Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 535

1.

Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans.

Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2019 Apr;47(4):377-385. doi: 10.1124/dmd.118.084665. Epub 2019 Jan 10.

PMID:
30630815
2.

Withdrawal from long-term use of zopiclone, zolpidem and temazepam may improve perceived sleep and quality of life in older adults with primary insomnia.

Lähteenmäki R, Neuvonen PJ, Puustinen J, Vahlberg T, Partinen M, Räihä I, Kivelä SL.

Basic Clin Pharmacol Toxicol. 2019 Mar;124(3):330-340. doi: 10.1111/bcpt.13144. Epub 2018 Dec 3.

PMID:
30295409
3.

Response to "Interaction of Dasabuvir With Clopidogrel: Did Predictions by Physiologically Based Pharmacokinetics Modeling Pass the Test?"

Itkonen MK, Tornio A, Lapatto-Reiniluoto O, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2019 Feb;105(2):322. doi: 10.1002/cpt.1195. Epub 2018 Sep 17. No abstract available.

PMID:
30226021
4.

Voriconazole greatly increases the exposure to oral buprenorphine.

Fihlman M, Hemmilä T, Hagelberg NM, Backman JT, Laitila J, Laine K, Neuvonen PJ, Olkkola KT, Saari TI.

Eur J Clin Pharmacol. 2018 Dec;74(12):1615-1622. doi: 10.1007/s00228-018-2548-8. Epub 2018 Aug 30.

PMID:
30167757
5.

Semimechanistic Population Pharmacokinetic Model to Predict the Drug-Drug Interaction Between S-ketamine and Ticlopidine in Healthy Human Volunteers.

Ashraf MW, Peltoniemi MA, Olkkola KT, Neuvonen PJ, Saari TI.

CPT Pharmacometrics Syst Pharmacol. 2018 Oct;7(10):687-697. doi: 10.1002/psp4.12346. Epub 2018 Sep 10.

6.

CYP3A4*22 Impairs the Elimination of Ticagrelor, But Has No Significant Effect on the Bioactivation of Clopidogrel or Prasugrel.

Holmberg MT, Tornio A, Paile-Hyvärinen M, Tarkiainen EK, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M.

Clin Pharmacol Ther. 2019 Feb;105(2):448-457. doi: 10.1002/cpt.1177. Epub 2018 Aug 20.

PMID:
29998574
7.

Does co-administration of paroxetine change oxycodone analgesia: An interaction study in chronic pain patients.

Lemberg KK, Heiskanen TE, Neuvonen M, Kontinen VK, Neuvonen PJ, Dahl ML, Kalso EA.

Scand J Pain. 2010 Jan 1;1(1):24-33. doi: 10.1016/j.sjpain.2009.09.003.

PMID:
29913934
8.

Long-term persistence of withdrawal of temazepam, zopiclone, and zolpidem in older adults: a 3-year follow-up study.

Puustinen J, Lähteenmäki R, Nurminen J, Vahlberg T, Aarnio P, Partinen M, Räihä I, Neuvonen PJ, Kivelä SL.

BMC Geriatr. 2018 Jun 15;18(1):142. doi: 10.1186/s12877-018-0829-9.

9.

Clopidogrel Increases Dasabuvir Exposure With or Without Ritonavir, and Ritonavir Inhibits the Bioactivation of Clopidogrel.

Itkonen MK, Tornio A, Lapatto-Reiniluoto O, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2019 Jan;105(1):219-228. doi: 10.1002/cpt.1099. Epub 2018 Aug 9.

10.

Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans.

Itkonen MK, Tornio A, Filppula AM, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2018 Sep;104(3):495-504. doi: 10.1002/cpt.947. Epub 2017 Dec 23.

11.

Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions.

Kahma H, Filppula AM, Neuvonen M, Tarkiainen EK, Tornio A, Holmberg MT, Itkonen MK, Finel M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2018 Feb;46(2):141-150. doi: 10.1124/dmd.117.078162. Epub 2017 Nov 14.

PMID:
29138287
12.

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects.

Neuvonen M, Tarkiainen EK, Tornio A, Hirvensalo P, Tapaninen T, Paile-Hyvärinen M, Itkonen MK, Holmberg MT, Kärjä V, Männistö VT, Neuvonen PJ, Pihlajamäki J, Backman JT, Niemi M.

Basic Clin Pharmacol Toxicol. 2018 Mar;122(3):341-345. doi: 10.1111/bcpt.12916. Epub 2017 Nov 17.

13.

Analgesic Plasma Concentrations of Oxycodone After Surgery for Breast Cancer-Which Factors Matter?

Cajanus K, Neuvonen M, Koskela O, Kaunisto MA, Neuvonen PJ, Niemi M, Kalso E.

Clin Pharmacol Ther. 2018 Apr;103(4):653-662. doi: 10.1002/cpt.771. Epub 2017 Aug 24.

PMID:
28643329
14.

Stress-Dose Corticosteroid Versus Placebo in Neonatal Cardiac Operations: A Randomized Controlled Trial.

Suominen PK, Keski-Nisula J, Ojala T, Rautiainen P, Jahnukainen T, Hästbacka J, Neuvonen PJ, Pitkänen O, Niemelä J, Kaskinen A, Salminen J, Lapatto R.

Ann Thorac Surg. 2017 Oct;104(4):1378-1385. doi: 10.1016/j.athoracsur.2017.01.111. Epub 2017 Apr 21.

PMID:
28434547
15.

Rifampicin decreases exposure to sublingual buprenorphine in healthy subjects.

Hagelberg NM, Fihlman M, Hemmilä T, Backman JT, Laitila J, Neuvonen PJ, Laine K, Olkkola KT, Saari TI.

Pharmacol Res Perspect. 2016 Nov 3;4(6):e00271. doi: 10.1002/prp2.271. eCollection 2016 Dec.

16.

Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters.

Tornio A, Neuvonen PJ, Niemi M, Backman JT.

Expert Opin Drug Metab Toxicol. 2017 Jan;13(1):83-95. Epub 2016 Aug 31. Review.

PMID:
27548563
17.

Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction.

Fihlman M, Hemmilä T, Hagelberg NM, Kuusniemi K, Backman JT, Laitila J, Laine K, Neuvonen PJ, Olkkola KT, Saari TI.

Eur J Clin Pharmacol. 2016 Nov;72(11):1363-1371. Epub 2016 Aug 10.

PMID:
27510521
18.

Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone.

Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2016 Aug;44(8):1364-71. doi: 10.1124/dmd.116.070375. Epub 2016 Jun 3.

PMID:
27260150
19.

High-Dose Methylprednisolone Has No Benefit Over Moderate Dose for the Correction of Tetralogy of Fallot.

Keski-Nisula J, Pesonen E, Olkkola KT, Ahlroth T, Puntila J, Andersson S, Neuvonen PJ, Suominen PK.

Ann Thorac Surg. 2016 Sep;102(3):870-876. doi: 10.1016/j.athoracsur.2016.02.089. Epub 2016 May 4.

PMID:
27154159
20.

Lipid Rescue - Efficacy and Safety Still Unproven.

Höjer J, Jacobsen D, Neuvonen PJ, Rosenberg PH.

Basic Clin Pharmacol Toxicol. 2016 Oct;119(4):345-8. doi: 10.1111/bcpt.12607. Epub 2016 May 20. No abstract available.

21.

Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions.

Backman JT, Filppula AM, Niemi M, Neuvonen PJ.

Pharmacol Rev. 2016 Jan;68(1):168-241. doi: 10.1124/pr.115.011411. Review.

PMID:
26721703
22.

Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin.

Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2015 Nov;43(11):1655-60. doi: 10.1124/dmd.115.065938. Epub 2015 Sep 1.

PMID:
26329790
23.

Drug-Related Inadvertent Deaths in a University Hospital--A Declining Trend.

Lapatto-Reiniluoto O, Patinen L, Niemi M, Backman JT, Neuvonen PJ.

Basic Clin Pharmacol Toxicol. 2015 Dec;117(6):421-6. doi: 10.1111/bcpt.12435. Epub 2015 Jul 21.

24.

SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid.

Tornio A, Vakkilainen J, Neuvonen M, Backman JT, Neuvonen PJ, Niemi M.

Pharmacogenet Genomics. 2015 Aug;25(8):382-7. doi: 10.1097/FPC.0000000000000148.

PMID:
26020121
25.

Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril.

Tarkiainen EK, Tornio A, Holmberg MT, Launiainen T, Neuvonen PJ, Backman JT, Niemi M.

Br J Clin Pharmacol. 2015 Nov;80(5):1131-8. doi: 10.1111/bcp.12667. Epub 2015 Jun 11.

26.

Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans.

Tarkiainen EK, Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M.

Clin Pharmacol Ther. 2015 Jun;97(6):650-8. doi: 10.1002/cpt.101. Epub 2015 May 9.

PMID:
25704243
27.

Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol.

Saarikoski T, Saari TI, Hagelberg NM, Backman JT, Neuvonen PJ, Scheinin M, Olkkola KT, Laine K.

Eur J Clin Pharmacol. 2015 Mar;71(3):321-7. doi: 10.1007/s00228-014-1799-2. Epub 2015 Jan 6.

PMID:
25560051
28.

Effect of grapefruit juice on the bioactivation of prasugrel.

Holmberg MT, Tornio A, Hyvärinen H, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M.

Br J Clin Pharmacol. 2015 Jul;80(1):139-45. doi: 10.1111/bcp.12581. Epub 2015 Jun 1.

29.

The role of concentration--effect relationships in the QTc interval prolongation: case sotalol.

Neuvonen PJ, Elonen E.

Br J Clin Pharmacol. 2015 Jun;79(6):1040-1. doi: 10.1111/bcp.12574. No abstract available.

30.

Effect of timing and route of methylprednisolone administration during pediatric cardiac surgical procedures.

Keski-Nisula J, Suominen PK, Olkkola KT, Peltola K, Neuvonen PJ, Tynkkynen P, Salminen JT, Andersson S, Pesonen E.

Ann Thorac Surg. 2015 Jan;99(1):180-5. doi: 10.1016/j.athoracsur.2014.08.042. Epub 2014 Nov 18.

PMID:
25440273
31.

Handgrip strength and balance in older adults following withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotics.

Nurminen J, Puustinen J, Lähteenmäki R, Vahlberg T, Lyles A, Partinen M, Räihä I, Neuvonen PJ, Kivelä SL.

BMC Geriatr. 2014 Nov 21;14:121. doi: 10.1186/1471-2318-14-121.

32.

Paroxetine markedly increases plasma concentrations of ophthalmic timolol; CYP2D6 inhibitors may increase the risk of cardiovascular adverse effects of 0.5% timolol eye drops.

Mäenpää J, Volotinen-Maja M, Kautiainen H, Neuvonen M, Niemi M, Neuvonen PJ, Backman JT.

Drug Metab Dispos. 2014 Dec;42(12):2068-76. doi: 10.1124/dmd.114.059576. Epub 2014 Sep 26.

PMID:
25261563
33.

Glucuronidation converts clopidogrel to a strong time-dependent inhibitor of CYP2C8: a phase II metabolite as a perpetrator of drug-drug interactions.

Tornio A, Filppula AM, Kailari O, Neuvonen M, Nyrönen TH, Tapaninen T, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2014 Oct;96(4):498-507. doi: 10.1038/clpt.2014.141. Epub 2014 Jun 27.

PMID:
24971633
34.

Infections and possible vaccine-drug interactions.

Raaska K, Neuvonen PJ.

Eur J Clin Pharmacol. 2014 Jul;70(7):889-90. doi: 10.1007/s00228-014-1688-8. Epub 2014 May 8. No abstract available.

PMID:
24801149
35.

In vitro assessment of time-dependent inhibitory effects on CYP2C8 and CYP3A activity by fourteen protein kinase inhibitors.

Filppula AM, Neuvonen PJ, Backman JT.

Drug Metab Dispos. 2014 Jul;42(7):1202-9. doi: 10.1124/dmd.114.057695. Epub 2014 Apr 8.

PMID:
24713129
36.

Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults.

Puustinen J, Lähteenmäki R, Polo-Kantola P, Salo P, Vahlberg T, Lyles A, Neuvonen PJ, Partinen M, Räihä I, Kivelä SL.

Eur J Clin Pharmacol. 2014 Mar;70(3):319-29. doi: 10.1007/s00228-013-1613-6. Epub 2013 Dec 12.

PMID:
24337417
37.

Melatonin for sedative withdrawal in older patients with primary insomnia: a randomized double-blind placebo-controlled trial.

Lähteenmäki R, Puustinen J, Vahlberg T, Lyles A, Neuvonen PJ, Partinen M, Räihä I, Kivelä SL.

Br J Clin Pharmacol. 2014 Jun;77(6):975-85. doi: 10.1111/bcp.12294.

38.

Grapefruit juice inhibits the metabolic activation of clopidogrel.

Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M.

Clin Pharmacol Ther. 2014 Mar;95(3):307-13. doi: 10.1038/clpt.2013.192. Epub 2013 Sep 25.

PMID:
24067745
39.

A randomized clinical trial of histamine 2 receptor antagonism in treatment-resistant schizophrenia.

Meskanen K, Ekelund H, Laitinen J, Neuvonen PJ, Haukka J, Panula P, Ekelund J.

J Clin Psychopharmacol. 2013 Aug;33(4):472-8. doi: 10.1097/JCP.0b013e3182970490.

PMID:
23764683
40.

Gemfibrozil impairs imatinib absorption and inhibits the CYP2C8-mediated formation of its main metabolite.

Filppula AM, Tornio A, Niemi M, Neuvonen PJ, Backman JT.

Clin Pharmacol Ther. 2013 Sep;94(3):383-93. doi: 10.1038/clpt.2013.92. Epub 2013 May 8.

PMID:
23657159
41.

A semiphysiological population pharmacokinetic model for dynamic inhibition of liver and gut wall cytochrome P450 3A by voriconazole.

Frechen S, Junge L, Saari TI, Suleiman AA, Rokitta D, Neuvonen PJ, Olkkola KT, Fuhr U.

Clin Pharmacokinet. 2013 Sep;52(9):763-81. doi: 10.1007/s40262-013-0070-9.

PMID:
23653047
42.

Intravenous lipid emulsion entraps amitriptyline into plasma and can lower its brain concentration--an experimental intoxication study in pigs.

Heinonen JA, Litonius E, Backman JT, Neuvonen PJ, Rosenberg PH.

Basic Clin Pharmacol Toxicol. 2013 Sep;113(3):193-200. doi: 10.1111/bcpt.12082. Epub 2013 May 29.

43.

Methylprednisolone in neonatal cardiac surgery: reduced inflammation without improved clinical outcome.

Keski-Nisula J, Pesonen E, Olkkola KT, Peltola K, Neuvonen PJ, Tuominen N, Sairanen H, Andersson S, Suominen PK.

Ann Thorac Surg. 2013 Jun;95(6):2126-32. doi: 10.1016/j.athoracsur.2013.02.013. Epub 2013 Apr 18.

PMID:
23602068
44.

[Prediction and prevention of severe adverse effects and hazardous interactions of drugs].

Neuvonen PJ.

Duodecim. 2013;129(1):22-30. Review. Finnish.

PMID:
23431879
45.

Rifampicin markedly decreases the exposure to oral and intravenous tramadol.

Saarikoski T, Saari TI, Hagelberg NM, Neuvonen M, Neuvonen PJ, Scheinin M, Olkkola KT, Laine K.

Eur J Clin Pharmacol. 2013 Jun;69(6):1293-301. doi: 10.1007/s00228-012-1460-x. Epub 2012 Dec 15.

PMID:
23242004
46.

SLCO2B1 c.935G>A single nucleotide polymorphism has no effect on the pharmacokinetics of montelukast and aliskiren.

Tapaninen T, Karonen T, Backman JT, Neuvonen PJ, Niemi M.

Pharmacogenet Genomics. 2013 Jan;23(1):19-24. doi: 10.1097/FPC.0b013e32835bac90.

PMID:
23151832
47.

Statins and hip fracture prevention--a population based cohort study in women.

Helin-Salmivaara A, Korhonen MJ, Lehenkari P, Junnila SY, Neuvonen PJ, Ruokoniemi P, Huupponen R.

PLoS One. 2012;7(10):e48095. doi: 10.1371/journal.pone.0048095. Epub 2012 Oct 29.

48.

Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects.

Holmberg MT, Tornio A, Joutsi-Korhonen L, Neuvonen M, Neuvonen PJ, Lassila R, Niemi M, Backman JT.

Br J Clin Pharmacol. 2013 Jun;75(6):1488-96. doi: 10.1111/bcp.12026.

49.

Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction.

Hagelberg NM, Saarikoski T, Saari TI, Neuvonen M, Neuvonen PJ, Turpeinen M, Scheinin M, Laine K, Olkkola KT.

Eur J Clin Pharmacol. 2013 Apr;69(4):867-75. doi: 10.1007/s00228-012-1433-0. Epub 2012 Oct 26.

PMID:
23099620
50.

Autoinhibition of CYP3A4 leads to important role of CYP2C8 in imatinib metabolism: variability in CYP2C8 activity may alter plasma concentrations and response.

Filppula AM, Neuvonen M, Laitila J, Neuvonen PJ, Backman JT.

Drug Metab Dispos. 2013 Jan;41(1):50-9. doi: 10.1124/dmd.112.048017. Epub 2012 Oct 1.

PMID:
23028140

Supplemental Content

Loading ...
Support Center