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Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages.

Souriant S, Balboa L, Dupont M, Pingris K, Kviatcovsky D, Cougoule C, Lastrucci C, Bah A, Gasser R, Poincloux R, Raynaud-Messina B, Al Saati T, Inwentarz S, Poggi S, Moraña EJ, González-Montaner P, Corti M, Lagane B, Vergne I, Allers C, Kaushal D, Kuroda MJ, Sasiain MDC, Neyrolles O, Maridonneau-Parini I, Lugo-Villarino G, Vérollet C.

Cell Rep. 2019 Mar 26;26(13):3586-3599.e7. doi: 10.1016/j.celrep.2019.02.091.


An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death.

Freire DM, Gutierrez C, Garza-Garcia A, Grabowska AD, Sala AJ, Ariyachaokun K, Panikova T, Beckham KSH, Colom A, Pogenberg V, Cianci M, Tuukkanen A, Boudehen YM, Peixoto A, Botella L, Svergun DI, Schnappinger D, Schneider TR, Genevaux P, de Carvalho LPS, Wilmanns M, Parret AHA, Neyrolles O.

Mol Cell. 2019 Mar 21;73(6):1282-1291.e8. doi: 10.1016/j.molcel.2019.01.028. Epub 2019 Feb 18.


Die another way: Ferroptosis drives tuberculosis pathology.

Meunier E, Neyrolles O.

J Exp Med. 2019 Mar 4;216(3):471-473. doi: 10.1084/jem.20190038. Epub 2019 Feb 20.


The Host Microbiota Contributes to Early Protection Against Lung Colonization by Mycobacterium tuberculosis.

Dumas A, Corral D, Colom A, Levillain F, Peixoto A, Hudrisier D, Poquet Y, Neyrolles O.

Front Immunol. 2018 Nov 14;9:2656. doi: 10.3389/fimmu.2018.02656. eCollection 2018.


The role of the lung microbiota and the gut-lung axis in respiratory infectious diseases.

Dumas A, Bernard L, Poquet Y, Lugo-Villarino G, Neyrolles O.

Cell Microbiol. 2018 Dec;20(12):e12966. doi: 10.1111/cmi.12966. Epub 2018 Oct 30. Review.


The C-Type Lectin Receptor DC-SIGN Has an Anti-Inflammatory Role in Human M(IL-4) Macrophages in Response to Mycobacterium tuberculosis.

Lugo-Villarino G, Troegeler A, Balboa L, Lastrucci C, Duval C, Mercier I, Bénard A, Capilla F, Al Saati T, Poincloux R, Kondova I, Verreck FAW, Cougoule C, Maridonneau-Parini I, Sasiain MDC, Neyrolles O.

Front Immunol. 2018 Jun 12;9:1123. doi: 10.3389/fimmu.2018.01123. eCollection 2018.


Podosomes, But Not the Maturation Status, Determine the Protease-Dependent 3D Migration in Human Dendritic Cells.

Cougoule C, Lastrucci C, Guiet R, Mascarau R, Meunier E, Lugo-Villarino G, Neyrolles O, Poincloux R, Maridonneau-Parini I.

Front Immunol. 2018 Apr 30;9:846. doi: 10.3389/fimmu.2018.00846. eCollection 2018.


Formation of Foamy Macrophages by Tuberculous Pleural Effusions Is Triggered by the Interleukin-10/Signal Transducer and Activator of Transcription 3 Axis through ACAT Upregulation.

Genoula M, Marín Franco JL, Dupont M, Kviatcovsky D, Milillo A, Schierloh P, Moraña EJ, Poggi S, Palmero D, Mata-Espinosa D, González-Domínguez E, León Contreras JC, Barrionuevo P, Rearte B, Córdoba Moreno MO, Fontanals A, Crotta Asis A, Gago G, Cougoule C, Neyrolles O, Maridonneau-Parini I, Sánchez-Torres C, Hernández-Pando R, Vérollet C, Lugo-Villarino G, Sasiain MDC, Balboa L.

Front Immunol. 2018 Mar 9;9:459. doi: 10.3389/fimmu.2018.00459. eCollection 2018.


Progress and challenges in TB vaccine development.

Voss G, Casimiro D, Neyrolles O, Williams A, Kaufmann SHE, McShane H, Hatherill M, Fletcher HA.

F1000Res. 2018 Feb 16;7:199. doi: 10.12688/f1000research.13588.1. eCollection 2018. Review.


Type-2 diabetes alters the basal phenotype of human macrophages and diminishes their capacity to respond, internalise, and control Mycobacterium tuberculosis.

Lopez-Lopez N, Martinez AGR, Garcia-Hernandez MH, Hernandez-Pando R, Castañeda-Delgado JE, Lugo-Villarino G, Cougoule C, Neyrolles O, Rivas-Santiago B, Valtierra-Alvarado MA, Rubio-Caceres M, Enciso-Moreno JA, Serrano CJ.

Mem Inst Oswaldo Cruz. 2018 Feb 19;113(4):e170326. doi: 10.1590/0074-02760170326.


Moonlighting activity of the epigenetic machinery restrains infection.

Gutierrez C, Boudehen YM, Neyrolles O.

EMBO J. 2018 Jan 17;37(2):161-163. doi: 10.15252/embj.201798679. Epub 2018 Jan 4. No abstract available.


Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation.

Levillain F, Poquet Y, Mallet L, Mazères S, Marceau M, Brosch R, Bange FC, Supply P, Magalon A, Neyrolles O.

PLoS Pathog. 2017 Nov 27;13(11):e1006752. doi: 10.1371/journal.ppat.1006752. eCollection 2017 Nov.


B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis.

Bénard A, Sakwa I, Schierloh P, Colom A, Mercier I, Tailleux L, Jouneau L, Boudinot P, Al-Saati T, Lang R, Rehwinkel J, Loxton AG, Kaufmann SHE, Anton-Leberre V, O'Garra A, Sasiain MDC, Gicquel B, Fillatreau S, Neyrolles O, Hudrisier D.

Am J Respir Crit Care Med. 2018 Mar 15;197(6):801-813. doi: 10.1164/rccm.201707-1475OC.


TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development.

Kaufmann SHE, Dockrell HM, Drager N, Ho MM, McShane H, Neyrolles O, Ottenhoff THM, Patel B, Roordink D, Spertini F, Stenger S, Thole J, Verreck FAW, Williams A; TBVAC2020 Consortium.

Front Immunol. 2017 Oct 4;8:1203. doi: 10.3389/fimmu.2017.01203. eCollection 2017. Review.


Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids.

Blanc L, Gilleron M, Prandi J, Song OR, Jang MS, Gicquel B, Drocourt D, Neyrolles O, Brodin P, Tiraby G, Vercellone A, Nigou J.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11205-11210. doi: 10.1073/pnas.1707840114. Epub 2017 Oct 2.


C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells.

Troegeler A, Mercier I, Cougoule C, Pietretti D, Colom A, Duval C, Vu Manh TP, Capilla F, Poincloux R, Pingris K, Nigou J, Rademann J, Dalod M, Verreck FA, Al Saati T, Lugo-Villarino G, Lepenies B, Hudrisier D, Neyrolles O.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E540-E549. doi: 10.1073/pnas.1613254114. Epub 2017 Jan 9.


Bacterial pathogenesis: A sand grain in antigen processing.

Neyrolles O.

Nat Microbiol. 2016 Dec 5;2:16234. doi: 10.1038/nmicrobiol.2016.234. No abstract available.


Role of Cathepsins in Mycobacterium tuberculosis Survival in Human Macrophages.

Pires D, Marques J, Pombo JP, Carmo N, Bettencourt P, Neyrolles O, Lugo-Villarino G, Anes E.

Sci Rep. 2016 Aug 30;6:32247. doi: 10.1038/srep32247.


Vaccination Against Tuberculosis With Whole-Cell Mycobacterial Vaccines.

Scriba TJ, Kaufmann SH, Henri Lambert P, Sanicas M, Martin C, Neyrolles O.

J Infect Dis. 2016 Sep 1;214(5):659-64. doi: 10.1093/infdis/jiw228. Epub 2016 May 30. Review.


Wheeling and Dealing With Antigen Presentation in Tuberculosis.

Hudrisier D, Neyrolles O.

Trends Microbiol. 2016 Mar;24(3):166-168. doi: 10.1016/j.tim.2016.01.001. Epub 2016 Jan 18.


Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16(+) monocyte population via the IL-10/STAT3 axis.

Lastrucci C, Bénard A, Balboa L, Pingris K, Souriant S, Poincloux R, Al Saati T, Rasolofo V, González-Montaner P, Inwentarz S, Moraña EJ, Kondova I, Verreck FA, Sasiain Mdel C, Neyrolles O, Maridonneau-Parini I, Lugo-Villarino G, Cougoule C.

Cell Res. 2015 Dec;25(12):1333-51. doi: 10.1038/cr.2015.123. Epub 2015 Oct 20.


[Lactobacillus acidophilus: a promising tool for the treatment of inflammatory bowel diseases?].

Thomas M, Langella P, Neyrolles O.

Med Sci (Paris). 2015 Aug-Sep;31(8-9):715-7. doi: 10.1051/medsci/20153108004. Epub 2015 Sep 4. French. No abstract available.


Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis.

Troegeler A, Lugo-Villarino G, Hansen S, Rasolofo V, Henriksen ML, Mori K, Ohtani K, Duval C, Mercier I, Bénard A, Nigou J, Hudrisier D, Wakamiya N, Neyrolles O.

PLoS One. 2015 Jul 14;10(7):e0132692. doi: 10.1371/journal.pone.0132692. eCollection 2015.


Metallobiology of Tuberculosis.

Marcela Rodriguez G, Neyrolles O.

Microbiol Spectr. 2014 Jun;2(3). doi: 10.1128/microbiolspec.MGM2-0012-2013. Review.


Diverging biological roles among human monocyte subsets in the context of tuberculosis infection.

Balboa L, Barrios-Payan J, González-Domínguez E, Lastrucci C, Lugo-Villarino G, Mata-Espinoza D, Schierloh P, Kviatcovsky D, Neyrolles O, Maridonneau-Parini I, Sánchez-Torres C, Sasiain Mdel C, Hernández-Pando R.

Clin Sci (Lond). 2015 Aug;129(4):319-30. doi: 10.1042/CS20150021.


SIGNing a symbiotic treaty with gut microbiota.

Lugo-Villarino G, Neyrolles O.

EMBO J. 2015 Apr 1;34(7):829-31. doi: 10.15252/embj.201591266. Epub 2015 Mar 3.


Mycobacteria, metals, and the macrophage.

Neyrolles O, Wolschendorf F, Mitra A, Niederweis M.

Immunol Rev. 2015 Mar;264(1):249-63. doi: 10.1111/imr.12265. Review.


Playing hide-and-seek with host macrophages through the use of mycobacterial cell envelope phthiocerol dimycocerosates and phenolic glycolipids.

Arbues A, Lugo-Villarino G, Neyrolles O, Guilhot C, Astarie-Dequeker C.

Front Cell Infect Microbiol. 2014 Dec 9;4:173. doi: 10.3389/fcimb.2014.00173. eCollection 2014.


Pyroptosis of resident macrophages differentially orchestrates inflammatory responses to Staphylococcus aureus in resistant and susceptible mice.

Accarias S, Lugo-Villarino G, Foucras G, Neyrolles O, Boullier S, Tabouret G.

Eur J Immunol. 2015 Mar;45(3):794-806. doi: 10.1002/eji.201445098. Epub 2015 Jan 21.


Nitrogen metabolism in Mycobacterium tuberculosis physiology and virulence.

Gouzy A, Poquet Y, Neyrolles O.

Nat Rev Microbiol. 2014 Nov;12(11):729-37. doi: 10.1038/nrmicro3349. Epub 2014 Sep 22. Review.


Manipulation of the mononuclear phagocyte system by Mycobacterium tuberculosis.

Lugo-Villarino G, Neyrolles O.

Cold Spring Harb Perspect Med. 2014 Aug 21;4(11):a018549. doi: 10.1101/cshperspect.a018549. Review.


Of clots and granulomas: platelets are new players in immunity to tuberculosis.

Lugo-Villarino G, Neyrolles O.

J Infect Dis. 2014 Dec 1;210(11):1687-90. doi: 10.1093/infdis/jiu356. Epub 2014 Jul 1. No abstract available.


Amino acid capture and utilization within the Mycobacterium tuberculosis phagosome.

Gouzy A, Poquet Y, Neyrolles O.

Future Microbiol. 2014;9(5):631-7. doi: 10.2217/fmb.14.28.


Antigen smuggling in tuberculosis.

Hudrisier D, Neyrolles O.

Cell Host Microbe. 2014 Jun 11;15(6):657-9. doi: 10.1016/j.chom.2014.05.018.


An efficient siRNA-mediated gene silencing in primary human monocytes, dendritic cells and macrophages.

Troegeler A, Lastrucci C, Duval C, Tanne A, Cougoule C, Maridonneau-Parini I, Neyrolles O, Lugo-Villarino G.

Immunol Cell Biol. 2014 Sep;92(8):699-708. doi: 10.1038/icb.2014.39. Epub 2014 Jun 3.


[Aspartate: an essential amino acid for the physiology and virulence of the tuberculosis bacillus].

Gouzy A, Poquet Y, Neyrolles O.

Med Sci (Paris). 2014 Mar;30(3):242-4. doi: 10.1051/medsci/20143003007. Epub 2014 Mar 31. French. No abstract available.


Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection.

Gouzy A, Larrouy-Maumus G, Bottai D, Levillain F, Dumas A, Wallach JB, Caire-Brandli I, de Chastellier C, Wu TD, Poincloux R, Brosch R, Guerquin-Kern JL, Schnappinger D, Sório de Carvalho LP, Poquet Y, Neyrolles O.

PLoS Pathog. 2014 Feb 20;10(2):e1003928. doi: 10.1371/journal.ppat.1003928. eCollection 2014 Feb.


A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection.

Siddle KJ, Deschamps M, Tailleux L, Nédélec Y, Pothlichet J, Lugo-Villarino G, Libri V, Gicquel B, Neyrolles O, Laval G, Patin E, Barreiro LB, Quintana-Murci L.

Genome Res. 2014 May;24(5):850-9. doi: 10.1101/gr.161471.113. Epub 2014 Jan 30.


Mycobacteria and the greasy macrophage: getting fat and frustrated.

Neyrolles O.

Infect Immun. 2014 Feb;82(2):472-5. doi: 10.1128/IAI.01512-13. Epub 2013 Dec 9.


Zinc and copper toxicity in host defense against pathogens: Mycobacterium tuberculosis as a model example of an emerging paradigm.

Neyrolles O, Mintz E, Catty P.

Front Cell Infect Microbiol. 2013 Nov 27;3:89. doi: 10.3389/fcimb.2013.00089. eCollection 2013. Review. No abstract available.


A central role for aspartate in Mycobacterium tuberculosis physiology and virulence.

Gouzy A, Poquet Y, Neyrolles O.

Front Cell Infect Microbiol. 2013 Oct 24;3:68. doi: 10.3389/fcimb.2013.00068. eCollection 2013. No abstract available.


Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate.

Gouzy A, Larrouy-Maumus G, Wu TD, Peixoto A, Levillain F, Lugo-Villarino G, Guerquin-Kern JL, de Carvalho LP, Poquet Y, Neyrolles O.

Nat Chem Biol. 2013 Nov;9(11):674-6. doi: 10.1038/nchembio.1355. Epub 2013 Sep 29. Erratum in: Nat Chem Biol. 2014 Feb;10(2):164. Gerquin-Kern, Jean-Luc [corrected to Guerquin-Kern, Jean-Luc].


Multiple deletions in the polyketide synthase gene repertoire of Mycobacterium tuberculosis reveal functional overlap of cell envelope lipids in host-pathogen interactions.

Passemar C, Arbués A, Malaga W, Mercier I, Moreau F, Lepourry L, Neyrolles O, Guilhot C, Astarie-Dequeker C.

Cell Microbiol. 2014 Feb;16(2):195-213. doi: 10.1111/cmi.12214. Epub 2013 Oct 16.


Actin-binding protein regulation by microRNAs as a novel microbial strategy to modulate phagocytosis by host cells: the case of N-Wasp and miR-142-3p.

Bettencourt P, Marion S, Pires D, Santos LF, Lastrucci C, Carmo N, Blake J, Benes V, Griffiths G, Neyrolles O, Lugo-Villarino G, Anes E.

Front Cell Infect Microbiol. 2013 Jun 5;3:19. doi: 10.3389/fcimb.2013.00019. eCollection 2013.


The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum.

Lefèvre L, Lugo-Villarino G, Meunier E, Valentin A, Olagnier D, Authier H, Duval C, Dardenne C, Bernad J, Lemesre JL, Auwerx J, Neyrolles O, Pipy B, Coste A.

Immunity. 2013 May 23;38(5):1038-49. doi: 10.1016/j.immuni.2013.04.010. Epub 2013 May 16.


Dressed not to kill: CD16+ monocytes impair immune defence against tuberculosis.

Lugo-Villarino G, Neyrolles O.

Eur J Immunol. 2013 Feb;43(2):327-30. doi: 10.1002/eji.201243256.


High throughput phenotypic selection of Mycobacterium tuberculosis mutants with impaired resistance to reactive oxygen species identifies genes important for intracellular growth.

Mestre O, Hurtado-Ortiz R, Dos Vultos T, Namouchi A, Cimino M, Pimentel M, Neyrolles O, Gicquel B.

PLoS One. 2013;8(1):e53486. doi: 10.1371/journal.pone.0053486. Epub 2013 Jan 8.


Emerging trends in the formation and function of tuberculosis granulomas.

Lugo-Villarino G, Hudrisier D, Benard A, Neyrolles O.

Front Immunol. 2013 Jan 7;3:405. doi: 10.3389/fimmu.2012.00405. eCollection 2012.


Tuberculosis 2012: biology, pathogenesis and intervention strategies; an update from the city of light.

Gouzy A, Nigou J, Gilleron M, Neyrolles O, Tailleux L, Gordon SV.

Res Microbiol. 2013 Apr;164(3):270-80. doi: 10.1016/j.resmic.2012.12.006. Epub 2012 Dec 20.


An interferon-related signature in the transcriptional core response of human macrophages to Mycobacterium tuberculosis infection.

Wu K, Dong D, Fang H, Levillain F, Jin W, Mei J, Gicquel B, Du Y, Wang K, Gao Q, Neyrolles O, Zhang J.

PLoS One. 2012;7(6):e38367. doi: 10.1371/journal.pone.0038367. Epub 2012 Jun 4.

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