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1.

[Viral Hepatitis: When to be Considered in Clinical Routine?]

Luxenburger H, Thimme R, Neumann-Haefelin C.

Dtsch Med Wochenschr. 2019 Apr;144(8):520-527. doi: 10.1055/a-0640-3627. Epub 2019 Apr 15. German.

PMID:
30986859
2.

OX40 stimulation and PD-L1 blockade synergistically augment HBV-specific CD4 T cells in patients with HBeAg-negative infection.

Jacobi FJ, Wild K, Smits M, Zoldan K, Csernalabics B, Flecken T, Lang J, Ehrenmann P, Emmerich F, Hofmann M, Thimme R, Neumann-Haefelin C, Boettler T.

J Hepatol. 2019 Jun;70(6):1103-1113. doi: 10.1016/j.jhep.2019.02.016. Epub 2019 Feb 28.

PMID:
30826436
3.

ERAP1 allotypes shape the epitope repertoire of virus-specific CD8+ T cell responses in acute hepatitis C virus infection.

Kemming J, Reeves E, Nitschke K, Widmeier V, Emmerich F, Hermle T, Gostick E, Walker A, Timm J, Price DA, Hofmann M, Thimme R, James E, Neumann-Haefelin C.

J Hepatol. 2019 Jun;70(6):1072-1081. doi: 10.1016/j.jhep.2019.01.034. Epub 2019 Feb 13.

4.

Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8+ T Cells and Evolve at the Population Level.

Karimzadeh H, Kiraithe MM, Oberhardt V, Salimi Alizei E, Bockmann J, Schulze Zur Wiesch J, Budeus B, Hoffmann D, Wedemeyer H, Cornberg M, Krawczyk A, Rashidi-Alavijeh J, Rodríguez-Frías F, Casillas R, Buti M, Smedile A, Alavian SM, Heinold A, Emmerich F, Panning M, Gostick E, Price DA, Timm J, Hofmann M, Raziorrouh B, Thimme R, Protzer U, Roggendorf M, Neumann-Haefelin C.

Gastroenterology. 2019 May;156(6):1820-1833. doi: 10.1053/j.gastro.2019.02.003. Epub 2019 Feb 12.

5.

Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load.

Schuch A, Salimi Alizei E, Heim K, Wieland D, Kiraithe MM, Kemming J, Llewellyn-Lacey S, Sogukpinar Ö, Ni Y, Urban S, Zimmermann P, Nassal M, Emmerich F, Price DA, Bengsch B, Luxenburger H, Neumann-Haefelin C, Hofmann M, Thimme R.

Gut. 2019 May;68(5):905-915. doi: 10.1136/gutjnl-2018-316641. Epub 2019 Jan 8.

6.

Immunological cure of HBV infection.

Lang J, Neumann-Haefelin C, Thimme R.

Hepatol Int. 2019 Mar;13(2):113-124. doi: 10.1007/s12072-018-9912-8. Epub 2019 Jan 2. Review.

PMID:
30600480
7.

HCV-Specific T Cell Responses During and After Chronic HCV Infection.

Luxenburger H, Neumann-Haefelin C, Thimme R, Boettler T.

Viruses. 2018 Nov 17;10(11). pii: E645. doi: 10.3390/v10110645. Review.

8.

NK-cell responses are biased towards CD16-mediated effector functions in chronic hepatitis B virus infection.

Schuch A, Zecher BF, Müller PA, Correia MP, Daul F, Rennert C, Tauber C, Schlitt K, Boettler T, Neumann-Haefelin C, Hengel H, Pircher H, Cerwenka A, Thimme R, Hofmann M.

J Hepatol. 2019 Mar;70(3):351-360. doi: 10.1016/j.jhep.2018.10.006. Epub 2018 Oct 18.

9.

Entering the spotlight: hepatitis B surface antigen-specific B cells.

Neumann-Haefelin C, Thimme R.

J Clin Invest. 2018 Oct 1;128(10):4257-4259. doi: 10.1172/JCI124098. Epub 2018 Sep 17.

10.

Follicular T Helper Cell Signatures in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis.

Adam L, Zoldan K, Hofmann M, Schultheiss M, Bettinger D, Neumann-Haefelin C, Thimme R, Böettler T.

Hepatol Commun. 2018 Sep 7;2(9):1051-1063. doi: 10.1002/hep4.1226. eCollection 2018 Sep.

11.

Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8+ T Cells.

Karimzadeh H, Kiraithe MM, Kosinska AD, Glaser M, Fiedler M, Oberhardt V, Salimi Alizei E, Hofmann M, Mok JY, Nguyen M, van Esch WJE, Budeus B, Grabowski J, Homs M, Olivero A, Keyvani H, Rodríguez-Frías F, Tabernero D, Buti M, Heinold A, Alavian SM, Bauer T, Schulze Zur Wiesch J, Raziorrouh B, Hoffmann D, Smedile A, Rizzetto M, Wedemeyer H, Timm J, Antes I, Neumann-Haefelin C, Protzer U, Roggendorf M.

J Virol. 2018 Jun 13;92(13). pii: e01891-17. doi: 10.1128/JVI.01891-17. Print 2018 Jul 1.

12.

Secretion of Hepatitis C Virus Replication Intermediates Reduces Activation of Toll-Like Receptor 3 in Hepatocytes.

Grünvogel O, Colasanti O, Lee JY, Klöss V, Belouzard S, Reustle A, Esser-Nobis K, Hesebeck-Brinckmann J, Mutz P, Hoffmann K, Mehrabi A, Koschny R, Vondran FWR, Gotthardt D, Schnitzler P, Neumann-Haefelin C, Thimme R, Binder M, Bartenschlager R, Dubuisson J, Dalpke AH, Lohmann V.

Gastroenterology. 2018 Jun;154(8):2237-2251.e16. doi: 10.1053/j.gastro.2018.03.020. Epub 2018 Mar 11.

13.

Differential virus-specific CD8+ T-cell epitope repertoire in hepatitis C virus genotype 1 versus 4.

Luxenburger H, Graß F, Baermann J, Boettler T, Marget M, Emmerich F, Panning M, Thimme R, Nitschke K, Neumann-Haefelin C.

J Viral Hepat. 2018 Jul;25(7):779-790. doi: 10.1111/jvh.12874. Epub 2018 Feb 27.

PMID:
29397015
14.

Survival benefit of transarterial chemoembolization in patients with metastatic hepatocellular carcinoma: a single center experience.

Bettinger D, Spode R, Glaser N, Buettner N, Boettler T, Neumann-Haefelin C, Brunner TB, Gkika E, Maruschke L, Thimme R, Schultheiss M.

BMC Gastroenterol. 2017 Aug 10;17(1):98. doi: 10.1186/s12876-017-0656-z.

15.

TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation.

Wieland D, Kemming J, Schuch A, Emmerich F, Knolle P, Neumann-Haefelin C, Held W, Zehn D, Hofmann M, Thimme R.

Nat Commun. 2017 May 3;8:15050. doi: 10.1038/ncomms15050.

16.

Erratum: Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.

Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, Florian WR, De Francesco R, Rice CM, Bartenschlager R, Lohmann V.

Nat Microbiol. 2017 Jan 23;2:17012. doi: 10.1038/nmicrobiol.2017.12. No abstract available.

PMID:
28112725
17.

Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.

Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, Vondran FW, De Francesco R, Rice CM, Bartenschlager R, Lohmann V.

Nat Microbiol. 2016 Dec 19;2:16247. doi: 10.1038/nmicrobiol.2016.247. Erratum in: Nat Microbiol. 2017 Jan 23;2:17012.

PMID:
27991882
18.

Hepitopes: A live interactive database of HLA class I epitopes in hepatitis B virus.

Lumley S, Noble H, Hadley MJ, Callow L, Malik A, Chua YY, Duffey OJ, Grolmusova N, Kumar A, Ravenscroft S, Spencer JI, Neumann-Haefelin C, Thimme R, Andersson M, Klenerman P, Barnes E, Matthews PC.

Wellcome Open Res. 2016 Nov 15;1:9. doi: 10.12688/wellcomeopenres.9952.1.

19.

Mapping the genomic diversity of HCV subtypes 1a and 1b: Implications of structural and immunological constraints for vaccine and drug development.

Cuypers L, Li G, Neumann-Haefelin C, Piampongsant S, Libin P, Van Laethem K, Vandamme AM, Theys K.

Virus Evol. 2016 Sep 6;2(2):vew024. eCollection 2016 Jul.

20.

[Hepatic amyloidosis as a rare differential diagnosis of progressive liver failure].

Bettinger D, Lutz L, Schultheiß M, Werner M, Thimme R, Neumann-Haefelin C.

Dtsch Med Wochenschr. 2016 Sep;141(19):1387-9. doi: 10.1055/s-0042-113053. Epub 2016 Sep 19. German.

PMID:
27642740
21.

CD8+ T-Cell Responses in Hepatitis B and C: The (HLA-) A, B, and C of Hepatitis B and C.

Nitschke K, Luxenburger H, Kiraithe MM, Thimme R, Neumann-Haefelin C.

Dig Dis. 2016;34(4):396-409. doi: 10.1159/000444555. Epub 2016 May 11. Review.

PMID:
27170395
22.

Sigmoid Colon Compression Due to Liver Migration and Hypertrophy.

Schultheiss M, Neeff HP, Neumann-Haefelin C.

Clin Gastroenterol Hepatol. 2016 Aug;14(8):A27. doi: 10.1016/j.cgh.2016.05.002. Epub 2016 May 7. No abstract available.

PMID:
27165468
23.

The cyclophilin-inhibitor alisporivir stimulates antigen presentation thereby promoting antigen-specific CD8(+) T cell activation.

Esser-Nobis K, Schmidt J, Nitschke K, Neumann-Haefelin C, Thimme R, Lohmann V.

J Hepatol. 2016 Jun;64(6):1305-14. doi: 10.1016/j.jhep.2016.02.027. Epub 2016 Feb 26.

PMID:
26921685
24.

Cardiac volume overload and pulmonary hypertension in long-term follow-up of patients with a transjugular intrahepatic portosystemic shunt.

Wannhoff A, Hippchen T, Weiss CS, Friedrich K, Rupp C, Neumann-Haefelin C, Dollinger M, Antoni C, Stampfl U, Schemmer P, Stremmel W, Weiss KH, Radeleff B, Katus HA, Gotthardt DN.

Aliment Pharmacol Ther. 2016 May;43(9):955-65. doi: 10.1111/apt.13569. Epub 2016 Feb 26.

25.

Coffee consumption protects against progression in liver cirrhosis and increases long-term survival after liver transplantation.

Friedrich K, Smit M, Wannhoff A, Rupp C, Scholl SG, Antoni C, Dollinger M, Neumann-Haefelin C, Stremmel W, Weiss KH, Schemmer P, Gotthardt DN.

J Gastroenterol Hepatol. 2016 Aug;31(8):1470-5. doi: 10.1111/jgh.13319.

PMID:
26880589
26.

Virus-Specific CD4+ T Cells Have Functional and Phenotypic Characteristics of Follicular T-Helper Cells in Patients With Acute and Chronic HCV Infections.

Raziorrouh B, Sacher K, Tawar RG, Emmerich F, Neumann-Haefelin C, Baumert TF, Thimme R, Boettler T.

Gastroenterology. 2016 Mar;150(3):696-706.e3. doi: 10.1053/j.gastro.2015.11.005. Epub 2015 Nov 14.

PMID:
26584604
27.

Association of serum zinc levels with liver function and survival in patients awaiting liver transplantation.

Friedrich K, Baumann C, Brune M, Wannhoff A, Rupp C, Scholl SG, Antoni C, Dollinger M, Neumann-Haefelin C, Weiss KH, Stremmel W, Schemmer P, Gotthardt DN.

Langenbecks Arch Surg. 2015 Oct;400(7):805-11. doi: 10.1007/s00423-015-1334-7. Epub 2015 Aug 26.

PMID:
26306416
28.

Importance of molecular typing in confirmation of the source of a national hepatitis A virus outbreak in Norway and the detection of a related cluster in Germany.

Guzman-Herrador BR, Panning M, Stene-Johansen K, Borgen K, Einöder-Moreno M, Huzly D, Jensvoll L, Lange H, Maassen S, Myking S, Myrmel M, Neumann-Haefelin C, Nygård K, Wenzel JJ, Øye AK, Vold L.

Arch Virol. 2015 Nov;160(11):2823-6. doi: 10.1007/s00705-015-2531-y. Epub 2015 Aug 7.

PMID:
26249822
29.

[Cure of chronic Hepatitis B and C: vision versus reality].

Boettler T, Thimme R, Neumann-Haefelin C.

Dtsch Med Wochenschr. 2015 Jul;140(14):1056-62. doi: 10.1055/s-0041-102928. Epub 2015 Jul 16. German.

PMID:
26182254
30.

An uncommon presentation of a common pathogen.

Boettler T, Lutz L, Schmidt N, Thimme R, Neumann-Haefelin C.

Gut. 2015 Sep;64(9):1411, 1453. doi: 10.1136/gutjnl-2014-308851. Epub 2015 Jan 6. No abstract available.

PMID:
25564406
31.

Tetramer enrichment reveals the presence of phenotypically diverse hepatitis C virus-specific CD8+ T cells in chronic infection.

Nitschke K, Flecken T, Schmidt J, Gostick E, Marget M, Neumann-Haefelin C, Blum HE, Price DA, Thimme R.

J Virol. 2015 Jan;89(1):25-34. doi: 10.1128/JVI.02242-14. Epub 2014 Oct 15.

32.

PNPLA3 in end-stage liver disease: alcohol consumption, hepatocellular carcinoma development, and transplantation-free survival.

Friedrich K, Wannhoff A, Kattner S, Brune M, Hov JR, Weiss KH, Antoni C, Dollinger M, Neumann-Haefelin C, Seufferlein T, Schemmer P, Schirmacher P, Stremmel W, Gotthardt DN.

J Gastroenterol Hepatol. 2014;29(7):1477-84. doi: 10.1111/jgh.12540.

PMID:
25273282
33.

Prediction of clinical outcome in advanced hepatitis C-associated liver disease: identification of patients at the highest need for antiviral treatment and surveillance.

Neumann-Haefelin C, Thimme R.

Gut. 2015 Feb;64(2):193-4. doi: 10.1136/gutjnl-2014-307490. Epub 2014 Jun 19. No abstract available.

PMID:
24946954
34.

Restoration of HCV-specific CD8+ T cell function by interferon-free therapy.

Martin B, Hennecke N, Lohmann V, Kayser A, Neumann-Haefelin C, Kukolj G, Böcher WO, Thimme R.

J Hepatol. 2014 Sep;61(3):538-43. doi: 10.1016/j.jhep.2014.05.043. Epub 2014 Jun 4.

PMID:
24905492
35.

Immunodominance and functional alterations of tumor-associated antigen-specific CD8+ T-cell responses in hepatocellular carcinoma.

Flecken T, Schmidt N, Hild S, Gostick E, Drognitz O, Zeiser R, Schemmer P, Bruns H, Eiermann T, Price DA, Blum HE, Neumann-Haefelin C, Thimme R.

Hepatology. 2014 Apr;59(4):1415-26. doi: 10.1002/hep.26731. Epub 2014 Feb 20.

36.

HLA-B*27 subtype specificity determines targeting and viral evolution of a hepatitis C virus-specific CD8+ T cell epitope.

Nitschke K, Barriga A, Schmidt J, Timm J, Viazov S, Kuntzen T, Kim AY, Lauer GM, Allen TM, Gaudieri S, Rauch A, Lange CM, Sarrazin C, Eiermann T, Sidney J, Sette A, Thimme R, López D, Neumann-Haefelin C.

J Hepatol. 2014 Jan;60(1):22-9. doi: 10.1016/j.jhep.2013.08.009. Epub 2013 Aug 23.

37.

HLA-B27-mediated protection in HIV and hepatitis C virus infection and pathogenesis in spondyloarthritis: two sides of the same coin?

Neumann-Haefelin C.

Curr Opin Rheumatol. 2013 Jul;25(4):426-33. doi: 10.1097/BOR.0b013e328362018f. Review.

PMID:
23656712
38.

Synergism of tapasin and human leukocyte antigens in resolving hepatitis C virus infection.

Ashraf S, Nitschke K, Warshow UM, Brooks CR, Kim AY, Lauer GM, Hydes TJ, Cramp ME, Alexander G, Little AM, Thimme R, Neumann-Haefelin C, Khakoo SI.

Hepatology. 2013 Sep;58(3):881-9. doi: 10.1002/hep.26415. Epub 2013 Jul 29.

39.

Adaptive immune responses in hepatitis C virus infection.

Neumann-Haefelin C, Thimme R.

Curr Top Microbiol Immunol. 2013;369:243-62. doi: 10.1007/978-3-642-27340-7_10. Review.

PMID:
23463204
40.

Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope.

Schmidt J, Iversen AK, Tenzer S, Gostick E, Price DA, Lohmann V, Distler U, Bowness P, Schild H, Blum HE, Klenerman P, Neumann-Haefelin C, Thimme R.

PLoS Pathog. 2012;8(11):e1003042. doi: 10.1371/journal.ppat.1003042. Epub 2012 Nov 29.

41.

Cellular immune responses to hepatocellular carcinoma: lessons for immunotherapy.

Schmidt N, Neumann-Haefelin C, Thimme R.

Dig Dis. 2012;30(5):483-91. doi: 10.1159/000341697. Epub 2012 Oct 24. Review.

PMID:
23108304
42.

Susceptibility to chronic hepatitis C virus infection is influenced by sequence differences in immunodominant CD8+ T cell epitopes.

Ziegler S, Ruhl M, Tenckhoff H, Wiese M, Heinemann FM, Horn PA, Spengler U, Neumann-Haefelin C, Nattermann J, Timm J; East-German HCV Study Group.

J Hepatol. 2013 Jan;58(1):24-30. doi: 10.1016/j.jhep.2012.08.016. Epub 2012 Aug 25.

PMID:
22925811
43.

[Direct antiviral treatment strategies in chronic hepatitis C].

Neumann-Haefelin C, Blum HE, Thimme R.

Dtsch Med Wochenschr. 2012 Jun;137(25-26):1360-5. doi: 10.1055/s-0032-1305064. Epub 2012 May 31. Review. German.

PMID:
22653493
44.

Differential antigen specificity of hepatitis C virus-specific interleukin 17- and interferon γ-producing CD8(+) T cells during chronic infection.

Grafmueller S, Billerbeck E, Blum HE, Neumann-Haefelin C, Thimme R.

J Infect Dis. 2012 Apr 1;205(7):1142-6. doi: 10.1093/infdis/jis018. Epub 2012 Feb 20.

PMID:
22351943
45.

Long-term severe diabetes only leads to mild cardiac diastolic dysfunction in Zucker diabetic fatty rats.

Daniels A, Linz D, van Bilsen M, Rütten H, Sadowski T, Ruf S, Juretschke HP, Neumann-Haefelin C, Munts C, van der Vusse GJ, van Nieuwenhoven FA.

Eur J Heart Fail. 2012 Feb;14(2):193-201. doi: 10.1093/eurjhf/hfr166.

46.

Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations.

Neumann-Haefelin C, Oniangue-Ndza C, Kuntzen T, Schmidt J, Nitschke K, Sidney J, Caillet-Saguy C, Binder M, Kersting N, Kemper MW, Power KA, Ingber S, Reyor LL, Hills-Evans K, Kim AY, Lauer GM, Lohmann V, Sette A, Henn MR, Bressanelli S, Thimme R, Allen TM.

Hepatology. 2011 Oct;54(4):1157-66. doi: 10.1002/hep.24541.

47.

Success and failure of virus-specific T cell responses in hepatitis C virus infection.

Neumann-Haefelin C, Thimme R.

Dig Dis. 2011;29(4):416-22. doi: 10.1159/000329807. Epub 2011 Aug 30. Review.

PMID:
21894013
48.

Compensatory mutations restore the replication defects caused by cytotoxic T lymphocyte escape mutations in hepatitis C virus polymerase.

Oniangue-Ndza C, Kuntzen T, Kemper M, Berical A, Wang YE, Neumann-Haefelin C, Foote PK, Hills-Evans K, Reyor LL, Kane K, Gladden AD, Bloom AK, Power KA, Thimme R, Lauer GM, Henn MR, Kim AY, Allen TM.

J Virol. 2011 Nov;85(22):11883-90. doi: 10.1128/JVI.00779-11. Epub 2011 Aug 31.

49.

Inhibitory molecules that regulate expansion and restoration of HCV-specific CD4+ T cells in patients with chronic infection.

Raziorrouh B, Ulsenheimer A, Schraut W, Heeg M, Kurktschiev P, Zachoval R, Jung MC, Thimme R, Neumann-Haefelin C, Horster S, Wächtler M, Spannagl M, Haas J, Diepolder HM, Grüner NH.

Gastroenterology. 2011 Oct;141(4):1422-31, 1431.e1-6. doi: 10.1053/j.gastro.2011.07.004. Epub 2011 Jul 18.

PMID:
21763239
50.

Host genetics in immune-mediated hepatitis C virus clearance.

Schmidt J, Thimme R, Neumann-Haefelin C.

Biomark Med. 2011 Apr;5(2):155-69. doi: 10.2217/bmm.11.19. Review.

PMID:
21473719

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