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Items: 1 to 50 of 220

1.

Isolation, Structure Elucidation, and Antiproliferative Activity of Butanolides and Lignan Glycosides from the Fruit of Hernandia nymphaeifolia.

Aimaiti S, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

Molecules. 2019 Nov 5;24(21). pii: E4005. doi: 10.3390/molecules24214005.

2.

Prenylated Acetophloroglucinol Dimers from Acronychia trifoliolata: Structure Elucidation and Total Synthesis.

Miyake K, Morita C, Suzuki A, Matsushita N, Saito Y, Goto M, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

J Nat Prod. 2019 Oct 25;82(10):2852-2858. doi: 10.1021/acs.jnatprod.9b00596. Epub 2019 Sep 24.

PMID:
31550158
3.

Spiro[3.5]nonenyl Meroterpenoid Lactones, Cryptolaevilactones G-L, an Ionone Derivative, and Total Synthesis of Cryptolaevilactone M from Cryptocarya laevigata.

Tsurumi F, Miura Y, Nakano M, Saito Y, Fukuyoshi S, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

J Nat Prod. 2019 Sep 27;82(9):2368-2378. doi: 10.1021/acs.jnatprod.8b00732. Epub 2019 Aug 23.

PMID:
31442048
4.

The NCI library of traditional Chinese medicinal plant extracts - Preliminary assessment of the NCI-60 activity and chemical profiling of selected species.

He M, Grkovic T, Evans JR, Thornburg CC, Akee RK, Thompson JR, Whitt JA, Harris MJ, Loyal JA, Britt JR, Jia L, White JD, Newman DJ, O'Keefe BR.

Fitoterapia. 2019 Sep;137:104285. doi: 10.1016/j.fitote.2019.104285. Epub 2019 Aug 3.

PMID:
31386897
5.

The "Utility" of Highly Toxic Marine-Sourced Compounds.

Newman DJ.

Mar Drugs. 2019 May 31;17(6). pii: E324. doi: 10.3390/md17060324. Review.

6.

The impact of decreasing biodiversity on novel drug discovery: is there a serious cause for concern?

Newman DJ.

Expert Opin Drug Discov. 2019 Jun;14(6):521-525. doi: 10.1080/17460441.2019.1593370. Epub 2019 Mar 22.

PMID:
30902034
7.

Special Issue in Honor of Dr. Barbara N. Timmermann.

Cardellina JH 2nd, Cragg GM, Kingston DGI, Newman DJ.

J Nat Prod. 2019 Mar 22;82(3):425-426. doi: 10.1021/acs.jnatprod.9b00008. No abstract available.

PMID:
30897909
8.

Erythrofordins D and E, two new cassaine-type diterpenes from Erythrophleum suaveolens.

Grkovic T, Evans JR, Akee RK, Guo L, Davis M, Jato J, Grothaus PG, Ahalt-Gottholm M, Hollingshead M, Collins JM, Newman DJ, O'Keefe BR.

Bioorg Med Chem Lett. 2019 Jan 15;29(2):134-137. doi: 10.1016/j.bmcl.2018.12.019. Epub 2018 Dec 10.

PMID:
30553734
9.

Are Microbial Endophytes the 'Actual' Producers of Bioactive Antitumor Agents?

Newman DJ.

Trends Cancer. 2018 Oct;4(10):662-670. doi: 10.1016/j.trecan.2018.08.002. Epub 2018 Sep 7. Review.

PMID:
30292350
10.

Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species.

Takeuchi M, Saito Y, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

J Nat Prod. 2018 Aug 24;81(8):1884-1891. doi: 10.1021/acs.jnatprod.8b00411. Epub 2018 Aug 14.

11.

NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening.

Thornburg CC, Britt JR, Evans JR, Akee RK, Whitt JA, Trinh SK, Harris MJ, Thompson JR, Ewing TL, Shipley SM, Grothaus PG, Newman DJ, Schneider JP, Grkovic T, O'Keefe BR.

ACS Chem Biol. 2018 Sep 21;13(9):2484-2497. doi: 10.1021/acschembio.8b00389. Epub 2018 Jun 13.

PMID:
29812901
12.

Predicting pork loin intramuscular fat using computer vision system.

Liu JH, Sun X, Young JM, Bachmeier LA, Newman DJ.

Meat Sci. 2018 Sep;143:18-23. doi: 10.1016/j.meatsci.2018.03.020. Epub 2018 Mar 26.

PMID:
29684840
13.

Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata.

Tsurumi F, Miura Y, Saito Y, Miyake K, Fujie T, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

Org Lett. 2018 Apr 20;20(8):2282-2286. doi: 10.1021/acs.orglett.8b00624. Epub 2018 Apr 6.

14.

Bioactive cyclic molecules and drug design.

Newman DJ.

Expert Opin Drug Discov. 2018 May;13(5):379-385. doi: 10.1080/17460441.2018.1445085. Epub 2018 Mar 7. No abstract available.

PMID:
29513042
15.

Novel Modifications of Glycopeptide Antibiotics via Total Synthesis.

Newman DJ.

ACS Med Chem Lett. 2018 Jan 26;9(2):66-67. doi: 10.1021/acsmedchemlett.8b00029. eCollection 2018 Feb 8.

16.

Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa.

Aimaiti S, Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

J Org Chem. 2018 Jan 19;83(2):951-963. doi: 10.1021/acs.joc.7b02951. Epub 2018 Jan 10.

17.

Early Stage Anodic Instability of Glassy Carbon Electrodes in Propylene Carbonate Solvent Containing Lithium Hexafluorophosphate.

Carino EV, Newman DJ, Connell JG, Kim C, Brushett FR.

Langmuir. 2017 Oct 31;33(43):11911-11918. doi: 10.1021/acs.langmuir.7b02243. Epub 2017 Oct 13.

PMID:
28927271
18.

Current Status of Marine-Derived Compounds as Warheads in Anti-Tumor Drug Candidates.

Newman DJ, Cragg GM.

Mar Drugs. 2017 Mar 29;15(4). pii: E99. doi: 10.3390/md15040099. Review.

19.

Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa.

Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

J Nat Prod. 2017 Apr 28;80(4):1065-1072. doi: 10.1021/acs.jnatprod.6b01151. Epub 2017 Mar 14.

20.

(-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks.

Suzuki Y, Saito Y, Goto M, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

J Nat Prod. 2017 Jan 27;80(1):220-224. doi: 10.1021/acs.jnatprod.6b01153. Epub 2017 Jan 18.

21.

Predominately Uncultured Microbes as Sources of Bioactive Agents.

Newman DJ.

Front Microbiol. 2016 Nov 18;7:1832. eCollection 2016. Review.

22.

Acetophenone Monomers from Acronychia trifoliolata.

Miyake K, Suzuki A, Morita C, Goto M, Newman DJ, O'Keefe BR, Morris-Natschke SL, Lee KH, Nakagawa-Goto K.

J Nat Prod. 2016 Nov 23;79(11):2883-2889. Epub 2016 Oct 24.

23.

Special Issue in Honor of Professors John W. Blunt and Murray H. G. Munro.

Copp BR, Cragg GM, Newman DJ, Pearce CJ.

J Nat Prod. 2016 Mar 25;79(3):453-4. doi: 10.1021/acs.jnatprod.6b00079. No abstract available.

PMID:
27012535
24.

Drugs and Drug Candidates from Marine Sources: An Assessment of the Current "State of Play".

Newman DJ, Cragg GM.

Planta Med. 2016 Jun;82(9-10):775-89. doi: 10.1055/s-0042-101353. Epub 2016 Feb 18. Review.

PMID:
26891002
25.

Natural Products as Sources of New Drugs from 1981 to 2014.

Newman DJ, Cragg GM.

J Nat Prod. 2016 Mar 25;79(3):629-61. doi: 10.1021/acs.jnatprod.5b01055. Epub 2016 Feb 7. Review.

PMID:
26852623
26.

Morphing Compression Garments for Space Medicine and Extravehicular Activity Using Active Materials.

Holschuh BT, Newman DJ.

Aerosp Med Hum Perform. 2016 Feb;87(2):84-92. doi: 10.3357/AMHP.4349.2016.

PMID:
26802372
27.

Developing natural product drugs: Supply problems and how they have been overcome.

Newman DJ.

Pharmacol Ther. 2016 Jun;162:1-9. doi: 10.1016/j.pharmthera.2015.12.002. Epub 2015 Dec 17. Review.

PMID:
26706239
28.

Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products.

Zarins-Tutt JS, Barberi TT, Gao H, Mearns-Spragg A, Zhang L, Newman DJ, Goss RJ.

Nat Prod Rep. 2016 Jan;33(1):54-72. doi: 10.1039/c5np00111k. Review.

PMID:
26538321
29.

Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis.

Hiraki M, Hwang SY, Cao S, Ramadhar TR, Byun S, Yoon KW, Lee JH, Chu K, Gurkar AU, Kolev V, Zhang J, Namba T, Murphy ME, Newman DJ, Mandinova A, Clardy J, Lee SW.

Chem Biol. 2015 Sep 17;22(9):1206-16. doi: 10.1016/j.chembiol.2015.07.016. Epub 2015 Aug 27.

30.

Cheminformatic comparison of approved drugs from natural product versus synthetic origins.

Stratton CF, Newman DJ, Tan DS.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4802-4807. doi: 10.1016/j.bmcl.2015.07.014. Epub 2015 Jul 14.

31.

Statistical Evaluation of Causal Factors Associated with Astronaut Shoulder Injury in Space Suits.

Anderson AP, Newman DJ, Welsch RE.

Aerosp Med Hum Perform. 2015 Jul;86(7):606-13. doi: 10.3357/AMHP.4220.2015.

PMID:
26102140
32.

Endophytic and epiphytic microbes as "sources" of bioactive agents.

Newman DJ, Cragg GM.

Front Chem. 2015 May 22;3:34. doi: 10.3389/fchem.2015.00034. eCollection 2015. Review.

33.

The Variable Vector Countermeasure Suit (V2Suit) for space habitation and exploration.

Duda KR, Vasquez RA, Middleton AJ, Hansberry ML, Newman DJ, Jacobs SE, West JJ.

Front Syst Neurosci. 2015 Apr 10;9:55. doi: 10.3389/fnsys.2015.00055. eCollection 2015.

34.

Technical developments of functional electrical stimulation to correct drop foot: sensing, actuation and control strategies.

Melo PL, Silva MT, Martins JM, Newman DJ.

Clin Biomech (Bristol, Avon). 2015 Feb;30(2):101-13. doi: 10.1016/j.clinbiomech.2014.11.007. Epub 2014 Nov 20. Review.

PMID:
25592486
35.

Consumption of ground beef obtained from cattle that had received steroidal growth promotants does not trigger early onset of estrus in prepubertal pigs.

Magolski JD, Shappell NW, Vonnahme KA, Anderson GM, Newman DJ, Berg EP.

J Nutr. 2014 Nov;144(11):1718-24. doi: 10.3945/jn.114.198127. Epub 2014 Sep 24.

PMID:
25332471
36.

Depletion of penicillin G residues in heavy sows after intramuscular injection. Part II: application of kidney inhibition swab tests.

Shelver WL, Lupton SJ, Newman DJ, Larsen S, Smith DJ.

J Agric Food Chem. 2014 Jul 30;62(30):7586-92. doi: 10.1021/jf501494w. Epub 2014 Jul 16.

PMID:
25029357
37.

Depletion of penicillin G residues in heavy sows after intramuscular injection. Part I: tissue residue depletion.

Lupton SJ, Shelver WL, Newman DJ, Larsen S, Smith DJ.

J Agric Food Chem. 2014 Jul 30;62(30):7577-85. doi: 10.1021/jf501492v. Epub 2014 Jul 15.

PMID:
25025185
38.

Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins.

Hassig CA, Zeng FY, Kung P, Kiankarimi M, Kim S, Diaz PW, Zhai D, Welsh K, Morshedian S, Su Y, O'Keefe B, Newman DJ, Rusman Y, Kaur H, Salomon CE, Brown SG, Baire B, Michel AR, Hoye TR, Francis S, Georg GI, Walters MA, Divlianska DB, Roth GP, Wright AE, Reed JC.

J Biomol Screen. 2014 Sep;19(8):1201-11. doi: 10.1177/1087057114536227. Epub 2014 May 27.

39.

New horizons for old drugs and drug leads.

Cragg GM, Grothaus PG, Newman DJ.

J Nat Prod. 2014 Mar 28;77(3):703-23. doi: 10.1021/np5000796. Epub 2014 Feb 5. Review.

PMID:
24499205
40.

Marine-sourced anti-cancer and cancer pain control agents in clinical and late preclinical development.

Newman DJ, Cragg GM.

Mar Drugs. 2014 Jan 14;12(1):255-78. doi: 10.3390/md12010255. Review.

41.

Tetramic acid analogues produced by coculture of Saccharopolyspora erythraea with Fusarium pallidoroseum.

Whitt J, Shipley SM, Newman DJ, Zuck KM.

J Nat Prod. 2014 Jan 24;77(1):173-7. doi: 10.1021/np400761g. Epub 2014 Jan 14.

42.

Prediction of troponin-T degradation using color image texture features in 10d aged beef longissimus steaks.

Sun X, Chen KJ, Berg EP, Newman DJ, Schwartz CA, Keller WL, Maddock Carlin KR.

Meat Sci. 2014 Feb;96(2 Pt A):837-42. doi: 10.1016/j.meatsci.2013.09.012. Epub 2013 Sep 19.

PMID:
24200578
43.

Significance of endangered and threatened plant natural products in the control of human disease.

Ibrahim MA, Na M, Oh J, Schinazi RF, McBrayer TR, Whitaker T, Doerksen RJ, Newman DJ, Zachos LG, Hamann MT.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16832-7. doi: 10.1073/pnas.1311528110. Epub 2013 Sep 30.

44.

Microbial natural products: molecular blueprints for antitumor drugs.

Giddings LA, Newman DJ.

J Ind Microbiol Biotechnol. 2013 Nov;40(11):1181-210. doi: 10.1007/s10295-013-1331-1. Epub 2013 Sep 3. Review.

PMID:
23999966
45.

Relationship between commercially available DNA analysis and phenotypic observations on beef quality and tenderness.

Magolski JD, Buchanan DS, Maddock-Carlin KR, Anderson VL, Newman DJ, Berg EP.

Meat Sci. 2013 Nov;95(3):480-5. doi: 10.1016/j.meatsci.2013.05.024. Epub 2013 May 25.

PMID:
23793083
46.

Natural products: a continuing source of novel drug leads.

Cragg GM, Newman DJ.

Biochim Biophys Acta. 2013 Jun;1830(6):3670-95. doi: 10.1016/j.bbagen.2013.02.008. Epub 2013 Feb 18. Review.

47.

The impact of the United Nations Convention on Biological Diversity on natural products research.

Cragg GM, Katz F, Newman DJ, Rosenthal J.

Nat Prod Rep. 2012 Dec;29(12):1407-23. doi: 10.1039/c2np20091k. Epub 2012 Oct 5. Review.

PMID:
23037777
48.

Dynamic understanding of human-skin movement and strain-field analysis.

Wessendorf AM, Newman DJ.

IEEE Trans Biomed Eng. 2012 Dec;59(12):3432-8. doi: 10.1109/TBME.2012.2215859. Epub 2012 Sep 3.

PMID:
22961262
49.

Antifungal cyclic peptides from the marine sponge Microscleroderma herdmani.

Zhang X, Jacob MR, Rao RR, Wang YH, Agarwal AK, Newman DJ, Khan IA, Clark AM, Li XC.

Res Rep Med Chem. 2012 May 22;2:7-14.

50.

Natural products as sources of new drugs over the 30 years from 1981 to 2010.

Newman DJ, Cragg GM.

J Nat Prod. 2012 Mar 23;75(3):311-35. doi: 10.1021/np200906s. Epub 2012 Feb 8. Review.

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