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Items: 29


Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics.

Popow O, Paulo JA, Tatham MH, Volk MS, Rojas-Fernandez A, Loyer N, Newton IP, Januschke J, Haigis KM, Näthke I.

Mol Cancer Res. 2019 Sep;17(9):1828-1841. doi: 10.1158/1541-7786.MCR-18-1154. Epub 2019 Jun 3.


Lgr5+ intestinal stem cells reside in an unlicensed G1 phase.

Carroll TD, Newton IP, Chen Y, Blow JJ, Näthke I.

J Cell Biol. 2018 May 7;217(5):1667-1685. doi: 10.1083/jcb.201708023. Epub 2018 Mar 29.


SAP97 Binding Partner CRIPT Promotes Dendrite Growth In Vitro and In Vivo.

Zhang L, Jablonski AM, Mojsilovic-Petrovic J, Ding H, Seeholzer S, Newton IP, Nathke I, Neve R, Zhai J, Shang Y, Zhang M, Kalb RG.

eNeuro. 2017 Dec 6;4(6). pii: ENEURO.0175-17.2017. doi: 10.1523/ENEURO.0175-17.2017. eCollection 2017 Nov-Dec.


Interkinetic nuclear migration and basal tethering facilitates post-mitotic daughter separation in intestinal organoids.

Carroll TD, Langlands AJ, Osborne JM, Newton IP, Appleton PL, Näthke I.

J Cell Sci. 2017 Nov 15;130(22):3862-3877. doi: 10.1242/jcs.211656. Epub 2017 Oct 5.


Acoustic Sensing and Ultrasonic Drug Delivery in Multimodal Theranostic Capsule Endoscopy.

Stewart FR, Qiu Y, Lay HS, Newton IP, Cox BF, Al-Rawhani MA, Beeley J, Liu Y, Huang Z, Cumming DRS, Näthke I, Cochran S.

Sensors (Basel). 2017 Jul 3;17(7). pii: E1553. doi: 10.3390/s17071553.


Ultrasound capsule endoscopy: sounding out the future.

Cox BF, Stewart F, Lay H, Cummins G, Newton IP, Desmulliez MPY, Steele RJC, Näthke I, Cochran S.

Ann Transl Med. 2017 May;5(9):201. doi: 10.21037/atm.2017.04.21.


Increased variability in Apc(Min)/+ intestinal tissue can be measured with microultrasound.

Fatehullah A, Sharma S, Newton IP, Langlands AJ, Lay H, Nelson SA, McMahon RK, McIlvenny N, Appleton PL, Cochran S, Näthke IS.

Sci Rep. 2016 Jul 13;6:29570. doi: 10.1038/srep29570.


Paneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche.

Langlands AJ, Almet AA, Appleton PL, Newton IP, Osborne JM, Näthke IS.

PLoS Biol. 2016 Jun 27;14(6):e1002491. doi: 10.1371/journal.pbio.1002491. eCollection 2016 Jun.


Opposing actions of the synapse-associated protein of 97-kDa molecular weight (SAP97) and Disrupted in Schizophrenia 1 (DISC1) on Wnt/β-catenin signaling.

Boccitto M, Doshi S, Newton IP, Nathke I, Neve R, Dong F, Mao Y, Zhai J, Zhang L, Kalb R.

Neuroscience. 2016 Jun 21;326:22-30. doi: 10.1016/j.neuroscience.2016.03.048. Epub 2016 Mar 26.


GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKβ.

Li Z, Wang Y, Newton IP, Zhang L, Ji P, Li Z.

Cell Signal. 2015 Jun;27(6):1237-45. doi: 10.1016/j.cellsig.2015.02.030. Epub 2015 Mar 5.


Expression, purification and renaturation of truncated human integrin β1 from inclusion bodies of Escherichia coli.

Shi T, Zhang L, Li Z, Newton IP, Zhang Q.

Protein Expr Purif. 2015 Mar;107:13-9. doi: 10.1016/j.pep.2014.11.007. Epub 2014 Nov 21.


Dichlorodiphenyldichloroethylene exposure reduces r-GCS via suppressed Nrf2 in HepG2 cells.

Jin X, Song L, Li Z, Newton IP, Zhao M, Liu W.

Environ Toxicol. 2016 Mar;31(3):350-9. doi: 10.1002/tox.22049. Epub 2014 Sep 29.


N-terminal truncation mutations of adenomatous polyposis coli are associated with primary cilia defects.

Song L, Jia Y, Zhu W, Newton IP, Li Z, Li W.

Int J Biochem Cell Biol. 2014 Oct;55:79-86. doi: 10.1016/j.biocel.2014.08.010. Epub 2014 Aug 21.


Direct contacts with colon cancer cells regulate the differentiation of bone marrow mesenchymal stem cells into tumor associated fibroblasts.

Peng Y, Li Z, Yang P, Newton IP, Ren H, Zhang L, Wu H, Li Z.

Biochem Biophys Res Commun. 2014 Aug 15;451(1):68-73. doi: 10.1016/j.bbrc.2014.07.074. Epub 2014 Jul 22.


The organochlorine p,p'-dichlorodiphenyltrichloroethane induces colorectal cancer growth through Wnt/β-catenin signaling.

Song L, Zhao J, Jin X, Li Z, Newton IP, Liu W, Xiao H, Zhao M.

Toxicol Lett. 2014 Aug 17;229(1):284-91. doi: 10.1016/j.toxlet.2014.06.003. Epub 2014 Jun 23.


A novel protein extracted from foxtail millet bran displays anti-carcinogenic effects in human colon cancer cells.

Shan S, Li Z, Newton IP, Zhao C, Li Z, Guo M.

Toxicol Lett. 2014 Jun 5;227(2):129-38. doi: 10.1016/j.toxlet.2014.03.008. Epub 2014 Mar 28.


The adenomatous polyposis coli protein contributes to normal compaction of mitotic chromatin.

Dikovskaya D, Khoudoli G, Newton IP, Chadha GS, Klotz D, Visvanathan A, Lamond A, Swedlow JR, Näthke IS.

PLoS One. 2012;7(6):e38102. doi: 10.1371/journal.pone.0038102. Epub 2012 Jun 13.


Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems.

Nelson SA, Li Z, Newton IP, Fraser D, Milne RE, Martin DM, Schiffmann D, Yang X, Dormann D, Weijer CJ, Appleton PL, Näthke IS.

Dis Model Mech. 2012 Nov;5(6):940-7. doi: 10.1242/dmm.008607. Epub 2012 Apr 5.


The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively.

Klotz DM, Nelson SA, Kroboth K, Newton IP, Radulescu S, Ridgway RA, Sansom OJ, Appleton PL, Näthke IS.

J Cell Sci. 2012 Feb 15;125(Pt 4):887-95. doi: 10.1242/jcs.091843. Epub 2012 Mar 7.


Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection.

Newton IP, Kenneth NS, Appleton PL, Näthke I, Rocha S.

Mol Biol Cell. 2010 Nov 1;21(21):3630-8. doi: 10.1091/mbc.E10-04-0312. Epub 2010 Sep 15.


Microtubule assembly by the Apc protein is regulated by importin-beta--RanGTP.

Dikovskaya D, Li Z, Newton IP, Davidson I, Hutchins JR, Kalab P, Clarke PR, Näthke IS.

J Cell Sci. 2010 Mar 1;123(Pt 5):736-46. doi: 10.1242/jcs.060806. Epub 2010 Feb 9.


Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.

Buchert M, Athineos D, Abud HE, Burke ZD, Faux MC, Samuel MS, Jarnicki AG, Winbanks CE, Newton IP, Meniel VS, Suzuki H, Stacker SA, Näthke IS, Tosh D, Huelsken J, Clarke AR, Heath JK, Sansom OJ, Ernst M.

PLoS Genet. 2010 Jan 15;6(1):e1000816. doi: 10.1371/journal.pgen.1000816.


Novel self-association of the APC molecule affects APC clusters and cell migration.

Li Z, Kroboth K, Newton IP, Näthke IS.

J Cell Sci. 2008 Jun 1;121(11):1916-25. doi: 10.1242/jcs.029470. Epub 2008 May 13.


Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis.

Dikovskaya D, Schiffmann D, Newton IP, Oakley A, Kroboth K, Sansom O, Jamieson TJ, Meniel V, Clarke A, Näthke IS.

J Cell Biol. 2007 Jan 15;176(2):183-95. Erratum in: J Cell Biol. 2007 Jan 29;176(3):369.


Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability.

Kroboth K, Newton IP, Kita K, Dikovskaya D, Zumbrunn J, Waterman-Storer CM, Näthke IS.

Mol Biol Cell. 2007 Mar;18(3):910-8. Epub 2006 Dec 27.


Open microscopy environment and findspots: integrating image informatics with quantitative multidimensional image analysis.

Schiffmann DA, Dikovskaya D, Appleton PL, Newton IP, Creager DA, Allan C, Näthke IS, Goldberg IG.

Biotechniques. 2006 Aug;41(2):199-208.


Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.

Sansom OJ, Reed KR, Hayes AJ, Ireland H, Brinkmann H, Newton IP, Batlle E, Simon-Assmann P, Clevers H, Nathke IS, Clarke AR, Winton DJ.

Genes Dev. 2004 Jun 15;18(12):1385-90.


The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts.

Dikovskaya D, Newton IP, Näthke IS.

Mol Biol Cell. 2004 Jun;15(6):2978-91. Epub 2004 Apr 9.


Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis.

Alonzi T, Newton IP, Bryce PJ, Di Carlo E, Lattanzio G, Tripodi M, Musiani P, Poli V.

Cytokine. 2004 Apr 21;26(2):45-56.


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