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Items: 1 to 50 of 186


Diacylglycerol kinase ζ is a negative regulator of GPVI-mediated platelet activation.

Moroi AJ, Zwifelhofer NM, Riese MJ, Newman DK, Newman PJ.

Blood Adv. 2019 Apr 9;3(7):1154-1166. doi: 10.1182/bloodadvances.2018026328.


Packaging functionally important plasma proteins into the α-granules of human-induced pluripotent stem cell-derived megakaryocytes.

Zhang N, Newman PJ.

J Tissue Eng Regen Med. 2019 Feb;13(2):244-252. doi: 10.1002/term.2785. Epub 2019 Jan 4.


Hemizygosity for the gene encoding glycoprotein Ibβ is not responsible for macrothrombocytopenia and bleeding in patients with 22q11 deletion syndrome.

Zwifelhofer NMJ, Bercovitz RS, Weik LA, Moroi A, LaRose S, Newman PJ, Newman DK.

J Thromb Haemost. 2019 Feb;17(2):295-305. doi: 10.1111/jth.14357. Epub 2019 Jan 22.


High-resolution mapping of the polyclonal immune response to the human platelet alloantigen HPA-1a (PlA1).

Zhi H, Ahlen MT, Thinn AMM, Weiler H, Curtis BR, Skogen B, Zhu J, Newman PJ.

Blood Adv. 2018 Nov 13;2(21):3001-3011. doi: 10.1182/bloodadvances.2018023341.


Frontline Science: PECAM-1 (CD31) expression in naïve and memory, but not acutely activated, CD8+ T cells.

Newman DK, Fu G, McOlash L, Schauder D, Newman PJ, Cui W, Rao S, Johnson BD, Gershan JA, Riese MJ.

J Leukoc Biol. 2018 Nov;104(5):883-893. doi: 10.1002/JLB.2HI0617-229RRR. Epub 2018 Jul 31.


Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration.

Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, McKenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1550-E1559. doi: 10.1073/pnas.1720553115. Epub 2018 Jan 31.


CRISPR-mediated deletion of the PECAM-1 cytoplasmic domain increases receptor lateral mobility and strengthens endothelial cell junctional integrity.

Liao D, Mei H, Hu Y, Newman DK, Newman PJ.

Life Sci. 2018 Jan 15;193:186-193. doi: 10.1016/j.lfs.2017.11.002. Epub 2017 Nov 6.


The Role of Sialylated Glycans in Human Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1)-mediated Trans Homophilic Interactions and Endothelial Cell Barrier Function.

Lertkiatmongkol P, Paddock C, Newman DK, Zhu J, Thomas MJ, Newman PJ.

J Biol Chem. 2016 Dec 9;291(50):26216-26225. Epub 2016 Oct 28.


Integrin-αIIbβ3-mediated outside-in signalling activates a negative feedback pathway to suppress platelet activation.

Dai B, Wu P, Xue F, Yang R, Yu Z, Dai K, Ruan C, Liu G, Newman PJ, Gao C.

Thromb Haemost. 2016 Oct 28;116(5):918-930. Epub 2016 Jul 28.


Antiendothelial αvβ3 Antibodies Are a Major Cause of Intracranial Bleeding in Fetal/Neonatal Alloimmune Thrombocytopenia.

Santoso S, Wihadmadyatami H, Bakchoul T, Werth S, Al-Fakhri N, Bein G, Kiefel V, Zhu J, Newman PJ, Bayat B, Sachs UJ.

Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1517-24. doi: 10.1161/ATVBAHA.116.307281. Epub 2016 Jun 9.


Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31).

Lertkiatmongkol P, Liao D, Mei H, Hu Y, Newman PJ.

Curr Opin Hematol. 2016 May;23(3):253-9. doi: 10.1097/MOH.0000000000000239. Review.


Structural basis for PECAM-1 homophilic binding.

Paddock C, Zhou D, Lertkiatmongkol P, Newman PJ, Zhu J.

Blood. 2016 Feb 25;127(8):1052-61. doi: 10.1182/blood-2015-07-660092. Epub 2015 Dec 23.


CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes.

Zhang N, Zhi H, Curtis BR, Rao S, Jobaliya C, Poncz M, French DL, Newman PJ.

Blood. 2016 Feb 11;127(6):675-80. doi: 10.1182/blood-2015-10-675751. Epub 2015 Dec 3.


Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase.

Zhi H, Dai J, Liu J, Zhu J, Newman DK, Gao C, Newman PJ.

PLoS One. 2015 Aug 20;10(8):e0135738. doi: 10.1371/journal.pone.0135738. eCollection 2015.


Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1.

Zheng Y, Adams T, Zhi H, Yu M, Wen R, Newman PJ, Wang D, Newman DK.

PLoS One. 2015 Mar 20;10(3):e0119739. doi: 10.1371/journal.pone.0119739. eCollection 2015.


Regulation of endothelial cell barrier function by antibody-driven affinity modulation of platelet endothelial cell adhesion molecule-1 (PECAM-1).

Mei H, Campbell JM, Paddock CM, Lertkiatmongkol P, Mosesson MW, Albrecht R, Newman PJ.

J Biol Chem. 2014 Jul 25;289(30):20836-44.


PECAM-1: regulator of endothelial junctional integrity.

Privratsky JR, Newman PJ.

Cell Tissue Res. 2014 Mar;355(3):607-19. doi: 10.1007/s00441-013-1779-3. Epub 2014 Jan 17. Review.


Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia.

Kanaji T, Kanaji S, Montgomery RR, Patel SB, Newman PJ.

Blood. 2013 Oct 10;122(15):2732-42. doi: 10.1182/blood-2013-06-510461. Epub 2013 Aug 7.


Inhibition of HPA-1a alloantibody-mediated platelet destruction by a deglycosylated anti-HPA-1a monoclonal antibody in mice: toward targeted treatment of fetal-alloimmune thrombocytopenia.

Bakchoul T, Greinacher A, Sachs UJ, Krautwurst A, Renz H, Harb H, Bein G, Newman PJ, Santoso S.

Blood. 2013 Jul 18;122(3):321-7. doi: 10.1182/blood-2012-11-468561. Epub 2013 May 3.


Immunoreceptor tyrosine-based inhibitory motif (ITIM)-mediated inhibitory signaling is regulated by sequential phosphorylation mediated by distinct nonreceptor tyrosine kinases: a case study involving PECAM-1.

Tourdot BE, Brenner MK, Keough KC, Holyst T, Newman PJ, Newman DK.

Biochemistry. 2013 Apr 16;52(15):2597-608. doi: 10.1021/bi301461t. Epub 2013 Apr 3.


Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo.

Zhi H, Rauova L, Hayes V, Gao C, Boylan B, Newman DK, McKenzie SE, Cooley BC, Poncz M, Newman PJ.

Blood. 2013 Mar 7;121(10):1858-67. doi: 10.1182/blood-2012-07-443325. Epub 2012 Dec 20.


Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function.

Kuckleburg CJ, Newman PJ.

Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):275-84. doi: 10.1161/ATVBAHA.112.300474. Epub 2012 Nov 29.


Cadherin 6 has a functional role in platelet aggregation and thrombus formation.

Dunne E, Spring CM, Reheman A, Jin W, Berndt MC, Newman DK, Newman PJ, Ni H, Kenny D.

Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1724-31. doi: 10.1161/ATVBAHA.112.250464. Epub 2012 Apr 26.


Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils.

Kuckleburg CJ, Tilkens SB, Santoso S, Newman PJ.

J Immunol. 2012 Mar 1;188(5):2419-26. doi: 10.4049/jimmunol.1102540. Epub 2012 Jan 20.


GPIbα regulates platelet size by controlling the subcellular localization of filamin.

Kanaji T, Ware J, Okamura T, Newman PJ.

Blood. 2012 Mar 22;119(12):2906-13. doi: 10.1182/blood-2011-08-376566. Epub 2011 Dec 15.


PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte trafficking.

Privratsky JR, Tilkens SB, Newman DK, Newman PJ.

Life Sci. 2012 Jan 30;90(5-6):177-84. doi: 10.1016/j.lfs.2011.11.002. Epub 2011 Nov 18.


Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity.

Privratsky JR, Paddock CM, Florey O, Newman DK, Muller WA, Newman PJ.

J Cell Sci. 2011 May 1;124(Pt 9):1477-85. doi: 10.1242/jcs.082271. Epub 2011 Apr 12.


Residues within a lipid-associated segment of the PECAM-1 cytoplasmic domain are susceptible to inducible, sequential phosphorylation.

Paddock C, Lytle BL, Peterson FC, Holyst T, Newman PJ, Volkman BF, Newman DK.

Blood. 2011 Jun 2;117(22):6012-23. doi: 10.1182/blood-2010-11-317867. Epub 2011 Apr 4.


Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling.

Gao C, Boylan B, Fang J, Wilcox DA, Newman DK, Newman PJ.

Blood. 2011 May 5;117(18):4946-52. doi: 10.1182/blood-2010-09-307751. Epub 2011 Mar 2.


Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation.

Ming Z, Hu Y, Xiang J, Polewski P, Newman PJ, Newman DK.

Blood. 2011 Apr 7;117(14):3903-6. doi: 10.1182/blood-2010-09-304816. Epub 2011 Feb 4.


Effect on ex vivo platelet aggregation and in vivo cyclic flow with Na+/H+ exchange inhibition: Gumina, NHE-1 inhibition and platelet aggregation.

Gumina RJ, Newman PJ, Gross GJ.

J Thromb Thrombolysis. 2011 May;31(4):431-5. doi: 10.1007/s11239-010-0530-0.


Mechanism of outside-in {alpha}IIb{beta}3-mediated activation of human platelets by the colonizing Bacterium, Streptococcus gordonii.

Keane C, Petersen H, Reynolds K, Newman DK, Cox D, Jenkinson HF, Newman PJ, Kerrigan SW.

Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2408-15. doi: 10.1161/ATVBAHA.110.216515. Epub 2010 Nov 11.


GPVI and the not so eager cleaver.

Newman PJ.

Blood. 2010 Oct 28;116(17):3124-6. doi: 10.1182/blood-2010-08-299255.


Drug-dependent clearance of human platelets in the NOD/scid mouse by antibodies from patients with drug-induced immune thrombocytopenia.

Bougie DW, Nayak D, Boylan B, Newman PJ, Aster RH.

Blood. 2010 Oct 21;116(16):3033-8. doi: 10.1182/blood-2010-03-277764. Epub 2010 Jun 29.


PECAM-1: conflicts of interest in inflammation.

Privratsky JR, Newman DK, Newman PJ.

Life Sci. 2010 Jul 17;87(3-4):69-82. doi: 10.1016/j.lfs.2010.06.001. Epub 2010 Jun 10. Review.


PECAM-1 functions as a negative regulator of laminin-induced platelet activation.

Crockett J, Newman DK, Newman PJ.

J Thromb Haemost. 2010 Jul;8(7):1584-93. doi: 10.1111/j.1538-7836.2010.03883.x. Epub 2010 Apr 16.


Neutrophil transmigration mediated by the neutrophil-specific antigen CD177 is influenced by the endothelial S536N dimorphism of platelet endothelial cell adhesion molecule-1.

Bayat B, Werth S, Sachs UJ, Newman DK, Newman PJ, Santoso S.

J Immunol. 2010 Apr 1;184(7):3889-96. doi: 10.4049/jimmunol.0903136. Epub 2010 Mar 1.


The anti-inflammatory actions of platelet endothelial cell adhesion molecule-1 do not involve regulation of endothelial cell NF-kappa B.

Privratsky JR, Tourdot BE, Newman DK, Newman PJ.

J Immunol. 2010 Mar 15;184(6):3157-63. doi: 10.4049/jimmunol.0901944. Epub 2010 Feb 19.


Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcgammaRIIa and the integrin beta3 cytoplasmic domain.

Gao C, Boylan B, Bougie D, Gill JC, Birenbaum J, Newman DK, Aster RH, Newman PJ.

J Clin Invest. 2009 Mar;119(3):504-11. doi: 10.1172/JCI36745. Epub 2009 Feb 9.


Blockade of maternal anti-HPA-1a-mediated platelet clearance by an HPA-1a epitope-specific F(ab') in an in vivo mouse model of alloimmune thrombocytopenia.

Bakchoul T, Boylan B, Sachs UJ, Bein G, Ruan C, Santoso S, Newman PJ.

Transfusion. 2009 Feb;49(2):265-70. doi: 10.1111/j.1537-2995.2008.01972.x. Epub 2008 Nov 4.


Site-specific effects of PECAM-1 on atherosclerosis in LDL receptor-deficient mice.

Goel R, Schrank BR, Arora S, Boylan B, Fleming B, Miura H, Newman PJ, Molthen RC, Newman DK.

Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):1996-2002. doi: 10.1161/ATVBAHA.108.172270. Epub 2008 Jul 31.


Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human platelets.

Boylan B, Gao C, Rathore V, Gill JC, Newman DK, Newman PJ.

Blood. 2008 Oct 1;112(7):2780-6. doi: 10.1182/blood-2008-02-142125. Epub 2008 Jul 18.


On the electrodeposition of titanium in ionic liquids.

Endres F, Zein El Abedin S, Saad AY, Moustafa EM, Borissenko N, Price WE, Wallace GG, MacFarlane DR, Newman PJ, Bund A.

Phys Chem Chem Phys. 2008 Apr 28;10(16):2189-99. doi: 10.1039/b800353j. Epub 2008 Feb 27.


The proinflammatory phenotype of PECAM-1-deficient mice results in atherogenic diet-induced steatohepatitis.

Goel R, Boylan B, Gruman L, Newman PJ, North PE, Newman DK.

Am J Physiol Gastrointest Liver Physiol. 2007 Dec;293(6):G1205-14. Epub 2007 Oct 11.


The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31).

Sachs UJ, Andrei-Selmer CL, Maniar A, Weiss T, Paddock C, Orlova VV, Choi EY, Newman PJ, Preissner KT, Chavakis T, Santoso S.

J Biol Chem. 2007 Aug 10;282(32):23603-12. Epub 2007 Jun 19.


HPA-1a/b(PlA1/A2,Zwa/b): the odyssey of an alloantigen system.

Aster RH, Newman PJ.

Immunohematology. 2007;23(1):2-8. Review. No abstract available.


Tests of the extension and deadbolt models of integrin activation.

Zhu J, Boylan B, Luo BH, Newman PJ, Springer TA.

J Biol Chem. 2007 Apr 20;282(16):11914-20. Epub 2007 Feb 13.


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