31128-9. doi: 10.1016/j.jsams.2018.11.006. [Epub ahead of print]


Three-dimensional optical clearing and imaging of pruritic atopic dermatitis and psoriasis skin reveals downregulation of epidermal innervation.

Tan Y, Ng WJ, Lee SZX, Lee Teck Kwong B, Nattkemper LA, Yosipovitch G, Ng LG, Tey HL.

J Invest Dermatol. 2018 Nov 21. pii: S0022-202X(18)32829-X. doi: 10.1016/j.jid.2018.11.006. [Epub ahead of print] No abstract available.


Fast Tracks and Roadblocks for Zika Vaccines.

Ghaffar KA, Ng LFP, Renia L.

Vaccines (Basel). 2018 Nov 21;6(4). pii: E77. doi: 10.3390/vaccines6040077. Review.


Multimodal assessments of Zika virus immune pathophysiological responses in marmosets.

Lum FM, Zhang W, Lim KC, Malleret B, Teo TH, Koh JJ, Lee KJ, Chua TK, Kam YW, Yee WX, Huen I, Tan JJL, Amrun SN, Prakash Kn B, Cozzone PJ, Renia L, Lee PTH, Ng LFP.

Sci Rep. 2018 Nov 20;8(1):17125. doi: 10.1038/s41598-018-35481-6.


Effectiveness of interventions aiming at reducing sedentary behaviour in a non-surgical population with overweight or obesity: A systematic review and meta-analysis.

Zabatiero J, Ng L, Clayton R, Middlemiss S, Kang K, Harrold M, Cavalheri V.

Obes Res Clin Pract. 2018 Nov 13. pii: S1871-403X(18)30149-2. doi: 10.1016/j.orcp.2018.10.004. [Epub ahead of print] Review.


Accuracy of urinary symptoms and urine microscopy in diagnosing urinary tract infection in women.

Tan NC, Koong AYL, Ng LP, Hu PL, Koh EYL, Tan KT, Moey PKS, Tan MX, Wong CS, Tan TY, Ho HJA, Chen MI.

Fam Pract. 2018 Nov 15. doi: 10.1093/fampra/cmy108. [Epub ahead of print]


Effects of kinesiology taping on shoulder girdle muscle activity and sports performance during badminton forehand overhead strokes in amateur badminton players with shoulder impingement syndrome.

Fong SS, Ng LL, Ma AW, Wang HK, Bae YH, Yam TT, Kam WK, Chung JW.

J Sports Med Phys Fitness. 2018 Oct 31. doi: 10.23736/S0022-4707.18.09125-9. [Epub ahead of print]


Using matrix assisted laser desorption ionisation mass spectrometry (MALDI-MS) profiling in order to predict clinical outcomes of patients with heart failure.

Cao TH, Jones DJL, Quinn PA, Chan DCS, Hafid N, Parry HM, Mohan M, Sandhu JK, Anker SD, Cleland JG, Dickstein K, Filippatos G, Hillege HL, Metra M, Ponikowski P, Samani NJ, Van Veldhuisen DJ, Zannad F, Zwinderman AH, Voors AA, Lang CC, Ng LL.

Clin Proteomics. 2018 Nov 2;15:35. doi: 10.1186/s12014-018-9213-1. eCollection 2018.


The crucible of early career psychiatry.

Ng L, Steane R, Scollay N, Harris S, Milosevic J, Young K, Tan D, Chow S.

Australas Psychiatry. 2018 Nov 7:1039856218810153. doi: 10.1177/1039856218810153. [Epub ahead of print]


Association with outcomes and response to treatment of trimethylamine N-oxide in heart failure (from BIOSTAT-CHF).

Suzuki T, Yazaki Y, Voors AA, Jones DJL, Chan DCS, Anker SD, Cleland JG, Dickstein K, Filippatos G, Hillege HL, Lang CC, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zannad F, Zwinderman AH, Metra M, Ng LL.

Eur J Heart Fail. 2018 Oct 29. doi: 10.1002/ejhf.1338. [Epub ahead of print]


Lipid profiling of C. elegans strains administered pro-longevity drugs and drug combinations.

Admasu TD, Batchu KC, Ng LF, Cazenave-Gassiot A, Wenk MR, Gruber J.

Sci Data. 2018 Oct 23;5:180231. doi: 10.1038/sdata.2018.231.


Heart failure in the outpatient versus inpatient setting: findings from the BIOSTAT-CHF study.

Ferreira JP, Metra M, Mordi I, Gregson J, Ter Maaten JM, Tromp J, Anker SD, Dickstein K, Hillege HL, Ng LL, van Veldhuisen DJ, Lang CC, Voors AA, Zannad F.

Eur J Heart Fail. 2018 Oct 19. doi: 10.1002/ejhf.1323. [Epub ahead of print]


Neutrophils instruct homeostatic and pathological states in naive tissues.

Casanova-Acebes M, Nicolás-Ávila JA, Li JL, García-Silva S, Balachander A, Rubio-Ponce A, Weiss LA, Adrover JM, Burrows K, A-González N, Ballesteros I, Devi S, Quintana JA, Crainiciuc G, Leiva M, Gunzer M, Weber C, Nagasawa T, Soehnlein O, Merad M, Mortha A, Ng LG, Peinado H, Hidalgo A.

J Exp Med. 2018 Nov 5;215(11):2778-2795. doi: 10.1084/jem.20181468. Epub 2018 Oct 3.


Streamlining volumetric multi-channel image cytometry using hue-saturation-brightness-based surface creation.

Tan Y, Li JLY, Goh CC, Lee BTK, Kwok IWH, Ng WJ, Evrard M, Poidinger M, Tey HL, Ng LG.

Commun Biol. 2018 Sep 6;1:136. doi: 10.1038/s42003-018-0139-y. eCollection 2018.


Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling.

Admasu TD, Chaithanya Batchu K, Barardo D, Ng LF, Lam VYM, Xiao L, Cazenave-Gassiot A, Wenk MR, Tolwinski NS, Gruber J.

Dev Cell. 2018 Oct 8;47(1):67-79.e5. doi: 10.1016/j.devcel.2018.09.001. Epub 2018 Sep 27.


Development of a real-time assay to determine the frequency of qac genes in methicillin resistant Staphylococcus aureus.

Chan MKL, Koo SH, Quek Q, Pang WS, Jiang B, Ng LSY, Tan SH, Tan TY.

J Microbiol Methods. 2018 Oct;153:133-138. doi: 10.1016/j.mimet.2018.09.017. Epub 2018 Sep 26.


Oral care measures for preventing nursing home-acquired pneumonia.

Liu C, Cao Y, Lin J, Ng L, Needleman I, Walsh T, Li C.

Cochrane Database Syst Rev. 2018 Sep 27;9:CD012416. doi: 10.1002/14651858.CD012416.pub2. Review.


Plasmodium co-infection protects against chikungunya virus-induced pathologies.

Teo TH, Lum FM, Ghaffar K, Chan YH, Amrun SN, Tan JJL, Lee CYP, Chua TK, Carissimo G, Lee WWL, Claser C, Rajarethinam R, Rénia L, Ng LFP.

Nat Commun. 2018 Sep 25;9(1):3905. doi: 10.1038/s41467-018-06227-9.


Highly Selective Transmission Success of Dengue Virus Type 1 Lineages in a Dynamic Virus Population: An Evolutionary and Fitness Perspective.

Koo C, Tien WP, Xu H, Ong J, Rajarethinam J, Lai YL, Ng LC, Hapuarachchi HC.

iScience. 2018 Aug 31;6:38-51. doi: 10.1016/j.isci.2018.07.008. Epub 2018 Jul 18.


Psychological interventions for bipolar disorder in low- and middle-income countries: systematic review.

Demissie M, Hanlon C, Birhane R, Ng L, Medhin G, Fekadu A.

BJPsych Open. 2018 Aug 30;4(5):375-384. doi: 10.1192/bjo.2018.46. eCollection 2018 Sep. Review.


Deliberations of the Strategic Advisory Group of Experts on Immunization on the use of CYD-TDV dengue vaccine.

Wilder-Smith A, Hombach J, Ferguson N, Selgelid M, O'Brien K, Vannice K, Barrett A, Ferdinand E, Flasche S, Guzman M, Novaes HM, Ng LC, Smith PG, Tharmaphornpilas P, Yoon IK, Cravioto A, Farrar J, Nolan TM.

Lancet Infect Dis. 2018 Sep 5. pii: S1473-3099(18)30494-8. doi: 10.1016/S1473-3099(18)30494-8. [Epub ahead of print] Review.


Mosquitoes (Diptera: Culicidae) of Singapore: Updated Checklist and New Records.

Lam-Phua SG, Yeo H, Lee RM, Chong CS, Png AB, Foo SY, Liew C, Ng LC, Tang CS, Rueda LM, Pecor JE, Harrison BA.

J Med Entomol. 2018 Aug 31. doi: 10.1093/jme/tjy154. [Epub ahead of print]


Laparoscopic versus open repair for small paraumbilical hernia: A retrospective review.

Chung I, Cheung BH, Law TT, Ng KK, Ng L, Wong KY.

Asian J Endosc Surg. 2018 Aug 30. doi: 10.1111/ases.12644. [Epub ahead of print]


Identifying Pathophysiological Mechanisms in Heart Failure With Reduced Versus Preserved Ejection Fraction.

Tromp J, Westenbrink BD, Ouwerkerk W, van Veldhuisen DJ, Samani NJ, Ponikowski P, Metra M, Anker SD, Cleland JG, Dickstein K, Filippatos G, van der Harst P, Lang CC, Ng LL, Zannad F, Zwinderman AH, Hillege HL, van der Meer P, Voors AA.

J Am Coll Cardiol. 2018 Sep 4;72(10):1081-1090. doi: 10.1016/j.jacc.2018.06.050.


Comparing biomarker profiles of patients with heart failure: atrial fibrillation vs. sinus rhythm and reduced vs. preserved ejection fraction.

Santema BT, Kloosterman M, Van Gelder IC, Mordi I, Lang CC, Lam CSP, Anker SD, Cleland JG, Dickstein K, Filippatos G, Van der Harst P, Hillege HL, Ter Maaten JM, Metra M, Ng LL, Ponikowski P, Samani NJ, Van Veldhuisen DJ, Zwinderman AH, Zannad F, Damman K, Van der Meer P, Rienstra M, Voors AA.

Eur Heart J. 2018 Nov 14;39(43):3867-3875. doi: 10.1093/eurheartj/ehy421.


Viperin Poisons Viral Replication.

Ng LFP, Hiscox JA.

Cell Host Microbe. 2018 Aug 8;24(2):181-183. doi: 10.1016/j.chom.2018.07.014.


Construction sites as an important driver of dengue transmission: implications for disease control.

Liang S, Hapuarachchi HC, Rajarethinam J, Koo C, Tang CS, Chong CS, Ng LC, Yap G.

BMC Infect Dis. 2018 Aug 8;18(1):382. doi: 10.1186/s12879-018-3311-6.


Neighbourhood level real-time forecasting of dengue cases in tropical urban Singapore.

Chen Y, Ong JHY, Rajarethinam J, Yap G, Ng LC, Cook AR.

BMC Med. 2018 Aug 6;16(1):129. doi: 10.1186/s12916-018-1108-5.


The 2016 Singapore Zika virus outbreak did not cause a surge in Guillain-Barré syndrome.

Umapathi T, Kam YW, Ohnmar O, Ng BCJ, Ng Y, Premikha M, Leo YS, Ng LFP.

J Peripher Nerv Syst. 2018 Sep;23(3):197-201. doi: 10.1111/jns.12284. Epub 2018 Aug 21.


Synchronous Chiari III Malformation and Polydactyly.

Tan GI, Low DC, Ng LP, Seow WT, Low SY.

World Neurosurg. 2018 Oct;118:301-303. doi: 10.1016/j.wneu.2018.07.155. Epub 2018 Jul 27.


Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.

Lim HY, Lim SY, Tan CK, Thiam CH, Goh CC, Carbajo D, Chew SHS, See P, Chakarov S, Wang XN, Lim LH, Johnson LA, Lum J, Fong CY, Bongso A, Biswas A, Goh C, Evrard M, Yeo KP, Basu R, Wang JK, Tan Y, Jain R, Tikoo S, Choong C, Weninger W, Poidinger M, Stanley RE, Collin M, Tan NS, Ng LG, Jackson DG, Ginhoux F, Angeli V.

Immunity. 2018 Aug 21;49(2):326-341.e7. doi: 10.1016/j.immuni.2018.06.008. Epub 2018 Jul 24.


Clonal expansion of mitochondrial DNA deletions is a private mechanism of aging in long-lived animals.

Lakshmanan LN, Yee Z, Ng LF, Gunawan R, Halliwell B, Gruber J.

Aging Cell. 2018 Oct;17(5):e12814. doi: 10.1111/acel.12814. Epub 2018 Jul 24.


The impact of a prescription review and prescriber feedback system on prescribing practices in primary care clinics: a cluster randomised trial.

Lim WY, Hss AS, Ng LM, John Jasudass SR, Sararaks S, Vengadasalam P, Hashim L, Praim Singh RK.

BMC Fam Pract. 2018 Jul 19;19(1):120. doi: 10.1186/s12875-018-0808-4.


Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides.

Vanga SR, Sävmarker J, Ng L, Larhed M, Hallberg M, Åqvist J, Hallberg A, Chai SY, Gutiérrez-de-Terán H.

ACS Omega. 2018 Apr 30;3(4):4509-4521. doi: 10.1021/acsomega.8b00595. Epub 2018 Apr 25.


Characteristics of older people in an inpatient haematology unit: A descriptive study.

Thillainadesan J, Ng L, Cunningham I, Wong Doo N, Naganathan V.

Australas J Ageing. 2018 Dec;37(4):293-299. doi: 10.1111/ajag.12560. Epub 2018 Jul 10.


Anti-Allergic Inflammatory Activity of Interleukin-37 Is Mediated by Novel Signaling Cascades in Human Eosinophils.

Zhu J, Dong J, Ji L, Jiang P, Leung TF, Liu D, Ng LG, Tsang MS, Jiao D, Lam CW, Wong CK.

Front Immunol. 2018 Jun 22;9:1445. doi: 10.3389/fimmu.2018.01445. eCollection 2018.


Waist-to-hip ratio and mortality in heart failure.

Streng KW, Voors AA, Hillege HL, Anker SD, Cleland JG, Dickstein K, Filippatos G, Metra M, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zwinderman AH, Zannad F, Damman K, van der Meer P, Lang CC.

Eur J Heart Fail. 2018 Sep;20(9):1269-1277. doi: 10.1002/ejhf.1244. Epub 2018 Jul 2.


Hyperammonemia Presenting as Refractory Status Epilepticus after Lung Transplant in a Patient Positive for Ureaplasma parvum.

McLaughlin DC, Mallea JM, Ng LK.

Indian J Crit Care Med. 2018 Jun;22(6):463-465. doi: 10.4103/ijccm.IJCCM_356_17.


Integrated adsorption-solar photocatalytic membrane reactor for degradation of hazardous Congo red using Fe-doped ZnO and Fe-doped ZnO/rGO nanocomposites.

Ong CB, Mohammad AW, Ng LY.

Environ Sci Pollut Res Int. 2018 Jun 25. doi: 10.1007/s11356-018-2557-2. [Epub ahead of print]


Reverse-engineering flow-cytometry gating strategies for phenotypic labelling and high-performance cell sorting.

Becht E, Simoni Y, Coustan-Smith E, Maximilien E, Cheng Y, Ng LG, Campana D, Newell E.

Bioinformatics. 2018 Jun 21. doi: 10.1093/bioinformatics/bty491. [Epub ahead of print]


Menstrual Blood Human Papillomavirus DNA and TAP1 Gene Polymorphisms as Potential Biomarkers for Screening and Monitoring of Cervical Squamous Intraepithelial Lesion.

Wong SCC, Au TCC, Chan SCS, Ng LPW, Tsang HF.

J Infect Dis. 2018 Oct 20;218(11):1739-1745. doi: 10.1093/infdis/jiy369.


Climate variability and salmonellosis in Singapore - A time series analysis.

Aik J, Heywood AE, Newall AT, Ng LC, Kirk MD, Turner R.

Sci Total Environ. 2018 Oct 15;639:1261-1267. doi: 10.1016/j.scitotenv.2018.05.254. Epub 2018 May 26.


Mapping dengue risk in Singapore using Random Forest.

Ong J, Liu X, Rajarethinam J, Kok SY, Liang S, Tang CS, Cook AR, Ng LC, Yap G.

PLoS Negl Trop Dis. 2018 Jun 18;12(6):e0006587. doi: 10.1371/journal.pntd.0006587. eCollection 2018 Jun.


B-type natriuretic peptide molecular forms for risk stratification and prediction of outcome after acute myocardial infarction.

Israr MZ, Heaney LM, Ng LL, Suzuki T.

Am Heart J. 2018 Jun;200:37-43. doi: 10.1016/j.ahj.2018.02.016. Epub 2018 Mar 3.


Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK3β/β-catenin pathway.

Ng L, Chow AKM, Man JHW, Yau TCC, Wan TMH, Iyer DN, Kwan VHT, Poon RTP, Pang RWC, Law WL.

BMC Cancer. 2018 Jun 1;18(1):621. doi: 10.1186/s12885-018-4326-5.

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