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Items: 42


Inhibition of protein nitration prevents cisplatin-induced inactivation of STAT3 and promotes anti-apoptotic signaling in organ of Corti cells.

Rosati R, Shahab M, Neumann WL, Jamesdaniel S.

Exp Cell Res. 2019 Aug 1;381(1):105-111. doi: 10.1016/j.yexcr.2019.05.008. Epub 2019 May 9.


Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain.

Chen Z, Doyle TM, Luongo L, Largent-Milnes TM, Giancotti LA, Kolar G, Squillace S, Boccella S, Walker JK, Pendleton A, Spiegel S, Neumann WL, Vanderah TW, Salvemini D.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10557-10562. doi: 10.1073/pnas.1820466116. Epub 2019 May 8.


Kinetics of Tetracaine Solvolysis in Propylene Glycol.

McPherson TB, Neumann WL, Goolsby M, Kolling WM.

Int J Pharm Compd. 2018 Jul-Aug;22(4):329-334.


Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain.

Stockstill K, Doyle TM, Yan X, Chen Z, Janes K, Little JW, Braden K, Lauro F, Giancotti LA, Harada CM, Yadav R, Xiao WH, Lionberger JM, Neumann WL, Bennett GJ, Weng HR, Spiegel S, Salvemini D.

J Exp Med. 2018 May 7;215(5):1301-1313. doi: 10.1084/jem.20170584. Epub 2018 Apr 27.


Synthesis of 3-(3-hydroxyphenyl)pyrrolidine dopamine D3 receptor ligands with extended functionality for probing the secondary binding pocket.

Omran A, Eslamimehr S, Crider AM, Neumann WL.

Bioorg Med Chem Lett. 2018 Jun 1;28(10):1897-1902. doi: 10.1016/j.bmcl.2018.03.084. Epub 2018 Apr 4.


2-Chlorofatty acids induce Weibel-Palade body mobilization.

Hartman CL, Duerr MA, Albert CJ, Neumann WL, McHowat J, Ford DA.

J Lipid Res. 2018 Jan;59(1):113-122. doi: 10.1194/jlr.M080200. Epub 2017 Nov 22.


Targeting nitrative stress for attenuating cisplatin-induced downregulation of cochlear LIM domain only 4 and ototoxicity.

Jamesdaniel S, Rathinam R, Neumann WL.

Redox Biol. 2016 Dec;10:257-265. doi: 10.1016/j.redox.2016.10.016. Epub 2016 Oct 31.


Primary Colonic Eosinophilia and Eosinophilic Colitis in Adults.

Turner KO, Sinkre RA, Neumann WL, Genta RM.

Am J Surg Pathol. 2017 Feb;41(2):225-233. doi: 10.1097/PAS.0000000000000760.


The cystine/glutamate antiporter system xc- drives breast tumor cell glutamate release and cancer-induced bone pain.

Slosky LM, BassiriRad NM, Symons AM, Thompson M, Doyle T, Forte BL, Staatz WD, Bui L, Neumann WL, Mantyh PW, Salvemini D, Largent-Milnes TM, Vanderah TW.

Pain. 2016 Nov;157(11):2605-2616.


Oral administration of SR-110, a peroxynitrite decomposing catalyst, enhances glucose homeostasis, insulin signaling, and islet architecture in B6D2F1 mice fed a high fat diet.

Johns M, Esmaeili Mohsen Abadi S, Malik N, Lee J, Neumann WL, Rausaria S, Imani-Nejad M, McPherson T, Schober J, Kwon G.

Arch Biochem Biophys. 2016 Apr 15;596:126-37. doi: 10.1016/ Epub 2016 Mar 10.


Cisplatin-induced apoptosis in auditory, renal, and neuronal cells is associated with nitration and downregulation of LMO4.

Rathinam R, Ghosh S, Neumann WL, Jamesdaniel S.

Cell Death Discov. 2015;1. pii: 15052. Epub 2015 Nov 9.


SR-135, a peroxynitrite decomposing catalyst, enhances β-cell function and survival in B6D2F1 mice fed a high fat diet.

Johns M, Fyalka R, Shea JA, Neumann WL, Rausaria S, Msengi EN, Imani-Nejad M, Zollars H, McPherson T, Schober J, Wooten J, Kwon G.

Arch Biochem Biophys. 2015 Jul;577-578:49-59. doi: 10.1016/ Epub 2015 Apr 29.


The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.

Janes K, Little JW, Li C, Bryant L, Chen C, Chen Z, Kamocki K, Doyle T, Snider A, Esposito E, Cuzzocrea S, Bieberich E, Obeid L, Petrache I, Nicol G, Neumann WL, Salvemini D.

J Biol Chem. 2014 Jul 25;289(30):21082-97.


Stability of non-aqueous topical tetracaine and clotrimazole solutions in polypropylene droptainer bottles.

McPherson TB, Neumann WL, Kolling WM.

Int J Pharm Compd. 2013 Nov-Dec;17(6):508-11.


Autoimmune atrophic gastritis--pathogenesis, pathology and management.

Neumann WL, Coss E, Rugge M, Genta RM.

Nat Rev Gastroenterol Hepatol. 2013 Sep;10(9):529-41. doi: 10.1038/nrgastro.2013.101. Epub 2013 Jun 18. Review.


Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance.

Little JW, Cuzzocrea S, Bryant L, Esposito E, Doyle T, Rausaria S, Neumann WL, Salvemini D.

Pain. 2013 Jul;154(7):978-86. doi: 10.1016/j.pain.2013.02.018. Epub 2013 Feb 27.


Reactive gastropathy is associated with inflammatory conditions throughout the gastrointestinal tract.

Maguilnik I, Neumann WL, Sonnenberg A, Genta RM.

Aliment Pharmacol Ther. 2012 Oct;36(8):736-43. doi: 10.1111/apt.12031. Epub 2012 Aug 28.


Supraspinal peroxynitrite modulates pain signaling by suppressing the endogenous opioid pathway.

Little JW, Chen Z, Doyle T, Porreca F, Ghaffari M, Bryant L, Neumann WL, Salvemini D.

J Neurosci. 2012 Aug 8;32(32):10797-808. doi: 10.1523/JNEUROSCI.6345-11.2012.


Prohibitin attenuates colitis-associated tumorigenesis in mice by modulating p53 and STAT3 apoptotic responses.

Kathiria AS, Neumann WL, Rhees J, Hotchkiss E, Cheng Y, Genta RM, Meltzer SJ, Souza RF, Theiss AL.

Cancer Res. 2012 Nov 15;72(22):5778-89. doi: 10.1158/0008-5472.CAN-12-0603. Epub 2012 Aug 6.


Inverse association of esophageal eosinophilia and Barrett esophagus.

Saboorian MH, Genta RM, Marcus PB, Lindberg GM, Neumann WL.

J Clin Gastroenterol. 2012 Oct;46(9):752-7. doi: 10.1097/MCG.0b013e3182568792.


Targeting the overproduction of peroxynitrite for the prevention and reversal of paclitaxel-induced neuropathic pain.

Doyle T, Chen Z, Muscoli C, Bryant L, Esposito E, Cuzzocrea S, Dagostino C, Ryerse J, Rausaria S, Kamadulski A, Neumann WL, Salvemini D.

J Neurosci. 2012 May 2;32(18):6149-60. doi: 10.1523/JNEUROSCI.6343-11.2012.


Exogenous fluorescent tracer agents based on pegylated pyrazine dyes for real-time point-of-care measurement of glomerular filtration rate.

Poreddy AR, Neumann WL, Freskos JN, Rajagopalan R, Asmelash B, Gaston KR, Fitch RM, Galen KP, Shieh JJ, Dorshow RB.

Bioorg Med Chem. 2012 Apr 15;20(8):2490-7. doi: 10.1016/j.bmc.2012.03.015. Epub 2012 Mar 10.


Gastric heterotopia in the proximal oesophagus ("inlet patch"): Association with adenocarcinomas arising in Barrett mucosa.

Neumann WL, Luján GM, Genta RM.

Dig Liver Dis. 2012 Apr;44(4):292-6. doi: 10.1016/j.dld.2011.11.008. Epub 2012 Jan 4.


Anti-superoxide and anti-peroxynitrite strategies in pain suppression.

Janes K, Neumann WL, Salvemini D.

Biochim Biophys Acta. 2012 May;1822(5):815-21. doi: 10.1016/j.bbadis.2011.12.008. Epub 2011 Dec 19.


Retooling manganese(III) porphyrin-based peroxynitrite decomposition catalysts for selectivity and oral activity: a potential new strategy for treating chronic pain.

Rausaria S, Ghaffari MM, Kamadulski A, Rodgers K, Bryant L, Chen Z, Doyle T, Shaw MJ, Salvemini D, Neumann WL.

J Med Chem. 2011 Dec 22;54(24):8658-69. doi: 10.1021/jm201233r. Epub 2011 Nov 22.


Influence of nanostructure morphology on host capacity and kinetics of guest release.

Lee NS, Lin LY, Neumann WL, Freskos JN, Karwa A, Shieh JJ, Dorshow RB, Wooley KL.

Small. 2011 Jul 18;7(14):1998-2003. doi: 10.1002/smll.201100567. Epub 2011 Jun 16. No abstract available.


Hydrophilic pyrazine dyes as exogenous fluorescent tracer agents for real-time point-of-care measurement of glomerular filtration rate.

Rajagopalan R, Neumann WL, Poreddy AR, Fitch RM, Freskos JN, Asmelash B, Gaston KR, Galen KP, Shieh JJ, Dorshow RB.

J Med Chem. 2011 Jul 28;54(14):5048-58. doi: 10.1021/jm200257k. Epub 2011 Jun 27.


Multicompartment polymer nanostructures with ratiometric dual-emission pH-sensitivity.

Sun G, Cui H, Lin LY, Lee NS, Yang C, Neumann WL, Freskos JN, Shieh JJ, Dorshow RB, Wooley KL.

J Am Chem Soc. 2011 Jun 8;133(22):8534-43. doi: 10.1021/ja200182t. Epub 2011 May 16.


Manganese(III) complexes of bis(hydroxyphenyl)dipyrromethenes are potent orally active peroxynitrite scavengers.

Rausaria S, Kamadulski A, Rath NP, Bryant L, Chen Z, Salvemini D, Neumann WL.

J Am Chem Soc. 2011 Mar 30;133(12):4200-3. doi: 10.1021/ja110427e. Epub 2011 Mar 3.


Roles of reactive oxygen and nitrogen species in pain.

Salvemini D, Little JW, Doyle T, Neumann WL.

Free Radic Biol Med. 2011 Sep 1;51(5):951-66. doi: 10.1016/j.freeradbiomed.2011.01.026. Epub 2011 Jan 28. Review.


Tunable dual-emitting shell-crosslinked nano-objects as single-component ratiometric pH-sensing materials.

Lee NS, Sun G, Lin LY, Neumann WL, Freskos JN, Karwa A, Shieh JJ, Dorshow RB, Wooley KL.

J Mater Chem. 2011;21(37):14193-14202.


{Omega}-oxidation of {alpha}-chlorinated fatty acids: identification of {alpha}-chlorinated dicarboxylic acids.

Brahmbhatt VV, Albert CJ, Anbukumar DS, Cunningham BA, Neumann WL, Ford DA.

J Biol Chem. 2010 Dec 31;285(53):41255-69. doi: 10.1074/jbc.M110.147157. Epub 2010 Oct 18.


Chlorinated lipid species in activated human neutrophils: lipid metabolites of 2-chlorohexadecanal.

Anbukumar DS, Shornick LP, Albert CJ, Steward MM, Zoeller RA, Neumann WL, Ford DA.

J Lipid Res. 2010 May;51(5):1085-92. doi: 10.1194/jlr.M003673. Epub 2009 Dec 17.


Photonic Shell-Crosslinked Nanoparticle Probes for Optical Imaging and Monitoring.

Lee NS, Sun G, Neumann WL, Freskos JN, Shieh JJ, Dorshow RB, Wooley KL.

Adv Mater. 2009 Apr 6;21(13):1344-1348.


Peroxynitrite: a strategic linchpin of opioid analgesic tolerance.

Salvemini D, Neumann WL.

Trends Pharmacol Sci. 2009 Apr;30(4):194-202. doi: 10.1016/ Epub 2009 Mar 2. Review.


Design, synthesis, and biological evaluation of pyrazinones containing novel P1 needles as inhibitors of TF/VIIa.

Trujillo JI, Huang HC, Neumann WL, Mahoney MW, Long S, Huang W, Garland DJ, Kusturin C, Abbas Z, South MS, Reitz DB.

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4568-74. Epub 2007 Jun 6.


Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa.

Schweitzer BA, Neumann WL, Rahman HK, Kusturin CL, Sample KR, Poda GI, Kurumbail RG, Stevens AM, Stegeman RA, Stallings WC, South MS.

Bioorg Med Chem Lett. 2005 Jun 15;15(12):3006-11.


Switchable catalysis: modular synthesis of functionalized Pyrimidinones via selective sulfide and halide cross-coupling chemistry.

Kusturin C, Liebeskind LS, Rahman H, Sample K, Schweitzer B, Srogl J, Neumann WL.

Org Lett. 2003 Nov 13;5(23):4349-52.


Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.

Parlow JJ, Case BL, Dice TA, Fenton RL, Hayes MJ, Jones DE, Neumann WL, Wood RS, Lachance RM, Girard TJ, Nicholson NS, Clare M, Stegeman RA, Stevens AM, Stallings WC, Kurumbail RG, South MS.

J Med Chem. 2003 Sep 11;46(19):4050-62.


A new catalytic cross-coupling approach for the synthesis of protected aryl and heteroaryl amidines.

Kusturin CL, Liebeskind LS, Neumann WL.

Org Lett. 2002 Mar 21;4(6):983-5.


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