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Items: 1 to 50 of 457

1.

Antiviral effects of selected nucleoside analogs against human parechoviruses A1 and A3.

Lanko K, Ma Y, Delang L, Mirabelli C, Neyts J.

Antiviral Res. 2018 Dec 11. pii: S0166-3542(18)30713-7. doi: 10.1016/j.antiviral.2018.12.009. [Epub ahead of print]

PMID:
30550798
2.

Progress in human picornavirus research: New findings from the AIROPico consortium.

Wolthers KC, Susi P, Jochmans D, Koskinen J, Landt O, Sanchez N, Palm K, Neyts J, Butcher SJ.

Antiviral Res. 2018 Nov 23;161:100-107. doi: 10.1016/j.antiviral.2018.11.010. [Epub ahead of print] Review.

3.

Favipiravir inhibits in vitro Usutu virus replication and delays disease progression in an infection model in mice.

Segura Guerrero NA, Sharma S, Neyts J, Kaptein SJF.

Antiviral Res. 2018 Dec;160:137-142. doi: 10.1016/j.antiviral.2018.10.026. Epub 2018 Oct 29.

PMID:
30385306
4.

Pyrimethamine inhibits rabies virus replication in vitro.

Rogée S, Larrous F, Jochmans D, Ben-Khalifa Y, Neyts J, Bourhy H.

Antiviral Res. 2018 Oct 25;161:1-9. doi: 10.1016/j.antiviral.2018.10.016. [Epub ahead of print]

5.

Species Specificity of Type III Interferon Activity and Development of a Sensitive Luciferase-Based Bioassay for Quantitation of Mouse Interferon-λ.

Jacobs S, Wavreil F, Schepens B, Gad HH, Hartmann R, Rocha-Pereira J, Neyts J, Saelens X, Michiels T.

J Interferon Cytokine Res. 2018 Nov;38(11):469-479. doi: 10.1089/jir.2018.0066. Epub 2018 Oct 18.

6.

A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission.

Xie X, Kum DB, Xia H, Luo H, Shan C, Zou J, Muruato AE, Medeiros DBA, Nunes BTD, Dallmeier K, Rossi SL, Weaver SC, Neyts J, Wang T, Vasconcelos PFC, Shi PY.

Cell Host Microbe. 2018 Oct 10;24(4):487-499.e5. doi: 10.1016/j.chom.2018.09.008.

PMID:
30308155
7.

CCL20, a direct-acting pro-angiogenic chemokine induced by hepatitis C virus (HCV): Potential role in HCV-related liver cancer.

Benkheil M, Van Haele M, Roskams T, Laporte M, Noppen S, Abbasi K, Delang L, Neyts J, Liekens S.

Exp Cell Res. 2018 Nov 15;372(2):168-177. doi: 10.1016/j.yexcr.2018.09.023. Epub 2018 Oct 2.

PMID:
30287142
8.

PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases.

Delang L, Harak C, Benkheil M, Khan H, Leyssen P, Andrews M, Lohmann V, Neyts J.

J Antimicrob Chemother. 2018 Dec 1;73(12):3375-3384. doi: 10.1093/jac/dky327.

PMID:
30219827
9.

Structure-Based Drug Design of Potent Pyrazole Derivatives against Rhinovirus Replication.

Da Costa L, Scheers E, Coluccia A, Casulli A, Roche M, Di Giorgio C, Neyts J, Terme T, Cirilli R, La Regina G, Silvestri R, Mirabelli C, Vanelle P.

J Med Chem. 2018 Sep 27;61(18):8402-8416. doi: 10.1021/acs.jmedchem.8b00931. Epub 2018 Sep 7.

PMID:
30153009
10.

Discovery of Indole Derivatives as Novel and Potent Dengue Virus Inhibitors.

Bardiot D, Koukni M, Smets W, Carlens G, McNaughton M, Kaptein S, Dallmeier K, Chaltin P, Neyts J, Marchand A.

J Med Chem. 2018 Sep 27;61(18):8390-8401. doi: 10.1021/acs.jmedchem.8b00913. Epub 2018 Sep 12.

PMID:
30149709
11.

A Single Nucleoside Viral Polymerase Inhibitor Against Norovirus, Rotavirus, and Sapovirus-Induced Diarrhea.

Van Dycke J, Arnoldi F, Papa G, Vandepoele J, Burrone OR, Mastrangelo E, Tarantino D, Heylen E, Neyts J, Rocha-Pereira J.

J Infect Dis. 2018 Oct 20;218(11):1753-1758. doi: 10.1093/infdis/jiy398.

PMID:
30085019
12.

Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection.

Ma Y, Cong W, Huang H, Sun L, Mai AH, Boonen K, Maryam W, De Borggraeve W, Luo G, Liu Q, Schoofs L, Van Kuppeveld F, Neyts J, Mirabelli C, Luyten W.

Int J Antimicrob Agents. 2018 Jul 28. pii: S0924-8579(18)30205-X. doi: 10.1016/j.ijantimicag.2018.07.014. [Epub ahead of print]

PMID:
30063999
13.

Antiplasmodial, anti-chikungunya virus and antioxidant activities of 64 endemic plants from the Mascarene Islands.

Ledoux A, Cao M, Jansen O, Mamede L, Campos PE, Payet B, Clerc P, Grondin I, Girard-Valenciennes E, Hermann T, Litaudon M, Vanderheydt C, Delang L, Neyts J, Leyssen P, Frédérich M, Smadja J.

Int J Antimicrob Agents. 2018 Nov;52(5):622-628. doi: 10.1016/j.ijantimicag.2018.07.017. Epub 2018 Jul 29.

PMID:
30063998
14.

HCV-induced EGFR-ERK signaling promotes a pro-inflammatory and pro-angiogenic signature contributing to liver cancer pathogenesis.

Benkheil M, Paeshuyse J, Neyts J, Van Haele M, Roskams T, Liekens S.

Biochem Pharmacol. 2018 Sep;155:305-315. doi: 10.1016/j.bcp.2018.07.011. Epub 2018 Jul 21.

PMID:
30012461
15.

Assessing medicinal plants traditionally used in the Chirang Reserve Forest, Northeast India for antimicrobial activity.

Panda SK, Das R, Leyssen P, Neyts J, Luyten W.

J Ethnopharmacol. 2018 Oct 28;225:220-233. doi: 10.1016/j.jep.2018.07.011. Epub 2018 Jul 11.

PMID:
30005956
16.

Antiviral effect of the nucleoside analogue cidofovir in the context of sexual transmission of a gammaherpesvirus in mice.

Zeippen C, Javaux J, Snoeck R, Neyts J, Gillet L.

J Antimicrob Chemother. 2018 Aug 1;73(8):2095-2103. doi: 10.1093/jac/dky161.

PMID:
29788354
17.

Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds.

Kaptein SJF, Vincetti P, Crespan E, Rivera JIA, Costantino G, Maga G, Neyts J, Radi M.

ChemMedChem. 2018 Jul 18;13(14):1371-1376. doi: 10.1002/cmdc.201800178. Epub 2018 Jun 1.

PMID:
29740962
18.

Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium.

Mirabelli C, Jaspers M, Boon M, Jorissen M, Koukni M, Bardiot D, Chaltin P, Marchand A, Neyts J, Jochmans D.

J Antimicrob Chemother. 2018 Mar 27. doi: 10.1093/jac/dky089. [Epub ahead of print]

19.

Favipiravir as a potential countermeasure against neglected and emerging RNA viruses.

Delang L, Abdelnabi R, Neyts J.

Antiviral Res. 2018 May;153:85-94. doi: 10.1016/j.antiviral.2018.03.003. Epub 2018 Mar 7. Review.

PMID:
29524445
20.

Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus.

Giancotti G, Cancellieri M, Balboni A, Giustiniano M, Novellino E, Delang L, Neyts J, Leyssen P, Brancale A, Bassetto M.

Eur J Med Chem. 2018 Apr 10;149:56-68. doi: 10.1016/j.ejmech.2018.02.054. Epub 2018 Feb 23.

PMID:
29499487
21.

Structurally Diverse Diterpenoids from Sandwithia guyanensis.

Remy S, Olivon F, Desrat S, Blanchard F, Eparvier V, Leyssen P, Neyts J, Roussi F, Touboul D, Litaudon M.

J Nat Prod. 2018 Apr 27;81(4):901-912. doi: 10.1021/acs.jnatprod.7b01025. Epub 2018 Mar 1.

PMID:
29493237
22.

Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold.

Belfrage AK, Abdurakhmanov E, Åkerblom E, Brandt P, Alogheli H, Neyts J, Danielson UH, Sandström A.

Eur J Med Chem. 2018 Mar 25;148:453-464. doi: 10.1016/j.ejmech.2018.02.032. Epub 2018 Feb 13.

PMID:
29477077
23.

Recommendations for enterovirus diagnostics and characterisation within and beyond Europe.

Harvala H, Broberg E, Benschop K, Berginc N, Ladhani S, Susi P, Christiansen C, McKenna J, Allen D, Makiello P, McAllister G, Carmen M, Zakikhany K, Dyrdak R, Nielsen X, Madsen T, Paul J, Moore C, von Eije K, Piralla A, Carlier M, Vanoverschelde L, Poelman R, Anton A, López-Labrador FX, Pellegrinelli L, Keeren K, Maier M, Cassidy H, Derdas S, Savolainen-Kopra C, Diedrich S, Nordbø S, Buesa J, Bailly JL, Baldanti F, MacAdam A, Mirand A, Dudman S, Schuffenecker I, Kadambari S, Neyts J, Griffiths MJ, Richter J, Margaretto C, Govind S, Morley U, Adams O, Krokstad S, Dean J, Pons-Salort M, Prochazka B, Cabrerizo M, Majumdar M, Nebbia G, Wiewel M, Cottrell S, Coyle P, Martin J, Moore C, Midgley S, Horby P, Wolthers K, Simmonds P, Niesters H, Fischer TK.

J Clin Virol. 2018 Apr;101:11-17. doi: 10.1016/j.jcv.2018.01.008. Epub 2018 Feb 6. Review.

24.

Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5- d]pyrimidin-7(6 H)-ones.

Gómez-SanJuan A, Gamo AM, Delang L, Pérez-Sánchez A, Amrun SN, Abdelnabi R, Jacobs S, Priego EM, Camarasa MJ, Jochmans D, Leyssen P, Ng LFP, Querat G, Neyts J, Pérez-Pérez MJ.

ACS Infect Dis. 2018 Apr 13;4(4):605-619. doi: 10.1021/acsinfecdis.7b00219. Epub 2018 Feb 14.

PMID:
29406692
25.

Hepatitis E virus replication and interferon responses in human placental cells.

Knegendorf L, Drave SA, Dao Thi VL, Debing Y, Brown RJP, Vondran FWR, Resner K, Friesland M, Khera T, Engelmann M, Bremer B, Wedemeyer H, Behrendt P, Neyts J, Pietschmann T, Todt D, Steinmann E.

Hepatol Commun. 2018 Jan 8;2(2):173-187. doi: 10.1002/hep4.1138. eCollection 2018 Feb.

26.

Design, synthesis and evaluation against Chikungunya virus of novel small-molecule antiviral agents.

Tardugno R, Giancotti G, De Burghgraeve T, Delang L, Neyts J, Leyssen P, Brancale A, Bassetto M.

Bioorg Med Chem. 2018 Feb 15;26(4):869-874. doi: 10.1016/j.bmc.2018.01.002. Epub 2018 Jan 6.

PMID:
29336951
27.

The path towards effective antivirals against rabies.

Jochmans D, Neyts J.

Vaccine. 2017 Dec 23. pii: S0264-410X(17)31812-1. doi: 10.1016/j.vaccine.2017.12.051. [Epub ahead of print]

28.

Mannitol treatment is not effective in therapy of rabies virus infection in mice.

Dufkova L, Sirmarova J, Salat J, Honig V, Palus M, Ruzek D, Fooks AR, Mansfield KL, Tordo N, Jochmans D, Neyts J, Martina B, Koraka P, Osterhaus ADME; ASKLEPIOS consortium.

Vaccine. 2017 Dec 20. pii: S0264-410X(17)31781-4. doi: 10.1016/j.vaccine.2017.12.028. [Epub ahead of print]

PMID:
29274698
29.

ZikaPLAN: Zika Preparedness Latin American Network.

Wilder-Smith A, Preet R, Renhorn KE, Ximenes RA, Rodrigues LC, Solomon T, Neyts J, Lambrechts L, Willison H, Peeling R, Falconar AK, Precioso AR, Logan J, Lang T, Endtz HP, Erasmus MC, Massad E.

Glob Health Action. 2017;10(1):1398485. doi: 10.1080/16549716.2017.1398485.

30.

New Models to Study Hepatitis E Virus Replication and Particular Characteristics of Infection: The Needle Hides in the Hay Stack.

Debing Y, Schmid MA, Neyts J.

Gastroenterology. 2018 Jan;154(1):20-22. doi: 10.1053/j.gastro.2017.11.014. Epub 2017 Nov 21. No abstract available.

PMID:
29174543
31.

Rational design of antiviral drug combinations based on equipotency using HCV subgenomic replicon as an in vitro model.

Mandour M, Vliegen I, Paeshuyse J, Neyts J.

Antiviral Res. 2018 Jan;149:150-153. doi: 10.1016/j.antiviral.2017.11.010. Epub 2017 Nov 14.

PMID:
29154807
32.

Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis.

Mirabelli C, Scheers E, Neyts J.

F1000Res. 2017 Oct 19;6:1860. doi: 10.12688/f1000research.11978.1. eCollection 2017. Review.

33.

Antimicrobial, Anthelmintic, and Antiviral Activity of Plants Traditionally Used for Treating Infectious Disease in the Similipal Biosphere Reserve, Odisha, India.

Panda SK, Padhi L, Leyssen P, Liu M, Neyts J, Luyten W.

Front Pharmacol. 2017 Oct 23;8:658. doi: 10.3389/fphar.2017.00658. eCollection 2017.

34.

Interferon lambda (IFN-λ) efficiently blocks norovirus transmission in a mouse model.

Rocha-Pereira J, Jacobs S, Noppen S, Verbeken E, Michiels T, Neyts J.

Antiviral Res. 2018 Jan;149:7-15. doi: 10.1016/j.antiviral.2017.10.017. Epub 2017 Nov 10.

PMID:
29080649
35.

New class of early-stage enterovirus inhibitors with a novel mechanism of action.

Ma Y, Abdelnabi R, Delang L, Froeyen M, Luyten W, Neyts J, Mirabelli C.

Antiviral Res. 2017 Nov;147:67-74. doi: 10.1016/j.antiviral.2017.10.004. Epub 2017 Oct 7.

PMID:
28993161
36.

Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: A combined computational and experimental study.

Da Costa L, Scheers E, Coluccia A, Rosetti A, Roche M, Neyts J, Terme T, Cirilli R, Mirabelli C, Silvestri R, Vanelle P.

Eur J Med Chem. 2017 Nov 10;140:528-541. doi: 10.1016/j.ejmech.2017.09.036. Epub 2017 Sep 21.

PMID:
28987610
37.

Upregulation of sodium taurocholate cotransporter polypeptide during hepatogenic differentiation of umbilical cord matrix mesenchymal stem cells facilitates hepatitis B entry.

Sargiacomo C, El-Kehdy H, Dallmeier K, de Kock J, Hernandez-Kelly C, Rogiers V, Ortega A, Neyts J, Sokal E, Najimi M.

Stem Cell Res Ther. 2017 Sep 29;8(1):204. doi: 10.1186/s13287-017-0656-5.

38.

Antiviral treatment efficiently inhibits chikungunya virus infection in the joints of mice during the acute but not during the chronic phase of the infection.

Abdelnabi R, Jochmans D, Verbeken E, Neyts J, Delang L.

Antiviral Res. 2018 Jan;149:113-117. doi: 10.1016/j.antiviral.2017.09.016. Epub 2017 Sep 25.

PMID:
28958920
39.

Bioactive Natural Products Prioritization Using Massive Multi-informational Molecular Networks.

Olivon F, Allard PM, Koval A, Righi D, Genta-Jouve G, Neyts J, Apel C, Pannecouque C, Nothias LF, Cachet X, Marcourt L, Roussi F, Katanaev VL, Touboul D, Wolfender JL, Litaudon M.

ACS Chem Biol. 2017 Oct 20;12(10):2644-2651. doi: 10.1021/acschembio.7b00413. Epub 2017 Sep 15.

PMID:
28829118
40.

Replication of the Zika virus in different iPSC-derived neuronal cells and implications to assess efficacy of antivirals.

Lanko K, Eggermont K, Patel A, Kaptein S, Delang L, Verfaillie CM, Neyts J.

Antiviral Res. 2017 Sep;145:82-86. doi: 10.1016/j.antiviral.2017.07.010. Epub 2017 Jul 20.

41.

Fluorination of Naturally Occurring N⁶-Benzyladenosine Remarkably Increased Its Antiviral Activity and Selectivity.

Oslovsky VE, Drenichev MS, Sun L, Kurochkin NN, Kunetsky VE, Mirabelli C, Neyts J, Leyssen P, Mikhailov SN.

Molecules. 2017 Jul 20;22(7). pii: E1219. doi: 10.3390/molecules22071219.

42.

Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking.

Esposito M, Nothias LF, Retailleau P, Costa J, Roussi F, Neyts J, Leyssen P, Touboul D, Litaudon M, Paolini J.

J Nat Prod. 2017 Jul 28;80(7):2051-2059. doi: 10.1021/acs.jnatprod.7b00233. Epub 2017 Jul 3.

PMID:
28671832
43.

Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1.

Gigante A, Gómez-SanJuan A, Delang L, Li C, Bueno O, Gamo AM, Priego EM, Camarasa MJ, Jochmans D, Leyssen P, Decroly E, Coutard B, Querat G, Neyts J, Pérez-Pérez MJ.

Antiviral Res. 2017 Aug;144:216-222. doi: 10.1016/j.antiviral.2017.06.003. Epub 2017 Jun 12.

44.

A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication.

Kim J, Jung YK, Kim C, Shin JS, Scheers E, Lee JY, Han SB, Lee CK, Neyts J, Ha JD, Jung YS.

J Med Chem. 2017 Jul 13;60(13):5472-5492. doi: 10.1021/acs.jmedchem.7b00175. Epub 2017 Jun 15.

PMID:
28581749
45.

Chikungunya virus infections: time to act, time to treat.

Abdelnabi R, Neyts J, Delang L.

Curr Opin Virol. 2017 Jun;24:25-30. doi: 10.1016/j.coviro.2017.03.016. Epub 2017 Apr 14. Review.

PMID:
28414993
46.

Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase.

Abdelnabi R, Morais ATS, Leyssen P, Imbert I, Beaucourt S, Blanc H, Froeyen M, Vignuzzi M, Canard B, Neyts J, Delang L.

J Virol. 2017 May 26;91(12). pii: e00487-17. doi: 10.1128/JVI.00487-17. Print 2017 Jun 15.

47.

Glutathione is a highly efficient thermostabilizer of poliovirus Sabin strains.

Abdelnabi R, Delang L, Neyts J.

Vaccine. 2017 Mar 7;35(10):1370-1372. doi: 10.1016/j.vaccine.2017.01.070. Epub 2017 Feb 8.

PMID:
28189401
48.

Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases.

Tassini S, Sun L, Lanko K, Crespan E, Langron E, Falchi F, Kissova M, Armijos-Rivera JI, Delang L, Mirabelli C, Neyts J, Pieroni M, Cavalli A, Costantino G, Maga G, Vergani P, Leyssen P, Radi M.

J Med Chem. 2017 Feb 23;60(4):1400-1416. doi: 10.1021/acs.jmedchem.6b01521. Epub 2017 Feb 10.

PMID:
28122178
49.

Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV.

Bassetto M, Leyssen P, Neyts J, Yerukhimovich MM, Frick DN, Brancale A.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):936-940. doi: 10.1016/j.bmcl.2016.12.087. Epub 2017 Jan 3.

PMID:
28089348
50.

Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307.

Albulescu L, Bigay J, Biswas B, Weber-Boyvat M, Dorobantu CM, Delang L, van der Schaar HM, Jung YS, Neyts J, Olkkonen VM, van Kuppeveld FJM, Strating JRPM.

Antiviral Res. 2017 Apr;140:37-44. doi: 10.1016/j.antiviral.2017.01.008. Epub 2017 Jan 11.

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