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G Protein-Coupled Estrogen Receptor Production Using an Escherichia coli Cell-Free Expression System.

Souza SA, Kurohara DT, Dabalos CL, Ng HL.

Curr Protoc Protein Sci. 2019 Sep;97(1):e88. doi: 10.1002/cpps.88.


Recent Insights from Molecular Dynamics Simulations for G Protein-Coupled Receptor Drug Discovery.

Zou Y, Ewalt J, Ng HL.

Int J Mol Sci. 2019 Aug 29;20(17). pii: E4237. doi: 10.3390/ijms20174237. Review.


Suboptimal stimulation by weak agonist epitope variants does not drive dysfunction of HIV-1-specific cytotoxic T lymphocyte clones.

Grossman MA, Hofmann C, Ng HL, Yang OO.

AIDS. 2019 Aug 1;33(10):1565-1574. doi: 10.1097/QAD.0000000000002259.


Disease-associated missense variants in ZBTB18 disrupt DNA binding and impair the development of neurons within the embryonic cerebral cortex.

Hemming IA, Clément O, Gladwyn-Ng IE, Cullen HD, Ng HL, See HB, Ngo L, Ulgiati D, Pfleger KDG, Agostino M, Heng JI.

Hum Mutat. 2019 May 21. doi: 10.1002/humu.23803. [Epub ahead of print]


Suicide in Parkinson's Disease.

Li W, Abbas MM, Acharyya S, Ng HL, Tay KY, Au WL, Tan LCS.

Mov Disord Clin Pract. 2018 Mar 2;5(2):177-182. doi: 10.1002/mdc3.12599. eCollection 2018 Mar-Apr.


Cross-Reactivity against Multiple HIV-1 Epitopes Is Characteristic of HIV-1-Specific Cytotoxic T Lymphocyte Clones.

Balamurugan A, Ng HL, Yang OO.

J Virol. 2018 Jul 31;92(16). pii: e00617-18. doi: 10.1128/JVI.00617-18. Print 2018 Aug 15.


Highly Attenuated Infection With a Vpr-Deleted Molecular Clone of Human Immunodeficiency Virus-1.

Ali A, Ng HL, Blankson JN, Burton DR, Buckheit RW 3rd, Moldt B, Fulcher JA, Ibarrondo FJ, Anton PA, Yang OO.

J Infect Dis. 2018 Sep 22;218(9):1447-1452. doi: 10.1093/infdis/jiy346.


Novel dual-targeting anti-proliferative dihydrotriazine-chalcone derivatives display suppression of cancer cell invasion and inflammation by inhibiting the NF-κB signaling pathway.

Gan FF, Zhang R, Ng HL, Karuppasamy M, Seah W, Yeap WH, Ong SM, Hadadi E, Wong SC, Chui WK, Chew EH.

Food Chem Toxicol. 2018 Jun;116(Pt B):238-248. doi: 10.1016/j.fct.2018.04.003. Epub 2018 Apr 7.


Acupuncture in the treatment of fatigue in Parkinson's disease: A pilot, randomized, controlled, study.

Kong KH, Ng HL, Li W, Ng DW, Tan SI, Tay KY, Au WL, Tan LCS.

Brain Behav. 2017 Dec 29;8(1):e00897. doi: 10.1002/brb3.897. eCollection 2018 Jan.


Solution Structures of Engineered Vault Particles.

Ding K, Zhang X, Mrazek J, Kickhoefer VA, Lai M, Ng HL, Yang OO, Rome LH, Zhou ZH.

Structure. 2018 Apr 3;26(4):619-626.e3. doi: 10.1016/j.str.2018.02.014. Epub 2018 Mar 15.


Mutation of Phenylalanine-223 to Leucine Enhances Transformation of Benzo[a]pyrene by Ring-Hydroxylating Dioxygenase of Sphingobium sp. FB3 by increasing Accessibility of the Catalytic Site.

Fu B, Xu T, Cui Z, Ng HL, Wang K, Li J, Li QX.

J Agric Food Chem. 2018 Feb 7;66(5):1206-1213. doi: 10.1021/acs.jafc.7b05018. Epub 2018 Jan 30.


Protection against β-amyloid neurotoxicity by a non-toxic endogenous N-terminal β-amyloid fragment and its active hexapeptide core sequence.

Forest KH, Alfulaij N, Arora K, Taketa R, Sherrin T, Todorovic C, Lawrence JLM, Yoshikawa GT, Ng HL, Hruby VJ, Nichols RA.

J Neurochem. 2018 Jan;144(2):201-217. doi: 10.1111/jnc.14257. Epub 2017 Dec 18.


Screening and Identifying Membrane Proteins Favorable for Crystallization.

Kim J, Ng HL.

Curr Protoc Protein Sci. 2017 Nov 1;90:29.19.1-29.19.10. doi: 10.1002/cpps.40.


Murine typhus masquerading as retiform purpura-like rashes.

Kuan LY, Ng HL, Ang B, Heng YK, Pan JY.

Clin Exp Dermatol. 2017 Dec;42(8):928-930. doi: 10.1111/ced.13239. Epub 2017 Sep 22. No abstract available.


Contacts of healthcare workers, patients and visitors in general wards in Singapore.

Jiang L, Ng HL, Ho HJ, Leo YS, Prem K, Cook AR, Chen MI.

Epidemiol Infect. 2017 Oct;145(14):3085-3095. doi: 10.1017/S0950268817002035. Epub 2017 Sep 8.


HIV-1 epitopes presented by MHC class I types associated with superior immune containment of viremia have highly constrained fitness landscapes.

Gorin AM, Du Y, Liu FY, Zhang TH, Ng HL, Hofmann C, Cumberland WG, Sun R, Yang OO.

PLoS Pathog. 2017 Aug 7;13(8):e1006541. doi: 10.1371/journal.ppat.1006541. eCollection 2017 Aug.


Structural and Biophysical Characterization of the Mycobacterium tuberculosis Protein Rv0577, a Protein Associated with Neutral Red Staining of Virulent Tuberculosis Strains and Homologue of the Streptomyces coelicolor Protein KbpA.

Buchko GW, Echols N, Flynn EM, Ng HL, Stephenson S, Kim HB, Myler PJ, Terwilliger TC, Alber T, Kim CY.

Biochemistry. 2017 Aug 1;56(30):4015-4027. doi: 10.1021/acs.biochem.7b00511. Epub 2017 Jul 25.


Recombinant expression in E. coli of human FGFR2 with its transmembrane and extracellular domains.

Bajinting A, Ng HL.

PeerJ. 2017 Jun 29;5:e3512. doi: 10.7717/peerj.3512. eCollection 2017.


HIV-1 Epitope Variability Is Associated with T Cell Receptor Repertoire Instability and Breadth.

Balamurugan A, Claiborne D, Ng HL, Yang OO.

J Virol. 2017 Jul 27;91(16). pii: e00771-17. doi: 10.1128/JVI.00771-17. Print 2017 Aug 15.


Faking handedness: Individual differences in ability to fake handedness, social cognitions of the handedness of others, and a forensic application using Bayes' theorem.

McManus IC, Buckens G, Harris N, Flint A, Ng HLA, Vovou F.

Laterality. 2018 Jan;23(1):67-100. doi: 10.1080/1357650X.2017.1315430. Epub 2017 Jun 7.


Outbreak of Zika virus infection in Singapore: an epidemiological, entomological, virological, and clinical analysis.

Singapore Zika Study Group.

Lancet Infect Dis. 2017 Aug;17(8):813-821. doi: 10.1016/S1473-3099(17)30249-9. Epub 2017 May 17.


Design, Synthesis, and Biological Evaluation of Coupled Bioactive Scaffolds as Potential Anticancer Agents for Dual Targeting of Dihydrofolate Reductase and Thioredoxin Reductase.

Ng HL, Ma X, Chew EH, Chui WK.

J Med Chem. 2017 Mar 9;60(5):1734-1745. doi: 10.1021/acs.jmedchem.6b01253. Epub 2017 Feb 24.


Acute vascular and metabolic actions of the green tea polyphenol epigallocatechin 3-gallate in rat skeletal muscle.

Ng HLH, Premilovac D, Rattigan S, Richards SM, Muniyappa R, Quon MJ, Keske MA.

J Nutr Biochem. 2017 Feb;40:23-31. doi: 10.1016/j.jnutbio.2016.10.005. Epub 2016 Oct 14.


Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.

Zhang X, Lai M, Chang W, Yu I, Ding K, Mrazek J, Ng HL, Yang OO, Maslov DA, Zhou ZH.

Nat Commun. 2016 Oct 18;7:13223. doi: 10.1038/ncomms13223.


Simulations reveal increased fluctuations in estrogen receptor-alpha conformation upon antagonist binding.

Ng HL.

J Mol Graph Model. 2016 Sep;69:72-7. doi: 10.1016/j.jmgm.2016.08.009. Epub 2016 Aug 24.


Structure-guided wavelength tuning in far-red fluorescent proteins.

Ng HL, Lin MZ.

Curr Opin Struct Biol. 2016 Aug;39:124-133. doi: 10.1016/ Epub 2016 Jul 25. Review.


Optimising peripheral venous catheter usage in the general inpatient ward: a prospective observational study.

Tan YH, Tai WL, Sim C, Ng HL.

J Clin Nurs. 2017 Jan;26(1-2):133-139. doi: 10.1111/jocn.13451.


Risk and prognostic factors for pneumonia and choking amongst Parkinson's disease patients with dysphagia.

Goh KH, Acharyya S, Ng SY, Boo JP, Kooi AH, Ng HL, Li W, Tay KY, Au WL, Tan LC.

Parkinsonism Relat Disord. 2016 Aug;29:30-4. doi: 10.1016/j.parkreldis.2016.05.034. Epub 2016 May 30.


Detection of Human Papillomavirus 16-Specific IgG and IgM Antibodies in Patient Sera: A Potential Indicator of Oral Squamous Cell Carcinoma Risk Factor.

Kerishnan JP, Gopinath SC, Kai SB, Tang TH, Ng HL, Rahman ZA, Hashim U, Chen Y.

Int J Med Sci. 2016 May 12;13(6):424-31. doi: 10.7150/ijms.14475. eCollection 2016.


A bright cyan-excitable orange fluorescent protein facilitates dual-emission microscopy and enhances bioluminescence imaging in vivo.

Chu J, Oh Y, Sens A, Ataie N, Dana H, Macklin JJ, Laviv T, Welf ES, Dean KM, Zhang F, Kim BB, Tang CT, Hu M, Baird MA, Davidson MW, Kay MA, Fiolka R, Yasuda R, Kim DS, Ng HL, Lin MZ.

Nat Biotechnol. 2016 Jul;34(7):760-7. doi: 10.1038/nbt.3550. Epub 2016 May 30.


HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies.

Ali A, Kitchen SG, Chen ISY, Ng HL, Zack JA, Yang OO.

J Virol. 2016 Jul 11;90(15):6999-7006. doi: 10.1128/JVI.00805-16. Print 2016 Aug 1.


Applying the designed multiple ligands approach to inhibit dihydrofolate reductase and thioredoxin reductase for anti-proliferative activity.

Ng HL, Chen S, Chew EH, Chui WK.

Eur J Med Chem. 2016 Jun 10;115:63-74. doi: 10.1016/j.ejmech.2016.03.002. Epub 2016 Mar 3.


Drug delivery system targeting advanced hepatocellular carcinoma: Current and future.

Zhang X, Ng HLH, Lu A, Lin C, Zhou L, Lin G, Zhang Y, Yang Z, Zhang H.

Nanomedicine. 2016 May;12(4):853-869. doi: 10.1016/j.nano.2015.12.381. Epub 2016 Jan 7. Review.


Treatment Preferences at the End-of-Life in Parkinson's Disease Patients.

Li W, Ng HL, Li W, Piano AN, Karim SA, Tay KY, Au WL, Tan LC.

Mov Disord Clin Pract. 2016 Jan 9;3(5):483-489. doi: 10.1002/mdc3.12313. eCollection 2016 Sep-Oct.


Correction: Clonal CD8+ T Cell Persistence and Variable Gene Usage Bias in a Human Transplanted Hand.

Kim JY, Balamurugan A, Azari K, Hofmann C, Ng HL, Reed EF, McDiarmid S, Yang OO.

PLoS One. 2015 Dec 23;10(12):e0146008. doi: 10.1371/journal.pone.0146008. eCollection 2015. No abstract available.


Structure of a TCR-Mimic Antibody with Target Predicts Pharmacogenetics.

Ataie N, Xiang J, Cheng N, Brea EJ, Lu W, Scheinberg DA, Liu C, Ng HL.

J Mol Biol. 2016 Jan 16;428(1):194-205. doi: 10.1016/j.jmb.2015.12.002. Epub 2015 Dec 11.


Exploring Different Strategies for Efficient Delivery of Colorectal Cancer Therapy.

Lin C, Ng HL, Pan W, Chen H, Zhang G, Bian Z, Lu A, Yang Z.

Int J Mol Sci. 2015 Nov 11;16(11):26936-52. doi: 10.3390/ijms161125995. Review.


Clonal CD8+ T Cell Persistence and Variable Gene Usage Bias in a Human Transplanted Hand.

Kim JY, Balamurugan A, Azari K, Hofmann C, Ng HL, Reed EF, McDiarmid S, Yang OO.

PLoS One. 2015 Aug 19;10(8):e0136235. doi: 10.1371/journal.pone.0136235. eCollection 2015. Erratum in: PLoS One. 2015;10(12):e0146008.


Large-scale identification of membrane proteins with properties favorable for crystallization.

Kim J, Kagawa A, Kurasaki K, Ataie N, Cho IK, Li QX, Ng HL.

Protein Sci. 2015 Nov;24(11):1756-63. doi: 10.1002/pro.2766. Epub 2015 Aug 27.


Perceived Gender Ratings for High and Low Scorers on the Autism-Spectrum Quotient Consistent with the Extreme Male Brain Account of Autism.

Tan DW, Russell-Smith SN, Simons JM, Maybery MT, Leung D, Ng HL, Whitehouse AJ.

PLoS One. 2015 Jul 17;10(7):e0131780. doi: 10.1371/journal.pone.0131780. eCollection 2015.


Ectopic expression of anti-HIV-1 shRNAs protects CD8(+) T cells modified with CD4ζ CAR from HIV-1 infection and alleviates impairment of cell proliferation.

Kamata M, Kim PY, Ng HL, Ringpis GE, Kranz E, Chan J, O'Connor S, Yang OO, Chen IS.

Biochem Biophys Res Commun. 2015 Jul 31;463(3):216-21. doi: 10.1016/j.bbrc.2015.05.026. Epub 2015 May 19.


Focused transcription from the human CR2/CD21 core promoter is regulated by synergistic activity of TATA and Initiator elements in mature B cells.

Taylor RL, Cruickshank MN, Karimi M, Ng HL, Quail E, Kaufman KM, Harley JB, Abraham LJ, Tsao BP, Boackle SA, Ulgiati D.

Cell Mol Immunol. 2016 Jan;13(1):119-31. doi: 10.1038/cmi.2014.138. Epub 2015 Feb 2.


Sulforaphane and its methylcarbonyl analogs inhibit the LPS-stimulated inflammatory response in human monocytes through modulating cytokine production, suppressing chemotactic migration and phagocytosis in a NF-κB- and MAPK-dependent manner.

Reddy SA, Shelar SB, Dang TM, Lee BN, Yang H, Ong SM, Ng HL, Chui WK, Wong SC, Chew EH.

Int Immunopharmacol. 2015 Feb;24(2):440-450. doi: 10.1016/j.intimp.2014.12.037. Epub 2015 Jan 10.


The potential of liposomes with carbonic anhydrase IX to deliver anticancer ingredients to cancer cells in vivo.

Ng HL, Lu A, Lin G, Qin L, Yang Z.

Int J Mol Sci. 2014 Dec 24;16(1):230-55. doi: 10.3390/ijms16010230. Review.


Vascular and metabolic actions of the green tea polyphenol epigallocatechin gallate.

Keske MA, Ng HL, Premilovac D, Rattigan S, Kim JA, Munir K, Yang P, Quon MJ.

Curr Med Chem. 2015;22(1):59-69. Review.


The role of Rdl in resistance to phenylpyrazoles in Drosophila melanogaster.

Remnant EJ, Morton CJ, Daborn PJ, Lumb C, Yang YT, Ng HL, Parker MW, Batterham P.

Insect Biochem Mol Biol. 2014 Nov;54:11-21. doi: 10.1016/j.ibmb.2014.08.008. Epub 2014 Sep 1.


Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA.

Zhao J, Giles BM, Taylor RL, Yette GA, Lough KM, Ng HL, Abraham LJ, Wu H, Kelly JA, Glenn SB, Adler AJ, Williams AH, Comeau ME, Ziegler JT, Marion M, Alarcón-Riquelme ME; BIOLUPUS and GENLES Networks, Alarcón GS, Anaya JM, Bae SC, Kim D, Lee HS, Criswell LA, Freedman BI, Gilkeson GS, Guthridge JM, Jacob CO, James JA, Kamen DL, Merrill JT, Sivils KM, Niewold TB, Petri MA, Ramsey-Goldman R, Reveille JD, Scofield RH, Stevens AM, Vilá LM, Vyse TJ, Kaufman KM, Harley JB, Langefeld CD, Gaffney PM, Brown EE, Edberg JC, Kimberly RP, Ulgiati D, Tsao BP, Boackle SA.

Ann Rheum Dis. 2016 Jan;75(1):242-52. doi: 10.1136/annrheumdis-2014-205584. Epub 2014 Sep 1.


Ineffectual targeting of HIV-1 Nef by cytotoxic T lymphocytes in acute infection results in no functional impairment or viremia reduction.

De La Cruz J, Vollbrecht T, Frohnen P, Ng HL, Daar ES, Yang OO, Lewis MJ.

J Virol. 2014 Jul;88(14):7881-92. doi: 10.1128/JVI.00482-14. Epub 2014 Apr 30.


Non-invasive intravital imaging of cellular differentiation with a bright red-excitable fluorescent protein.

Chu J, Haynes RD, Corbel SY, Li P, González-González E, Burg JS, Ataie NJ, Lam AJ, Cranfill PJ, Baird MA, Davidson MW, Ng HL, Garcia KC, Contag CH, Shen K, Blau HM, Lin MZ.

Nat Methods. 2014 May;11(5):572-8. doi: 10.1038/nmeth.2888. Epub 2014 Mar 16.


Differential blood and mucosal immune responses against an HIV-1 vaccine administered via inguinal or deltoid injection.

Yang OO, Ibarrondo FJ, Price C, Hultin LE, Elliott J, Hultin PM, Shih R, Hausner MA, Ng HL, Hoffman J, Jamieson BD, Anton PA.

PLoS One. 2014 Feb 18;9(2):e88621. doi: 10.1371/journal.pone.0088621. eCollection 2014.

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