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Structure of the Bcs1 AAA-ATPase suggests an airlock-like translocation mechanism for folded proteins.

Kater L, Wagener N, Berninghausen O, Becker T, Neupert W, Beckmann R.

Nat Struct Mol Biol. 2020 Feb;27(2):142-149. doi: 10.1038/s41594-019-0364-1. Epub 2020 Jan 27.


Publisher Correction: Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.

Su T, Izawa T, Thoms M, Yamashita Y, Cheng J, Berninghausen O, Hartl FU, Inada T, Neupert W, Beckmann R.

Nature. 2019 Jul;571(7764):E4. doi: 10.1038/s41586-019-1360-7.


Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.

Su T, Izawa T, Thoms M, Yamashita Y, Cheng J, Berninghausen O, Hartl FU, Inada T, Neupert W, Beckmann R.

Nature. 2019 Jun;570(7762):538-542. doi: 10.1038/s41586-019-1307-z. Epub 2019 Jun 12. Erratum in: Nature. 2019 Jun 25;:.


A mutagenesis analysis of Tim50, the major receptor of the TIM23 complex, identifies regions that affect its interaction with Tim23.

Dayan D, Bandel M, Günsel U, Nussbaum I, Prag G, Mokranjac D, Neupert W, Azem A.

Sci Rep. 2019 Feb 14;9(1):2012. doi: 10.1038/s41598-018-38353-1.


Cytosolic Protein Vms1 Links Ribosome Quality Control to Mitochondrial and Cellular Homeostasis.

Izawa T, Park SH, Zhao L, Hartl FU, Neupert W.

Cell. 2017 Nov 2;171(4):890-903.e18. doi: 10.1016/j.cell.2017.10.002. Epub 2017 Oct 26.


Analysis of Yeast Mitochondria by Electron Microscopy.

Unger AK, Geimer S, Harner M, Neupert W, Westermann B.

Methods Mol Biol. 2017;1567:293-314. doi: 10.1007/978-1-4939-6824-4_18.


Role of Tim17 in coupling the import motor to the translocation channel of the mitochondrial presequence translocase.

Demishtein-Zohary K, Günsel U, Marom M, Banerjee R, Neupert W, Azem A, Mokranjac D.

Elife. 2017 Feb 6;6. pii: e22696. doi: 10.7554/eLife.22696.


An evidence based hypothesis on the existence of two pathways of mitochondrial crista formation.

Harner ME, Unger AK, Geerts WJ, Mari M, Izawa T, Stenger M, Geimer S, Reggiori F, Westermann B, Neupert W.

Elife. 2016 Nov 16;5. pii: e18853. doi: 10.7554/eLife.18853.


Mitochondrial Gene Expression: A Playground of Evolutionary Tinkering.

Neupert W.

Annu Rev Biochem. 2016 Jun 2;85:65-76. doi: 10.1146/annurev-biochem-011116-110824. Epub 2016 Apr 8. Review.


Cell biology: Architecture of a protein entry gate.

Mokranjac D, Neupert W.

Nature. 2015 Dec 10;528(7581):201-2. doi: 10.1038/nature16318. Epub 2015 Nov 25. No abstract available.


Parallel Structural Evolution of Mitochondrial Ribosomes and OXPHOS Complexes.

van der Sluis EO, Bauerschmitt H, Becker T, Mielke T, Frauenfeld J, Berninghausen O, Neupert W, Herrmann JM, Beckmann R.

Genome Biol Evol. 2015 Apr 9;7(5):1235-51. doi: 10.1093/gbe/evv061.


GxxxG motifs hold the TIM23 complex together.

Demishtein-Zohary K, Marom M, Neupert W, Mokranjac D, Azem A.

FEBS J. 2015 Jun;282(11):2178-86. doi: 10.1111/febs.13266. Epub 2015 Apr 10.


A perspective on transport of proteins into mitochondria: a myriad of open questions.

Neupert W.

J Mol Biol. 2015 Mar 27;427(6 Pt A):1135-58. doi: 10.1016/j.jmb.2015.02.001. Epub 2015 Feb 9.


Cooperation of TOM and TIM23 complexes during translocation of proteins into mitochondria.

Waegemann K, Popov-Čeleketić D, Neupert W, Azem A, Mokranjac D.

J Mol Biol. 2015 Mar 13;427(5):1075-84. doi: 10.1016/j.jmb.2014.07.015. Epub 2014 Jul 30.


Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture.

Harner ME, Unger AK, Izawa T, Walther DM, Ozbalci C, Geimer S, Reggiori F, Brügger B, Mann M, Westermann B, Neupert W.

Elife. 2014 Jan 1;3:e01684. doi: 10.7554/eLife.01684.


Uniform nomenclature for the mitochondrial contact site and cristae organizing system.

Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS, Taylor SS, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman JS, Westermann B, Zha J, Neupert W, Nunnari J.

J Cell Biol. 2014 Mar 31;204(7):1083-6. doi: 10.1083/jcb.201401006.


Characterization of the insertase for β-barrel proteins of the outer mitochondrial membrane.

Klein A, Israel L, Lackey SW, Nargang FE, Imhof A, Baumeister W, Neupert W, Thomas DR.

J Cell Biol. 2012 Nov 12;199(4):599-611. doi: 10.1083/jcb.201207161. Epub 2012 Nov 5.


Biogenesis of the mitochondrial Hsp70 chaperone.

Blamowska M, Neupert W, Hell K.

J Cell Biol. 2012 Oct 1;199(1):125-35. doi: 10.1083/jcb.201205012. Epub 2012 Sep 24.


Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria.

Schreiner B, Westerburg H, Forné I, Imhof A, Neupert W, Mokranjac D.

Mol Biol Cell. 2012 Nov;23(22):4335-46. doi: 10.1091/mbc.E12-05-0420. Epub 2012 Sep 19.


A mitochondrial odyssey.

Neupert W.

Annu Rev Biochem. 2012;81:1-33. doi: 10.1146/annurev-biochem-083109-171531.


Bcs1, a AAA protein of the mitochondria with a role in the biogenesis of the respiratory chain.

Wagener N, Neupert W.

J Struct Biol. 2012 Aug;179(2):121-5. doi: 10.1016/j.jsb.2012.04.019. Epub 2012 May 7. Review.


SnapShot: Mitochondrial architecture.

Neupert W.

Cell. 2012 Apr 27;149(3):722-722.e1. doi: 10.1016/j.cell.2012.04.010. No abstract available.


The C-terminal domain of Fcj1 is required for formation of crista junctions and interacts with the TOB/SAM complex in mitochondria.

Körner C, Barrera M, Dukanovic J, Eydt K, Harner M, Rabl R, Vogel F, Rapaport D, Neupert W, Reichert AS.

Mol Biol Cell. 2012 Jun;23(11):2143-55. doi: 10.1091/mbc.E11-10-0831. Epub 2012 Apr 11.


A pathway of protein translocation in mitochondria mediated by the AAA-ATPase Bcs1.

Wagener N, Ackermann M, Funes S, Neupert W.

Mol Cell. 2011 Oct 21;44(2):191-202. doi: 10.1016/j.molcel.2011.07.036.


The mitochondrial contact site complex, a determinant of mitochondrial architecture.

Harner M, Körner C, Walther D, Mokranjac D, Kaesmacher J, Welsch U, Griffith J, Mann M, Reggiori F, Neupert W.

EMBO J. 2011 Oct 18;30(21):4356-70. doi: 10.1038/emboj.2011.379.


Direct interaction of mitochondrial targeting presequences with purified components of the TIM23 protein complex.

Marom M, Dayan D, Demishtein-Zohary K, Mokranjac D, Neupert W, Azem A.

J Biol Chem. 2011 Dec 23;286(51):43809-15. doi: 10.1074/jbc.M111.261040. Epub 2011 Oct 3.


Lateral release of proteins from the TOM complex into the outer membrane of mitochondria.

Harner M, Neupert W, Deponte M.

EMBO J. 2011 Jul 15;30(16):3232-41. doi: 10.1038/emboj.2011.235.


Role of the import motor in insertion of transmembrane segments by the mitochondrial TIM23 complex.

Popov-Čeleketić D, Waegemann K, Mapa K, Neupert W, Mokranjac D.

EMBO Rep. 2011 Jun;12(6):542-8. doi: 10.1038/embor.2011.72. Epub 2011 May 6.


Intramembrane proteolysis of Mgm1 by the mitochondrial rhomboid protease is highly promiscuous regarding the sequence of the cleaved hydrophobic segment.

Schäfer A, Zick M, Kief J, Steger M, Heide H, Duvezin-Caubet S, Neupert W, Reichert AS.

J Mol Biol. 2010 Aug 13;401(2):182-93. doi: 10.1016/j.jmb.2010.06.014. Epub 2010 Jun 15.


The conformational dynamics of the mitochondrial Hsp70 chaperone.

Mapa K, Sikor M, Kudryavtsev V, Waegemann K, Kalinin S, Seidel CA, Neupert W, Lamb DC, Mokranjac D.

Mol Cell. 2010 Apr 9;38(1):89-100. doi: 10.1016/j.molcel.2010.03.010.


Roles of the Mdm10, Tom7, Mdm12, and Mmm1 proteins in the assembly of mitochondrial outer membrane proteins in Neurospora crassa.

Wideman JG, Go NE, Klein A, Redmond E, Lackey SW, Tao T, Kalbacher H, Rapaport D, Neupert W, Nargang FE.

Mol Biol Cell. 2010 May 15;21(10):1725-36. doi: 10.1091/mbc.E09-10-0844. Epub 2010 Mar 24.


The many faces of the mitochondrial TIM23 complex.

Mokranjac D, Neupert W.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1045-54. doi: 10.1016/j.bbabio.2010.01.026. Epub 2010 Jan 28. Review.


ATPase domain and interdomain linker play a key role in aggregation of mitochondrial Hsp70 chaperone Ssc1.

Blamowska M, Sichting M, Mapa K, Mokranjac D, Neupert W, Hell K.

J Biol Chem. 2010 Feb 12;285(7):4423-31. doi: 10.1074/jbc.M109.061697. Epub 2009 Dec 10.


Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g.

Rabl R, Soubannier V, Scholz R, Vogel F, Mendl N, Vasiljev-Neumeyer A, Körner C, Jagasia R, Keil T, Baumeister W, Cyrklaff M, Neupert W, Reichert AS.

J Cell Biol. 2009 Jun 15;185(6):1047-63. doi: 10.1083/jcb.200811099.


Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion.

Zick M, Duvezin-Caubet S, Schäfer A, Vogel F, Neupert W, Reichert AS.

FEBS Lett. 2009 Jul 7;583(13):2237-43. doi: 10.1016/j.febslet.2009.05.053. Epub 2009 Jun 6.


Role of Tim50 in the transfer of precursor proteins from the outer to the inner membrane of mitochondria.

Mokranjac D, Sichting M, Popov-Celeketić D, Mapa K, Gevorkyan-Airapetov L, Zohary K, Hell K, Azem A, Neupert W.

Mol Biol Cell. 2009 Mar;20(5):1400-7. doi: 10.1091/mbc.E08-09-0934. Epub 2009 Jan 14.


Interaction of Tim23 with Tim50 Is essential for protein translocation by the mitochondrial TIM23 complex.

Gevorkyan-Airapetov L, Zohary K, Popov-Celeketic D, Mapa K, Hell K, Neupert W, Azem A, Mokranjac D.

J Biol Chem. 2009 Feb 20;284(8):4865-72. doi: 10.1074/jbc.M807041200. Epub 2008 Nov 18.


The disulfide relay system of mitochondria is required for the biogenesis of mitochondrial Ccs1 and Sod1.

Reddehase S, Grumbt B, Neupert W, Hell K.

J Mol Biol. 2009 Jan 16;385(2):331-8. doi: 10.1016/j.jmb.2008.10.088. Epub 2008 Nov 7.


Thirty years of protein translocation into mitochondria: unexpectedly complex and still puzzling.

Mokranjac D, Neupert W.

Biochim Biophys Acta. 2009 Jan;1793(1):33-41. doi: 10.1016/j.bbamcr.2008.06.021. Epub 2008 Jul 12. Review.


Energetics of protein translocation into mitochondria.

Mokranjac D, Neupert W.

Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):758-62. doi: 10.1016/j.bbabio.2008.04.009. Epub 2008 Apr 12. Review.


Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria.

Popov-Celeketić D, Mapa K, Neupert W, Mokranjac D.

EMBO J. 2008 May 21;27(10):1469-80. doi: 10.1038/emboj.2008.79. Epub 2008 Apr 17.


Protein import into isolated mitochondria.

Mokranjac D, Neupert W.

Methods Mol Biol. 2007;372:277-86. doi: 10.1007/978-1-59745-365-3_20.


OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria.

Duvezin-Caubet S, Koppen M, Wagener J, Zick M, Israel L, Bernacchia A, Jagasia R, Rugarli EI, Imhof A, Neupert W, Langer T, Reichert AS.

Mol Biol Cell. 2007 Sep;18(9):3582-90. Epub 2007 Jul 5.


Association of the Tim14.Tim16 subcomplex with the TIM23 translocase is crucial for function of the mitochondrial protein import motor.

Mokranjac D, Berg A, Adam A, Neupert W, Hell K.

J Biol Chem. 2007 Jun 22;282(25):18037-45. Epub 2007 Apr 23.


Analysis and prediction of mitochondrial targeting signals.

Habib SJ, Neupert W, Rapaport D.

Methods Cell Biol. 2007;80:761-81. Review. No abstract available.


The sulfhydryl oxidase Erv1 is a substrate of the Mia40-dependent protein translocation pathway.

Terziyska N, Grumbt B, Bien M, Neupert W, Herrmann JM, Hell K.

FEBS Lett. 2007 Mar 20;581(6):1098-102. Epub 2007 Feb 15.


Translocation of proteins into mitochondria.

Neupert W, Herrmann JM.

Annu Rev Biochem. 2007;76:723-49. Review.


The N-terminal domain of Tob55 has a receptor-like function in the biogenesis of mitochondrial beta-barrel proteins.

Habib SJ, Waizenegger T, Niewienda A, Paschen SA, Neupert W, Rapaport D.

J Cell Biol. 2007 Jan 1;176(1):77-88. Epub 2006 Dec 26.


The metalloprotease encoded by ATP23 has a dual function in processing and assembly of subunit 6 of mitochondrial ATPase.

Zeng X, Neupert W, Tzagoloff A.

Mol Biol Cell. 2007 Feb;18(2):617-26. Epub 2006 Nov 29.

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