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Items: 22


Proteolysis suppresses spontaneous prion generation in yeast.

Okamoto A, Hosoda N, Tanaka A, Newnam GP, Chernoff YO, Hoshino SI.

J Biol Chem. 2017 Dec 8;292(49):20113-20124. doi: 10.1074/jbc.M117.811323. Epub 2017 Oct 16.


To CURe or not to CURe? Differential effects of the chaperone sorting factor Cur1 on yeast prions are mediated by the chaperone Sis1.

Barbitoff YA, Matveenko AG, Moskalenko SE, Zemlyanko OM, Newnam GP, Patel A, Chernova TA, Chernoff YO, Zhouravleva GA.

Mol Microbiol. 2017 Jul;105(2):242-257. doi: 10.1111/mmi.13697. Epub 2017 May 9.


RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils.

Zaarur N, Xu X, Lestienne P, Meriin AB, McComb M, Costello CE, Newnam GP, Ganti R, Romanova NV, Shanmugasundaram M, Silva ST, Bandeiras TM, Matias PM, Lobachev KS, Lednev IK, Chernoff YO, Sherman MY.

EMBO J. 2015 Sep 14;34(18):2363-82. doi: 10.15252/embj.201591245. Epub 2015 Aug 24.


Feedback control of prion formation and propagation by the ribosome-associated chaperone complex.

Kiktev DA, Melomed MM, Lu CD, Newnam GP, Chernoff YO.

Mol Microbiol. 2015 May;96(3):621-32. doi: 10.1111/mmi.12960. Epub 2015 Mar 11.


Stress-dependent proteolytic processing of the actin assembly protein Lsb1 modulates a yeast prion.

Ali M, Chernova TA, Newnam GP, Yin L, Shanks J, Karpova TS, Lee A, Laur O, Subramanian S, Kim D, McNally JG, Seyfried NT, Chernoff YO, Wilkinson KD.

J Biol Chem. 2014 Oct 3;289(40):27625-39. doi: 10.1074/jbc.M114.582429. Epub 2014 Aug 20.


Polyglutamine toxicity is controlled by prion composition and gene dosage in yeast.

Gong H, Romanova NV, Allen KD, Chandramowlishwaran P, Gokhale K, Newnam GP, Mieczkowski P, Sherman MY, Chernoff YO.

PLoS Genet. 2012;8(4):e1002634. doi: 10.1371/journal.pgen.1002634. Epub 2012 Apr 19.


Destabilization and recovery of a yeast prion after mild heat shock.

Newnam GP, Birchmore JL, Chernoff YO.

J Mol Biol. 2011 May 6;408(3):432-48. doi: 10.1016/j.jmb.2011.02.034. Epub 2011 Mar 15.


Genetic and epigenetic control of the efficiency and fidelity of cross-species prion transmission.

Chen B, Bruce KL, Newnam GP, Gyoneva S, Romanyuk AV, Chernoff YO.

Mol Microbiol. 2010 Jun;76(6):1483-99. doi: 10.1111/j.1365-2958.2010.07177.x. Epub 2010 Apr 23.


Prion species barrier between the closely related yeast proteins is detected despite coaggregation.

Chen B, Newnam GP, Chernoff YO.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2791-6. Epub 2007 Feb 12.


Modulation of prion formation, aggregation, and toxicity by the actin cytoskeleton in yeast.

Ganusova EE, Ozolins LN, Bhagat S, Newnam GP, Wegrzyn RD, Sherman MY, Chernoff YO.

Mol Cell Biol. 2006 Jan;26(2):617-29.


Prion variant maintained only at high levels of the Hsp104 disaggregase.

Borchsenius AS, Müller S, Newnam GP, Inge-Vechtomov SG, Chernoff YO.

Curr Genet. 2006 Jan;49(1):21-9. Epub 2005 Nov 24.


Modulation of prion-dependent polyglutamine aggregation and toxicity by chaperone proteins in the yeast model.

Gokhale KC, Newnam GP, Sherman MY, Chernoff YO.

J Biol Chem. 2005 Jun 17;280(24):22809-18. Epub 2005 Apr 11.


Hsp70 chaperones as modulators of prion life cycle: novel effects of Ssa and Ssb on the Saccharomyces cerevisiae prion [PSI+].

Allen KD, Wegrzyn RD, Chernova TA, Müller S, Newnam GP, Winslett PA, Wittich KB, Wilkinson KD, Chernoff YO.

Genetics. 2005 Mar;169(3):1227-42. Epub 2004 Nov 15.


Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1.

Meriin AB, Zhang X, He X, Newnam GP, Chernoff YO, Sherman MY.

J Cell Biol. 2002 Jun 10;157(6):997-1004. Epub 2002 Jun 10. Erratum in: J Cell Biol 2002 Aug 5;158(3):591.


Yeast prion protein derivative defective in aggregate shearing and production of new 'seeds'.

Borchsenius AS, Wegrzyn RD, Newnam GP, Inge-Vechtomov SG, Chernoff YO.

EMBO J. 2001 Dec 3;20(23):6683-91.


Mechanism of prion loss after Hsp104 inactivation in yeast.

Wegrzyn RD, Bapat K, Newnam GP, Zink AD, Chernoff YO.

Mol Cell Biol. 2001 Jul;21(14):4656-69.


An antiprion effect of the anticytoskeletal drug latrunculin A in yeast.

Bailleul-Winslett PA, Newnam GP, Wegrzyn RD, Chernoff YO.

Gene Expr. 2000;9(3):145-56.


Evolutionary conservation of prion-forming abilities of the yeast Sup35 protein.

Chernoff YO, Galkin AP, Lewitin E, Chernova TA, Newnam GP, Belenkiy SM.

Mol Microbiol. 2000 Feb;35(4):865-76.


Antagonistic interactions between yeast chaperones Hsp104 and Hsp70 in prion curing.

Newnam GP, Wegrzyn RD, Lindquist SL, Chernoff YO.

Mol Cell Biol. 1999 Feb;19(2):1325-33.


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