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Items: 1 to 50 of 70

1.

Association between grayscale sonographic and clinical findings in severe knee osteoarthritis.

Kauppinen K, Pylväläinen J, Pamilo K, Helminen O, Haapea M, Saarakkala SS, Nevalainen MT.

J Clin Ultrasound. 2019 Oct 3. doi: 10.1002/jcu.22779. [Epub ahead of print]

PMID:
31580500
2.

Enzalutamide Induced Feed-Forward Signaling Loop Promotes Therapy-Resistant Prostate Cancer Growth Providing an Exploitable Molecular Target for Jak2 Inhibitors.

Udhane V, Maranto C, Hoang DT, Gu L, Erickson A, Devi S, Talati PG, Banerjee A, Iczkowski KA, Jacobsohn K, See WA, Mirtti T, Kilari D, Nevalainen MT.

Mol Cancer Ther. 2019 Sep 23. pii: molcanther.0508.2019. doi: 10.1158/1535-7163.MCT-19-0508. [Epub ahead of print]

PMID:
31548294
3.

Positive STAT5 Protein and Locus Amplification Status Predicts Recurrence after Radical Prostatectomy to Assist Clinical Precision Management of Prostate Cancer.

Haddad BR, Erickson A, Udhane V, LaViolette PS, Rone JD, Kallajoki MA, See WA, Rannikko A, Mirtti T, Nevalainen MT.

Cancer Epidemiol Biomarkers Prev. 2019 Oct;28(10):1642-1651. doi: 10.1158/1055-9965.EPI-18-1358. Epub 2019 Jul 10.

PMID:
31292140
4.

Gleason Probability Maps: A Radiomics Tool for Mapping Prostate Cancer Likelihood in MRI Space.

McGarry SD, Bukowy JD, Iczkowski KA, Unteriner JG, Duvnjak P, Lowman AK, Jacobsohn K, Hohenwalter M, Griffin MO, Barrington AW, Foss HE, Keuter T, Hurrell SL, See WA, Nevalainen MT, Banerjee A, LaViolette PS.

Tomography. 2019 Mar;5(1):127-134. doi: 10.18383/j.tom.2018.00033.

5.

MRI of a painful carpal boss: variations at the extensor carpi radialis brevis insertion and imaging findings in regional traumatic and overuse injuries.

Nevalainen MT, Roedl JB, Morrison WB, Zoga AC.

Skeletal Radiol. 2019 Jul;48(7):1079-1085. doi: 10.1007/s00256-018-3136-9. Epub 2019 Jan 12.

6.

Targeting the STAT5 pathway in Ph+ acute lymphoblastic leukemia.

Minieri V, De Dominici M, Nevalainen MT, Calabretta B.

Oncotarget. 2018 Dec 4;9(95):36726-36727. doi: 10.18632/oncotarget.26412. eCollection 2018 Dec 4. No abstract available.

7.

Osteoarthritis year in review 2018: imaging.

Nieminen MT, Casula V, Nevalainen MT, Saarakkala S.

Osteoarthritis Cartilage. 2019 Mar;27(3):401-411. doi: 10.1016/j.joca.2018.12.009. Epub 2018 Dec 25. Review.

PMID:
30590194
8.

Ultrasonography of the late-stage knee osteoarthritis prior to total knee arthroplasty: comparison of the ultrasonographic, radiographic and intra-operative findings.

Nevalainen MT, Kauppinen K, Pylväläinen J, Pamilo K, Pesola M, Haapea M, Koski J, Saarakkala S.

Sci Rep. 2018 Dec 10;8(1):17742. doi: 10.1038/s41598-018-35824-3.

9.

Targeting STAT5 or STAT5-Regulated Pathways Suppresses Leukemogenesis of Ph+ Acute Lymphoblastic Leukemia.

Minieri V, De Dominici M, Porazzi P, Mariani SA, Spinelli O, Rambaldi A, Peterson LF, Porcu P, Nevalainen MT, Calabretta B.

Cancer Res. 2018 Oct 15;78(20):5793-5807. doi: 10.1158/0008-5472.CAN-18-0195. Epub 2018 Aug 28.

10.

Radio-pathomic Maps of Epithelium and Lumen Density Predict the Location of High-Grade Prostate Cancer.

McGarry SD, Hurrell SL, Iczkowski KA, Hall W, Kaczmarowski AL, Banerjee A, Keuter T, Jacobsohn K, Bukowy JD, Nevalainen MT, Hohenwalter MD, See WA, LaViolette PS.

Int J Radiat Oncol Biol Phys. 2018 Aug 1;101(5):1179-1187. doi: 10.1016/j.ijrobp.2018.04.044. Epub 2018 Apr 24.

11.

Successful Treatment of Early Talar Osteonecrosis by Core Decompression Combined with Intraosseous Stem Cell Injection: A Case Report.

Nevalainen MT, Repo JP, Pesola M, Nyrhinen JP.

J Orthop Case Rep. 2018 Jan-Feb;8(1):23-26. doi: 10.13107/jocr.2250-0685.982.

12.

STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA Repair.

Maranto C, Udhane V, Hoang DT, Gu L, Alexeev V, Malas K, Cardenas K, Brody JR, Rodeck U, Bergom C, Iczkowski KA, Jacobsohn K, See W, Schmitt SM, Nevalainen MT.

Clin Cancer Res. 2018 Apr 15;24(8):1917-1931. doi: 10.1158/1078-0432.CCR-17-2768. Epub 2018 Feb 26.

13.

Lumbosacral transitional vertebrae: significance of local bone marrow edema at the transverse processes.

Nevalainen MT, McCarthy E, Morrison WB, Zoga AC, Roedl JB.

Skeletal Radiol. 2018 Aug;47(8):1145-1149. doi: 10.1007/s00256-018-2900-1. Epub 2018 Feb 16.

PMID:
29453618
14.

Estimation of the Effect of Body Weight on the Development of Osteoarthritis Based on Cumulative Stresses in Cartilage: Data from the Osteoarthritis Initiative.

Klets O, Mononen ME, Liukkonen MK, Nevalainen MT, Nieminen MT, Saarakkala S, Korhonen RK.

Ann Biomed Eng. 2018 Feb;46(2):334-344. doi: 10.1007/s10439-017-1974-6. Epub 2017 Dec 26.

15.

Optimized b-value selection for the discrimination of prostate cancer grades, including the cribriform pattern, using diffusion weighted imaging.

Hurrell SL, McGarry SD, Kaczmarowski A, Iczkowski KA, Jacobsohn K, Hohenwalter MD, Hall WA, See WA, Banerjee A, Charles DK, Nevalainen MT, Mackinnon AC, LaViolette PS.

J Med Imaging (Bellingham). 2018 Jan;5(1):011004. doi: 10.1117/1.JMI.5.1.011004. Epub 2017 Oct 27.

16.

Erratum: ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development.

Sreenath TL, Macalindong SS, Mikhalkevich N, Sharad S, Mohamed A, Young D, Borbiev T, Xavier C, Gupta R, Jamal M, Babcock K, Tan SH, Nevalainen MT, Dobi A, Petrovics G, Sesterhenn IA, Rosner IL, Bieberich CJ, Nelson P, Vasioukhin V, Srivastava S.

Sci Rep. 2017 Sep 6;7(1):10693. doi: 10.1038/s41598-017-09612-4.

17.

ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development.

Sreenath TL, Macalindong SS, Mikhalkevich N, Sharad S, Mohamed A, Young D, Borbiev T, Xavier C, Gupta R, Jamal M, Babcock K, Tan SH, Nevalainen MT, Dobi A, Petrovics G, Sesterhenn IA, Rosner IL, Bieberich CJ, Nelson P, Vasioukhin V, Srivastava S.

Sci Rep. 2017 Apr 24;7(1):1109. doi: 10.1038/s41598-017-01187-4. Erratum in: Sci Rep. 2017 Sep 6;7(1):10693.

18.

Imaging findings of arthroereisis in planovalgus feet.

Nevalainen MT, Roedl JB, Zoga AC, Morrison WB.

Radiol Case Rep. 2016 Sep 22;11(4):398-404. eCollection 2016 Dec.

19.

Androgen receptor-dependent and -independent mechanisms driving prostate cancer progression: Opportunities for therapeutic targeting from multiple angles.

Hoang DT, Iczkowski KA, Kilari D, See W, Nevalainen MT.

Oncotarget. 2017 Jan 10;8(2):3724-3745. doi: 10.18632/oncotarget.12554. Review.

20.

Distal clavicular osteolysis in adults: association with bench pressing intensity.

Nevalainen MT, Ciccotti MG, Morrison WB, Zoga AC, Roedl JB.

Skeletal Radiol. 2016 Nov;45(11):1473-9. doi: 10.1007/s00256-016-2446-z. Epub 2016 Aug 22.

PMID:
27550324
21.

Ultrasound-guided Interventions for Core and Hip Injuries in Athletes.

McCarthy E, Hegazi TM, Zoga AC, Morrison WB, Meyers WC, Poor AE, Nevalainen MT, Roedl JB.

Radiol Clin North Am. 2016 Sep;54(5):875-92. doi: 10.1016/j.rcl.2016.04.008. Review.

PMID:
27545426
22.

Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype.

Singh A, Fedele C, Lu H, Nevalainen MT, Keen JH, Languino LR.

Mol Cancer Res. 2016 Nov;14(11):1136-1146. Epub 2016 Jul 20.

23.

Potential Utility of a Combined Approach with US and MR Arthrography to Image Medial Elbow Pain in Baseball Players.

Roedl JB, Gonzalez FM, Zoga AC, Morrison WB, Nevalainen MT, Ciccotti MG, Nazarian LN.

Radiology. 2016 Jul;280(1):328. doi: 10.1148/radiol.2016164016. No abstract available.

PMID:
27322983
24.

Potential Utility of a Combined Approach with US and MR Arthrography to Image Medial Elbow Pain in Baseball Players.

Roedl JB, Gonzalez FM, Zoga AC, Morrison WB, Nevalainen MT, Ciccotti MG, Nazarian LN.

Radiology. 2016 Jun;279(3):827-37. doi: 10.1148/radiol.2015151256. Epub 2016 Jan 27. Erratum in: Radiology. 2016 Jul;280(1):328.

PMID:
27183408
25.

Cervical facet oedema: prevalence, correlation to symptoms, and follow-up imaging.

Nevalainen MT, Foran PJ, Roedl JB, Zoga AC, Morrison WB.

Clin Radiol. 2016 Jun;71(6):570-5. doi: 10.1016/j.crad.2016.02.026. Epub 2016 Apr 4.

PMID:
27055743
26.

MRI findings of subchondroplasty of the knee: a two-case report.

Nevalainen MT, Sharkey PF, Cohen SB, Roedl JB, Zoga AC, Morrison WB.

Clin Imaging. 2016 Mar-Apr;40(2):241-3. doi: 10.1016/j.clinimag.2015.11.015. Epub 2015 Nov 30.

PMID:
26995579
27.

Peptidylarginine Deiminase 3 (PAD3) Is Upregulated by Prolactin Stimulation of CID-9 Cells and Expressed in the Lactating Mouse Mammary Gland.

Li G, Hayward IN, Jenkins BR, Rothfuss HM, Young CH, Nevalainen MT, Muth A, Thompson PR, Navratil AM, Cherrington BD.

PLoS One. 2016 Jan 22;11(1):e0147503. doi: 10.1371/journal.pone.0147503. eCollection 2016.

28.

Jak2-Stat5a/b Signaling Induces Epithelial-to-Mesenchymal Transition and Stem-Like Cell Properties in Prostate Cancer.

Talati PG, Gu L, Ellsworth EM, Girondo MA, Trerotola M, Hoang DT, Leiby B, Dagvadorj A, McCue PA, Lallas CD, Trabulsi EJ, Gomella L, Aplin AE, Languino L, Fatatis A, Rui H, Nevalainen MT.

Am J Pathol. 2015 Sep;185(9):2505-22. doi: 10.1016/j.ajpath.2015.04.026.

29.

Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia.

Liao Z, Gu L, Vergalli J, Mariani SA, De Dominici M, Lokareddy RK, Dagvadorj A, Purushottamachar P, McCue PA, Trabulsi E, Lallas CD, Gupta S, Ellsworth E, Blackmon S, Ertel A, Fortina P, Leiby B, Xia G, Rui H, Hoang DT, Gomella LG, Cingolani G, Njar V, Pattabiraman N, Calabretta B, Nevalainen MT.

Mol Cancer Ther. 2015 Aug;14(8):1777-93. doi: 10.1158/1535-7163.MCT-14-0883. Epub 2015 May 29.

30.

Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.

Hoang DT, Gu L, Liao Z, Shen F, Talati PG, Koptyra M, Tan SH, Ellsworth E, Gupta S, Montie H, Dagvadorj A, Savolainen S, Leiby B, Mirtti T, Merry DE, Nevalainen MT.

Mol Cancer Ther. 2015 Mar;14(3):713-26. doi: 10.1158/1535-7163.MCT-14-0819. Epub 2014 Dec 31.

31.

Pharmacologic suppression of JAK1/2 by JAK1/2 inhibitor AZD1480 potently inhibits IL-6-induced experimental prostate cancer metastases formation.

Gu L, Talati P, Vogiatzi P, Romero-Weaver AL, Abdulghani J, Liao Z, Leiby B, Hoang DT, Mirtti T, Alanen K, Zinda M, Huszar D, Nevalainen MT.

Mol Cancer Ther. 2014 May;13(5):1246-58. doi: 10.1158/1535-7163.MCT-13-0605. Epub 2014 Feb 27.

32.

Pharmacologic inhibition of Jak2-Stat5 signaling By Jak2 inhibitor AZD1480 potently suppresses growth of both primary and castrate-resistant prostate cancer.

Gu L, Liao Z, Hoang DT, Dagvadorj A, Gupta S, Blackmon S, Ellsworth E, Talati P, Leiby B, Zinda M, Lallas CD, Trabulsi EJ, McCue P, Gomella L, Huszar D, Nevalainen MT.

Clin Cancer Res. 2013 Oct 15;19(20):5658-74. doi: 10.1158/1078-0432.CCR-13-0422. Epub 2013 Aug 13.

33.

STAT5A/B gene locus undergoes amplification during human prostate cancer progression.

Haddad BR, Gu L, Mirtti T, Dagvadorj A, Vogiatzi P, Hoang DT, Bajaj R, Leiby B, Ellsworth E, Blackmon S, Ruiz C, Curtis M, Fortina P, Ertel A, Liu C, Rui H, Visakorpi T, Bubendorf L, Lallas CD, Trabulsi EJ, McCue P, Gomella L, Nevalainen MT.

Am J Pathol. 2013 Jun;182(6):2264-75. doi: 10.1016/j.ajpath.2013.02.044. Epub 2013 May 7.

34.

Nuclear Stat5a/b predicts early recurrence and prostate cancer-specific death in patients treated by radical prostatectomy.

Mirtti T, Leiby BE, Abdulghani J, Aaltonen E, Pavela M, Mamtani A, Alanen K, Egevad L, Granfors T, Josefsson A, Stattin P, Bergh A, Nevalainen MT.

Hum Pathol. 2013 Mar;44(3):310-9. doi: 10.1016/j.humpath.2012.06.001. Epub 2012 Sep 29.

35.

Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity.

Stankiewicz TR, Loucks FA, Schroeder EK, Nevalainen MT, Tyler KL, Aktories K, Bouchard RJ, Linseman DA.

J Biol Chem. 2012 May 11;287(20):16835-48. doi: 10.1074/jbc.M111.302166. Epub 2012 Feb 29.

36.

Prolactin regulation of the prostate gland: a female player in a male game.

Goffin V, Hoang DT, Bogorad RL, Nevalainen MT.

Nat Rev Urol. 2011 Oct 4;8(11):597-607. doi: 10.1038/nrurol.2011.143. Review.

37.

Signal transducer and activator of transcription-3 and breast cancer prognosis.

Sato T, Neilson LM, Peck AR, Liu C, Tran TH, Witkiewicz A, Hyslop T, Nevalainen MT, Sauter G, Rui H.

Am J Cancer Res. 2011;1(3):347-55.

38.

Signal transducer and activator of transcription 5a/b: biomarker and therapeutic target in prostate and breast cancer.

Koptyra M, Gupta S, Talati P, Nevalainen MT.

Int J Biochem Cell Biol. 2011 Oct;43(10):1417-21. doi: 10.1016/j.biocel.2011.06.007. Epub 2011 Jun 17. Review.

39.

Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure.

Peck AR, Witkiewicz AK, Liu C, Stringer GA, Klimowicz AC, Pequignot E, Freydin B, Tran TH, Yang N, Rosenberg AL, Hooke JA, Kovatich AJ, Nevalainen MT, Shriver CD, Hyslop T, Sauter G, Rimm DL, Magliocco AM, Rui H.

J Clin Oncol. 2011 Jun 20;29(18):2448-58. doi: 10.1200/JCO.2010.30.3552. Epub 2011 May 16.

40.

Targeting transcription factor Stat5a/b as a therapeutic strategy for prostate cancer.

Liao Z, Nevalainen MT.

Am J Transl Res. 2011 Feb;3(2):133-8. Epub 2010 Nov 21.

41.

Activating mutation (V617F) in the tyrosine kinase JAK2 is absent in locally-confined or castration-resistant prostate cancer.

Gu L, Zhu XH, Visakorpi T, Alanen K, Mirtti T, Edmonston TB, Nevalainen MT.

Anal Cell Pathol (Amst). 2010;33(2):55-9. doi: 10.3233/ACP-CLO-2010-0534.

42.

N-terminal truncation of Stat5a/b circumvents PIAS3-mediated transcriptional inhibition of Stat5 in prostate cancer cells.

Dagvadorj A, Tan SH, Liao Z, Xie J, Nurmi M, Alanen K, Rui H, Mirtti T, Nevalainen MT.

Int J Biochem Cell Biol. 2010 Dec;42(12):2037-46. doi: 10.1016/j.biocel.2010.09.008. Epub 2010 Sep 18.

43.

Robust gene network analysis reveals alteration of the STAT5a network as a hallmark of prostate cancer.

Reddy A, Huang CC, Liu H, Delisi C, Nevalainen MT, Szalma S, Bhanot G.

Genome Inform. 2010;24:139-53.

44.

Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.

Gu L, Vogiatzi P, Puhr M, Dagvadorj A, Lutz J, Ryder A, Addya S, Fortina P, Cooper C, Leiby B, Dasgupta A, Hyslop T, Bubendorf L, Alanen K, Mirtti T, Nevalainen MT.

Endocr Relat Cancer. 2010 May 18;17(2):481-93. doi: 10.1677/ERC-09-0328. Print 2010 Jun.

45.

Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth.

Gu L, Dagvadorj A, Lutz J, Leiby B, Bonuccelli G, Lisanti MP, Addya S, Fortina P, Dasgupta A, Hyslop T, Bubendorf L, Nevalainen MT.

Am J Pathol. 2010 Apr;176(4):1959-72. doi: 10.2353/ajpath.2010.090653. Epub 2010 Feb 18.

46.

Transcription factor Stat5a/b as a therapeutic target protein for prostate cancer.

Liao Z, Lutz J, Nevalainen MT.

Int J Biochem Cell Biol. 2010 Feb;42(2):186-92. doi: 10.1016/j.biocel.2009.11.001. Epub 2009 Nov 13. Review.

47.

Androgen-regulated and highly tumorigenic human prostate cancer cell line established from a transplantable primary CWR22 tumor.

Dagvadorj A, Tan SH, Liao Z, Cavalli LR, Haddad BR, Nevalainen MT.

Clin Cancer Res. 2008 Oct 1;14(19):6062-72. doi: 10.1158/1078-0432.CCR-08-0979.

48.

Signal transducer and activator of transcription 5A/B in prostate and breast cancers.

Tan SH, Nevalainen MT.

Endocr Relat Cancer. 2008 Jun;15(2):367-90. doi: 10.1677/ERC-08-0013. Review.

49.

Stat3 promotes metastatic progression of prostate cancer.

Abdulghani J, Gu L, Dagvadorj A, Lutz J, Leiby B, Bonuccelli G, Lisanti MP, Zellweger T, Alanen K, Mirtti T, Visakorpi T, Bubendorf L, Nevalainen MT.

Am J Pathol. 2008 Jun;172(6):1717-28. doi: 10.2353/ajpath.2008.071054. Epub 2008 May 15.

50.

Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo.

Dagvadorj A, Kirken RA, Leiby B, Karras J, Nevalainen MT.

Clin Cancer Res. 2008 Mar 1;14(5):1317-24. doi: 10.1158/1078-0432.CCR-07-2024.

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