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PHLPP1 counter-regulates STAT1-mediated inflammatory signaling.

Cohen Katsenelson K, Stender JD, Kawashima AT, Lordén G, Uchiyama S, Nizet V, Glass CK, Newton AC.

Elife. 2019 Aug 13;8. pii: e48609. doi: 10.7554/eLife.48609.


The PHLPP2 phosphatase is a druggable driver of prostate cancer progression.

Nowak DG, Katsenelson KC, Watrud KE, Chen M, Mathew G, D'Andrea VD, Lee MF, Swamynathan MM, Casanova-Salas I, Jibilian MC, Buckholtz CL, Ambrico AJ, Pan CH, Wilkinson JE, Newton AC, Trotman LC.

J Cell Biol. 2019 Jun 3;218(6):1943-1957. doi: 10.1083/jcb.201902048. Epub 2019 May 15.


Protein kinases in tune.

Newton AC.

IUBMB Life. 2019 Jun;71(6):670-671. doi: 10.1002/iub.2065. Epub 2019 May 6. No abstract available.


Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.

Baffi TR, Van AN, Zhao W, Mills GB, Newton AC.

Mol Cell. 2019 Apr 18;74(2):378-392.e5. doi: 10.1016/j.molcel.2019.02.018. Epub 2019 Mar 20.


Apical-basal polarity inhibits epithelial-mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation.

Jung HY, Fattet L, Tsai JH, Kajimoto T, Chang Q, Newton AC, Yang J.

Nat Cell Biol. 2019 Mar;21(3):359-371. doi: 10.1038/s41556-019-0291-8. Epub 2019 Feb 25.


Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter.

Kajimoto T, Caliman AD, Tobias IS, Okada T, Pilo CA, Van AN, Andrew McCammon J, Nakamura SI, Newton AC.

Sci Signal. 2019 Jan 1;12(562). pii: eaat6662. doi: 10.1126/scisignal.aat6662.


Impacts of deforestation on plant-pollinator networks assessed using an agent based model.

Newton AC, Boscolo D, Ferreira PA, Lopes LE, Evans P.

PLoS One. 2018 Dec 31;13(12):e0209406. doi: 10.1371/journal.pone.0209406. eCollection 2018.


Contrasting nutrient-disease relationships: Potassium gradients in barley leaves have opposite effects on two fungal pathogens with different sensitivities to jasmonic acid.

Davis JL, Armengaud P, Larson TR, Graham IA, White PJ, Newton AC, Amtmann A.

Plant Cell Environ. 2018 Oct;41(10):2357-2372. doi: 10.1111/pce.13350. Epub 2018 Jun 29.


Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation.

Callender JA, Yang Y, Lordén G, Stephenson NL, Jones AC, Brognard J, Newton AC.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5497-E5505. doi: 10.1073/pnas.1805046115. Epub 2018 May 29.


Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity.

Balasuriya N, Kunkel MT, Liu X, Biggar KK, Li SS, Newton AC, O'Donoghue P.

J Biol Chem. 2018 Jul 6;293(27):10744-10756. doi: 10.1074/jbc.RA118.002357. Epub 2018 May 17.


Post-translational modifications in priming the plant immune system: ripe for exploitation?

de Vega D, Newton AC, Sadanandom A.

FEBS Lett. 2018 Jun;592(12):1929-1936. doi: 10.1002/1873-3468.13076. Epub 2018 May 21. Review.


Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources.

Huang LC, Ross KE, Baffi TR, Drabkin H, Kochut KJ, Ruan Z, D'Eustachio P, McSkimming D, Arighi C, Chen C, Natale DA, Smith C, Gaudet P, Newton AC, Wu C, Kannan N.

Sci Rep. 2018 Apr 25;8(1):6518. doi: 10.1038/s41598-018-24457-1.


Protein kinase C: perfectly balanced.

Newton AC.

Crit Rev Biochem Mol Biol. 2018 Apr;53(2):208-230. doi: 10.1080/10409238.2018.1442408. Review.


Analysis of ecological thresholds in a temperate forest undergoing dieback.

Martin P, Newton AC, Cantarello E, Evans PM.

PLoS One. 2017 Dec 14;12(12):e0189578. doi: 10.1371/journal.pone.0189578. eCollection 2017.


Quantifying resilience of multiple ecosystem services and biodiversity in a temperate forest landscape.

Cantarello E, Newton AC, Martin PA, Evans PM, Gosal A, Lucash MS.

Ecol Evol. 2017 Oct 16;7(22):9661-9675. doi: 10.1002/ece3.3491. eCollection 2017 Nov.


The opposing effects of isotropic and anisotropic attraction on association kinetics of proteins and colloids.

Newton AC, Kools R, Swenson DWH, Bolhuis PG.

J Chem Phys. 2017 Oct 21;147(15):155101. doi: 10.1063/1.5006485.


Liming impacts on soils, crops and biodiversity in the UK: A review.

Holland JE, Bennett AE, Newton AC, White PJ, McKenzie BM, George TS, Pakeman RJ, Bailey JS, Fornara DA, Hayes RC.

Sci Total Environ. 2018 Jan 1;610-611:316-332. doi: 10.1016/j.scitotenv.2017.08.020. Epub 2017 Aug 11. Review.


Thresholds of biodiversity and ecosystem function in a forest ecosystem undergoing dieback.

Evans PM, Newton AC, Cantarello E, Martin P, Sanderson N, Jones DL, Barsoum N, Cottrell JE, A'Hara SW, Fuller L.

Sci Rep. 2017 Jul 28;7(1):6775. doi: 10.1038/s41598-017-06082-6.


Modelling critical Casimir force induced self-assembly experiments on patchy colloidal dumbbells.

Newton AC, Nguyen TA, Veen SJ, Kraft DJ, Schall P, Bolhuis PG.

Soft Matter. 2017 Jul 19;13(28):4903-4915. doi: 10.1039/c7sm00668c.


The role of multivalency in the association kinetics of patchy particle complexes.

Newton AC, Groenewold J, Kegel WK, Bolhuis PG.

J Chem Phys. 2017 Jun 21;146(23):234901. doi: 10.1063/1.4984966.


Modelling the role of groundwater hydro-refugia in East African hominin evolution and dispersal.

Cuthbert MO, Gleeson T, Reynolds SC, Bennett MR, Newton AC, McCormack CJ, Ashley GM.

Nat Commun. 2017 May 30;8:15696. doi: 10.1038/ncomms15696.


Protein kinase C as a tumor suppressor.

Newton AC.

Semin Cancer Biol. 2018 Feb;48:18-26. doi: 10.1016/j.semcancer.2017.04.017. Epub 2017 May 2. Review.


Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor.

Newton AC, Brognard J.

Trends Pharmacol Sci. 2017 May;38(5):438-447. doi: 10.1016/ Epub 2017 Mar 8. Review.


Impacts of invasive plants on carbon pools depend on both species' traits and local climate.

Martin PA, Newton AC, Bullock JM.

Ecology. 2017 Apr;98(4):1026-1035. doi: 10.1002/ecy.1711.


PHLPPing through history: a decade in the life of PHLPP phosphatases.

Grzechnik AT, Newton AC.

Biochem Soc Trans. 2016 Dec 15;44(6):1675-1682. Review.


KinView: a visual comparative sequence analysis tool for integrated kinome research.

McSkimming DI, Dastgheib S, Baffi TR, Byrne DP, Ferries S, Scott ST, Newton AC, Eyers CE, Kochut KJ, Eyers PA, Kannan N.

Mol Biosyst. 2016 Nov 15;12(12):3651-3665.


Second Messengers.

Newton AC, Bootman MD, Scott JD.

Cold Spring Harb Perspect Biol. 2016 Aug 1;8(8). pii: a005926. doi: 10.1101/cshperspect.a005926. Review.


Protein kinase C mechanisms that contribute to cardiac remodelling.

Newton AC, Antal CE, Steinberg SF.

Clin Sci (Lond). 2016 Sep 1;130(17):1499-510. doi: 10.1042/CS20160036. Review.


Bacterial spore coat protein kinases: A new twist to an old story.

Scott JD, Newton AC.

Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6811-2. doi: 10.1073/pnas.1607004113. Epub 2016 Jun 10. No abstract available.


Exploitation of Diversity within Crops-the Key to Disease Tolerance?

Newton AC.

Front Plant Sci. 2016 May 20;7:665. doi: 10.3389/fpls.2016.00665. eCollection 2016.


Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity.

Hollands A, Corriden R, Gysler G, Dahesh S, Olson J, Raza Ali S, Kunkel MT, Lin AE, Forli S, Newton AC, Kumar GB, Nair BG, Perry JJ, Nizet V.

J Biol Chem. 2016 Jul 1;291(27):13964-73. doi: 10.1074/jbc.M115.695866. Epub 2016 May 13.


Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease.

Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R.

Sci Signal. 2016 May 10;9(427):ra47. doi: 10.1126/scisignal.aaf6209.


Science Signaling Podcast for 10 May 2016: PKCα in Alzheimer's disease.

Newton AC, Tanzi RE, VanHook AM.

Sci Signal. 2016 May 10;9(427):pc11. doi: 10.1126/scisignal.aaf9436.


Protein Scaffolds Control Localized Protein Kinase Cζ Activity.

Tobias IS, Newton AC.

J Biol Chem. 2016 Jun 24;291(26):13809-22. doi: 10.1074/jbc.M116.729483. Epub 2016 May 3.


Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival.

Dowling CM, Phelan J, Callender JA, Cathcart MC, Mehigan B, McCormick P, Dalton T, Coffey JC, Newton AC, O'Sullivan J, Kiely PA.

Oncotarget. 2016 Apr 12;7(15):20919-33. doi: 10.18632/oncotarget.8062.


Similar biodiversity of ectomycorrhizal fungi in set-aside plantations and ancient old-growth broadleaved forests.

Spake R, van der Linde S, Newton AC, Suz LM, Bidartondo MI, Doncaster CP.

Biol Conserv. 2016 Feb;194:71-79.


Drivers of the composition and diversity of carabid functional traits in UK coniferous plantations.

Spake R, Barsoum N, Newton AC, Doncaster CP.

For Ecol Manage. 2016 Jan 1;359:300-308.


Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation.

Tobias IS, Kaulich M, Kim PK, Simon N, Jacinto E, Dowdy SF, King CC, Newton AC.

Biochem J. 2016 Feb 15;473(4):509-23. doi: 10.1042/BJ20151013. Epub 2015 Dec 3.


Rotational diffusion affects the dynamical self-assembly pathways of patchy particles.

Newton AC, Groenewold J, Kegel WK, Bolhuis PG.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15308-13. doi: 10.1073/pnas.1513210112. Epub 2015 Nov 30.


A transcriptional reference map of defence hormone responses in potato.

Wiesel L, Davis JL, Milne L, Redondo Fernandez V, Herold MB, Middlefell Williams J, Morris J, Hedley PE, Harrower B, Newton AC, Birch PRJ, Gilroy EM, Hein I.

Sci Rep. 2015 Oct 19;5:15229. doi: 10.1038/srep15229.


Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII.

Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC.

Cell Rep. 2015 Aug 25;12(8):1252-60. doi: 10.1016/j.celrep.2015.07.039. Epub 2015 Aug 13.


Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62.

Tsai LC, Xie L, Dore K, Xie L, Del Rio JC, King CC, Martinez-Ariza G, Hulme C, Malinow R, Bourne PE, Newton AC.

J Biol Chem. 2015 Sep 4;290(36):21845-56. doi: 10.1074/jbc.M115.676221. Epub 2015 Jul 17.


The Relative Impact of Climate Change on the Extinction Risk of Tree Species in the Montane Tropical Andes.

Tejedor Garavito N, Newton AC, Golicher D, Oldfield S.

PLoS One. 2015 Jul 15;10(7):e0131388. doi: 10.1371/journal.pone.0131388. eCollection 2015.


Habitat Fragmentation Intensifies Trade-Offs between Biodiversity and Ecosystem Services in a Heathland Ecosystem in Southern England.

Cordingley JE, Newton AC, Rose RJ, Clarke RT, Bullock JM.

PLoS One. 2015 Jun 26;10(6):e0130004. doi: 10.1371/journal.pone.0130004. eCollection 2015.


A meta-analysis of functional group responses to forest recovery outside of the tropics.

Spake R, Ezard TH, Martin PA, Newton AC, Doncaster CP.

Conserv Biol. 2015 Dec;29(6):1695-703. doi: 10.1111/cobi.12548. Epub 2015 Jun 3.


Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation.

Bradley EW, Carpio LR, Newton AC, Westendorf JJ.

J Biol Chem. 2015 Jun 26;290(26):16272-80. doi: 10.1074/jbc.M114.612937. Epub 2015 May 7.


Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.

Midde KK, Aznar N, Laederich MB, Ma GS, Kunkel MT, Newton AC, Ghosh P.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E937-46. doi: 10.1073/pnas.1420140112. Epub 2015 Feb 17. Erratum in: Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1509.


Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor.

Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC.

Cell. 2015 Jan 29;160(3):489-502. doi: 10.1016/j.cell.2015.01.001. Epub 2015 Jan 22.


Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation.

Kunkel MT, Newton AC.

Chem Biol. 2015 Jan 22;22(1):98-106. doi: 10.1016/j.chembiol.2014.11.014. Epub 2014 Dec 31.


Molecular effects of resistance elicitors from biological origin and their potential for crop protection.

Wiesel L, Newton AC, Elliott I, Booty D, Gilroy EM, Birch PR, Hein I.

Front Plant Sci. 2014 Nov 21;5:655. doi: 10.3389/fpls.2014.00655. eCollection 2014. Review.

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