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Items: 1 to 50 of 52

1.

Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody.

Sampei Z, Haraya K, Tachibana T, Fukuzawa T, Shida-Kawazoe M, Gan SW, Shimizu Y, Ruike Y, Feng S, Kuramochi T, Muraoka M, Kitazawa T, Kawabe Y, Igawa T, Hattori K, Nezu J.

PLoS One. 2018 Dec 28;13(12):e0209509. doi: 10.1371/journal.pone.0209509. eCollection 2018.

2.

Engineering a bispecific antibody with a common light chain: Identification and optimization of an anti-CD3 epsilon and anti-GPC3 bispecific antibody, ERY974.

Shiraiwa H, Narita A, Kamata-Sakurai M, Ishiguro T, Sano Y, Hironiwa N, Tsushima T, Segawa H, Tsunenari T, Ikeda Y, Kayukawa Y, Noguchi M, Wakabayashi T, Sakamoto A, Konishi H, Kuramochi T, Endo M, Hattori K, Nezu J, Igawa T.

Methods. 2019 Feb 1;154:10-20. doi: 10.1016/j.ymeth.2018.10.005. Epub 2018 Oct 13.

PMID:
30326272
3.

Corrigendum: Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3-mediated therapeutics.

Ueda O, Wada NA, Kinoshita Y, Hino H, Kakefuda M, Ito T, Fujii E, Noguchi M, Sato K, Morita M, Tateishi H, Matsumoto K, Goto C, Kawase Y, Kato A, Hattori K, Nezu J, Ishiguro T, Jishage KI.

Sci Rep. 2018 Mar 19;8:46960. doi: 10.1038/srep46960.

4.

An anti-glypican 3/CD3 bispecific T cell-redirecting antibody for treatment of solid tumors.

Ishiguro T, Sano Y, Komatsu SI, Kamata-Sakurai M, Kaneko A, Kinoshita Y, Shiraiwa H, Azuma Y, Tsunenari T, Kayukawa Y, Sonobe Y, Ono N, Sakata K, Fujii T, Miyazaki Y, Noguchi M, Endo M, Harada A, Frings W, Fujii E, Nanba E, Narita A, Sakamoto A, Wakabayashi T, Konishi H, Segawa H, Igawa T, Tsushima T, Mutoh H, Nishito Y, Takahashi M, Stewart L, ElGabry E, Kawabe Y, Ishigai M, Chiba S, Aoki M, Hattori K, Nezu J.

Sci Transl Med. 2017 Oct 4;9(410). pii: eaal4291. doi: 10.1126/scitranslmed.aal4291.

PMID:
28978751
5.

Quantitative prediction of therapeutic antibody pharmacokinetics after intravenous and subcutaneous injection in human.

Haraya K, Tachibana T, Nezu J.

Drug Metab Pharmacokinet. 2017 Aug;32(4):208-217. doi: 10.1016/j.dmpk.2017.05.002. Epub 2017 May 29.

PMID:
28734646
6.

Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases.

Fukuzawa T, Sampei Z, Haraya K, Ruike Y, Shida-Kawazoe M, Shimizu Y, Gan SW, Irie M, Tsuboi Y, Tai H, Sakiyama T, Sakamoto A, Ishii S, Maeda A, Iwayanagi Y, Shibahara N, Shibuya M, Nakamura G, Nambu T, Hayasaka A, Mimoto F, Okura Y, Hori Y, Habu K, Wada M, Miura T, Tachibana T, Honda K, Tsunoda H, Kitazawa T, Kawabe Y, Igawa T, Hattori K, Nezu J.

Sci Rep. 2017 Apr 24;7(1):1080. doi: 10.1038/s41598-017-01087-7.

7.

Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3-mediated therapeutics.

Ueda O, Wada NA, Kinoshita Y, Hino H, Kakefuda M, Ito T, Fujii E, Noguchi M, Sato K, Morita M, Tateishi H, Matsumoto K, Goto C, Kawase Y, Kato A, Hattori K, Nezu J, Ishiguro T, Jishage KI.

Sci Rep. 2017 Apr 3;7:45839. doi: 10.1038/srep45839. Erratum in: Sci Rep. 2018 Mar 19;8:46960.

8.

Predicting pharmacokinetic profile of therapeutic antibodies after iv injection from only the data after sc injection in cynomolgus monkey.

Haraya K, Tachibana T, Nezu J.

Xenobiotica. 2017 Mar;47(3):194-201. doi: 10.1080/00498254.2016.1174792. Epub 2016 May 5.

PMID:
27151820
9.

PK/PD analysis of a novel pH-dependent antigen-binding antibody using a dynamic antibody-antigen binding model.

Haraya K, Tachibana T, Iwayanagi Y, Maeda A, Ozeki K, Nezu J, Ishigai M, Igawa T.

Drug Metab Pharmacokinet. 2016 Apr;31(2):123-32. doi: 10.1016/j.dmpk.2015.12.007. Epub 2016 Jan 6.

PMID:
26944099
10.

Development of tetravalent, bispecific CCR5 antibodies with antiviral activity against CCR5 monoclonal antibody-resistant HIV-1 strains.

Schanzer J, Jekle A, Nezu J, Lochner A, Croasdale R, Dioszegi M, Zhang J, Hoffmann E, Dormeyer W, Stracke J, Schäfer W, Ji C, Heilek G, Cammack N, Brandt M, Umana P, Brinkmann U.

Antimicrob Agents Chemother. 2011 May;55(5):2369-78. doi: 10.1128/AAC.00215-10. Epub 2011 Feb 7.

11.

Anti-glypican 3 antibodies cause ADCC against human hepatocellular carcinoma cells.

Nakano K, Orita T, Nezu J, Yoshino T, Ohizumi I, Sugimoto M, Furugaki K, Kinoshita Y, Ishiguro T, Hamakubo T, Kodama T, Aburatani H, Yamada-Okabe H, Tsuchiya M.

Biochem Biophys Res Commun. 2009 Jan 9;378(2):279-84. doi: 10.1016/j.bbrc.2008.11.033. Epub 2008 Nov 18.

PMID:
19022220
12.

Transport of carnitine and acetylcarnitine by carnitine/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa.

Kobayashi D, Tamai I, Sai Y, Yoshida K, Wakayama T, Kido Y, Nezu J, Iseki S, Tsuji A.

Reproduction. 2007 Nov;134(5):651-8.

PMID:
17965255
13.

Viral envelope protein gp64 transgenic mouse facilitates the generation of monoclonal antibodies against exogenous membrane proteins displayed on baculovirus.

Saitoh R, Ohtomo T, Yamada Y, Kamada N, Nezu J, Kimura N, Funahashi S, Furugaki K, Yoshino T, Kawase Y, Kato A, Ueda O, Jishage K, Suzuki M, Fukuda R, Arai M, Iwanari H, Takahashi K, Sakihama T, Ohizumi I, Kodama T, Tsuchiya M, Hamakubo T.

J Immunol Methods. 2007 Apr 30;322(1-2):104-17. Epub 2007 Mar 7.

PMID:
17374538
14.

Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice.

Nagawa F, Kishishita N, Shimizu K, Hirose S, Miyoshi M, Nezu J, Nishimura T, Nishizumi H, Takahashi Y, Hashimoto S, Takeuchi M, Miyajima A, Takemori T, Otsuka AJ, Sakano H.

Nat Immunol. 2007 Feb;8(2):206-13. Epub 2006 Dec 24.

PMID:
17187071
15.

Organic anion transporting polypeptide-C mediates arsenic uptake in HEK-293 cells.

Lu WJ, Tamai I, Nezu J, Lai ML, Huang JD.

J Biomed Sci. 2006 Jul;13(4):525-33. Epub 2006 Feb 15.

PMID:
16479312
16.

Recovery of functional peptide transporter PepT1 in budded baculovirus fraction.

Saitoh R, Ohtomo T, Ito Y, Nezu J, Kimura N, Funahashi S, Aso Y, Ohizumi I, Kodama T, Hamakubo T, Tsuchiya M.

Protein Expr Purif. 2006 Mar;46(1):130-5. Epub 2005 Sep 13.

PMID:
16198124
17.

Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A.

Kwok B, Yamauchi A, Rajesan R, Chan L, Dhillon U, Gao W, Xu H, Wang B, Takahashi S, Semple J, Tamai I, Nezu J, Tsuji A, Harper P, Ito S.

Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R793-802. Epub 2005 Sep 29.

18.

OCTN2-mediated transport of carnitine in isolated Sertoli cells.

Kobayashi D, Goto A, Maeda T, Nezu J, Tsuji A, Tamai I.

Reproduction. 2005 Jun;129(6):729-36.

PMID:
15923388
19.

Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations.

Tamai I, Nakanishi T, Kobayashi D, China K, Kosugi Y, Nezu J, Sai Y, Tsuji A.

Mol Pharm. 2004 Jan 12;1(1):57-66.

PMID:
15832501
20.

Expression of organic cation transporter OCTN1 in hematopoietic cells during erythroid differentiation.

Kobayashi D, Aizawa S, Maeda T, Tsuboi I, Yabuuchi H, Nezu J, Tsuji A, Tamai I.

Exp Hematol. 2004 Dec;32(12):1156-62.

PMID:
15588940
21.

A novel therapeutic approach for thrombocytopenia by minibody agonist of the thrombopoietin receptor.

Orita T, Tsunoda H, Yabuta N, Nakano K, Yoshino T, Hirata Y, Ohtomo T, Nezu J, Sakumoto H, Ono K, Saito M, Kumagai E, Nanami M, Kaneko A, Yoshikubo T, Tsuchiya M.

Blood. 2005 Jan 15;105(2):562-6. Epub 2004 Sep 16.

22.

Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma.

Hippo Y, Watanabe K, Watanabe A, Midorikawa Y, Yamamoto S, Ihara S, Tokita S, Iwanari H, Ito Y, Nakano K, Nezu J, Tsunoda H, Yoshino T, Ohizumi I, Tsuchiya M, Ohnishi S, Makuuchi M, Hamakubo T, Kodama T, Aburatani H.

Cancer Res. 2004 Apr 1;64(7):2418-23.

23.

Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity.

Nozawa T, Sugiura S, Nakajima M, Goto A, Yokoi T, Nezu J, Tsuji A, Tamai I.

Drug Metab Dispos. 2004 Mar;32(3):291-4.

PMID:
14977862
24.

Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human.

Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I.

J Pharmacol Exp Ther. 2004 Feb;308(2):438-45. Epub 2003 Nov 10.

PMID:
14610227
25.

Silent and symptomatic primary carnitine deficiency within the same family due to identical mutations in the organic cation/carnitine transporter OCTN2.

Spiekerkoetter U, Huener G, Baykal T, Demirkol M, Duran M, Wanders R, Nezu J, Mayatepek E.

J Inherit Metab Dis. 2003;26(6):613-5.

PMID:
14605509
26.
27.

Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane.

Kobayashi D, Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I.

J Pharmacol Exp Ther. 2003 Aug;306(2):703-8. Epub 2003 Apr 30.

PMID:
12724351
29.

Studies on functional sites of organic cation/carnitine transporter OCTN2 (SLC22A5) using a Ser467Cys mutant protein.

Ohashi R, Tamai I, Inano A, Katsura M, Sai Y, Nezu J, Tsuji A.

J Pharmacol Exp Ther. 2002 Sep;302(3):1286-94.

PMID:
12183691
30.

Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis.

Nozawa T, Nakajima M, Tamai I, Noda K, Nezu J, Sai Y, Tsuji A, Yokoi T.

J Pharmacol Exp Ther. 2002 Aug;302(2):804-13.

PMID:
12130747
31.

Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis.

Jishage K, Nezu J, Kawase Y, Iwata T, Watanabe M, Miyoshi A, Ose A, Habu K, Kake T, Kamada N, Ueda O, Kinoshita M, Jenne DE, Shimane M, Suzuki H.

Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8903-8. Epub 2002 Jun 11.

32.

Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier.

Kido Y, Tamai I, Ohnari A, Sai Y, Kagami T, Nezu J, Nikaido H, Hashimoto N, Asano M, Tsuji A.

J Neurochem. 2001 Dec;79(5):959-69.

33.

Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C.

Tamai I, Nozawa T, Koshida M, Nezu J, Sai Y, Tsuji A.

Pharm Res. 2001 Sep;18(9):1262-9.

PMID:
11683238
34.

Na(+)-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney.

Tamai I, China K, Sai Y, Kobayashi D, Nezu J, Kawahara E, Tsuji A.

Biochim Biophys Acta. 2001 Jun 6;1512(2):273-84.

35.

Molecular and functional characterization of organic cation/carnitine transporter family in mice.

Tamai I, Ohashi R, Nezu JI, Sai Y, Kobayashi D, Oku A, Shimane M, Tsuji A.

J Biol Chem. 2000 Dec 22;275(51):40064-72.

36.

Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.

Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A.

Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60.

PMID:
10873595
37.

No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas.

Launonen V, Avizienyte E, Loukola A, Laiho P, Salovaara R, Järvinen H, Mecklin JP, Oku A, Shimane M, Kim HC, Kim JC, Nezu J, Aaltonen LA.

Cancer Res. 2000 Feb 1;60(3):546-8.

38.

A novel family of bromodomain genes.

Jones MH, Hamana N, Nezu Ji, Shimane M.

Genomics. 2000 Jan 1;63(1):40-5.

PMID:
10662543
39.

Two novel missense mutations of the OCTN2 gene (W283R and V446F) in a patient with primary systemic carnitine deficiency.

Mayatepek E, Nezu J, Tamai I, Oku A, Katsura M, Shimane M, Tsuji A.

Hum Mutat. 2000 Jan;15(1):118.

PMID:
10612840
40.

Genetic epidemiology of the carnitine transporter OCTN2 gene in a Japanese population and phenotypic characterization in Japanese pedigrees with primary systemic carnitine deficiency.

Koizumi A, Nozaki J, Ohura T, Kayo T, Wada Y, Nezu J, Ohashi R, Tamai I, Shoji Y, Takada G, Kibira S, Matsuishi T, Tsuji A.

Hum Mol Genet. 1999 Nov;8(12):2247-54.

PMID:
10545605
41.

Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.

Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A.

J Pharmacol Exp Ther. 1999 Nov;291(2):778-84.

PMID:
10525100
42.

Loss of wild-type carrier-mediated L-carnitine transport activity in hepatocytes of juvenile visceral steatosis mice.

Yokogawa K, Yonekawa M, Tamai I, Ohashi R, Tatsumi Y, Higashi Y, Nomura M, Hashimoto N, Nikaido H, Hayakawa J, Nezu J, Oku A, Shimane M, Miyamoto K, Tsuji A.

Hepatology. 1999 Oct;30(4):997-1001.

PMID:
10498652
43.

Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patients.

Nezu J, Oku A, Shimane M.

Biochem Biophys Res Commun. 1999 Aug 11;261(3):750-5.

PMID:
10441497
44.

Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.

Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A.

J Pharmacol Exp Ther. 1999 May;289(2):768-73.

PMID:
10215651
45.

Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter.

Nezu J, Tamai I, Oku A, Ohashi R, Yabuuchi H, Hashimoto N, Nikaido H, Sai Y, Koizumi A, Shoji Y, Takada G, Matsuishi T, Yoshino M, Kato H, Ohura T, Tsujimoto G, Hayakawa J, Shimane M, Tsuji A.

Nat Genet. 1999 Jan;21(1):91-4.

PMID:
9916797
46.

Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.

Mehenni H, Gehrig C, Nezu J, Oku A, Shimane M, Rossier C, Guex N, Blouin JL, Scott HS, Antonarakis SE.

Am J Hum Genet. 1998 Dec;63(6):1641-50.

47.

Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2.

Tamai I, Ohashi R, Nezu J, Yabuuchi H, Oku A, Shimane M, Sai Y, Tsuji A.

J Biol Chem. 1998 Aug 7;273(32):20378-82.

48.

Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1.

Tamai I, Yabuuchi H, Nezu J, Sai Y, Oku A, Shimane M, Tsuji A.

FEBS Lett. 1997 Dec 8;419(1):107-11.

49.

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.

Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Müller O, Back W, Zimmer M.

Nat Genet. 1998 Jan;18(1):38-43.

PMID:
9425897
50.

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