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Items: 47


Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology.

Bloodworth MH, Rusznak M, Pfister CC, Zhang J, Bastarache L, Calvillo SA, Chappell JD, Boyd KL, Toki S, Newcomb DC, Stier MT, Zhou W, Goleniewska K, Moore ML, Hartert TV, Niswender KD, Peebles RS Jr.

J Allergy Clin Immunol. 2018 Apr 17. pii: S0091-6749(18)30561-X. doi: 10.1016/j.jaci.2018.01.053. [Epub ahead of print] No abstract available.


Endogenous PGI2 signaling through IP inhibits neutrophilic lung inflammation in LPS-induced acute lung injury mice model.

Toki S, Zhou W, Goleniewska K, Reiss S, Dulek DE, Newcomb DC, Lawson WE, Peebles RS Jr.

Prostaglandins Other Lipid Mediat. 2018 May;136:33-43. doi: 10.1016/j.prostaglandins.2018.04.001. Epub 2018 Apr 13.


Hormones, sex, and asthma.

Yung JA, Fuseini H, Newcomb DC.

Ann Allergy Asthma Immunol. 2018 May;120(5):488-494. doi: 10.1016/j.anai.2018.01.016. Epub 2018 Feb 2. Review.


Glucagon-like peptide 1 signaling inhibits allergen-induced lung IL-33 release and reduces group 2 innate lymphoid cell cytokine production in vivo.

Toki S, Goleniewska K, Reiss S, Zhang J, Bloodworth MH, Stier MT, Zhou W, Newcomb DC, Ware LB, Stanwood GD, Galli A, Boyd KL, Niswender KD, Peebles RS Jr.

J Allergy Clin Immunol. 2018 Jan 10. pii: S0091-6749(18)30027-7. doi: 10.1016/j.jaci.2017.11.043. [Epub ahead of print]


IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow.

Stier MT, Zhang J, Goleniewska K, Cephus JY, Rusznak M, Wu L, Van Kaer L, Zhou B, Newcomb DC, Peebles RS Jr.

J Exp Med. 2018 Jan 2;215(1):263-281. doi: 10.1084/jem.20170449. Epub 2017 Dec 8.


Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation.

Cephus JY, Stier MT, Fuseini H, Yung JA, Toki S, Bloodworth MH, Zhou W, Goleniewska K, Zhang J, Garon SL, Hamilton RG, Poloshukin VV, Boyd KL, Peebles RS Jr, Newcomb DC.

Cell Rep. 2017 Nov 28;21(9):2487-2499. doi: 10.1016/j.celrep.2017.10.110.


STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection.

Stier MT, Goleniewska K, Cephus JY, Newcomb DC, Sherrill TP, Boyd KL, Bloodworth MH, Moore ML, Chen K, Kolls JK, Peebles RS Jr.

J Immunol. 2017 Jul 15;199(2):510-519. doi: 10.4049/jimmunol.1601984. Epub 2017 Jun 2.


Mechanisms Driving Gender Differences in Asthma.

Fuseini H, Newcomb DC.

Curr Allergy Asthma Rep. 2017 Mar;17(3):19. doi: 10.1007/s11882-017-0686-1. Review.


Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation.

Zhou W, Zhang J, Goleniewska K, Dulek DE, Toki S, Newcomb DC, Cephus JY, Collins RD, Wu P, Boothby MR, Peebles RS Jr.

J Immunol. 2016 Sep 1;197(5):1577-86. doi: 10.4049/jimmunol.1501063. Epub 2016 Jul 25.


Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietin.

Stier MT, Bloodworth MH, Toki S, Newcomb DC, Goleniewska K, Boyd KL, Quitalig M, Hotard AL, Moore ML, Hartert TV, Zhou B, McKenzie AN, Peebles RS Jr.

J Allergy Clin Immunol. 2016 Sep;138(3):814-824.e11. doi: 10.1016/j.jaci.2016.01.050. Epub 2016 Apr 9.


The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation.

Toki S, Goleniewska K, Reiss S, Zhou W, Newcomb DC, Bloodworth MH, Stier MT, Boyd KL, Polosukhin VV, Subramaniam S, Peebles RS Jr.

Thorax. 2016 Jul;71(7):633-45. doi: 10.1136/thoraxjnl-2015-207728. Epub 2016 Apr 12.


STAT6 Signaling Attenuates Interleukin-17-Producing γδ T Cells during Acute Klebsiella pneumoniae Infection.

Bloodworth MH, Newcomb DC, Dulek DE, Stier MT, Cephus JY, Zhang J, Goleniewska K, Kolls JK, Peebles RS Jr.

Infect Immun. 2016 Apr 22;84(5):1548-1555. doi: 10.1128/IAI.00646-15. Print 2016 May.


Heat Shock-Related Protein 20 Peptide Decreases Human Airway Constriction Downstream of β2-Adrenergic Receptor.

Banathy A, Cheung-Flynn J, Goleniewska K, Boyd KL, Newcomb DC, Peebles RS Jr, Komalavilas P.

Am J Respir Cell Mol Biol. 2016 Aug;55(2):225-33. doi: 10.1165/rcmb.2015-0139OC.


Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses.

Zhou W, Toki S, Zhang J, Goleniewksa K, Newcomb DC, Cephus JY, Dulek DE, Bloodworth MH, Stier MT, Polosuhkin V, Gangula RD, Mallal SA, Broide DH, Peebles RS Jr.

Am J Respir Crit Care Med. 2016 Jan 1;193(1):31-42. doi: 10.1164/rccm.201410-1793OC.


Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma.

Newcomb DC, Cephus JY, Boswell MG, Fahrenholz JM, Langley EW, Feldman AS, Zhou W, Dulek DE, Goleniewska K, Woodward KB, Sevin CM, Hamilton RG, Kolls JK, Peebles RS Jr.

J Allergy Clin Immunol. 2015 Oct;136(4):1025-34.e11. doi: 10.1016/j.jaci.2015.05.046. Epub 2015 Aug 1.


Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis.

Hotard AL, Lee S, Currier MG, Crowe JE Jr, Sakamoto K, Newcomb DC, Peebles RS Jr, Plemper RK, Moore ML.

J Virol. 2015 Jan;89(1):512-22. doi: 10.1128/JVI.02472-14. Epub 2014 Oct 22.


Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling.

Zhou W, Goleniewska K, Zhang J, Dulek DE, Toki S, Lotz MT, Newcomb DC, Boswell MG, Polosukhin VV, Milne GL, Wu P, Moore ML, FitzGerald GA, Peebles RS Jr.

J Allergy Clin Immunol. 2014 Sep;134(3):698-705.e5. doi: 10.1016/j.jaci.2014.06.004. Epub 2014 Jul 18.


Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner.

Dulek DE, Newcomb DC, Goleniewska K, Cephus J, Zhou W, Reiss S, Toki S, Ye F, Zaynagetdinov R, Sherrill TP, Blackwell TS, Moore ML, Boyd KL, Kolls JK, Peebles RS Jr.

Infect Immun. 2014 Sep;82(9):3723-39. doi: 10.1128/IAI.00035-14. Epub 2014 Jun 23.


STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge.

Dulek DE, Newcomb DC, Toki S, Goliniewska K, Cephus J, Reiss S, Bates JT, Crowe JE Jr, Boyd KL, Moore ML, Zhou W, Peebles RS Jr.

J Virol. 2014 Sep 1;88(17):9655-72. doi: 10.1128/JVI.03299-13. Epub 2014 Jun 11.


Th17-mediated inflammation in asthma.

Newcomb DC, Peebles RS Jr.

Curr Opin Immunol. 2013 Dec;25(6):755-60. doi: 10.1016/j.coi.2013.08.002. Epub 2013 Sep 11. Review.


PGI₂ signaling inhibits antigen uptake and increases migration of immature dendritic cells.

Toki S, Goleniewska K, Huckabee MM, Zhou W, Newcomb DC, Fitzgerald GA, Lawson WE, Peebles RS Jr.

J Leukoc Biol. 2013 Jul;94(1):77-88. doi: 10.1189/jlb.1112559. Epub 2013 Apr 26.


Deficiency of gp91phox inhibits allergic airway inflammation.

Sevin CM, Newcomb DC, Toki S, Han W, Sherrill TP, Boswell MG, Zhu Z, Collins RD, Boyd KL, Goleniewska K, Huckabee MM, Blackwell TS, Peebles RS Jr.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):396-402. doi: 10.1165/rcmb.2012-0442OC.


IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation.

Newcomb DC, Boswell MG, Reiss S, Zhou W, Goleniewska K, Toki S, Harintho MT, Lukacs NW, Kolls JK, Peebles RS Jr.

Thorax. 2013 Aug;68(8):717-23. doi: 10.1136/thoraxjnl-2012-202404. Epub 2013 Feb 19.


IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia.

Newcomb DC, Boswell MG, Sherrill TP, Polosukhin VV, Boyd KL, Goleniewska K, Brody SL, Kolls JK, Adler KB, Peebles RS Jr.

Am J Respir Cell Mol Biol. 2013 Jun;48(6):711-6. doi: 10.1165/rcmb.2013-0017OC.


β-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin.

Tanjore H, Degryse AL, Crossno PF, Xu XC, McConaha ME, Jones BR, Polosukhin VV, Bryant AJ, Cheng DS, Newcomb DC, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE.

Am J Respir Crit Care Med. 2013 Mar 15;187(6):630-9. doi: 10.1164/rccm.201205-0972OC. Epub 2013 Jan 10.


Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis.

Zhou W, Dowell DR, Huckabee MM, Newcomb DC, Boswell MG, Goleniewska K, Lotz MT, Toki S, Yin H, Yao S, Natarajan C, Wu P, Sriram S, Breyer RM, Fitzgerald GA, Peebles RS Jr.

PLoS One. 2012;7(5):e33518. doi: 10.1371/journal.pone.0033518. Epub 2012 May 10.


Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice.

Polosukhin VV, Degryse AL, Newcomb DC, Jones BR, Ware LB, Lee JW, Loyd JE, Blackwell TS, Lawson WE.

Exp Lung Res. 2012 Apr;38(3):135-46. doi: 10.3109/01902148.2012.658595.


IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner.

Newcomb DC, Boswell MG, Huckabee MM, Goleniewska K, Dulek DE, Reiss S, Lukacs NW, Kolls JK, Peebles RS Jr.

J Immunol. 2012 Feb 1;188(3):1027-35. doi: 10.4049/jimmunol.1102216. Epub 2011 Dec 30.


PGI2 as a regulator of CD4+ subset differentiation and function.

Boswell MG, Zhou W, Newcomb DC, Peebles RS Jr.

Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):21-6. doi: 10.1016/j.prostaglandins.2011.08.003. Epub 2011 Aug 12. Review.


PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression.

Zhou W, Dowell DR, Geraci MW, Blackwell TS, Collins RD, Polosukhin VV, Lawson WE, Wu P, Sussan T, Biswal S, Goleniewska K, O'Neal J, Newcomb DC, Toki S, Morrow JD, Peebles RS Jr.

Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L615-22. doi: 10.1152/ajplung.00224.2010. Epub 2011 Jul 15.


Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs.

Lawson WE, Cheng DS, Degryse AL, Tanjore H, Polosukhin VV, Xu XC, Newcomb DC, Jones BR, Roldan J, Lane KB, Morrisey EE, Beers MF, Yull FE, Blackwell TS.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10562-7. doi: 10.1073/pnas.1107559108. Epub 2011 Jun 13.


Differential pathogenesis of respiratory syncytial virus clinical isolates in BALB/c mice.

Stokes KL, Chi MH, Sakamoto K, Newcomb DC, Currier MG, Huckabee MM, Lee S, Goleniewska K, Pretto C, Williams JV, Hotard A, Sherrill TP, Peebles RS Jr, Moore ML.

J Virol. 2011 Jun;85(12):5782-93. doi: 10.1128/JVI.01693-10. Epub 2011 Apr 6.


Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production.

Newcomb DC, Boswell MG, Zhou W, Huckabee MM, Goleniewska K, Sevin CM, Hershey GK, Kolls JK, Peebles RS Jr.

J Allergy Clin Immunol. 2011 Apr;127(4):1006-13.e1-4. doi: 10.1016/j.jaci.2010.11.043. Epub 2011 Jan 13.


STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection.

Moore ML, Newcomb DC, Parekh VV, Van Kaer L, Collins RD, Zhou W, Goleniewska K, Chi MH, Mitchell D, Boyce JA, Durbin JE, Sturkie C, Peebles RS Jr.

J Immunol. 2009 Aug 1;183(3):2016-26. doi: 10.4049/jimmunol.0803167. Epub 2009 Jul 8.


Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice.

Zaynagetdinov R, Ryzhov S, Goldstein AE, Yin H, Novitskiy SV, Goleniewska K, Polosukhin VV, Newcomb DC, Mitchell D, Morschl E, Zhou Y, Blackburn MR, Peebles RS Jr, Biaggioni I, Feoktistov I.

Am J Respir Cell Mol Biol. 2010 May;42(5):564-71. doi: 10.1165/rcmb.2008-0391OC. Epub 2009 Jun 25.


Bugs and asthma: a different disease?

Newcomb DC, Peebles RS Jr.

Proc Am Thorac Soc. 2009 May 1;6(3):266-71. doi: 10.1513/pats.200806-056RM. Review.


A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production.

Newcomb DC, Zhou W, Moore ML, Goleniewska K, Hershey GK, Kolls JK, Peebles RS Jr.

J Immunol. 2009 May 1;182(9):5317-21. doi: 10.4049/jimmunol.0803868.


A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction.

Moore ML, Chi MH, Luongo C, Lukacs NW, Polosukhin VV, Huckabee MM, Newcomb DC, Buchholz UJ, Crowe JE Jr, Goleniewska K, Williams JV, Collins PL, Peebles RS Jr.

J Virol. 2009 May;83(9):4185-94. doi: 10.1128/JVI.01853-08. Epub 2009 Feb 11.


Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses.

Zhou W, Newcomb DC, Moore ML, Goleniewska K, O'Neal JF, Peebles RS Jr.

J Immunol. 2008 Oct 15;181(8):5360-7.


Human rhinovirus 1B exposure induces phosphatidylinositol 3-kinase-dependent airway inflammation in mice.

Newcomb DC, Sajjan US, Nagarkar DR, Wang Q, Nanua S, Zhou Y, McHenry CL, Hennrick KT, Tsai WC, Bentley JK, Lukacs NW, Johnston SL, Hershenson MB.

Am J Respir Crit Care Med. 2008 May 15;177(10):1111-21. doi: 10.1164/rccm.200708-1243OC. Epub 2008 Feb 14.


Cooperative effects of rhinovirus and TNF-{alpha} on airway epithelial cell chemokine expression.

Newcomb DC, Sajjan US, Nagarkar DR, Goldsmith AM, Bentley JK, Hershenson MB.

Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L1021-8. Epub 2007 Jul 13.


Rhinovirus activates interleukin-8 expression via a Src/p110beta phosphatidylinositol 3-kinase/Akt pathway in human airway epithelial cells.

Bentley JK, Newcomb DC, Goldsmith AM, Jia Y, Sajjan US, Hershenson MB.

J Virol. 2007 Feb;81(3):1186-94. Epub 2006 Nov 22.


H. influenzae potentiates airway epithelial cell responses to rhinovirus by increasing ICAM-1 and TLR3 expression.

Sajjan US, Jia Y, Newcomb DC, Bentley JK, Lukacs NW, LiPuma JJ, Hershenson MB.

FASEB J. 2006 Oct;20(12):2121-3. Epub 2006 Aug 16.


Phosphatidylinositol 3-kinase is required for rhinovirus-induced airway epithelial cell interleukin-8 expression.

Newcomb DC, Sajjan U, Nanua S, Jia Y, Goldsmith AM, Bentley JK, Hershenson MB.

J Biol Chem. 2005 Nov 4;280(44):36952-61. Epub 2005 Aug 24.


Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma.

Zhou L, Li J, Goldsmith AM, Newcomb DC, Giannola DM, Vosk RG, Eves EM, Rosner MR, Solway J, Hershenson MB.

Am J Respir Crit Care Med. 2004 Mar 15;169(6):703-11. Epub 2003 Dec 23.


Proliferation of the airway epithelium in asthma: are inflammatory cells required?

Booth BW, Newcomb DC, McKane SA, Crews AL, Adler KB, Bonner JC, Martin LD.

Chest. 2003 Mar;123(3 Suppl):384S-5S. Review. No abstract available.


Temporal-signal detection and individual differences in timing.

Brown SW, Newcomb DC, Kahrl KG.

Perception. 1995;24(5):525-38.


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