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The role of ALPPS in intrahepatic cholangiocarcinoma.

Bednarsch J, Czigany Z, Lurje I, Strnad P, Bruners P, Ulmer TF, den Dulk M, Lurje G, Neumann UP.

Langenbecks Arch Surg. 2019 Nov 16. doi: 10.1007/s00423-019-01838-2. [Epub ahead of print]


A Newly Established Murine Cell Line as a Model for Hepatocellular Cancer in Non-Alcoholic Steatohepatitis.

Kroh A, Walter J, Schüler H, Nolting J, Eickhoff R, Heise D, Neumann UP, Cramer T, Ulmer TF, Fragoulis A.

Int J Mol Sci. 2019 Nov 12;20(22). pii: E5658. doi: 10.3390/ijms20225658.


Tau deletion reduces plaque-associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease.

Peters F, Salihoglu H, Pratsch K, Herzog E, Pigoni M, Sgobio C, Lichtenthaler SF, Neumann U, Herms J.

EMBO J. 2019 Nov 7:e2019102345. doi: 10.15252/embj.2019102345. [Epub ahead of print]


[Complication management after bile duct surgery].

Bednarsch J, Trauwein C, Neumann UP, Ulmer TF.

Chirurg. 2019 Nov 5. doi: 10.1007/s00104-019-01059-9. [Epub ahead of print] Review. German.


In memoriam - Chris Hawes.

Neumann U.

J Microsc. 2019 Oct;276(1):3-12. doi: 10.1111/jmi.12833. No abstract available.


Hypothermic Oxygenated Machine Perfusion of Extended Criteria Kidney Allografts from Brain Dead Donors: Protocol for a Prospective Pilot Study.

Meister FA, Czigany Z, Bednarsch J, Böcker J, Amygdalos I, Morales Santana DA, Rietzler K, Moeller M, Tolba R, Boor P, Rohlfs W, Neumann UP, Lurje G.

JMIR Res Protoc. 2019 Oct 14;8(10):e14622. doi: 10.2196/14622.


A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients.

Baier V, Cordes H, Thiel C, Castell JV, Neumann UP, Blank LM, Kuepfer L.

Front Physiol. 2019 Sep 27;10:1192. doi: 10.3389/fphys.2019.01192. eCollection 2019.


Chemoembolization with Degradable Starch Microspheres for Treatment of Patients with Primary or Recurrent Unresectable, Locally Advanced Intrahepatic Cholangiocarcinoma: A Pilot Study.

Goerg F, Zimmermann M, Bruners P, Neumann U, Luedde T, Kuhl C.

Cardiovasc Intervent Radiol. 2019 Dec;42(12):1709-1717. doi: 10.1007/s00270-019-02344-0. Epub 2019 Oct 2.


Myosteatosis to predict inferior perioperative outcome in patients undergoing orthotopic liver transplantation.

Czigany Z, Kramp W, Bednarsch J, van der Kroft G, Boecker J, Strnad P, Zimmermann M, Koek G, Neumann UP, Lurje G.

Am J Transplant. 2019 Aug 26. doi: 10.1111/ajt.15577. [Epub ahead of print]


Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer's disease.

Hijazi S, Heistek TS, Scheltens P, Neumann U, Shimshek DR, Mansvelder HD, Smit AB, van Kesteren RE.

Mol Psychiatry. 2019 Aug 20. doi: 10.1038/s41380-019-0483-4. [Epub ahead of print]


Low Postoperative Platelet Counts Are Associated with Major Morbidity and Inferior Survival in Adult Recipients of Orthotopic Liver Transplantation.

Amygdalos I, Czigany Z, Bednarsch J, Boecker J, Santana DAM, Meister FA, von der Massen J, Liu WJ, Strnad P, Neumann UP, Lurje G.

J Gastrointest Surg. 2019 Aug 6. doi: 10.1007/s11605-019-04337-3. [Epub ahead of print]


Left- versus right-sided hepatectomy with hilar en-bloc resection in perihilar cholangiocarcinoma.

Bednarsch J, Czigany Z, Lurje I, Tacke F, Strnad P, Ulmer TF, Gaisa NT, Bruners P, Neumann UP, Lurje G.

HPB (Oxford). 2019 Aug 2. pii: S1365-182X(19)30617-3. doi: 10.1016/j.hpb.2019.07.003. [Epub ahead of print]


Early Aβ reduction prevents progression of cerebral amyloid angiopathy.

Schelle J, Wegenast-Braun BM, Fritschi SK, Kaeser SA, Jährling N, Eicke D, Skodras A, Beschorner N, Obermueller U, Häsler LM, Wolfer DP, Mueggler T, Shimshek DR, Neumann U, Dodt HU, Staufenbiel M, Jucker M.

Ann Neurol. 2019 Oct;86(4):561-571. doi: 10.1002/ana.25562. Epub 2019 Aug 19.


Hypothermic oxygenated machine perfusion-Preliminary experience with end-ischemic reconditioning of marginal kidney allografts.

Meister FA, Czigany Z, Bednarsch J, Boecker J, Wiltberger G, Rohlfs W, Neumann UP, Lurje G.

Clin Transplant. 2019 Oct;33(10):e13673. doi: 10.1111/ctr.13673. Epub 2019 Aug 7. No abstract available.


First Result of a Tailored Progressive Multistep Approach for the Treatment of Aorto-esophageal Fistulae.

Helmedag MJ, Eickhoff R, Lambertz A, Heise D, Grommes J, Jacobs M, Neumann UP, Klink C.

Thorac Cardiovasc Surg. 2019 Jul 15. doi: 10.1055/s-0039-1692659. [Epub ahead of print]


Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second Generation Amyloid-beta Mouse Model.

Sacher C, Blume T, Beyer L, Peters F, Eckenweber F, Sgobio C, Deussing M, Albert NL, Unterrainer M, Lindner S, Gildehaus FJ, von Ungern-Sternberg B, Brzak I, Neumann U, Saito T, Saido TC, Bartenstein P, Rominger A, Herms J, Brendel M.

J Nucl Med. 2019 Jul 13. pii: jnumed.119.227322. doi: 10.2967/jnumed.119.227322. [Epub ahead of print]


A new device to prevent fascial retraction in the open abdomen - proof of concept in vivo.

Eickhoff R, Guschlbauer M, Maul AC, Klink CD, Neumann UP, Engel M, Hellmich M, Sterner-Kock A, Krieglstein CF.

BMC Surg. 2019 Jul 8;19(1):82. doi: 10.1186/s12893-019-0543-3.


Fucoxanthin, A Carotenoid Derived from Phaeodactylum tricornutum Exerts Antiproliferative and Antioxidant Activities In Vitro.

Neumann U, Derwenskus F, Flaiz Flister V, Schmid-Staiger U, Hirth T, Bischoff SC.

Antioxidants (Basel). 2019 Jun 19;8(6). pii: E183. doi: 10.3390/antiox8060183.


Systematic review of team performance in minimally invasive abdominal surgery.

van der Vliet WJ, Haenen SM, Solis-Velasco M, Dejong CHC, Neumann UP, Moser AJ, van Dam RM.

BJS Open. 2019 Jan 30;3(3):252-259. doi: 10.1002/bjs5.50133. eCollection 2019 Jun. Review.


Reply to: Does lymphovascular invasion really associate with decreased overall survival for patients with resected cholangiocarcinoma?

Bednarsch J, Neumann UP, Lurje G.

Eur J Surg Oncol. 2019 Aug;45(8):1513-1514. doi: 10.1016/j.ejso.2019.05.030. Epub 2019 May 31. No abstract available.


Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer.

Kather JN, Pearson AT, Halama N, Jäger D, Krause J, Loosen SH, Marx A, Boor P, Tacke F, Neumann UP, Grabsch HI, Yoshikawa T, Brenner H, Chang-Claude J, Hoffmeister M, Trautwein C, Luedde T.

Nat Med. 2019 Jul;25(7):1054-1056. doi: 10.1038/s41591-019-0462-y. Epub 2019 Jun 3.


Comparative analysis of clonal hematopoiesis of multipotent stem cells in healthy elderly in blood and bone marrow.

Jann JC, Nolte F, Mossner M, Flach J, Altrock E, Schmitt N, Röhl H, Jawhar A, Neumann U, Nowak V, Danner J, Obländer J, Palme I, Hofmann WK, Nowak D.

Leuk Res. 2019 Jul;82:15-18. doi: 10.1016/j.leukres.2019.05.005. Epub 2019 May 16. No abstract available.


The prognostic role of lymphovascular invasion and lymph node metastasis in perihilar and intrahepatic cholangiocarcinoma.

Lurje G, Bednarsch J, Czigany Z, Lurje I, Schlebusch IK, Boecker J, Meister FA, Tacke F, Roderburg C, Den Dulk M, Gaisa NT, Bruners P, Neumann UP.

Eur J Surg Oncol. 2019 Aug;45(8):1468-1478. doi: 10.1016/j.ejso.2019.04.019. Epub 2019 Apr 25.


Power of computed-tomography-defined sarcopenia for prediction of morbidity after pancreaticoduodenectomy.

Linder N, Schaudinn A, Langenhan K, Krenzien F, Hau HM, Benzing C, Atanasov G, Schmelzle M, Kahn T, Busse H, Bartels M, Neumann U, Wiltberger G.

BMC Med Imaging. 2019 Apr 27;19(1):32. doi: 10.1186/s12880-019-0332-6.


Median Arcuate Ligament Compression in Orthotopic Liver Transplantation: Results from a Single-Center Analysis and a European Survey Study.

Czigany Z, Boecker J, Morales Santana DA, Bednarsch J, Meister FA, Amygdalos I, Isfort P, Liebl M, Neumann UP, Lurje G.

J Clin Med. 2019 Apr 23;8(4). pii: E550. doi: 10.3390/jcm8040550.


Non-invasive assessment of NAFLD as systemic disease-A machine learning perspective.

Canbay A, Kälsch J, Neumann U, Rau M, Hohenester S, Baba HA, Rust C, Geier A, Heider D, Sowa JP.

PLoS One. 2019 Mar 26;14(3):e0214436. doi: 10.1371/journal.pone.0214436. eCollection 2019.


Treatment Strategies for Hepatocellular Carcinoma ⁻ a Multidisciplinary Approach.

Lurje I, Czigany Z, Bednarsch J, Roderburg C, Isfort P, Neumann UP, Lurje G.

Int J Mol Sci. 2019 Mar 22;20(6). pii: E1465. doi: 10.3390/ijms20061465. Review.


Potential value and limitations of different clinical scoring systems in the assessment of short- and long-term outcome following orthotopic liver transplantation.

Boecker J, Czigany Z, Bednarsch J, Amygdalos I, Meister F, Santana DAM, Liu WJ, Strnad P, Neumann UP, Lurje G.

PLoS One. 2019 Mar 21;14(3):e0214221. doi: 10.1371/journal.pone.0214221. eCollection 2019.


Noninvasive Evaluation of Liver Function in Morbidly Obese Patients.

Alizai PH, Lurje I, Kroh A, Schmitz S, Luedde T, Andruszkow J, Neumann UP, Ulmer F.

Gastroenterol Res Pract. 2019 Feb 3;2019:4307462. doi: 10.1155/2019/4307462. eCollection 2019.


Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma in cirrhosis.

Wiltberger G, Wu Y, Lange U, Hau HM, Tapper E, Krenzien F, Atanasov G, Benzing C, Feldbrügge L, Csizmadia E, Broschewitz J, Bartels M, Seehofer D, Jonas S, Berg T, Hessel P, Ascherl R, Neumann UP, Pratschke J, Robson SC, Schmelzle M.

Aliment Pharmacol Ther. 2019 Mar;49(6):779-788. doi: 10.1111/apt.15089.


High baseline soluble urokinase plasminogen activator receptor (suPAR) serum levels indicate adverse outcome after resection of pancreatic adenocarcinoma.

Loosen SH, Tacke F, Püthe N, Binneboesel M, Wiltberger G, Alizai PH, Kather JN, Paffenholz P, Ritz T, Koch A, Bergmann F, Trautwein C, Longerich T, Roderburg C, Neumann UP, Luedde T.

Carcinogenesis. 2019 Aug 22;40(8):947-955. doi: 10.1093/carcin/bgz033.


Elevated serum levels of bone sialoprotein (BSP) predict long-term mortality in patients with pancreatic adenocarcinoma.

Loosen SH, Hoening P, Puethe N, Luedde M, Spehlmann M, Ulmer TF, Cardenas DV, Roy S, Tacke F, Trautwein C, Neumann UP, Luedde T, Roderburg C.

Sci Rep. 2019 Feb 6;9(1):1489. doi: 10.1038/s41598-018-38352-2.


Loco-regional hepatocellular carcinoma treatment services as a bridge to liver transplantation.

Schmitz S, Lurje G, Ulmer F, Andert A, Bruners P, Schulze-Hagen M, Neumann U, Schoening W.

Hepatobiliary Pancreat Dis Int. 2019 Jun;18(3):228-236. doi: 10.1016/j.hbpd.2019.01.004. Epub 2019 Jan 21.


Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

Vogel A, Cervantes A, Chau I, Daniele B, Llovet JM, Meyer T, Nault JC, Neumann U, Ricke J, Sangro B, Schirmacher P, Verslype C, Zech CJ, Arnold D, Martinelli E.

Ann Oncol. 2019 May 1;30(5):871-873. doi: 10.1093/annonc/mdy510. No abstract available.


CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4+ T-Cell-Dependent Control of Senescence.

Mossanen JC, Kohlhepp M, Wehr A, Krenkel O, Liepelt A, Roeth AA, Möckel D, Heymann F, Lammers T, Gassler N, Hermann J, Jankowski J, Neumann UP, Luedde T, Trautwein C, Tacke F.

Gastroenterology. 2019 May;156(6):1877-1889.e4. doi: 10.1053/j.gastro.2019.01.247. Epub 2019 Jan 30.


Modeling of magnetoliposome uptake in human pancreatic tumor cells in vitro.

Slabu I, Roeth AA, Engelmann UM, Wiekhorst F, Buhl EM, Neumann UP, Schmitz-Rode T.

Nanotechnology. 2019 May 3;30(18):184004. doi: 10.1088/1361-6528/ab033e. Epub 2019 Jan 30.


Systematic Review on Characteristics and Reporting Quality of Animal Studies in Liver Regeneration Triggered by Portal Vein Occlusion and Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy: Adherence to the ARRIVE Guidelines.

Tihanyi DK, Szijarto A, Fülöp A, Denecke B, Lurje G, Neumann UP, Czigany Z, Tolba R.

J Surg Res. 2019 Mar;235:578-590. doi: 10.1016/j.jss.2018.10.038. Epub 2018 Dec 5.


FGB1 and WSC3 are in planta-induced β-glucan-binding fungal lectins with different functions.

Wawra S, Fesel P, Widmer H, Neumann U, Lahrmann U, Becker S, Hehemann JH, Langen G, Zuccaro A.

New Phytol. 2019 May;222(3):1493-1506. doi: 10.1111/nph.15711. Epub 2019 Mar 4.


Polypropylene mesh implantation for hernia repair causes myeloid cell-driven persistent inflammation.

Heymann F, von Trotha KT, Preisinger C, Lynen-Jansen P, Roeth AA, Geiger M, Geisler LJ, Frank AK, Conze J, Luedde T, Trautwein C, Binnebösel M, Neumann UP, Tacke F.

JCI Insight. 2019 Jan 24;4(2). pii: 123862. doi: 10.1172/jci.insight.123862. [Epub ahead of print]


The β-secretase (BACE) inhibitor NB-360 in preclinical models: From amyloid-β reduction to downstream disease-relevant effects.

Neumann U, Machauer R, Shimshek DR.

Br J Pharmacol. 2019 Sep;176(18):3435-3446. doi: 10.1111/bph.14582. Epub 2019 Mar 10. Review.


Serum levels of miR-29, miR-122, miR-155 and miR-192 are elevated in patients with cholangiocarcinoma.

Loosen SH, Lurje G, Wiltberger G, Vucur M, Koch A, Kather JN, Paffenholz P, Tacke F, Ulmer FT, Trautwein C, Luedde T, Neumann UP, Roderburg C.

PLoS One. 2019 Jan 17;14(1):e0210944. doi: 10.1371/journal.pone.0210944. eCollection 2019.


The Role of Macrophage Migration Inhibitory Factor in Remote Ischemic Conditioning Induced Hepatoprotection in a Rodent Model of Liver Transplantation.

Emontzpohl C, Stoppe C, Theißen A, Beckers C, Neumann UP, Lurje G, Ju C, Bernhagen J, Tolba RH, Czigany Z.

Shock. 2019 Nov;52(5):e124-e134. doi: 10.1097/SHK.0000000000001307.


Heterozygosity for the Alpha-1-Antitrypsin Z Allele in Cirrhosis Is Associated With More Advanced Disease.

Meister F, Lurje G, Neumann UP, Trautwein C, Strnad P.

Liver Transpl. 2019 Feb;25(2):342-343. doi: 10.1002/lt.25393. No abstract available.


Improved biocompatibility of profiled sutures through lower macrophages adhesion.

Eickhoff RM, Bolle T, Kossel K, Heise D, Kroh A, Lambertz A, Blaeser A, Gries T, Jockenhoevel S, Neumann UP, Klink CD.

J Biomed Mater Res B Appl Biomater. 2019 Aug;107(6):1772-1778. doi: 10.1002/jbm.b.34269. Epub 2018 Nov 19.


Recurrence of Hepatitis B Infection in Liver Transplant Patients Receiving Long-Term Hepatitis B Immunoglobulin Prophylaxis.

Beckebaum S, Herzer K, Bauhofer A, Gelson W, De Simone P, de Man R, Engelmann C, Müllhaupt B, Vionnet J, Salizzoni M, Volpes R, Ercolani G, De Carlis L, Angeli P, Burra P, Dufour JF, Rossi M, Cillo U, Neumann U, Fischer L, Niemann G, Toti L, Tisone G.

Ann Transplant. 2018 Nov 13;23:789-801. doi: 10.12659/AOT.910176.


A New Physiologic Mouse Model of One Anastomosis Gastric Bypass.

Kroh A, Eickhoff RM, Heise D, Alizai PH, Rheinwalt KP, Neumann UP, Ulmer FT.

Eur Surg Res. 2018;59(5-6):320-328. doi: 10.1159/000493385. Epub 2018 Nov 12.


Circulating Levels of Osteopontin Predict Patients' Outcome after Resection of Colorectal Liver Metastases.

Loosen SH, Heise D, Dejong CH, Roy S, Tacke F, Trautwein C, Roderburg C, Luedde T, Neumann UP, Binnebösel M.

J Clin Med. 2018 Oct 26;7(11). pii: E390. doi: 10.3390/jcm7110390.


Leptin contributes to the beneficial effects of insulin treatment in streptozotocin-diabetic male mice.

Neumann UH, Kwon MM, Baker RK, Kieffer TJ.

Am J Physiol Endocrinol Metab. 2018 Dec 1;315(6):E1264-E1273. doi: 10.1152/ajpendo.00159.2018. Epub 2018 Oct 9.


Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

Vogel A, Cervantes A, Chau I, Daniele B, Llovet J, Meyer T, Nault JC, Neumann U, Ricke J, Sangro B, Schirmacher P, Verslype C, Zech CJ, Arnold D, Martinelli E; ESMO Guidelines Committee.

Ann Oncol. 2018 Oct 1;29(Suppl 4):iv238-iv255. doi: 10.1093/annonc/mdy308. No abstract available.


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