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TGF-β Prodomain Alignments Reveal Unexpected Cysteine Conservation Consistent with Phylogenetic Predictions of Cross-Subfamily Heterodimerization.

Wisotzkey RG, Newfeld SJ.

Genetics. 2020 Feb;214(2):447-465. doi: 10.1534/genetics.119.302255. Epub 2019 Dec 16.


Transgenic Analyses in Drosophila Reveal That mCORL1 Is Functionally Distinct from mCORL2 and dCORL.

Stinchfield MJ, Miyazawa K, Newfeld SJ.

G3 (Bethesda). 2019 Nov 5;9(11):3781-3789. doi: 10.1534/g3.119.400647.


CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila.

Tran NL, Goldsmith SL, Dimitriadou A, Takaesu NT, Consoulas C, Newfeld SJ.

G3 (Bethesda). 2018 Aug 30;8(9):2979-2990. doi: 10.1534/g3.118.200572.


CORL Expression in the Drosophila Central Nervous System Is Regulated by Stage Specific Interactions of Intertwined Activators and Repressors.

Tran NL, Takaesu NT, Cornell EF, Newfeld SJ.

G3 (Bethesda). 2018 Jul 2;8(7):2527-2536. doi: 10.1534/g3.118.200282.


lolal Is an Evolutionarily New Epigenetic Regulator of dpp Transcription during Dorsal-Ventral Axis Formation.

Quijano JC, Wisotzkey RG, Tran NL, Huang Y, Stinchfield MJ, Haerry TE, Shimmi O, Newfeld SJ.

Mol Biol Evol. 2016 Oct;33(10):2621-32. doi: 10.1093/molbev/msw132. Epub 2016 Jul 8.


New gene evolution in the bonus-TIF1-γ/TRIM33 family impacted the architecture of the vertebrate dorsal-ventral patterning network.

Wisotzkey RG, Quijano JC, Stinchfield MJ, Newfeld SJ.

Mol Biol Evol. 2014 Sep;31(9):2309-21. doi: 10.1093/molbev/msu175. Epub 2014 May 31.


Automated annotation of developmental stages of Drosophila embryos in images containing spatial patterns of expression.

Yuan L, Pan C, Ji S, McCutchan M, Zhou ZH, Newfeld SJ, Kumar S, Ye J.

Bioinformatics. 2014 Jan 15;30(2):266-73. doi: 10.1093/bioinformatics/btt648. Epub 2013 Dec 3.


Meeting report - TGF-β superfamily: signaling in development and disease.

Zhang YE, Newfeld SJ.

J Cell Sci. 2013 Nov 1;126(Pt 21):4809-13. doi: 10.1242/jcs.142398.


New insights into extracellular and post-translational regulation of TGF-β family signalling pathways.

Shimmi O, Newfeld SJ.

J Biochem. 2013 Jul;154(1):11-9. doi: 10.1093/jb/mvt046. Epub 2013 May 22. Review.


Hippo pathway phylogenetics predicts monoubiquitylation of Salvador and Merlin/Nf2.

Wisotzkey RG, Konikoff CE, Newfeld SJ.

PLoS One. 2012;7(12):e51599. doi: 10.1371/journal.pone.0051599. Epub 2012 Dec 14.


Drosophila CORL is required for Smad2-mediated activation of Ecdysone Receptor expression in the mushroom body.

Takaesu NT, Stinchfield MJ, Shimizu K, Arase M, Quijano JC, Watabe T, Miyazono K, Newfeld SJ.

Development. 2012 Sep;139(18):3392-401. doi: 10.1242/dev.079442. Epub 2012 Aug 8.


Fat facets deubiquitylation of Medea/Smad4 modulates interpretation of a Dpp morphogen gradient.

Stinchfield MJ, Takaesu NT, Quijano JC, Castillo AM, Tiusanen N, Shimmi O, Enzo E, Dupont S, Piccolo S, Newfeld SJ.

Development. 2012 Aug;139(15):2721-9. doi: 10.1242/dev.077206. Epub 2012 Jun 28.


Regulation of TGF-β signal transduction by mono- and deubiquitylation of Smads.

Dupont S, Inui M, Newfeld SJ.

FEBS Lett. 2012 Jul 4;586(14):1913-20. doi: 10.1016/j.febslet.2012.03.037. Epub 2012 Mar 24. Review.


FlyExpress: visual mining of spatiotemporal patterns for genes and publications in Drosophila embryogenesis.

Kumar S, Konikoff C, Van Emden B, Busick C, Davis KT, Ji S, Wu LW, Ramos H, Brody T, Panchanathan S, Ye J, Karr TL, Gerold K, McCutchan M, Newfeld SJ.

Bioinformatics. 2011 Dec 1;27(23):3319-20. doi: 10.1093/bioinformatics/btr567. Epub 2011 Oct 12.


Comparison of embryonic expression within multigene families using the FlyExpress discovery platform reveals more spatial than temporal divergence.

Konikoff CE, Karr TL, McCutchan M, Newfeld SJ, Kumar S.

Dev Dyn. 2012 Jan;241(1):150-60. doi: 10.1002/dvdy.22749. Epub 2011 Sep 29.


Wg signaling via Zw3 and mad restricts self-renewal of sensory organ precursor cells in Drosophila.

Quijano JC, Stinchfield MJ, Newfeld SJ.

Genetics. 2011 Nov;189(3):809-24. doi: 10.1534/genetics.111.133801. Epub 2011 Aug 25.


The Sno oncogene antagonizes Wingless signaling during wing development in Drosophila.

Quijano JC, Stinchfield MJ, Zerlanko B, Gibbens YY, Takaesu NT, Hyman-Walsh C, Wotton D, Newfeld SJ.

PLoS One. 2010 Jul 16;5(7):e11619. doi: 10.1371/journal.pone.0011619.


Distinct molecular evolutionary mechanisms underlie the functional diversification of the Wnt and TGFbeta signaling pathways.

Konikoff CE, Wisotzkey RG, Stinchfield MJ, Newfeld SJ.

J Mol Evol. 2010 Apr;70(4):303-12. doi: 10.1007/s00239-010-9337-z. Epub 2010 Mar 26.


Informatics approaches to understanding TGFbeta pathway regulation.

Kahlem P, Newfeld SJ.

Development. 2009 Nov;136(22):3729-40. doi: 10.1242/dev.030320. Review.


FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.

Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena N, Argenton F, Newfeld SJ, Piccolo S.

Cell. 2009 Jan 9;136(1):123-35. doi: 10.1016/j.cell.2008.10.051.


Current topics in organogenesis and gametogenesis.

Campbell G, Newfeld SJ.

Fly (Austin). 2008 May-Jun;2(3):125-8. Epub 2008 May 23.


Salmonella pathogenesis reveals that BMP signaling regulates blood cell homeostasis and immune responses in Drosophila.

Frandsen JL, Gunn B, Muratoglu S, Fossett N, Newfeld SJ.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14952-7. doi: 10.1073/pnas.0808208105. Epub 2008 Sep 24.


Lysine conservation and context in TGFbeta and Wnt signaling suggest new targets and general themes for posttranslational modification.

Konikoff CE, Wisotzkey RG, Newfeld SJ.

J Mol Evol. 2008 Oct;67(4):323-33. doi: 10.1007/s00239-008-9159-4. Epub 2008 Sep 17.


A combinatorial enhancer recognized by Mad, TCF and Brinker first activates then represses dpp expression in the posterior spiracles of Drosophila.

Takaesu NT, Bulanin DS, Johnson AN, Orenic TV, Newfeld SJ.

Dev Biol. 2008 Jan 15;313(2):829-43. Epub 2007 Oct 24.


Defective decapentaplegic signaling results in heart overgrowth and reduced cardiac output in Drosophila.

Johnson AN, Burnett LA, Sellin J, Paululat A, Newfeld SJ.

Genetics. 2007 Jul;176(3):1609-24. Epub 2007 May 16.


dSno facilitates baboon signaling in the Drosophila brain by switching the affinity of Medea away from Mad and toward dSmad2.

Takaesu NT, Hyman-Walsh C, Ye Y, Wisotzkey RG, Stinchfield MJ, O'connor MB, Wotton D, Newfeld SJ.

Genetics. 2006 Nov;174(3):1299-313. Epub 2006 Sep 1.


DNA-binding domain mutations in SMAD genes yield dominant-negative proteins or a neomorphic protein that can activate WG target genes in Drosophila.

Takaesu NT, Herbig E, Zhitomersky D, O'Connor MB, Newfeld SJ.

Development. 2005 Nov;132(21):4883-94. Epub 2005 Sep 28.


Drosophila TGIF proteins are transcriptional activators.

Hyman CA, Bartholin L, Newfeld SJ, Wotton D.

Mol Cell Biol. 2003 Dec;23(24):9262-74.


The TGF-beta family: signaling pathways, developmental roles, and tumor suppressor activities.

Johnson AN, Newfeld SJ.

ScientificWorldJournal. 2002 Apr 5;2:892-925. Review.


BEST: a novel computational approach for comparing gene expression patterns from early stages of Drosophila melanogaster development.

Kumar S, Jayaraman K, Panchanathan S, Gurunathan R, Marti-Subirana A, Newfeld SJ.

Genetics. 2002 Dec;162(4):2037-47.


Posterior spiracle specific GAL4 lines: new reagents for developmental biology and respiratory physiology.

Takaesu NT, Johnson AN, Newfeld SJ.

Genesis. 2002 Sep-Oct;34(1-2):16-8. No abstract available.


Mothers against dpp participates in a DDP/TGF-beta responsive serine-threonine kinase signal transduction cascade.

Newfeld SJ, Mehra A, Singer MA, Wrana JL, Attisano L, Gelbart WM.

Development. 1997 Aug;124(16):3167-76.


Molecular evolution at the decapentaplegic locus in Drosophila.

Newfeld SJ, Padgett RW, Findley SD, Richter BG, Sanicola M, de Cuevas M, Gelbart WM.

Genetics. 1997 Feb;145(2):297-309.


Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells.

Newfeld SJ, Chartoff EH, Graff JM, Melton DA, Gelbart WM.

Development. 1996 Jul;122(7):2099-108.


Interspecific RNA in situ hybridization reveals perinuclear mastermind transcripts in drosophila virilis.

Schmid AT, Newfeld SJ, Yedvobnick B.

Mol Biol Evol. 1996 Jan;13(1):280-2. No abstract available.


Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

Sekelsky JJ, Newfeld SJ, Raftery LA, Chartoff EH, Gelbart WM.

Genetics. 1995 Mar;139(3):1347-58.


Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila.

Brummel TJ, Twombly V, Marqués G, Wrana JL, Newfeld SJ, Attisano L, Massagué J, O'Connor MB, Gelbart WM.

Cell. 1994 Jul 29;78(2):251-61.


Drive-selection equilibrium: homopolymer evolution in the Drosophila gene mastermind.

Newfeld SJ, Tachida H, Yedvobnick B.

J Mol Evol. 1994 Jun;38(6):637-41.


Homopolymer length variation in the Drosophila gene mastermind.

Newfeld SJ, Schmid AT, Yedvobnick B.

J Mol Evol. 1993 Nov;37(5):483-95.


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