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Allergen Delivery Inhibitors: Characterisation of Potent and Selective Inhibitors of Der p 1 and Their Attenuation of Airway Responses to House Dust Mite Allergens.

Zhang J, Chen J, Zuo J, Newton GK, Stewart MR, Perrior TR, Garrod DR, Robinson C.

Int J Mol Sci. 2018 Oct 15;19(10). pii: E3166. doi: 10.3390/ijms19103166.


Allergen Delivery Inhibitors: A Rationale for Targeting Sentinel Innate Immune Signaling of Group 1 House Dust Mite Allergens through Structure-Based Protease Inhibitor Design.

Zhang J, Chen J, Newton GK, Perrior TR, Robinson C.

Mol Pharmacol. 2018 Sep;94(3):1007-1030. doi: 10.1124/mol.118.112730. Epub 2018 Jul 5.


The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma.

Newton GK, Perrior TR, Jenkins K, Major MR, Key RE, Stewart MR, Firth-Clark S, Lloyd SM, Zhang J, Francis-Newton NJ, Richardson JP, Chen J, Lai P, Garrod DR, Robinson C.

J Med Chem. 2014 Nov 26;57(22):9447-62. doi: 10.1021/jm501102h. Epub 2014 Nov 17.


Nonhuman targets in allergic lung conditions.

Robinson C, Zhang J, Newton GK, Perrior TR.

Future Med Chem. 2013 Feb;5(2):147-61. doi: 10.4155/fmc.12.204. Review.


Future inhaled drugs by virtual innovation: allergen delivery inhibitors.

Robinson C, Zhang J, Garrod DR, Newton GK, Jenkins K, Perrior TR.

Future Med Chem. 2011 Oct;3(13):1567-70. doi: 10.4155/fmc.11.107. No abstract available.


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