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Items: 1 to 50 of 80

1.

Mycobacterium tuberculosis Exploits a Molecular Off Switch of the Immune System for Intracellular Survival.

von Both U, Berk M, Agapow PM, Wright JD, Git A, Hamilton MS, Goldgof G, Siddiqui N, Bellos E, Wright VJ, Coin LJ, Newton SM, Levin M.

Sci Rep. 2018 Jan 12;8(1):661. doi: 10.1038/s41598-017-18528-y.

2.

Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function.

Hemingway C, Berk M, Anderson ST, Wright VJ, Hamilton S, Eleftherohorinou H, Kaforou M, Goldgof GM, Hickman K, Kampmann B, Schoeman J, Eley B, Beatty D, Pienaar S, Nicol MP, Griffiths MJ, Waddell SJ, Newton SM, Coin LJ, Relman DA, Montana G, Levin M.

PLoS One. 2017 Nov 15;12(11):e0185973. doi: 10.1371/journal.pone.0185973. eCollection 2017.

3.

Innate activation of human primary epithelial cells broadens the host response to Mycobacterium tuberculosis in the airways.

Reuschl AK, Edwards MR, Parker R, Connell DW, Hoang L, Halliday A, Jarvis H, Siddiqui N, Wright C, Bremang S, Newton SM, Beverley P, Shattock RJ, Kon OM, Lalvani A.

PLoS Pathog. 2017 Sep 1;13(9):e1006577. doi: 10.1371/journal.ppat.1006577. eCollection 2017 Sep.

4.

Disruption of drug-resistant biofilms using de novo designed short α-helical antimicrobial peptides with idealized facial amphiphilicity.

Khara JS, Obuobi S, Wang Y, Hamilton MS, Robertson BD, Newton SM, Yang YY, Langford PR, Ee PLR.

Acta Biomater. 2017 Jul 15;57:103-114. doi: 10.1016/j.actbio.2017.04.032. Epub 2017 Apr 29.

5.

Fluorescence High-Throughput Screening for Inhibitors of TonB Action.

Nairn BL, Eliasson OS, Hyder DR, Long NJ, Majumdar A, Chakravorty S, McDonald P, Roy A, Newton SM, Klebba PE.

J Bacteriol. 2017 Apr 25;199(10). pii: e00889-16. doi: 10.1128/JB.00889-16. Print 2017 May 15.

6.

TonB-Dependent Heme/Hemoglobin Utilization by Caulobacter crescentus HutA.

Balhesteros H, Shipelskiy Y, Long NJ, Majumdar A, Katz BB, Santos NM, Leaden L, Newton SM, Marques MV, Klebba PE.

J Bacteriol. 2017 Feb 28;199(6). pii: e00723-16. doi: 10.1128/JB.00723-16. Print 2017 Mar 15.

7.

Confined Mobility of TonB and FepA in Escherichia coli Membranes.

Lill Y, Jordan LD, Smallwood CR, Newton SM, Lill MA, Klebba PE, Ritchie K.

PLoS One. 2016 Dec 9;11(12):e0160862. doi: 10.1371/journal.pone.0160862. eCollection 2016.

8.

Unnatural amino acid analogues of membrane-active helical peptides with anti-mycobacterial activity and improved stability.

Khara JS, Priestman M, Uhía I, Hamilton MS, Krishnan N, Wang Y, Yang YY, Langford PR, Newton SM, Robertson BD, Ee PL.

J Antimicrob Chemother. 2016 Aug;71(8):2181-91. doi: 10.1093/jac/dkw107. Epub 2016 Apr 26.

9.

The Creation of a Biocontainment Unit at a Tertiary Care Hospital. The Johns Hopkins Medicine Experience.

Garibaldi BT, Kelen GD, Brower RG, Bova G, Ernst N, Reimers M, Langlotz R, Gimburg A, Iati M, Smith C, MacConnell S, James H, Lewin JJ, Trexler P, Black MA, Lynch C, Clarke W, Marzinke MA, Sokoll LJ, Carroll KC, Parish NM, Dionne K, Biddison EL, Gwon HS, Sauer L, Hill P, Newton SM, Garrett MR, Miller RG, Perl TM, Maragakis LL.

Ann Am Thorac Soc. 2016 May;13(5):600-8. doi: 10.1513/AnnalsATS.201509-587PS.

PMID:
27057583
10.

High-Throughput Screening Assay for Inhibitors of TonB-Dependent Iron Transport.

Hanson M, Jordan LD, Shipelskiy Y, Newton SM, Klebba PE.

J Biomol Screen. 2016 Mar;21(3):316-22. doi: 10.1177/1087057115613788. Epub 2015 Oct 30.

PMID:
26518031
11.

Interhospital Transfer Center Model: Components, Themes, and Design Elements.

Newton SM, Fralic M.

Air Med J. 2015 Jul-Aug;34(4):207-12. doi: 10.1016/j.amj.2015.03.008.

PMID:
26206546
12.

Understanding immune protection against tuberculosis using RNA expression profiling.

von Both U, Kaforou M, Levin M, Newton SM.

Vaccine. 2015 Sep 29;33(40):5289-93. doi: 10.1016/j.vaccine.2015.05.025. Epub 2015 May 23. Review.

13.

Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion.

Schiebler M, Brown K, Hegyi K, Newton SM, Renna M, Hepburn L, Klapholz C, Coulter S, Obregón-Henao A, Henao Tamayo M, Basaraba R, Kampmann B, Henry KM, Burgon J, Renshaw SA, Fleming A, Kay RR, Anderson KE, Hawkins PT, Ordway DJ, Rubinsztein DC, Floto RA.

EMBO Mol Med. 2015 Feb;7(2):127-39. doi: 10.15252/emmm.201404137.

14.

Novel mechanism of hemin capture by Hbp2, the hemoglobin-binding hemophore from Listeria monocytogenes.

Malmirchegini GR, Sjodt M, Shnitkind S, Sawaya MR, Rosinski J, Newton SM, Klebba PE, Clubb RT.

J Biol Chem. 2014 Dec 12;289(50):34886-99. doi: 10.1074/jbc.M114.583013. Epub 2014 Oct 14.

15.

Influence of Inbreeding on Female Mate Choice in Two Species of Drosophila.

McKee AA, Newton SM, Carter AJR.

J Insect Behav. 2014 Sep;27(5):613-625. doi: 10.1007/s10905-014-9453-5. Epub 2014 Jun 6.

16.

Concerted loop motion triggers induced fit of FepA to ferric enterobactin.

Smallwood CR, Jordan L, Trinh V, Schuerch DW, Gala A, Hanson M, Shipelskiy Y, Majumdar A, Newton SM, Klebba PE.

J Gen Physiol. 2014 Jul;144(1):71-80. doi: 10.1085/jgp.201311159. Erratum in: J Gen Physiol. 2014 Aug;144(2):201. Hanson, Matthew [corrected to Hanson, Mathew].

17.

Anti-mycobacterial activities of synthetic cationic α-helical peptides and their synergism with rifampicin.

Khara JS, Wang Y, Ke XY, Liu S, Newton SM, Langford PR, Yang YY, Ee PL.

Biomaterials. 2014 Feb;35(6):2032-8. doi: 10.1016/j.biomaterials.2013.11.035. Epub 2013 Dec 4.

PMID:
24314557
18.

Energy-dependent motion of TonB in the Gram-negative bacterial inner membrane.

Jordan LD, Zhou Y, Smallwood CR, Lill Y, Ritchie K, Yip WT, Newton SM, Klebba PE.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11553-8. doi: 10.1073/pnas.1304243110. Epub 2013 Jun 24.

19.

Role of catecholate siderophores in gram-negative bacterial colonization of the mouse gut.

Pi H, Jones SA, Mercer LE, Meador JP, Caughron JE, Jordan L, Newton SM, Conway T, Klebba PE.

PLoS One. 2012;7(11):e50020. doi: 10.1371/journal.pone.0050020. Epub 2012 Nov 29.

20.

Flagellar display of bone-protein-derived peptides for studying peptide-mediated biomineralization.

Li D, Newton SM, Klebba PE, Mao C.

Langmuir. 2012 Nov 27;28(47):16338-46. doi: 10.1021/la303237u. Epub 2012 Nov 14.

21.

Single-molecule study of molecular mobility in the cytoplasm of Escherichia coli.

Lill Y, Kaserer WA, Newton SM, Lill M, Klebba PE, Ritchie K.

Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Aug;86(2 Pt 1):021907. Epub 2012 Aug 9.

PMID:
23005785
22.
23.

Mechanisms of iron and haem transport by Listeria monocytogenes.

Klebba PE, Charbit A, Xiao Q, Jiang X, Newton SM.

Mol Membr Biol. 2012 May-Jun;29(3-4):69-86. doi: 10.3109/09687688.2012.694485. Review.

PMID:
22703022
24.

Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection.

Renna M, Schaffner C, Brown K, Shang S, Tamayo MH, Hegyi K, Grimsey NJ, Cusens D, Coulter S, Cooper J, Bowden AR, Newton SM, Kampmann B, Helm J, Jones A, Haworth CS, Basaraba RJ, DeGroote MA, Ordway DJ, Rubinsztein DC, Floto RA.

J Clin Invest. 2011 Sep;121(9):3554-63. doi: 10.1172/JCI46095. Epub 2011 Aug 1.

25.

Sortase independent and dependent systems for acquisition of haem and haemoglobin in Listeria monocytogenes.

Xiao Q, Jiang X, Moore KJ, Shao Y, Pi H, Dubail I, Charbit A, Newton SM, Klebba PE.

Mol Microbiol. 2011 Jun;80(6):1581-97. doi: 10.1111/j.1365-2958.2011.07667.x. Epub 2011 May 6.

26.

Direct measurements of the outer membrane stage of ferric enterobactin transport: postuptake binding.

Newton SM, Trinh V, Pi H, Klebba PE.

J Biol Chem. 2010 Jun 4;285(23):17488-97. doi: 10.1074/jbc.M109.100206. Epub 2010 Mar 24.

27.

Association between Gc genotype and susceptibility to TB is dependent on vitamin D status.

Martineau AR, Leandro AC, Anderson ST, Newton SM, Wilkinson KA, Nicol MP, Pienaar SM, Skolimowska KH, Rocha MA, Rolla VC, Levin M, Davidson RN, Bremner SA, Griffiths CJ, Eley BS, Bonecini-Almeida MG, Wilkinson RJ.

Eur Respir J. 2010 May;35(5):1106-12. doi: 10.1183/09031936.00087009. Epub 2009 Sep 24.

28.

Genetic determination of the effect of post-translational modification on the innate immune response to the 19 kDa lipoprotein of Mycobacterium tuberculosis.

Wilkinson KA, Newton SM, Stewart GR, Martineau AR, Patel J, Sullivan SM, Herrmann JL, Neyrolles O, Young DB, Wilkinson RJ.

BMC Microbiol. 2009 May 14;9:93. doi: 10.1186/1471-2180-9-93.

29.

Fluoresceination of FepA during colicin B killing: effects of temperature, toxin and TonB.

Smallwood CR, Marco AG, Xiao Q, Trinh V, Newton SM, Klebba PE.

Mol Microbiol. 2009 Jun;72(5):1171-80. doi: 10.1111/j.1365-2958.2009.06715.x. Epub 2009 Apr 30.

30.

1alpha,25-dihydroxyvitamin D3 inhibits matrix metalloproteinases induced by Mycobacterium tuberculosis infection.

Coussens A, Timms PM, Boucher BJ, Venton TR, Ashcroft AT, Skolimowska KH, Newton SM, Wilkinson KA, Davidson RN, Griffiths CJ, Wilkinson RJ, Martineau AR.

Immunology. 2009 Aug;127(4):539-48. doi: 10.1111/j.1365-2567.2008.03024.x. Epub 2008 Dec 18.

31.

Anti-flagellin antibody responses elicited in mice orally immunized with attenuated Salmonella enterica serovar Typhimurium vaccine strains.

Massis LM, Braga CJ, Sbrogio-Almeida ME, Lauand C, Newton SM, Klebba PE, Ferreira LC.

Mem Inst Oswaldo Cruz. 2008 Sep;103(6):606-10.

32.

Paediatric tuberculosis.

Newton SM, Brent AJ, Anderson S, Whittaker E, Kampmann B.

Lancet Infect Dis. 2008 Aug;8(8):498-510. doi: 10.1016/S1473-3099(08)70182-8. Review.

33.

Insight from TonB hybrid proteins into the mechanism of iron transport through the outer membrane.

Kaserer WA, Jiang X, Xiao Q, Scott DC, Bauler M, Copeland D, Newton SM, Klebba PE.

J Bacteriol. 2008 Jun;190(11):4001-16. doi: 10.1128/JB.00135-08. Epub 2008 Apr 4.

34.

Reduction of chemokine secretion in response to mycobacteria in infliximab-treated patients.

Newton SM, Mackie SL, Martineau AR, Wilkinson KA, Kampmann B, Fisher C, Dutta S, Levin M, Wilkinson RJ, Pasvol G.

Clin Vaccine Immunol. 2008 Mar;15(3):506-12. Epub 2007 Dec 26.

35.

IL-21 enhances antitumor responses without stimulating proliferation of malignant T cells of patients with Sézary syndrome.

Yoon JS, Newton SM, Wysocka M, Troxel AB, Hess SD, Richardson SK, Lin JH, Benoit BM, Kasprzycka M, Wasik MA, Rook AH.

J Invest Dermatol. 2008 Feb;128(2):473-80. Epub 2007 Aug 23.

36.

Neutrophil-mediated innate immune resistance to mycobacteria.

Martineau AR, Newton SM, Wilkinson KA, Kampmann B, Hall BM, Nawroly N, Packe GE, Davidson RN, Griffiths CJ, Wilkinson RJ.

J Clin Invest. 2007 Jul;117(7):1988-94.

37.

FepA- and TonB-dependent bacteriophage H8: receptor binding and genomic sequence.

Rabsch W, Ma L, Wiley G, Najar FZ, Kaserer W, Schuerch DW, Klebba JE, Roe BA, Laverde Gomez JA, Schallmey M, Newton SM, Klebba PE.

J Bacteriol. 2007 Aug;189(15):5658-74. Epub 2007 May 25.

38.

IFN-gamma- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37.

Martineau AR, Wilkinson KA, Newton SM, Floto RA, Norman AW, Skolimowska K, Davidson RN, Sørensen OE, Kampmann B, Griffiths CJ, Wilkinson RJ.

J Immunol. 2007 Jun 1;178(11):7190-8. Erratum in: J Immunol. 2007 Dec 15;179(12):8569-70.

39.

A single dose of vitamin D enhances immunity to mycobacteria.

Martineau AR, Wilkinson RJ, Wilkinson KA, Newton SM, Kampmann B, Hall BM, Packe GE, Davidson RN, Eldridge SM, Maunsell ZJ, Rainbow SJ, Berry JL, Griffiths CJ.

Am J Respir Crit Care Med. 2007 Jul 15;176(2):208-13. Epub 2007 Apr 26.

PMID:
17463418
40.

Evidence of ball-and-chain transport of ferric enterobactin through FepA.

Ma L, Kaserer W, Annamalai R, Scott DC, Jin B, Jiang X, Xiao Q, Maymani H, Massis LM, Ferreira LC, Newton SM, Klebba PE.

J Biol Chem. 2007 Jan 5;282(1):397-406. Epub 2006 Oct 20.

41.

A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion.

Newton SM, Smith RJ, Wilkinson KA, Nicol MP, Garton NJ, Staples KJ, Stewart GR, Wain JR, Martineau AR, Fandrich S, Smallie T, Foxwell B, Al-Obaidi A, Shafi J, Rajakumar K, Kampmann B, Andrew PW, Ziegler-Heitbrock L, Barer MR, Wilkinson RJ.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15594-8. Epub 2006 Oct 6. Erratum in: Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):685.

42.

Transmission of Mycobacterium tuberculosis undetected by tuberculin skin testing.

Anderson ST, Williams AJ, Brown JR, Newton SM, Simsova M, Nicol MP, Sebo P, Levin M, Wilkinson RJ, Wilkinson KA.

Am J Respir Crit Care Med. 2006 May 1;173(9):1038-42. Epub 2006 Feb 2.

PMID:
16456140
43.

Iron acquisition systems for ferric hydroxamates, haemin and haemoglobin in Listeria monocytogenes.

Jin B, Newton SM, Shao Y, Jiang X, Charbit A, Klebba PE.

Mol Microbiol. 2006 Feb;59(4):1185-98.

44.

Effect of treatment of latent tuberculosis infection on the T cell response to Mycobacterium tuberculosis antigens.

Wilkinson KA, Kon OM, Newton SM, Meintjes G, Davidson RN, Pasvol G, Wilkinson RJ.

J Infect Dis. 2006 Feb 1;193(3):354-9. Epub 2005 Dec 29.

PMID:
16388482
45.

Effect of deletion or overexpression of the 19-kilodalton lipoprotein Rv3763 on the innate response to Mycobacterium tuberculosis.

Stewart GR, Wilkinson KA, Newton SM, Sullivan SM, Neyrolles O, Wain JR, Patel J, Pool KL, Young DB, Wilkinson RJ.

Infect Immun. 2005 Oct;73(10):6831-7.

46.

Infection biology of a novel alpha-crystallin of Mycobacterium tuberculosis: Acr2.

Wilkinson KA, Stewart GR, Newton SM, Vordermeier HM, Wain JR, Murphy HN, Horner K, Young DB, Wilkinson RJ.

J Immunol. 2005 Apr 1;174(7):4237-43.

47.

The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis.

Stewart GR, Newton SM, Wilkinson KA, Humphreys IR, Murphy HN, Robertson BD, Wilkinson RJ, Young DB.

Mol Microbiol. 2005 Feb;55(4):1127-37.

48.

The svpA-srtB locus of Listeria monocytogenes: fur-mediated iron regulation and effect on virulence.

Newton SM, Klebba PE, Raynaud C, Shao Y, Jiang X, Dubail I, Archer C, Frehel C, Charbit A.

Mol Microbiol. 2005 Feb;55(3):927-40.

49.

Recognition of ferric catecholates by FepA.

Annamalai R, Jin B, Cao Z, Newton SM, Klebba PE.

J Bacteriol. 2004 Jun;186(11):3578-89.

50.

Spectroscopic observations of ferric enterobactin transport.

Cao Z, Warfel P, Newton SM, Klebba PE.

J Biol Chem. 2003 Jan 10;278(2):1022-8. Epub 2002 Oct 29.

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