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Items: 1 to 50 of 190

1.

Targeting mitochondria as an anticancer strategy.

Dong L, Neuzil J.

Cancer Commun (Lond). 2019 Oct 25;39(1):63. doi: 10.1186/s40880-019-0412-6. No abstract available.

2.

Intracellular and Intercellular Mitochondrial Dynamics in Parkinson's Disease.

Valdinocci D, Simões RF, Kovarova J, Cunha-Oliveira T, Neuzil J, Pountney DL.

Front Neurosci. 2019 Sep 18;13:930. doi: 10.3389/fnins.2019.00930. eCollection 2019. Review.

3.

Exosomal transfer of miR-126 promotes the anti-tumour response in malignant mesothelioma: Role of miR-126 in cancer-stroma communication.

Monaco F, Gaetani S, Alessandrini F, Tagliabracci A, Bracci M, Valentino M, Neuzil J, Amati M, Bovenzi M, Tomasetti M, Santarelli L.

Cancer Lett. 2019 Oct 28;463:27-36. doi: 10.1016/j.canlet.2019.08.001. Epub 2019 Aug 7.

PMID:
31400405
4.

Mitochondria break through cellular boundaries.

Neuzil J, Berridge MV.

Aging (Albany NY). 2019 Jul 13;11(13):4308-4309. doi: 10.18632/aging.102103. No abstract available.

5.

Clinical, Diagnostic, and Treatment Characteristics of SDHA-Related Metastatic Pheochromocytoma and Paraganglioma.

Jha A, de Luna K, Balili CA, Millo C, Paraiso CA, Ling A, Gonzales MK, Viana B, Alrezk R, Adams KT, Tena I, Chen A, Neuzil J, Raygada M, Kebebew E, Taieb D, O'Dorisio MS, O'Dorisio T, Civelek AC, Stratakis CA, Mercado-Asis L, Pacak K.

Front Oncol. 2019 Feb 22;9:53. doi: 10.3389/fonc.2019.00053. eCollection 2019.

6.

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.

Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman WJH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J.

Cell Metab. 2019 Feb 5;29(2):399-416.e10. doi: 10.1016/j.cmet.2018.10.014. Epub 2018 Nov 15.

PMID:
30449682
7.

Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity.

Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, Xiong D, Tsaih SW, Hardy M, Flister M, Olsen CM, Wang Y, Vang O, Neuzil J, Myers CR, Kalyanaraman B, You M.

iScience. 2018 May 25;3:192-207. doi: 10.1016/j.isci.2018.04.013. Epub 2018 Apr 22.

8.

Mitochondria-driven elimination of cancer and senescent cells.

Hubackova S, Magalhaes Novais S, Davidova E, Neuzil J, Rohlena J.

Biol Chem. 2019 Jan 28;400(2):141-148. doi: 10.1515/hsz-2018-0256. Review.

PMID:
30281511
9.

Mitochondrial Genome Transfer to Tumor Cells Breaks The Rules and Establishes a New Precedent in Cancer Biology.

Berridge MV, Crasso C, Neuzil J.

Mol Cell Oncol. 2018 May 9;5(5):e1023929. doi: 10.1080/23723556.2015.1023929. eCollection 2018.

10.

Four-miRNA Signature to Identify Asbestos-Related Lung Malignancies.

Santarelli L, Gaetani S, Monaco F, Bracci M, Valentino M, Amati M, Rubini C, Sabbatini A, Pasquini E, Zanotta N, Comar M, Neuzil J, Tomasetti M, Bovenzi M.

Cancer Epidemiol Biomarkers Prev. 2019 Jan;28(1):119-126. doi: 10.1158/1055-9965.EPI-18-0453. Epub 2018 Sep 26.

PMID:
30257964
11.

MiR-126 in intestinal-type sinonasal adenocarcinomas: exosomal transfer of MiR-126 promotes anti-tumour responses.

Tomasetti M, Re M, Monaco F, Gaetani S, Rubini C, Bertini A, Pasquini E, Bersaglieri C, Bracci M, Staffolani S, Colomba M, Gregorini A, Valentino M, Tagliabracci A, Bovenzi M, Neuzil J, Amati M, Santarelli L.

BMC Cancer. 2018 Sep 17;18(1):896. doi: 10.1186/s12885-018-4801-z.

12.

Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints.

Bezawork-Geleta A, Wen H, Dong L, Yan B, Vider J, Boukalova S, Krobova L, Vanova K, Zobalova R, Sobol M, Hozak P, Novais SM, Caisova V, Abaffy P, Naraine R, Pang Y, Zaw T, Zhang P, Sindelka R, Kubista M, Zuryn S, Molloy MP, Berridge MV, Pacak K, Rohlena J, Park S, Neuzil J.

Nat Commun. 2018 Jun 7;9(1):2221. doi: 10.1038/s41467-018-04603-z.

13.

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2.

Hubackova S, Davidova E, Rohlenova K, Stursa J, Werner L, Andera L, Dong L, Terp MG, Hodny Z, Ditzel HJ, Rohlena J, Neuzil J.

Cell Death Differ. 2019 Jan;26(2):276-290. doi: 10.1038/s41418-018-0118-3. Epub 2018 May 21.

14.

Metformin directly targets the H3K27me3 demethylase KDM6A/UTX.

Cuyàs E, Verdura S, Llorach-Pares L, Fernández-Arroyo S, Luciano-Mateo F, Cabré N, Stursa J, Werner L, Martin-Castillo B, Viollet B, Neuzil J, Joven J, Nonell-Canals A, Sanchez-Martinez M, Menendez JA.

Aging Cell. 2018 Aug;17(4):e12772. doi: 10.1111/acel.12772. Epub 2018 May 8.

15.

TRAIL induces apoptosis but not necroptosis in colorectal and pancreatic cancer cells preferentially via the TRAIL-R2/DR5 receptor.

Nahacka Z, Svadlenka J, Peterka M, Ksandrova M, Benesova S, Neuzil J, Andera L.

Biochim Biophys Acta Mol Cell Res. 2018 Mar;1865(3):522-531. doi: 10.1016/j.bbamcr.2017.12.006. Epub 2017 Dec 24.

16.

Exosomal miR-126 as a circulating biomarker in non-small-cell lung cancer regulating cancer progression.

Grimolizzi F, Monaco F, Leoni F, Bracci M, Staffolani S, Bersaglieri C, Gaetani S, Valentino M, Amati M, Rubini C, Saccucci F, Neuzil J, Tomasetti M, Santarelli L.

Sci Rep. 2017 Nov 10;7(1):15277. doi: 10.1038/s41598-017-15475-6.

17.

Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism.

Cuyàs E, Fernández-Arroyo S, Verdura S, García RÁ, Stursa J, Werner L, Blanco-González E, Montes-Bayón M, Joven J, Viollet B, Neuzil J, Menendez JA.

Oncogene. 2018 Feb 15;37(7):963-970. doi: 10.1038/onc.2017.367. Epub 2017 Oct 23.

PMID:
29059169
18.

Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death.

Blecha J, Novais SM, Rohlenova K, Novotna E, Lettlova S, Schmitt S, Zischka H, Neuzil J, Rohlena J.

Free Radic Biol Med. 2017 Nov;112:253-266. doi: 10.1016/j.freeradbiomed.2017.07.033. Epub 2017 Jul 31.

PMID:
28774815
19.

The mobility of mitochondria: Intercellular trafficking in health and disease.

Berridge MV, Neuzil J.

Clin Exp Pharmacol Physiol. 2017 Dec;44 Suppl 1:15-20. doi: 10.1111/1440-1681.12764. Epub 2017 Sep 20. Review.

PMID:
28409855
20.

Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells.

Dong LF, Kovarova J, Bajzikova M, Bezawork-Geleta A, Svec D, Endaya B, Sachaphibulkij K, Coelho AR, Sebkova N, Ruzickova A, Tan AS, Kluckova K, Judasova K, Zamecnikova K, Rychtarcikova Z, Gopalan V, Andera L, Sobol M, Yan B, Pattnaik B, Bhatraju N, Truksa J, Stopka P, Hozak P, Lam AK, Sedlacek R, Oliveira PJ, Kubista M, Agrawal A, Dvorakova-Hortova K, Rohlena J, Berridge MV, Neuzil J.

Elife. 2017 Feb 15;6. pii: e22187. doi: 10.7554/eLife.22187.

21.

Mitochondrial Complex II: At the Crossroads.

Bezawork-Geleta A, Rohlena J, Dong L, Pacak K, Neuzil J.

Trends Biochem Sci. 2017 Apr;42(4):312-325. doi: 10.1016/j.tibs.2017.01.003. Epub 2017 Feb 7. Review.

PMID:
28185716
22.

Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy.

Tomasetti M, Lee W, Santarelli L, Neuzil J.

Exp Mol Med. 2017 Jan 20;49(1):e285. doi: 10.1038/emm.2016.153. Review.

23.

Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism.

Rychtarcikova Z, Lettlova S, Tomkova V, Korenkova V, Langerova L, Simonova E, Zjablovskaja P, Alberich-Jorda M, Neuzil J, Truksa J.

Oncotarget. 2017 Jan 24;8(4):6376-6398. doi: 10.18632/oncotarget.14093.

24.

Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer.

Boukalova S, Stursa J, Werner L, Ezrova Z, Cerny J, Bezawork-Geleta A, Pecinova A, Dong L, Drahota Z, Neuzil J.

Mol Cancer Ther. 2016 Dec;15(12):2875-2886. Epub 2016 Oct 7.

25.

The Assembly Factor SDHAF2 Is Dispensable for Flavination of the Catalytic Subunit of Mitochondrial Complex II in Breast Cancer Cells.

Bezawork-Geleta A, Dong L, Rohlena J, Neuzil J.

J Biol Chem. 2016 Oct 7;291(41):21414-21420. Epub 2016 Sep 1.

26.

Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2high Breast Cancer.

Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alizadeh Pesdar E, Yan B, Nguyen MN, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong LF, Neuzil J.

Antioxid Redox Signal. 2017 Jan 10;26(2):84-103. doi: 10.1089/ars.2016.6677. Epub 2016 Aug 22.

27.

Circulating epigenetic biomarkers in lung malignancies: From early diagnosis to therapy.

Tomasetti M, Amati M, Neuzil J, Santarelli L.

Lung Cancer. 2017 May;107:65-72. doi: 10.1016/j.lungcan.2016.05.023. Epub 2016 Jun 2. Review.

PMID:
27312601
28.

Horizontal transfer of mitochondria between mammalian cells: beyond co-culture approaches.

Berridge MV, McConnell MJ, Grasso C, Bajzikova M, Kovarova J, Neuzil J.

Curr Opin Genet Dev. 2016 Jun;38:75-82. doi: 10.1016/j.gde.2016.04.003. Epub 2016 May 21. Review.

PMID:
27219870
29.

MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis.

Tomasetti M, Amati M, Santarelli L, Neuzil J.

Int J Mol Sci. 2016 May 18;17(5). pii: E754. doi: 10.3390/ijms17050754. Review.

30.

Correction: Characterisation of Mesothelioma-Initiating Cells and Their Susceptibility to Anti-Cancer Agents.

Pasdar EA, Smits M, Stapelberg M, Bajzikova M, Stantic M, Goodwin J, Yan B, Stursa J, Kovarova J, Sachaphibulkij K, Bezawork-Geleta A, Sobol M, Filimonenko A, Tomasetti M, Zobalova R, Hozak P, Dong LF, Neuzil J.

PLoS One. 2016 May 17;11(5):e0156012. doi: 10.1371/journal.pone.0156012. eCollection 2016.

31.

Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells.

Vanova K, Boukalova S, Gbelcova H, Muchova L, Neuzil J, Gurlich R, Ruml T, Vitek L.

BMC Cancer. 2016 May 12;16:309. doi: 10.1186/s12885-016-2343-9.

32.

Rotenone Susceptibility Phenotype in Olfactory Derived Patient Cells as a Model of Idiopathic Parkinson's Disease.

Murtaza M, Shan J, Matigian N, Todorovic M, Cook AL, Ravishankar S, Dong LF, Neuzil J, Silburn P, Mackay-Sim A, Mellick GD, Wood SA.

PLoS One. 2016 Apr 28;11(4):e0154544. doi: 10.1371/journal.pone.0154544. eCollection 2016.

33.

MicroRNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma.

Tomasetti M, Monaco F, Manzella N, Rohlena J, Rohlenova K, Staffolani S, Gaetani S, Ciarapica V, Amati M, Bracci M, Valentino M, Goodwin J, Nguyen M, Truksa J, Sobol M, Hozak P, Dong LF, Santarelli L, Neuzil J.

Oncotarget. 2016 Jun 14;7(24):36338-36352. doi: 10.18632/oncotarget.8916.

34.

The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria.

Rohlenova K, Neuzil J, Rohlena J.

Biol Chem. 2016 Jul 1;397(7):607-15. doi: 10.1515/hsz-2016-0130. Review.

PMID:
27082923
35.

Mitochondria: An intriguing target for killing tumour-initiating cells.

Yan B, Dong L, Neuzil J.

Mitochondrion. 2016 Jan;26:86-93. doi: 10.1016/j.mito.2015.12.007. Epub 2015 Dec 15. Review.

PMID:
26702582
36.

Isolating dividing neural and brain tumour cells for gene expression profiling.

Endaya B, Cavanagh B, Alowaidi F, Walker T, de Pennington N, Ng JM, Lam PY, Mackay-Sim A, Neuzil J, Meedeniya AC.

J Neurosci Methods. 2016 Jan 15;257:121-33. doi: 10.1016/j.jneumeth.2015.09.020. Epub 2015 Oct 9.

PMID:
26432933
37.

Combined circulating epigenetic markers to improve mesothelin performance in the diagnosis of malignant mesothelioma.

Santarelli L, Staffolani S, Strafella E, Nocchi L, Manzella N, Grossi P, Bracci M, Pignotti E, Alleva R, Borghi B, Pompili C, Sabbatini A, Rubini C, Zuccatosta L, Bichisecchi E, Valentino M, Horwood K, Comar M, Bovenzi M, Dong LF, Neuzil J, Amati M, Tomasetti M.

Lung Cancer. 2015 Dec;90(3):457-64. doi: 10.1016/j.lungcan.2015.09.021. Epub 2015 Sep 25.

PMID:
26431916
38.

Transcriptional profiling of dividing tumor cells detects intratumor heterogeneity linked to cell proliferation in a brain tumor model.

Endaya BB, Lam PY, Meedeniya AC, Neuzil J.

Mol Oncol. 2016 Jan;10(1):126-37. doi: 10.1016/j.molonc.2015.09.001. Epub 2015 Sep 10.

39.

Mitochondrial DNA in Tumor Initiation, Progression, and Metastasis: Role of Horizontal mtDNA Transfer.

Berridge MV, Dong L, Neuzil J.

Cancer Res. 2015 Aug 15;75(16):3203-8. doi: 10.1158/0008-5472.CAN-15-0859. Epub 2015 Jul 29. Review.

40.

Selenium supplementation induces mitochondrial biogenesis in trophoblasts.

Khera A, Dong LF, Holland O, Vanderlelie J, Pasdar EA, Neuzil J, Perkins AV.

Placenta. 2015 Aug;36(8):863-9. doi: 10.1016/j.placenta.2015.06.010. Epub 2015 Jun 23.

PMID:
26154583
41.

Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner.

Yan B, Stantic M, Zobalova R, Bezawork-Geleta A, Stapelberg M, Stursa J, Prokopova K, Dong L, Neuzil J.

BMC Cancer. 2015 May 13;15:401. doi: 10.1186/s12885-015-1394-7.

42.

Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation.

Kluckova K, Sticha M, Cerny J, Mracek T, Dong L, Drahota Z, Gottlieb E, Neuzil J, Rohlena J.

Cell Death Dis. 2015 May 7;6:e1749. doi: 10.1038/cddis.2015.110.

43.

Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents.

Pasdar EA, Smits M, Stapelberg M, Bajzikova M, Stantic M, Goodwin J, Yan B, Stursa J, Kovarova J, Sachaphibulkij K, Bezawork-Geleta A, Sobol M, Filimonenko A, Tomasetti M, Zobalova R, Hozak P, Dong LF, Neuzil J.

PLoS One. 2015 May 1;10(5):e0119549. doi: 10.1371/journal.pone.0119549. eCollection 2015. Erratum in: PLoS One. 2016;11(5):e0156012.

44.

Liposomal delivery systems for anti-cancer analogues of vitamin E.

Koudelka S, Turanek Knotigova P, Masek J, Prochazka L, Lukac R, Miller AD, Neuzil J, Turanek J.

J Control Release. 2015 Jun 10;207:59-69. doi: 10.1016/j.jconrel.2015.04.003. Epub 2015 Apr 7. Review.

PMID:
25861728
45.

The effect of mitochondrially targeted anticancer agents on mitochondrial (super)complexes.

Vondrusova M, Bezawork-Geleta A, Sachaphibulkij K, Truksa J, Neuzil J.

Methods Mol Biol. 2015;1265:195-208. doi: 10.1007/978-1-4939-2288-8_15.

PMID:
25634277
46.

Evaluation of respiration of mitochondria in cancer cells exposed to mitochondria-targeted agents.

Kluckova K, Dong LF, Bajzikova M, Rohlena J, Neuzil J.

Methods Mol Biol. 2015;1265:181-94. doi: 10.1007/978-1-4939-2288-8_14.

PMID:
25634276
47.

Mitochondrially targeted vitamin E succinate modulates expression of mitochondrial DNA transcripts and mitochondrial biogenesis.

Truksa J, Dong LF, Rohlena J, Stursa J, Vondrusova M, Goodwin J, Nguyen M, Kluckova K, Rychtarcikova Z, Lettlova S, Spacilova J, Stapelberg M, Zoratti M, Neuzil J.

Antioxid Redox Signal. 2015 Apr 10;22(11):883-900. doi: 10.1089/ars.2013.5594. Epub 2015 Feb 25.

PMID:
25578105
48.

Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA.

Tan AS, Baty JW, Dong LF, Bezawork-Geleta A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M, Yan B, Pesdar EA, Sobol M, Filimonenko A, Stuart S, Vondrusova M, Kluckova K, Sachaphibulkij K, Rohlena J, Hozak P, Truksa J, Eccles D, Haupt LM, Griffiths LR, Neuzil J, Berridge MV.

Cell Metab. 2015 Jan 6;21(1):81-94. doi: 10.1016/j.cmet.2014.12.003.

49.

Structural re-arrangement and peroxidase activation of cytochrome c by anionic analogues of vitamin E, tocopherol succinate and tocopherol phosphate.

Yanamala N, Kapralov AA, Djukic M, Peterson J, Mao G, Klein-Seetharaman J, Stoyanovsky DA, Stursa J, Neuzil J, Kagan VE.

J Biol Chem. 2014 Nov 21;289(47):32488-98. doi: 10.1074/jbc.M114.601377. Epub 2014 Oct 2.

50.

Redox-active and redox-silent compounds: synergistic therapeutics in cancer.

Tomasetti M, Santarelli L, Alleva R, Dong LF, Neuzil J.

Curr Med Chem. 2015;22(5):552-68.

PMID:
25245377

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