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Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma.

Lim CJ, Lee YH, Pan L, Lai L, Chua C, Wasser M, Lim TKH, Yeong J, Toh HC, Lee SY, Chan CY, Goh BK, Chung A, Heikenwälder M, Ng IO, Chow P, Albani S, Chew V.

Gut. 2018 Jul 3. pii: gutjnl-2018-316510. doi: 10.1136/gutjnl-2018-316510. [Epub ahead of print]


Hepatitis transactivator protein X promotes extracellular matrix modification through HIF/LOX pathway in liver cancer.

Tse AP, Sze KM, Shea QT, Chiu EY, Tsang FH, Chiu DK, Zhang MS, Lee D, Xu IM, Chan CY, Koh HY, Wong CM, Zheng YP, Ng IO, Wong CC.

Oncogenesis. 2018 May 25;7(5):44. doi: 10.1038/s41389-018-0052-8.


IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma.

Cheng BY, Lau EY, Leung HW, Leung CO, Ho NP, Gurung S, Cheng LK, Lin CH, Lo RC, Ma S, Ng IO, Lee TK.

Cancer Res. 2018 May 1;78(9):2332-2342. doi: 10.1158/0008-5472.CAN-17-2445. Epub 2018 Feb 26.


Cripto-1 contributes to stemness in hepatocellular carcinoma by stabilizing Dishevelled-3 and activating Wnt/β-catenin pathway.

Lo RC, Leung CO, Chan KK, Ho DW, Wong CM, Lee TK, Ng IO.

Cell Death Differ. 2018 Aug;25(8):1426-1441. doi: 10.1038/s41418-018-0059-x. Epub 2018 Feb 14.


Expression of hepatic progenitor cell markers in acute cellular rejection of liver allografts-An immunohistochemical study.

Lo RC, Chan KK, Leung CO, Ng IO.

Clin Transplant. 2018 Mar;32(3):e13203. doi: 10.1111/ctr.13203. Epub 2018 Feb 2.


Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications.

Wong CM, Tsang FH, Ng IO.

Nat Rev Gastroenterol Hepatol. 2018 Mar;15(3):137-151. doi: 10.1038/nrgastro.2017.169. Epub 2018 Jan 10. Review.


Oval Cells Contribute to Fibrogenesis of Marginal Liver Grafts under Stepwise Regulation of Aldose Reductase and Notch Signaling.

Liu XB, Lo CM, Cheng Q, Ng KT, Shao Y, Li CX, Chung SK, Ng IOL, Yu J, Man K.

Theranostics. 2017 Oct 24;7(19):4879-4893. doi: 10.7150/thno.20085. eCollection 2017.


RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2.

Chen M, Wei L, Law CT, Tsang FH, Shen J, Cheng CL, Tsang LH, Ho DW, Chiu DK, Lee JM, Wong CC, Ng IO, Wong CM.

Hepatology. 2018 Jun;67(6):2254-2270. doi: 10.1002/hep.29683. Epub 2018 Apr 19.


Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration.

Liu JA, Rao Y, Cheung MPL, Hui MN, Wu MH, Chan LK, Ng IO, Niu B, Cheah KSE, Sharma R, Hodgson L, Cheung M.

Nat Commun. 2017 Oct 30;8(1):1185. doi: 10.1038/s41467-017-01107-0.


Immunoglobulin G4-related sclerosing disease involving the mandible.

Tong AC, Ng IO, Lo MC.

Hong Kong Med J. 2017 Oct;23(5):534-6. doi: 10.12809/hkmj154733. No abstract available.


Nuclear Met promotes hepatocellular carcinoma tumorigenesis and metastasis by upregulation of TAK1 and activation of NF-κB pathway.

Tey SK, Tse EYT, Mao X, Ko FCF, Wong AST, Lo RC, Ng IO, Yam JWP.

Cancer Lett. 2017 Dec 28;411:150-161. doi: 10.1016/j.canlet.2017.09.047. Epub 2017 Oct 6.


Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma.

Chiu DK, Tse AP, Xu IM, Di Cui J, Lai RK, Li LL, Koh HY, Tsang FH, Wei LL, Wong CM, Ng IO, Wong CC.

Nat Commun. 2017 Sep 11;8(1):517. doi: 10.1038/s41467-017-00530-7.


Liver allograft biopsies with histological cholestasis: a clinicopathological study of 254 cases from a single centre.

Lo RC, Chan KK, Chok KS, Ng IO.

J Clin Pathol. 2018 Jan;71(1):72-78. doi: 10.1136/jclinpath-2017-204334. Epub 2017 Jul 27.


Secretory Stanniocalcin 1 promotes metastasis of hepatocellular carcinoma through activation of JNK signaling pathway.

Chan KK, Leung CO, Wong CC, Ho DW, Chok KS, Lai CL, Ng IO, Lo RC.

Cancer Lett. 2017 Sep 10;403:330-338. doi: 10.1016/j.canlet.2017.06.034. Epub 2017 Jul 6.


Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation.

Ma MKF, Lau EYT, Leung DHW, Lo J, Ho NPY, Cheng LKW, Ma S, Lin CH, Copland JA, Ding J, Lo RCL, Ng IOL, Lee TKW.

J Hepatol. 2017 Nov;67(5):979-990. doi: 10.1016/j.jhep.2017.06.015. Epub 2017 Jun 22.


Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3.

Wei L, Chiu DK, Tsang FH, Law CT, Cheng CL, Au SL, Lee JM, Wong CC, Ng IO, Wong CM.

J Hepatol. 2017 Oct;67(4):758-769. doi: 10.1016/j.jhep.2017.05.015. Epub 2017 May 19.


Dishevelled-3 phosphorylation is governed by HIPK2/PP1Cα/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma.

Tsui YM, Sze KM, Tung EK, Ho DW, Lee TK, Ng IO.

Oncotarget. 2017 Jun 13;8(24):39430-39442. doi: 10.18632/oncotarget.17049.


Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma.

Lee D, Xu IM, Chiu DK, Lai RK, Tse AP, Lan Li L, Law CT, Tsang FH, Wei LL, Chan CY, Wong CM, Ng IO, Wong CC.

J Clin Invest. 2017 May 1;127(5):1856-1872. doi: 10.1172/JCI90253. Epub 2017 Apr 10.


Hepatic IFIT3 predicts interferon-α therapeutic response in patients of hepatocellular carcinoma.

Yang Y, Zhou Y, Hou J, Bai C, Li Z, Fan J, Ng IOL, Zhou W, Sun H, Dong Q, Lee JMF, Lo CM, Man K, Yang Y, Li N, Ding G, Yu Y, Cao X.

Hepatology. 2017 Jul;66(1):152-166. doi: 10.1002/hep.29156. Epub 2017 May 26.


SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop.

Cui CP, Wong CC, Kai AK, Ho DW, Lau EY, Tsui YM, Chan LK, Cheung TT, Chok KS, Chan ACY, Lo RC, Lee JM, Lee TK, Ng IOL.

Gut. 2017 Dec;66(12):2149-2159. doi: 10.1136/gutjnl-2016-313264. Epub 2017 Mar 3.


C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway.

Ching RHH, Sze KMF, Lau EYT, Chiu YT, Lee JMF, Ng IOL, Lee TKW.

Oncotarget. 2017 Apr 4;8(14):23507-23516. doi: 10.18632/oncotarget.15183.


miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression.

Leong KW, Cheng CW, Wong CM, Ng IO, Kwong YL, Tse E.

Oncotarget. 2017 Feb 14;8(7):11343-11355. doi: 10.18632/oncotarget.14526.


TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication.

Ho DWH, Chan LK, Chiu YT, Xu IMJ, Poon RTP, Cheung TT, Tang CN, Tang VWL, Lo ILO, Lam PWY, Yau DTW, Li MX, Wong CM, Ng IOL.

Gut. 2017 Aug;66(8):1496-1506. doi: 10.1136/gutjnl-2016-312734. Epub 2016 Dec 14.


Mechanisms through Which Hypoxia-Induced Caveolin-1 Drives Tumorigenesis and Metastasis in Hepatocellular Carcinoma.

Mao X, Wong SY, Tse EY, Ko FC, Tey SK, Yeung YS, Man K, Lo RC, Ng IO, Yam JW.

Cancer Res. 2016 Dec 15;76(24):7242-7253. Epub 2016 Oct 26.


Molecular Pathogenesis of Hepatocellular Carcinoma.

Ho DW, Lo RC, Chan LK, Ng IO.

Liver Cancer. 2016 Oct;5(4):290-302. Epub 2016 Sep 14.


PAK4 Phosphorylates p53 at Serine 215 to Promote Liver Cancer Metastasis.

Xu HT, Lai WL, Liu HF, Wong LL, Ng IO, Ching YP.

Cancer Res. 2016 Oct 1;76(19):5732-5742. Epub 2016 Aug 5.


The effect of wide resection margin in patients with intrahepatic cholangiocarcinoma: A single-center experience.

Ma KW, Cheung TT, She WH, Chok KS, Chan AC, Ng IO, Chan SC, Lo CM.

Medicine (Baltimore). 2016 Jul;95(28):e4133. doi: 10.1097/MD.0000000000004133.


Gender disparity of hepatocellular carcinoma: role of hepatitis B virus X protein and androgen receptor.

Chiu YT, Ng IO.

Hong Kong Med J. 2016 Jun;22(3 Suppl 4):43-7. No abstract available.


Hormonal control of the metabolic machinery of hepatocellular carcinoma.

Wong CC, Wong CM, Ng IO.

Hepatobiliary Surg Nutr. 2016 Jun;5(3):195-7. doi: 10.21037/hbsn.2016.03.07.


Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26.

Chiu DK, Xu IM, Lai RK, Tse AP, Wei LL, Koh HY, Li LL, Lee D, Lo RC, Wong CM, Ng IO, Wong CC.

Hepatology. 2016 Sep;64(3):797-813. doi: 10.1002/hep.28655. Epub 2016 Jun 30.


RhoE/ROCK2 regulates chemoresistance through NF-κB/IL-6/ STAT3 signaling in hepatocellular carcinoma.

Ma W, Sze KM, Chan LK, Lee JM, Wei LL, Wong CM, Lee TK, Wong CC, Ng IO.

Oncotarget. 2016 Jul 5;7(27):41445-41459. doi: 10.18632/oncotarget.9441.


Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling.

Lau EY, Lo J, Cheng BY, Ma MK, Lee JM, Ng JK, Chai S, Lin CH, Tsang SY, Ma S, Ng IO, Lee TK.

Cell Rep. 2016 May 10;15(6):1175-89. doi: 10.1016/j.celrep.2016.04.019. Epub 2016 Apr 28.


Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling.

Leung CO, Mak WN, Kai AK, Chan KS, Lee TK, Ng IO, Lo RC.

Oncotarget. 2016 May 17;7(20):29371-86. doi: 10.18632/oncotarget.8835.


Down-regulation of TIMP2 by HIF-1α/miR-210/HIF-3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma.

Kai AK, Chan LK, Lo RC, Lee JM, Wong CC, Wong JC, Ng IO.

Hepatology. 2016 Aug;64(2):473-87. doi: 10.1002/hep.28577. Epub 2016 Apr 30.


Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma.

Chiu YT, Wong JK, Choi SW, Sze KM, Ho DW, Chan LK, Lee JM, Man K, Cherny S, Yang WL, Wong CM, Sham PC, Ng IO.

J Hepatol. 2016 Jun;64(6):1256-64. doi: 10.1016/j.jhep.2016.02.005. Epub 2016 Feb 8.


NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma.

Lai RK, Xu IM, Chiu DK, Tse AP, Wei LL, Law CT, Lee D, Wong CM, Wong MP, Ng IO, Wong CC.

Clin Cancer Res. 2016 Jun 15;22(12):3105-17. doi: 10.1158/1078-0432.CCR-15-1987. Epub 2016 Jan 27.


Transketolase counteracts oxidative stress to drive cancer development.

Xu IM, Lai RK, Lin SH, Tse AP, Chiu DK, Koh HY, Law CT, Wong CM, Cai Z, Wong CC, Ng IO.

Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):E725-34. doi: 10.1073/pnas.1508779113. Epub 2016 Jan 25.


Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma.

Garnelo M, Tan A, Her Z, Yeong J, Lim CJ, Chen J, Lim KH, Weber A, Chow P, Chung A, Ooi LL, Toh HC, Heikenwalder M, Ng IO, Nardin A, Chen Q, Abastado JP, Chew V.

Gut. 2017 Feb;66(2):342-351. doi: 10.1136/gutjnl-2015-310814. Epub 2015 Dec 15.


Phosphorylation of nucleophosmin at threonine 234/237 is associated with HCC metastasis.

Ching RH, Lau EY, Ling PM, Lee JM, Ma MK, Cheng BY, Lo RC, Ng IO, Lee TK.

Oncotarget. 2015 Dec 22;6(41):43483-95. doi: 10.18632/oncotarget.5820.


Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis.

Wong CM, Wei L, Law CT, Ho DW, Tsang FH, Au SL, Sze KM, Lee JM, Wong CC, Ng IO.

Hepatology. 2016 Feb;63(2):474-87. doi: 10.1002/hep.28304. Epub 2015 Dec 14. Erratum in: Hepatology. 2016 Apr;63(4):1403.


Anti-CD47 antibody suppresses tumour growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma.

Lo J, Lau EY, So FT, Lu P, Chan VS, Cheung VC, Ching RH, Cheng BY, Ma MK, Ng IO, Lee TK.

Liver Int. 2016 May;36(5):737-45. doi: 10.1111/liv.12963. Epub 2015 Oct 6.


MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility.

Tsang FH, Au SL, Wei L, Fan DN, Lee JM, Wong CC, Ng IO, Wong CM.

Front Med. 2015 Sep;9(3):331-43. doi: 10.1007/s11684-015-0409-8. Epub 2015 Aug 19.


TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma.

Ho DW, Kai AK, Ng IO.

Front Med. 2015 Sep;9(3):322-30. doi: 10.1007/s11684-015-0408-9. Epub 2015 Aug 14.


Role of hepatitis B virus X protein in liver cancer.

Ng IO, Sze KM, Chu GK.

Hong Kong Med J. 2015 Jun;21 Suppl 4:27-30. No abstract available.


MiR-200b/200c/429 subfamily negatively regulates Rho/ROCK signaling pathway to suppress hepatocellular carcinoma metastasis.

Wong CM, Wei L, Au SL, Fan DN, Zhou Y, Tsang FH, Law CT, Lee JM, He X, Shi J, Wong CC, Ng IO.

Oncotarget. 2015 May 30;6(15):13658-70.


Nuclear factor kappa B-mediated CD47 up-regulation promotes sorafenib resistance and its blockade synergizes the effect of sorafenib in hepatocellular carcinoma in mice.

Lo J, Lau EY, Ching RH, Cheng BY, Ma MK, Ng IO, Lee TK.

Hepatology. 2015 Aug;62(2):534-45. doi: 10.1002/hep.27859. Epub 2015 Jun 3.


Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus.

Zhang Y, Wang YF, Yang J, Zhang J, Sun L, Hirankarn N, Pan HF, Lau CS, Chan TM, Lee TL, Leung AM, Mok CC, Zhang L, Shen JJ, Wong SN, Lee KW, Ho MH, Lee PP, Chung BH, Chong CY, Wong RW, Mok MY, Wong WH, Tong KL, Tse NK, Li XP, Avihingsanon Y, Rianthavorn P, Deekajorndej T, Suphapeetiporn K, Shotelersuk V, Ying SK, Fung SK, Lai WM, Wong CM, Ng IO, Garcia-Barcelo MM, Cherny SS, Tam PK, Sham PC, Yang S, Ye DQ, Cui Y, Zhang XJ, Yang W, Lau YL.

Arthritis Res Ther. 2015 Mar 20;17:67. doi: 10.1186/s13075-015-0577-6.

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