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Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure.

Younge NE, Newgard CB, Cotten CM, Goldberg RN, Muehlbauer MJ, Bain JR, Stevens RD, O'Connell TM, Rawls JF, Seed PC, Ashley PL.

Sci Rep. 2019 Jun 3;9(1):8167. doi: 10.1038/s41598-019-44547-y.


Peripheral blood metabolite profiles associated with new onset atrial fibrillation.

Harskamp RE, Granger TM, Clare RM, White KR, Lopes RD, Pieper KS, Granger CB, Newgard CB, Shah SH, Newby LK.

Am Heart J. 2019 May;211:54-59. doi: 10.1016/j.ahj.2019.01.010. Epub 2019 Feb 14. French.


Respiratory Capacity and Reserve Predict Cell Sensitivity to Mitochondria Inhibitors: Mechanism-Based Markers to Identify Metformin-Responsive Cancers.

Teh JT, Zhu WL, Newgard CB, Casey PJ, Wang M.

Mol Cancer Ther. 2019 Mar;18(3):693-705. doi: 10.1158/1535-7163.MCT-18-0766.


Branched-chain amino acids in disease.

White PJ, Newgard CB.

Science. 2019 Feb 8;363(6427):582-583. doi: 10.1126/science.aav0558. No abstract available.


Improving human β-cell maturation in vitro.

Hohmeier HE, An J, Newgard CB.

Nat Cell Biol. 2019 Feb;21(2):119-121. doi: 10.1038/s41556-019-0277-6. No abstract available.


Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing.

Haldeman JM, Conway AE, Arlotto ME, Slentz DH, Muoio DM, Becker TC, Newgard CB.

Nucleic Acids Res. 2019 Feb 28;47(4):e23. doi: 10.1093/nar/gky1286.


Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose.

Meyer JG, Softic S, Basisty N, Rardin MJ, Verdin E, Gibson BW, Ilkayeva O, Newgard CB, Kahn CR, Schilling B.

PLoS One. 2018 Dec 26;13(12):e0208973. doi: 10.1371/journal.pone.0208973. eCollection 2018.


Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries.

Kadakia R, Nodzenski M, Talbot O, Kuang A, Bain JR, Muehlbauer MJ, Stevens RD, Ilkayeva OR, O'Neal SK, Lowe LP, Metzger BE, Newgard CB, Scholtens DM, Lowe WL Jr; HAPO Study Cooperative Research Group.

Diabetologia. 2019 Mar;62(3):473-484. doi: 10.1007/s00125-018-4781-1. Epub 2018 Nov 27.


Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP.

Ravi S, Parry TL, Willis MS, Lockyer P, Patterson C, Bain JR, Stevens RD, Ilkayeva OR, Newgard CB, Schisler JC.

J Cardiovasc Dev Dis. 2018 Aug 15;5(3). pii: E43. doi: 10.3390/jcdd5030043.


Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.

Peterson BS, Campbell JE, Ilkayeva O, Grimsrud PA, Hirschey MD, Newgard CB.

Cell Rep. 2018 Jul 3;24(1):209-223.e6. doi: 10.1016/j.celrep.2018.05.088.


John Denis McGarry, PhD: A Remembrance of a Master Metabolic Physiologist.

Newgard CB.

Diabetes Care. 2018 Jul;41(7):1330-1336. doi: 10.2337/dci18-0022. No abstract available.


Dietary Patterns among Asian Indians Living in the United States Have Distinct Metabolomic Profiles That Are Associated with Cardiometabolic Risk.

Bhupathiraju SN, Guasch-Ferré M, Gadgil MD, Newgard CB, Bain JR, Muehlbauer MJ, Ilkayeva OR, Scholtens DM, Hu FB, Kanaya AM, Kandula NR.

J Nutr. 2018 Jul 1;148(7):1150-1159. doi: 10.1093/jn/nxy074.


Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid.

Shantavasinkul PC, Muehlbauer MJ, Bain JR, Ilkayeva OR, Craig DM, Newgard CB, Svetkey LP, Shah SH, Torquati A.

Surg Obes Relat Dis. 2018 Aug;14(8):1126-1132. doi: 10.1016/j.soard.2018.03.033. Epub 2018 Apr 17.


The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.

White PJ, McGarrah RW, Grimsrud PA, Tso SC, Yang WH, Haldeman JM, Grenier-Larouche T, An J, Lapworth AL, Astapova I, Hannou SA, George T, Arlotto M, Olson LB, Lai M, Zhang GF, Ilkayeva O, Herman MA, Wynn RM, Chuang DT, Newgard CB.

Cell Metab. 2018 Jun 5;27(6):1281-1293.e7. doi: 10.1016/j.cmet.2018.04.015. Epub 2018 May 17.


Cardiovascular Metabolomics.

McGarrah RW, Crown SB, Zhang GF, Shah SH, Newgard CB.

Circ Res. 2018 Apr 27;122(9):1238-1258. doi: 10.1161/CIRCRESAHA.117.311002. Review.


Physiological mechanisms of sustained fumagillin-induced weight loss.

An J, Wang L, Patnode ML, Ridaura VK, Haldeman JM, Stevens RD, Ilkayeva O, Bain JR, Muehlbauer MJ, Glynn EL, Thomas S, Muoio D, Summers SA, Vath JE, Hughes TE, Gordon JI, Newgard CB.

JCI Insight. 2018 Mar 8;3(5). pii: 99453. doi: 10.1172/jci.insight.99453.


Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.

Softic S, Gupta MK, Wang GX, Fujisaka S, O'Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard CB, Cohen DE, Kahn CR.

J Clin Invest. 2018 Mar 1;128(3):1199. doi: 10.1172/JCI99009. Epub 2018 Mar 1. No abstract available.


Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial.

Chondronikola M, Magkos F, Yoshino J, Okunade AL, Patterson BW, Muehlbauer MJ, Newgard CB, Klein S.

Obesity (Silver Spring). 2018 Apr;26(4):683-688. doi: 10.1002/oby.22129. Epub 2018 Feb 24.


Kruppel-like factor 15 is required for the cardiac adaptive response to fasting.

Sugi K, Hsieh PN, Ilkayeva O, Shelkay S, Moroney B, Baadh P, Haynes B, Pophal M, Fan L, Newgard CB, Prosdocimo DA, Jain MK.

PLoS One. 2018 Feb 6;13(2):e0192376. doi: 10.1371/journal.pone.0192376. eCollection 2018.


Erratum. Maternal BMI and Glycemia Impact the Fetal Metabolome. Diabetes Care 2017;40:902-910.

Lowe WL Jr, Bain JR, Nodzenski M, Reisetter AC, Muehlbauer MJ, Stevens RD, Ilkayeva OR, Lowe LP, Metzger BE, Newgard CB, Scholtens DM; HAPO Study Cooperative Research Group.

Diabetes Care. 2018 Mar;41(3):640. doi: 10.2337/dc18-er03b. Epub 2018 Jan 8. No abstract available.


Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis.

Jensen BC, Parry TL, Huang W, Beak JY, Ilaiwy A, Bain JR, Newgard CB, Muehlbauer MJ, Patterson C, Johnson GL, Willis MS.

Br J Pharmacol. 2017 Dec;174(24):4797-4811. doi: 10.1111/bph.14062. Epub 2017 Nov 24.


Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.

Softic S, Gupta MK, Wang GX, Fujisaka S, O'Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard CB, Cohen DE, Kahn CR.

J Clin Invest. 2017 Nov 1;127(11):4059-4074. doi: 10.1172/JCI94585. Epub 2017 Oct 3. Erratum in: J Clin Invest. 2018 Mar 1;128(3):1199.


Metabolomics applied to islet nutrient sensing mechanisms.

Jensen MV, Gooding JR, Ferdaoussi M, Dai XQ, Peterson BS, MacDonald PE, Newgard CB.

Diabetes Obes Metab. 2017 Sep;19 Suppl 1:90-94. doi: 10.1111/dom.13010. Review.


The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis.

Stephens SB, Edwards RJ, Sadahiro M, Lin WJ, Jiang C, Salton SR, Newgard CB.

Cell Rep. 2017 Sep 5;20(10):2480-2489. doi: 10.1016/j.celrep.2017.08.050.


Recommendations for Improving Identification and Quantification in Non-Targeted, GC-MS-Based Metabolomic Profiling of Human Plasma.

Wang H, Muehlbauer MJ, O'Neal SK, Newgard CB, Hauser ER, Bain JR, Shah SH.

Metabolites. 2017 Aug 25;7(3). pii: E45. doi: 10.3390/metabo7030045.


Non-Targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo.

Abdullah M, Kornegay JN, Honcoop A, Parry TL, Balog-Alvarez CJ, O'Neal SK, Bain JR, Muehlbauer MJ, Newgard CB, Patterson C, Willis MS.

Metabolites. 2017 Jul 29;7(3). pii: E38. doi: 10.3390/metabo7030038.


Plasma acylcarnitines are associated with pulmonary hypertension.

Luo N, Craig D, Ilkayeva O, Muehlbauer M, Kraus WE, Newgard CB, Shah SH, Rajagopal S.

Pulm Circ. 2017 Feb 1;7(1):211-218. doi: 10.1086/690554. eCollection 2017 Mar.


Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI, Glucose, and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups.

Jacob S, Nodzenski M, Reisetter AC, Bain JR, Muehlbauer MJ, Stevens RD, Ilkayeva OR, Lowe LP, Metzger BE, Newgard CB, Scholtens DM, Lowe WL Jr; HAPO Study Cooperative Research Group.

Diabetes Care. 2017 Jul;40(7):911-919. doi: 10.2337/dc16-2453.


Maternal BMI and Glycemia Impact the Fetal Metabolome.

Lowe WL Jr, Bain JR, Nodzenski M, Reisetter AC, Muehlbauer MJ, Stevens RD, Ilkayeva OR, Lowe LP, Metzger BE, Newgard CB, Scholtens DM; HAPO Study Cooperative Research Group.

Diabetes Care. 2017 Jul;40(7):902-910. doi: 10.2337/dc16-2452. Erratum in: Diabetes Care. 2018 Jan 8;:.


Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.

Fu J, Dai X, Plummer G, Suzuki K, Bautista A, Githaka JM, Senior L, Jensen M, Greitzer-Antes D, Manning Fox JE, Gaisano HY, Newgard CB, Touret N, MacDonald PE.

Diabetes. 2017 Jul;66(7):1890-1900. doi: 10.2337/db16-1170. Epub 2017 Jun 12.


Sildenafil Treatment in Heart Failure With Preserved Ejection Fraction: Targeted Metabolomic Profiling in the RELAX Trial.

Wang H, Anstrom K, Ilkayeva O, Muehlbauer MJ, Bain JR, McNulty S, Newgard CB, Kraus WE, Hernandez A, Felker GM, Redfield M, Shah SH.

JAMA Cardiol. 2017 Aug 1;2(8):896-901. doi: 10.1001/jamacardio.2017.1239.


Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival.

Hayes HL, Peterson BS, Haldeman JM, Newgard CB, Hohmeier HE, Stephens SB.

PLoS One. 2017 Feb 17;12(2):e0172567. doi: 10.1371/journal.pone.0172567. eCollection 2017.


Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data.

Reisetter AC, Muehlbauer MJ, Bain JR, Nodzenski M, Stevens RD, Ilkayeva O, Metzger BE, Newgard CB, Lowe WL Jr, Scholtens DM.

BMC Bioinformatics. 2017 Feb 2;18(1):84. doi: 10.1186/s12859-017-1501-7.


Metabolomics and Metabolic Diseases: Where Do We Stand?

Newgard CB.

Cell Metab. 2017 Jan 10;25(1):43-56. doi: 10.1016/j.cmet.2016.09.018. Epub 2016 Oct 27. Review.


Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions.

Griffin NW, Ahern PP, Cheng J, Heath AC, Ilkayeva O, Newgard CB, Fontana L, Gordon JI.

Cell Host Microbe. 2017 Jan 11;21(1):84-96. doi: 10.1016/j.chom.2016.12.006. Epub 2016 Dec 29.


Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes.

Sandler V, Reisetter AC, Bain JR, Muehlbauer MJ, Nodzenski M, Stevens RD, Ilkayeva O, Lowe LP, Metzger BE, Newgard CB, Scholtens DM, Lowe WL Jr; HAPO Study Cooperative Research Group.

Diabetologia. 2017 Mar;60(3):518-530. doi: 10.1007/s00125-016-4182-2. Epub 2016 Dec 16.


Plasma amino acid levels are elevated in young, healthy low birth weight men exposed to short-term high-fat overfeeding.

Ribel-Madsen A, Hellgren LI, Brøns C, Ribel-Madsen R, Newgard CB, Vaag AA.

Physiol Rep. 2016 Dec;4(23). pii: e13044.


Evidence for Feedback Regulation Following Cholesterol Lowering Therapy in a Prostate Cancer Xenograft Model.

Masko EM, Alfaqih MA, Solomon KR, Barry WT, Newgard CB, Muehlbauer MJ, Valilis NA, Phillips TE, Poulton SH, Freedland AR, Sun S, Dambal SK, Sanders SE, Macias E, Freeman MR, Dewhirst MW, Pizzo SV, Freedland SJ.

Prostate. 2017 Apr;77(5):446-457. doi: 10.1002/pros.23282. Epub 2016 Nov 30.


Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition.

Wagner VE, Dey N, Guruge J, Hsiao A, Ahern PP, Semenkovich NP, Blanton LV, Cheng J, Griffin N, Stappenbeck TS, Ilkayeva O, Newgard CB, Petri W, Haque R, Ahmed T, Gordon JI.

Sci Transl Med. 2016 Nov 23;8(366):366ra164.


HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism.

Bradley T, Yang G, Ilkayeva O, Holl TM, Zhang R, Zhang J, Santra S, Fox CB, Reed SG, Parks R, Bowman CM, Bouton-Verville H, Sutherland LL, Scearce RM, Vandergrift N, Kepler TB, Moody MA, Liao HX, Alam SM, McLendon R, Everitt JI, Newgard CB, Verkoczy L, Kelsoe G, Haynes BF.

J Immunol. 2016 Dec 15;197(12):4663-4673. Epub 2016 Nov 14.


Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men.

Ribel-Madsen A, Ribel-Madsen R, Brøns C, Newgard CB, Vaag AA, Hellgren LI.

Physiol Rep. 2016 Oct;4(19). pii: e12977.


Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism.

Gurley JM, Ilkayeva O, Jackson RM, Griesel BA, White P, Matsuzaki S, Qaisar R, Van Remmen H, Humphries KM, Newgard CB, Olson AL.

Diabetes. 2016 Dec;65(12):3585-3597. Epub 2016 Sep 27.


A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation.

Hayes HL, Zhang L, Becker TC, Haldeman JM, Stephens SB, Arlotto M, Moss LG, Newgard CB, Hohmeier HE.

Mol Cell Biol. 2016 Nov 14;36(23):2918-2930. doi: 10.1128/MCB.00103-16. Print 2016 Dec 1.


Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs administered new generation lipid emulsions.

Guthrie G, Kulkarni M, Vlaardingerbroek H, Stoll B, Ng K, Martin C, Belmont J, Hadsell D, Heird W, Newgard CB, Olutoye O, van Goudoever J, Lauridsen C, He X, Schuchman EH, Burrin D.

J Lipid Res. 2016 Sep;57(9):1696-711. doi: 10.1194/jlr.M069526. Epub 2016 Jul 29.


Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure.

Hunter WG, Kelly JP, McGarrah RW 3rd, Khouri MG, Craig D, Haynes C, Ilkayeva O, Stevens RD, Bain JR, Muehlbauer MJ, Newgard CB, Felker GM, Hernandez AF, Velazquez EJ, Kraus WE, Shah SH.

J Am Heart Assoc. 2016 Jul 29;5(8). pii: e003190. doi: 10.1161/JAHA.115.003190.


Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export.

White PJ, Lapworth AL, An J, Wang L, McGarrah RW, Stevens RD, Ilkayeva O, George T, Muehlbauer MJ, Bain JR, Trimmer JK, Brosnan MJ, Rolph TP, Newgard CB.

Mol Metab. 2016 Apr 22;5(7):538-551. doi: 10.1016/j.molmet.2016.04.006. eCollection 2016 Jul.


Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity.

Kucejova B, Duarte J, Satapati S, Fu X, Ilkayeva O, Newgard CB, Brugarolas J, Burgess SC.

Cell Rep. 2016 Jul 12;16(2):508-519. doi: 10.1016/j.celrep.2016.06.006. Epub 2016 Jun 23.


Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling.

Quintana MT, Parry TL, He J, Yates CC, Sidorova TN, Murray KT, Bain JR, Newgard CB, Muehlbauer MJ, Eaton SC, Hishiya A, Takayama S, Willis MS.

Am J Pathol. 2016 Aug;186(8):1989-2007. doi: 10.1016/j.ajpath.2016.03.017. Epub 2016 Jun 17.


Metabolic Networks and Metabolites Underlie Associations Between Maternal Glucose During Pregnancy and Newborn Size at Birth.

Scholtens DM, Bain JR, Reisetter AC, Muehlbauer MJ, Nodzenski M, Stevens RD, Ilkayeva O, Lowe LP, Metzger BE, Newgard CB, Lowe WL Jr; HAPO Study Cooperative Research Group.

Diabetes. 2016 Jul;65(7):2039-50. doi: 10.2337/db15-1748. Epub 2016 Apr 5.


Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia-Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats.

Quinones QJ, Zhang Z, Ma Q, Smith MP, Soderblom E, Moseley MA, Bain J, Newgard CB, Muehlbauer MJ, Hirschey M, Drew KL, Barnes BM, Podgoreanu MV.

Anesthesiology. 2016 Jun;124(6):1296-310. doi: 10.1097/ALN.0000000000001113.

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