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Viral engagement with host (co-)receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid.

Sun L, Lee H, Thibaut HJ, Lanko K, Rivero-Buceta E, Bator C, Martinez-Gualda B, Dallmeier K, Delang L, Leyssen P, Gago F, San-Félix A, Hafenstein S, Mirabelli C, Neyts J.

PLoS Pathog. 2019 May 9;15(5):e1007760. doi: 10.1371/journal.ppat.1007760. [Epub ahead of print]


A Viral Polymerase Inhibitor Reduces Zika Virus Replication in the Reproductive Organs of Male Mice.

Jacobs S, Delang L, Verbeken E, Neyts J, Kaptein SJF.

Int J Mol Sci. 2019 Apr 29;20(9). pii: E2122. doi: 10.3390/ijms20092122.


Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication.

Vincetti P, Kaptein SJF, Costantino G, Neyts J, Radi M.

ACS Med Chem Lett. 2019 Jan 23;10(4):558-563. doi: 10.1021/acsmedchemlett.8b00583. eCollection 2019 Apr 11.


Targeting the Viral Polymerase of Diarrhea-Causing Viruses as a Strategy to Develop a Single Broad-Spectrum Antiviral Therapy.

Bassetto M, Van Dycke J, Neyts J, Brancale A, Rocha-Pereira J.

Viruses. 2019 Feb 20;11(2). pii: E173. doi: 10.3390/v11020173. Review.


Structural and functional similarities in bunyaviruses: Perspectives for pan-bunya antivirals.

Ter Horst S, Conceição-Neto N, Neyts J, Rocha-Pereira J.

Rev Med Virol. 2019 May;29(3):e2039. doi: 10.1002/rmv.2039. Epub 2019 Feb 11. Review.


Antiviral Compounds from Codiaeum peltatum Targeted by a Multi-informative Molecular Networks Approach.

Olivon F, Remy S, Grelier G, Apel C, Eydoux C, Guillemot JC, Neyts J, Delang L, Touboul D, Roussi F, Litaudon M.

J Nat Prod. 2019 Feb 22;82(2):330-340. doi: 10.1021/acs.jnatprod.8b00800. Epub 2019 Jan 25.


Human stem cell-derived hepatocyte-like cells support Zika virus replication and provide a relevant model to assess the efficacy of potential antivirals.

Tricot T, Helsen N, Kaptein SJF, Neyts J, Verfaillie CM.

PLoS One. 2018 Dec 19;13(12):e0209097. doi: 10.1371/journal.pone.0209097. eCollection 2018.


A yellow fever-Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice.

Kum DB, Mishra N, Boudewijns R, Gladwyn-Ng I, Alfano C, Ma J, Schmid MA, Marques RE, Schols D, Kaptein S, Nguyen L, Neyts J, Dallmeier K.

NPJ Vaccines. 2018 Dec 13;3:56. doi: 10.1038/s41541-018-0092-2. eCollection 2018.


Antiviral effects of selected nucleoside analogues against human parechoviruses A1 and A3.

Lanko K, Ma Y, Delang L, Mirabelli C, Neyts J.

Antiviral Res. 2019 Feb;162:51-53. doi: 10.1016/j.antiviral.2018.12.009. Epub 2018 Dec 12.


Progress in human picornavirus research: New findings from the AIROPico consortium.

Wolthers KC, Susi P, Jochmans D, Koskinen J, Landt O, Sanchez N, Palm K, Neyts J, Butcher SJ.

Antiviral Res. 2019 Jan;161:100-107. doi: 10.1016/j.antiviral.2018.11.010. Epub 2018 Nov 23. Review.


Favipiravir inhibits in vitro Usutu virus replication and delays disease progression in an infection model in mice.

Segura Guerrero NA, Sharma S, Neyts J, Kaptein SJF.

Antiviral Res. 2018 Dec;160:137-142. doi: 10.1016/j.antiviral.2018.10.026. Epub 2018 Oct 29.


Pyrimethamine inhibits rabies virus replication in vitro.

Rogée S, Larrous F, Jochmans D, Ben-Khalifa Y, Neyts J, Bourhy H.

Antiviral Res. 2019 Jan;161:1-9. doi: 10.1016/j.antiviral.2018.10.016. Epub 2018 Oct 25.


Species Specificity of Type III Interferon Activity and Development of a Sensitive Luciferase-Based Bioassay for Quantitation of Mouse Interferon-λ.

Jacobs S, Wavreil F, Schepens B, Gad HH, Hartmann R, Rocha-Pereira J, Neyts J, Saelens X, Michiels T.

J Interferon Cytokine Res. 2018 Nov;38(11):469-479. doi: 10.1089/jir.2018.0066. Epub 2018 Oct 18.


A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission.

Xie X, Kum DB, Xia H, Luo H, Shan C, Zou J, Muruato AE, Medeiros DBA, Nunes BTD, Dallmeier K, Rossi SL, Weaver SC, Neyts J, Wang T, Vasconcelos PFC, Shi PY.

Cell Host Microbe. 2018 Oct 10;24(4):487-499.e5. doi: 10.1016/j.chom.2018.09.008.


CCL20, a direct-acting pro-angiogenic chemokine induced by hepatitis C virus (HCV): Potential role in HCV-related liver cancer.

Benkheil M, Van Haele M, Roskams T, Laporte M, Noppen S, Abbasi K, Delang L, Neyts J, Liekens S.

Exp Cell Res. 2018 Nov 15;372(2):168-177. doi: 10.1016/j.yexcr.2018.09.023. Epub 2018 Oct 2.


PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases.

Delang L, Harak C, Benkheil M, Khan H, Leyssen P, Andrews M, Lohmann V, Neyts J.

J Antimicrob Chemother. 2018 Dec 1;73(12):3375-3384. doi: 10.1093/jac/dky327.


Structure-Based Drug Design of Potent Pyrazole Derivatives against Rhinovirus Replication.

Da Costa L, Scheers E, Coluccia A, Casulli A, Roche M, Di Giorgio C, Neyts J, Terme T, Cirilli R, La Regina G, Silvestri R, Mirabelli C, Vanelle P.

J Med Chem. 2018 Sep 27;61(18):8402-8416. doi: 10.1021/acs.jmedchem.8b00931. Epub 2018 Sep 7.


Discovery of Indole Derivatives as Novel and Potent Dengue Virus Inhibitors.

Bardiot D, Koukni M, Smets W, Carlens G, McNaughton M, Kaptein S, Dallmeier K, Chaltin P, Neyts J, Marchand A.

J Med Chem. 2018 Sep 27;61(18):8390-8401. doi: 10.1021/acs.jmedchem.8b00913. Epub 2018 Sep 12.


A Single Nucleoside Viral Polymerase Inhibitor Against Norovirus, Rotavirus, and Sapovirus-Induced Diarrhea.

Van Dycke J, Arnoldi F, Papa G, Vandepoele J, Burrone OR, Mastrangelo E, Tarantino D, Heylen E, Neyts J, Rocha-Pereira J.

J Infect Dis. 2018 Oct 20;218(11):1753-1758. doi: 10.1093/infdis/jiy398.


Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection.

Ma Y, Cong W, Huang H, Sun L, Mai AH, Boonen K, Maryam W, De Borggraeve W, Luo G, Liu Q, Schoofs L, Van Kuppeveld F, Neyts J, Mirabelli C, Luyten W.

Int J Antimicrob Agents. 2019 Feb;53(2):128-136. doi: 10.1016/j.ijantimicag.2018.07.014. Epub 2018 Jul 29.


Antiplasmodial, anti-chikungunya virus and antioxidant activities of 64 endemic plants from the Mascarene Islands.

Ledoux A, Cao M, Jansen O, Mamede L, Campos PE, Payet B, Clerc P, Grondin I, Girard-Valenciennes E, Hermann T, Litaudon M, Vanderheydt C, Delang L, Neyts J, Leyssen P, Frédérich M, Smadja J.

Int J Antimicrob Agents. 2018 Nov;52(5):622-628. doi: 10.1016/j.ijantimicag.2018.07.017. Epub 2018 Jul 29.


HCV-induced EGFR-ERK signaling promotes a pro-inflammatory and pro-angiogenic signature contributing to liver cancer pathogenesis.

Benkheil M, Paeshuyse J, Neyts J, Van Haele M, Roskams T, Liekens S.

Biochem Pharmacol. 2018 Sep;155:305-315. doi: 10.1016/j.bcp.2018.07.011. Epub 2018 Jul 21.


Assessing medicinal plants traditionally used in the Chirang Reserve Forest, Northeast India for antimicrobial activity.

Panda SK, Das R, Leyssen P, Neyts J, Luyten W.

J Ethnopharmacol. 2018 Oct 28;225:220-233. doi: 10.1016/j.jep.2018.07.011. Epub 2018 Jul 11.


Antiviral effect of the nucleoside analogue cidofovir in the context of sexual transmission of a gammaherpesvirus in mice.

Zeippen C, Javaux J, Snoeck R, Neyts J, Gillet L.

J Antimicrob Chemother. 2018 Aug 1;73(8):2095-2103. doi: 10.1093/jac/dky161.


Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds.

Kaptein SJF, Vincetti P, Crespan E, Rivera JIA, Costantino G, Maga G, Neyts J, Radi M.

ChemMedChem. 2018 Jul 18;13(14):1371-1376. doi: 10.1002/cmdc.201800178. Epub 2018 Jun 1.


Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium.

Mirabelli C, Jaspers M, Boon M, Jorissen M, Koukni M, Bardiot D, Chaltin P, Marchand A, Neyts J, Jochmans D.

J Antimicrob Chemother. 2018 Jul 1;73(7):1823-1829. doi: 10.1093/jac/dky089.


Favipiravir as a potential countermeasure against neglected and emerging RNA viruses.

Delang L, Abdelnabi R, Neyts J.

Antiviral Res. 2018 May;153:85-94. doi: 10.1016/j.antiviral.2018.03.003. Epub 2018 Mar 7. Review.


Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus.

Giancotti G, Cancellieri M, Balboni A, Giustiniano M, Novellino E, Delang L, Neyts J, Leyssen P, Brancale A, Bassetto M.

Eur J Med Chem. 2018 Apr 10;149:56-68. doi: 10.1016/j.ejmech.2018.02.054. Epub 2018 Feb 23.


Structurally Diverse Diterpenoids from Sandwithia guyanensis.

Remy S, Olivon F, Desrat S, Blanchard F, Eparvier V, Leyssen P, Neyts J, Roussi F, Touboul D, Litaudon M.

J Nat Prod. 2018 Apr 27;81(4):901-912. doi: 10.1021/acs.jnatprod.7b01025. Epub 2018 Mar 1.


Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold.

Belfrage AK, Abdurakhmanov E, Åkerblom E, Brandt P, Alogheli H, Neyts J, Danielson UH, Sandström A.

Eur J Med Chem. 2018 Mar 25;148:453-464. doi: 10.1016/j.ejmech.2018.02.032. Epub 2018 Feb 13.


Recommendations for enterovirus diagnostics and characterisation within and beyond Europe.

Harvala H, Broberg E, Benschop K, Berginc N, Ladhani S, Susi P, Christiansen C, McKenna J, Allen D, Makiello P, McAllister G, Carmen M, Zakikhany K, Dyrdak R, Nielsen X, Madsen T, Paul J, Moore C, von Eije K, Piralla A, Carlier M, Vanoverschelde L, Poelman R, Anton A, López-Labrador FX, Pellegrinelli L, Keeren K, Maier M, Cassidy H, Derdas S, Savolainen-Kopra C, Diedrich S, Nordbø S, Buesa J, Bailly JL, Baldanti F, MacAdam A, Mirand A, Dudman S, Schuffenecker I, Kadambari S, Neyts J, Griffiths MJ, Richter J, Margaretto C, Govind S, Morley U, Adams O, Krokstad S, Dean J, Pons-Salort M, Prochazka B, Cabrerizo M, Majumdar M, Nebbia G, Wiewel M, Cottrell S, Coyle P, Martin J, Moore C, Midgley S, Horby P, Wolthers K, Simmonds P, Niesters H, Fischer TK.

J Clin Virol. 2018 Apr;101:11-17. doi: 10.1016/j.jcv.2018.01.008. Epub 2018 Feb 6. Review.


Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5- d]pyrimidin-7(6 H)-ones.

Gómez-SanJuan A, Gamo AM, Delang L, Pérez-Sánchez A, Amrun SN, Abdelnabi R, Jacobs S, Priego EM, Camarasa MJ, Jochmans D, Leyssen P, Ng LFP, Querat G, Neyts J, Pérez-Pérez MJ.

ACS Infect Dis. 2018 Apr 13;4(4):605-619. doi: 10.1021/acsinfecdis.7b00219. Epub 2018 Feb 14.


Hepatitis E virus replication and interferon responses in human placental cells.

Knegendorf L, Drave SA, Dao Thi VL, Debing Y, Brown RJP, Vondran FWR, Resner K, Friesland M, Khera T, Engelmann M, Bremer B, Wedemeyer H, Behrendt P, Neyts J, Pietschmann T, Todt D, Steinmann E.

Hepatol Commun. 2018 Jan 8;2(2):173-187. doi: 10.1002/hep4.1138. eCollection 2018 Feb.


Design, synthesis and evaluation against Chikungunya virus of novel small-molecule antiviral agents.

Tardugno R, Giancotti G, De Burghgraeve T, Delang L, Neyts J, Leyssen P, Brancale A, Bassetto M.

Bioorg Med Chem. 2018 Feb 15;26(4):869-874. doi: 10.1016/j.bmc.2018.01.002. Epub 2018 Jan 6.


The path towards effective antivirals against rabies.

Jochmans D, Neyts J.

Vaccine. 2017 Dec 23. pii: S0264-410X(17)31812-1. doi: 10.1016/j.vaccine.2017.12.051. [Epub ahead of print]


Mannitol treatment is not effective in therapy of rabies virus infection in mice.

Dufkova L, Sirmarova J, Salat J, Honig V, Palus M, Ruzek D, Fooks AR, Mansfield KL, Tordo N, Jochmans D, Neyts J, Martina B, Koraka P, Osterhaus ADME; ASKLEPIOS consortium.

Vaccine. 2017 Dec 20. pii: S0264-410X(17)31781-4. doi: 10.1016/j.vaccine.2017.12.028. [Epub ahead of print]


ZikaPLAN: Zika Preparedness Latin American Network.

Wilder-Smith A, Preet R, Renhorn KE, Ximenes RA, Rodrigues LC, Solomon T, Neyts J, Lambrechts L, Willison H, Peeling R, Falconar AK, Precioso AR, Logan J, Lang T, Endtz HP, Erasmus MC, Massad E.

Glob Health Action. 2017;10(1):1398485. doi: 10.1080/16549716.2017.1398485.


New Models to Study Hepatitis E Virus Replication and Particular Characteristics of Infection: The Needle Hides in the Hay Stack.

Debing Y, Schmid MA, Neyts J.

Gastroenterology. 2018 Jan;154(1):20-22. doi: 10.1053/j.gastro.2017.11.014. Epub 2017 Nov 21. No abstract available.


Rational design of antiviral drug combinations based on equipotency using HCV subgenomic replicon as an in vitro model.

Mandour M, Vliegen I, Paeshuyse J, Neyts J.

Antiviral Res. 2018 Jan;149:150-153. doi: 10.1016/j.antiviral.2017.11.010. Epub 2017 Nov 14.


Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis.

Mirabelli C, Scheers E, Neyts J.

F1000Res. 2017 Oct 19;6:1860. doi: 10.12688/f1000research.11978.1. eCollection 2017. Review.


Antimicrobial, Anthelmintic, and Antiviral Activity of Plants Traditionally Used for Treating Infectious Disease in the Similipal Biosphere Reserve, Odisha, India.

Panda SK, Padhi L, Leyssen P, Liu M, Neyts J, Luyten W.

Front Pharmacol. 2017 Oct 23;8:658. doi: 10.3389/fphar.2017.00658. eCollection 2017.


Interferon lambda (IFN-λ) efficiently blocks norovirus transmission in a mouse model.

Rocha-Pereira J, Jacobs S, Noppen S, Verbeken E, Michiels T, Neyts J.

Antiviral Res. 2018 Jan;149:7-15. doi: 10.1016/j.antiviral.2017.10.017. Epub 2017 Nov 10.


New class of early-stage enterovirus inhibitors with a novel mechanism of action.

Ma Y, Abdelnabi R, Delang L, Froeyen M, Luyten W, Neyts J, Mirabelli C.

Antiviral Res. 2017 Nov;147:67-74. doi: 10.1016/j.antiviral.2017.10.004. Epub 2017 Oct 7.


Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: A combined computational and experimental study.

Da Costa L, Scheers E, Coluccia A, Rosetti A, Roche M, Neyts J, Terme T, Cirilli R, Mirabelli C, Silvestri R, Vanelle P.

Eur J Med Chem. 2017 Nov 10;140:528-541. doi: 10.1016/j.ejmech.2017.09.036. Epub 2017 Sep 21.


Upregulation of sodium taurocholate cotransporter polypeptide during hepatogenic differentiation of umbilical cord matrix mesenchymal stem cells facilitates hepatitis B entry.

Sargiacomo C, El-Kehdy H, Dallmeier K, de Kock J, Hernandez-Kelly C, Rogiers V, Ortega A, Neyts J, Sokal E, Najimi M.

Stem Cell Res Ther. 2017 Sep 29;8(1):204. doi: 10.1186/s13287-017-0656-5.


Antiviral treatment efficiently inhibits chikungunya virus infection in the joints of mice during the acute but not during the chronic phase of the infection.

Abdelnabi R, Jochmans D, Verbeken E, Neyts J, Delang L.

Antiviral Res. 2018 Jan;149:113-117. doi: 10.1016/j.antiviral.2017.09.016. Epub 2017 Sep 25.


Bioactive Natural Products Prioritization Using Massive Multi-informational Molecular Networks.

Olivon F, Allard PM, Koval A, Righi D, Genta-Jouve G, Neyts J, Apel C, Pannecouque C, Nothias LF, Cachet X, Marcourt L, Roussi F, Katanaev VL, Touboul D, Wolfender JL, Litaudon M.

ACS Chem Biol. 2017 Oct 20;12(10):2644-2651. doi: 10.1021/acschembio.7b00413. Epub 2017 Sep 15.


Replication of the Zika virus in different iPSC-derived neuronal cells and implications to assess efficacy of antivirals.

Lanko K, Eggermont K, Patel A, Kaptein S, Delang L, Verfaillie CM, Neyts J.

Antiviral Res. 2017 Sep;145:82-86. doi: 10.1016/j.antiviral.2017.07.010. Epub 2017 Jul 20.


Fluorination of Naturally Occurring N⁶-Benzyladenosine Remarkably Increased Its Antiviral Activity and Selectivity.

Oslovsky VE, Drenichev MS, Sun L, Kurochkin NN, Kunetsky VE, Mirabelli C, Neyts J, Leyssen P, Mikhailov SN.

Molecules. 2017 Jul 20;22(7). pii: E1219. doi: 10.3390/molecules22071219.


Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking.

Esposito M, Nothias LF, Retailleau P, Costa J, Roussi F, Neyts J, Leyssen P, Touboul D, Litaudon M, Paolini J.

J Nat Prod. 2017 Jul 28;80(7):2051-2059. doi: 10.1021/acs.jnatprod.7b00233. Epub 2017 Jul 3.


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