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Human and animal evidence of potential transgenerational inheritance of health effects: An evidence map and state-of-the-science evaluation.

Walker VR, Boyles AL, Pelch KE, Holmgren SD, Shapiro AJ, Blystone CR, Devito MJ, Newbold RR, Blain R, Hartman P, Thayer KA, Rooney AA.

Environ Int. 2018 Jun;115:48-69. doi: 10.1016/j.envint.2017.12.032. Epub 2018 Mar 14. Review.


Functional role of SETD2, BAP1, PARP-3 and PBRM1 candidate genes on the regulation of hTERT gene expression.

Linne H, Yasaei H, Marriott A, Harvey A, Mokbel K, Newbold R, Roberts T.

Oncotarget. 2017 Jun 27;8(37):61890-61900. doi: 10.18632/oncotarget.18712. eCollection 2017 Sep 22.


Correlation between Ferumoxytol Uptake in Tumor Lesions by MRI and Response to Nanoliposomal Irinotecan in Patients with Advanced Solid Tumors: A Pilot Study.

Ramanathan RK, Korn RL, Raghunand N, Sachdev JC, Newbold RG, Jameson G, Fetterly GJ, Prey J, Klinz SG, Kim J, Cain J, Hendriks BS, Drummond DC, Bayever E, Fitzgerald JB.

Clin Cancer Res. 2017 Jul 15;23(14):3638-3648. doi: 10.1158/1078-0432.CCR-16-1990. Epub 2017 Feb 3.


Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6) in breast cancer.

Corda G, Sala G, Lattanzio R, Iezzi M, Sallese M, Fragassi G, Lamolinara A, Mirza H, Barcaroli D, Ermler S, Silva E, Yasaei H, Newbold RF, Vagnarelli P, Mottolese M, Natali PG, Perracchio L, Quist J, Grigoriadis A, Marra P, Tutt AN, Piantelli M, Iacobelli S, De Laurenzi V, Sala A.

J Pathol. 2017 Feb;241(3):350-361. doi: 10.1002/path.4841. Epub 2016 Dec 29.


A mechanistic evaluation of the Syrian hamster embryo cell transformation assay (pH 6.7) and molecular events leading to senescence bypass in SHE cells.

Pickles JC, Pant K, Mcginty LA, Yasaei H, Roberts T, Scott AD, Newbold RF.

Mutat Res Genet Toxicol Environ Mutagen. 2016 May;802:50-8. doi: 10.1016/j.mrgentox.2016.04.002. Epub 2016 Apr 9.


Erratum to: A round robin approach to the analysis of bisphenol a (BPA) in human blood samples.

Vandenberg LN, Gerona RR, Kannan K, Taylor JA, van Breemen RB, Dickenson CA, Liao C, Yuan Y, Newbold RR, Padmanabhan V, Vom Saal FS, Woodruff TJ.

Environ Health. 2016 Mar 8;15:43. doi: 10.1186/s12940-016-0126-z. No abstract available.


Effect of the acute general surgical unit: a regional perspective.

Pritchard N, Newbold R, Robinson K, Ooi WM.

ANZ J Surg. 2017 Jul;87(7-8):595-599. doi: 10.1111/ans.13403. Epub 2015 Dec 17.


Lou Guillette--in memorandum.

Heindel JJ, Newbold RR, Williams CJ, Iguchi T, Tyler CR.

Mol Reprod Dev. 2015 Oct;82(10):Fmi-v. doi: 10.1002/mrd.22587. No abstract available.


Endocrine disruptors and obesity.

Heindel JJ, Newbold R, Schug TT.

Nat Rev Endocrinol. 2015 Nov;11(11):653-61. doi: 10.1038/nrendo.2015.163. Epub 2015 Sep 22. Review.


NIEHS/FDA CLARITY-BPA research program update.

Heindel JJ, Newbold RR, Bucher JR, Camacho L, Delclos KB, Lewis SM, Vanlandingham M, Churchwell MI, Twaddle NC, McLellen M, Chidambaram M, Bryant M, Woodling K, Gamboa da Costa G, Ferguson SA, Flaws J, Howard PC, Walker NJ, Zoeller RT, Fostel J, Favaro C, Schug TT.

Reprod Toxicol. 2015 Dec;58:33-44. doi: 10.1016/j.reprotox.2015.07.075. Epub 2015 Jul 29. Review.


Reconstitution of human rRNA gene transcription in mouse cells by a complete SL1 complex.

Murano K, Okuwaki M, Momose F, Kumakura M, Ueshima S, Newbold RF, Nagata K.

J Cell Sci. 2014 Aug 1;127(Pt 15):3309-19. doi: 10.1242/jcs.146787. Epub 2014 Jun 13.


A round robin approach to the analysis of bisphenol A (BPA) in human blood samples.

Vandenberg LN, Gerona RR, Kannan K, Taylor JA, van Breemen RB, Dickenson CA, Liao C, Yuan Y, Newbold RR, Padmanabhan V, Vom Saal FS, Woodruff TJ.

Environ Health. 2014 Apr 1;13(1):25. doi: 10.1186/1476-069X-13-25. Erratum in: Environ Health. 2016;15:43.


Persistently altered epigenetic marks in the mouse uterus after neonatal estrogen exposure.

Jefferson WN, Chevalier DM, Phelps JY, Cantor AM, Padilla-Banks E, Newbold RR, Archer TK, Kinyamu HK, Williams CJ.

Mol Endocrinol. 2013 Oct;27(10):1666-77. doi: 10.1210/me.2013-1211. Epub 2013 Sep 3.


A new approach to synergize academic and guideline-compliant research: the CLARITY-BPA research program.

Schug TT, Heindel JJ, Camacho L, Delclos KB, Howard P, Johnson AF, Aungst J, Keefe D, Newbold R, Walker NJ, Thomas Zoeller R, Bucher JR.

Reprod Toxicol. 2013 Sep;40:35-40. doi: 10.1016/j.reprotox.2013.05.010. Epub 2013 Jun 5. Review.


P14ARF is down-regulated during tumour progression and predicts the clinical outcome in human breast cancer.

Wazir U, Jiang WG, Yasaei H, Linne H, Newbold RF, Mokbel K.

Anticancer Res. 2013 May;33(5):2185-9.


Prognostic and therapeutic implications of mTORC1 and Rictor expression in human breast cancer.

Wazir U, Newbold RF, Jiang WG, Sharma AK, Mokbel K.

Oncol Rep. 2013 May;29(5):1969-74. doi: 10.3892/or.2013.2346. Epub 2013 Mar 13.


The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis.

Nowrouzi A, Cheung WT, Li T, Zhang X, Arens A, Paruzynski A, Waddington SN, Osejindu E, Reja S, von Kalle C, Wang Y, Al-Allaf F, Gregory L, Themis M, Holder M, Dighe N, Ruthe A, Buckley SM, Bigger B, Montini E, Thrasher AJ, Andrews R, Roberts TP, Newbold RF, Coutelle C, Schmidt M, Themis M.

Mol Ther. 2013 Feb;21(2):324-37. doi: 10.1038/mt.2012.224. Epub 2012 Nov 13.


Comment on prognostic and therapeutic implications of mTORC2 and rictor expression in human breast cancer.

Wazir U, Newbold RF, Jiang WG, Sharma AK, Mokbel K.

Breast Cancer Res Treat. 2012 Dec;136(3):927; author reply 928-9. doi: 10.1007/s10549-012-2248-5. Epub 2012 Sep 29. No abstract available.


Expression of a dominant negative estrogen receptor alpha variant in transgenic mice accelerates uterine cancer induced by the potent estrogen diethylstilbestrol.

Davis VL, Newbold RR, Couse JF, Rea SL, Gallagher KM, Hamilton KJ, Goulding EH, Jefferson W, Eddy EM, Bullock BC, Korach KS.

Reprod Toxicol. 2012 Dec;34(4):512-21. doi: 10.1016/j.reprotox.2012.08.005. Epub 2012 Aug 31.


Identification and characterisation of STMN4 and ROBO2 gene involvement in neuroblastoma cell differentiation.

Sung PJ, Boulos N, Tilby MJ, Andrews WD, Newbold RF, Tweddle DA, Lunec J.

Cancer Lett. 2013 Jan 1;328(1):168-75. doi: 10.1016/j.canlet.2012.08.015. Epub 2012 Aug 17.


An ethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents.

Mercado-Feliciano M, Cora MC, Witt KL, Granville CA, Hejtmancik MR, Fomby L, Knostman KA, Ryan MJ, Newbold R, Smith C, Foster PM, Vallant MK, Stout MD.

Toxicol Appl Pharmacol. 2012 Sep 1;263(2):138-47. doi: 10.1016/j.taap.2012.05.022. Epub 2012 Jun 9.


THE DIABETES EPIDEMIC: Environmental Chemical Exposure in Etiology and Treatment.

Sargis RM, Howard SG, Newbold RR, Heindel JJ.

San Franc Med. 2012 Jun;85(5):18-20. No abstract available.


Prenatal exposure to diethylstilbestrol and long-term impact on the breast and reproductive tract in humans and mice.

Newbold RR.

J Dev Orig Health Dis. 2012 Apr;3(2):73-82. doi: 10.1017/S2040174411000754.


Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells.

Yasaei H, Gilham E, Pickles JC, Roberts TP, O'Donovan M, Newbold RF.

Oncogene. 2013 Jan 10;32(2):171-9. doi: 10.1038/onc.2012.45. Epub 2012 Mar 12.


Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer.

Patani N, Jiang WG, Newbold RF, Mokbel K.

Anticancer Res. 2011 Dec;31(12):4115-25.


Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay.

Dixon D, Reed CE, Moore AB, Gibbs-Flournoy EA, Hines EP, Wallace EA, Stanko JP, Lu Y, Jefferson WN, Newbold RR, Fenton SE.

Reprod Toxicol. 2012 Jul;33(4):506-512. doi: 10.1016/j.reprotox.2011.10.011. Epub 2011 Nov 28.


Developmental exposure to endocrine-disrupting chemicals programs for reproductive tract alterations and obesity later in life.

Newbold RR.

Am J Clin Nutr. 2011 Dec;94(6 Suppl):1939S-1942S. doi: 10.3945/ajcn.110.001057. Epub 2011 Nov 16.


Perinatal environmental exposures affect mammary development, function, and cancer risk in adulthood.

Fenton SE, Reed C, Newbold RR.

Annu Rev Pharmacol Toxicol. 2012;52:455-79. doi: 10.1146/annurev-pharmtox-010611-134659. Epub 2011 Oct 19. Review.


Cell transformation assays for prediction of carcinogenic potential: state of the science and future research needs.

Creton S, Aardema MJ, Carmichael PL, Harvey JS, Martin FL, Newbold RF, O'Donovan MR, Pant K, Poth A, Sakai A, Sasaki K, Scott AD, Schechtman LM, Shen RR, Tanaka N, Yasaei H.

Mutagenesis. 2012 Jan;27(1):93-101. doi: 10.1093/mutage/ger053. Epub 2011 Aug 17.


Prognostic implications of carboxyl-terminus of Hsc70 interacting protein and lysyl-oxidase expression in human breast cancer.

Patani N, Jiang W, Newbold R, Mokbel K.

J Carcinog. 2010 Nov 12;9:9. doi: 10.4103/1477-3163.72505.


Evidence for a tumour suppressor function of SETD2 in human breast cancer: a new hypothesis.

Newbold RF, Mokbel K.

Anticancer Res. 2010 Sep;30(9):3309-11.


Impact of environmental endocrine disrupting chemicals on the development of obesity.

Newbold RR.

Hormones (Athens). 2010 Jul-Sep;9(3):206-17. Review.


Evidence of a tumour suppressor function for DLEC1 in human breast cancer.

Al Sarakbi W, Reefy S, Jiang WG, Roberts T, Newbold RF, Mokbel K.

Anticancer Res. 2010 Apr;30(4):1079-82. Erratum in: Anticancer Res. 2010 Jun;30(6):2481.


Oral exposure to genistin, the glycosylated form of genistein, during neonatal life adversely affects the female reproductive system.

Jefferson WN, Doerge D, Padilla-Banks E, Woodling KA, Kissling GE, Newbold R.

Environ Health Perspect. 2009 Dec;117(12):1883-9. doi: 10.1289/ehp.0900923. Epub 2009 Jul 27.


A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitivity in a patient with xeroderma pigmentosum.

Abbaszadeh F, Clingen PH, Arlett CF, Plowman PN, Bourton EC, Themis M, Makarov EM, Newbold RF, Green MH, Parris CN.

J Med Genet. 2010 Mar;47(3):176-81. doi: 10.1136/jmg.2009.068866. Epub 2009 Sep 24.


Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.

Loizidou MA, Cariolou MA, Neuhausen SL, Newbold RF, Bashiardes E, Marcou Y, Michael T, Daniel M, Kakouri E, Papadopoulos P, Malas S, Hadjisavvas A, Kyriacou K.

Breast Cancer Res Treat. 2010 May;121(1):147-56. doi: 10.1007/s10549-009-0518-7. Epub 2009 Aug 28.


The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters.

Al Sarakbi W, Sasi W, Jiang WG, Roberts T, Newbold RF, Mokbel K.

BMC Cancer. 2009 Aug 21;9:290. doi: 10.1186/1471-2407-9-290.


The mRNA expression of SATB1 and SATB2 in human breast cancer.

Patani N, Jiang W, Mansel R, Newbold R, Mokbel K.

Cancer Cell Int. 2009 Jul 30;9:18. doi: 10.1186/1475-2867-9-18.


Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in life.

Newbold RR, Jefferson WN, Padilla-Banks E.

Environ Health Perspect. 2009 Jun;117(6):879-85. doi: 10.1289/ehp.0800045. Epub 2009 Jan 15.


Neonatal bisphenol-a exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin-releasing hormone neurons.

Adewale HB, Jefferson WN, Newbold RR, Patisaul HB.

Biol Reprod. 2009 Oct;81(4):690-9. doi: 10.1095/biolreprod.109.078261. Epub 2009 Jun 17.


Few effects of multi-generational dietary exposure to genistein or nonylphenol on sodium solution intake in male and female Sprague-Dawley rats.

Ferguson SA, Delclos KB, Newbold RR, Flynn KM.

Neurotoxicol Teratol. 2009 May-Jun;31(3):143-8.


Environmental estrogens and obesity.

Newbold RR, Padilla-Banks E, Jefferson WN.

Mol Cell Endocrinol. 2009 May 25;304(1-2):84-9. doi: 10.1016/j.mce.2009.02.024. Epub 2009 Mar 9. Review.


Genistein and ethinyl estradiol dietary exposure in multigenerational and chronic studies induce similar proliferative lesions in mammary gland of male Sprague-Dawley rats.

Latendresse JR, Bucci TJ, Olson G, Mellick P, Weis CC, Thorn B, Newbold RR, Delclos KB.

Reprod Toxicol. 2009 Nov;28(3):342-53. doi: 10.1016/j.reprotox.2009.04.006. Epub 2009 Apr 19.


Overlapping but distinct effects of genistein and ethinyl estradiol (EE(2)) in female Sprague-Dawley rats in multigenerational reproductive and chronic toxicity studies.

Delclos KB, Weis CC, Bucci TJ, Olson G, Mellick P, Sadovova N, Latendresse JR, Thorn B, Newbold RR.

Reprod Toxicol. 2009 Apr;27(2):117-32. doi: 10.1016/j.reprotox.2008.12.005. Epub 2008 Dec 30.


Chromosomes 6 and 18 induce neoplastic suppression in epithelial ovarian cancer cells.

Dafou D, Ramus SJ, Choi K, Grun B, Trott DA, Newbold RF, Jacobs IJ, Jones C, Gayther SA.

Int J Cancer. 2009 Mar 1;124(5):1037-44. doi: 10.1002/ijc.24058.


Neonatal exposure to genistein disrupts ability of female mouse reproductive tract to support preimplantation embryo development and implantation.

Jefferson WN, Padilla-Banks E, Goulding EH, Lao SP, Newbold RR, Williams CJ.

Biol Reprod. 2009 Mar;80(3):425-31. doi: 10.1095/biolreprod.108.073171. Epub 2008 Nov 12.


Vinclozolin modulates splenic natural killer cell activity, antibody-forming cell response and phenotypic marker expression in sprague dawley rats: a two-generation feeding study.

White KL Jr, Germolec DR, Musgrove DL, Delclos KB, Newbold RR, Weis C, Guo TL.

J Immunotoxicol. 2004 Apr;1(2):113-21. doi: 10.1080/15476910490518893.


Mutation of C20orf7 disrupts complex I assembly and causes lethal neonatal mitochondrial disease.

Sugiana C, Pagliarini DJ, McKenzie M, Kirby DM, Salemi R, Abu-Amero KK, Dahl HH, Hutchison WM, Vascotto KA, Smith SM, Newbold RF, Christodoulou J, Calvo S, Mootha VK, Ryan MT, Thorburn DR.

Am J Hum Genet. 2008 Oct;83(4):468-78. doi: 10.1016/j.ajhg.2008.09.009.


Evidence of a tumour suppressive function of E2F1 gene in human breast cancer.

Worku D, Jouhra F, Jiang GW, Patani N, Newbold RF, Mokbel K.

Anticancer Res. 2008 Jul-Aug;28(4B):2135-9.

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