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Noninvasive Evaluation of Liver Function in Morbidly Obese Patients.

Alizai PH, Lurje I, Kroh A, Schmitz S, Luedde T, Andruszkow J, Neumann UP, Ulmer F.

Gastroenterol Res Pract. 2019 Feb 3;2019:4307462. doi: 10.1155/2019/4307462. eCollection 2019.


Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma in cirrhosis.

Wiltberger G, Wu Y, Lange U, Hau HM, Tapper E, Krenzien F, Atanasov G, Benzing C, Feldbrügge L, Csizmadia E, Broschewitz J, Bartels M, Seehofer D, Jonas S, Berg T, Hessel P, Ascherl R, Neumann UP, Pratschke J, Robson SC, Schmelzle M.

Aliment Pharmacol Ther. 2019 Mar;49(6):779-788. doi: 10.1111/apt.15089.


High baseline soluble urokinase plasminogen activator receptor (suPAR) serum levels indicate adverse outcome after resection of pancreatic adenocarcinoma.

Loosen SH, Tacke F, Püthe N, Binneboesel M, Wiltberger G, Alizai PH, Kather JN, Paffenholz P, Ritz T, Koch A, Bergmann F, Trautwein C, Longerich T, Roderburg C, Neumann UP, Luedde T.

Carcinogenesis. 2019 Feb 26. pii: bgz033. doi: 10.1093/carcin/bgz033. [Epub ahead of print]


Elevated serum levels of bone sialoprotein (BSP) predict long-term mortality in patients with pancreatic adenocarcinoma.

Loosen SH, Hoening P, Puethe N, Luedde M, Spehlmann M, Ulmer TF, Cardenas DV, Roy S, Tacke F, Trautwein C, Neumann UP, Luedde T, Roderburg C.

Sci Rep. 2019 Feb 6;9(1):1489. doi: 10.1038/s41598-018-38352-2.


Loco-regional HCC treatment services as a bridge to liver transplantation.

Schmitz S, Lurje G, Ulmer F, Andert A, Bruners P, Schulze-Hagen M, Neumann U, Schoening W.

Hepatobiliary Pancreat Dis Int. 2019 Jan 21. pii: S1499-3872(19)30023-2. doi: 10.1016/j.hbpd.2019.01.004. [Epub ahead of print]


Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

Vogel A, Cervantes A, Chau I, Daniele B, Llovet JM, Meyer T, Nault JC, Neumann U, Ricke J, Sangro B, Schirmacher P, Verslype C, Zech CJ, Arnold D, Martinelli E.

Ann Oncol. 2019 Jan 31. doi: 10.1093/annonc/mdy510. [Epub ahead of print] No abstract available.


CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T and CD4+ T cell-Dependent Control of Senescence.

Mossanen JC, Kohlhepp M, Wehr A, Krenkel O, Liepelt A, Roeth AA, Möckel D, Heymann F, Lammers T, Gassler N, Hermann J, Jankowski J, Neumann UP, Luedde T, Trautwein C, Tacke F.

Gastroenterology. 2019 Jan 30. pii: S0016-5085(19)30342-7. doi: 10.1053/j.gastro.2019.01.247. [Epub ahead of print]


Modeling of magnetoliposome uptake in human pancreatic tumor cells in vitro.

Slabu I, Roeth AA, Engelmann UM, Wiekhorst F, Buhl EM, Neumann UP, Schmitz-Rode T.

Nanotechnology. 2019 May 3;30(18):184004. doi: 10.1088/1361-6528/ab033e. Epub 2019 Jan 30.


Systematic Review on Characteristics and Reporting Quality of Animal Studies in Liver Regeneration Triggered by Portal Vein Occlusion and Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy: Adherence to the ARRIVE Guidelines.

Tihanyi DK, Szijarto A, Fülöp A, Denecke B, Lurje G, Neumann UP, Czigany Z, Tolba R.

J Surg Res. 2019 Mar;235:578-590. doi: 10.1016/j.jss.2018.10.038. Epub 2018 Dec 5. Review.


FGB1 and WSC3 are in planta-induced β-glucan-binding fungal lectins with different functions.

Wawra S, Fesel P, Widmer H, Neumann U, Lahrmann U, Becker S, Hehemann JH, Langen G, Zuccaro A.

New Phytol. 2019 Jan 28. doi: 10.1111/nph.15711. [Epub ahead of print]


Polypropylene mesh implantation for hernia repair causes myeloid cell-driven persistent inflammation.

Heymann F, von Trotha KT, Preisinger C, Lynen-Jansen P, Roeth AA, Geiger M, Geisler LJ, Frank AK, Conze J, Luedde T, Trautwein C, Binnebösel M, Neumann UP, Tacke F.

JCI Insight. 2019 Jan 24;4(2). pii: 123862. doi: 10.1172/jci.insight.123862. [Epub ahead of print]


The β-secretase (BACE) inhibitor NB-360 in preclinical models: From amyloid-β reduction to downstream disease-relevant effects.

Neumann U, Machauer R, Shimshek DR.

Br J Pharmacol. 2019 Jan 18. doi: 10.1111/bph.14582. [Epub ahead of print] Review.


Serum levels of miR-29, miR-122, miR-155 and miR-192 are elevated in patients with cholangiocarcinoma.

Loosen SH, Lurje G, Wiltberger G, Vucur M, Koch A, Kather JN, Paffenholz P, Tacke F, Ulmer FT, Trautwein C, Luedde T, Neumann UP, Roderburg C.

PLoS One. 2019 Jan 17;14(1):e0210944. doi: 10.1371/journal.pone.0210944. eCollection 2019.


The Role of Macrophage Migration Inhibitory Factor in Remote Ischemic Conditioning Induced Hepatoprotection in A Rodent Model of Liver Transplantation.

Emontzpohl C, Stoppe C, Theißen A, Beckers C, Neumann UP, Lurje G, Ju C, Bernhagen J, Tolba RH, Czigany Z.

Shock. 2018 Dec 21. doi: 10.1097/SHK.0000000000001307. [Epub ahead of print]


Heterozygosity for the Alpha-1-Antitrypsin Z Allele in Cirrhosis Is Associated With More Advanced Disease.

Meister F, Lurje G, Neumann UP, Trautwein C, Strnad P.

Liver Transpl. 2019 Feb;25(2):342-343. doi: 10.1002/lt.25393. No abstract available.


Improved biocompatibility of profiled sutures through lower macrophages adhesion.

Eickhoff RM, Bolle T, Kossel K, Heise D, Kroh A, Lambertz A, Blaeser A, Gries T, Jockenhoevel S, Neumann UP, Klink CD.

J Biomed Mater Res B Appl Biomater. 2018 Nov 19. doi: 10.1002/jbm.b.34269. [Epub ahead of print]


Recurrence of Hepatitis B Infection in Liver Transplant Patients Receiving Long-Term Hepatitis B Immunoglobulin Prophylaxis.

Beckebaum S, Herzer K, Bauhofer A, Gelson W, De Simone P, de Man R, Engelmann C, Müllhaupt B, Vionnet J, Salizzoni M, Volpes R, Ercolani G, De Carlis L, Angeli P, Burra P, Dufour JF, Rossi M, Cillo U, Neumann U, Fischer L, Niemann G, Toti L, Tisone G.

Ann Transplant. 2018 Nov 13;23:789-801. doi: 10.12659/AOT.910176.


A New Physiologic Mouse Model of One Anastomosis Gastric Bypass.

Kroh A, Eickhoff RM, Heise D, Alizai PH, Rheinwalt KP, Neumann UP, Ulmer FT.

Eur Surg Res. 2018;59(5-6):320-328. doi: 10.1159/000493385. Epub 2018 Nov 12.


Circulating Levels of Osteopontin Predict Patients' Outcome after Resection of Colorectal Liver Metastases.

Loosen SH, Heise D, Dejong CH, Roy S, Tacke F, Trautwein C, Roderburg C, Luedde T, Neumann UP, Binnebösel M.

J Clin Med. 2018 Oct 26;7(11). pii: E390. doi: 10.3390/jcm7110390.


Leptin contributes to the beneficial effects of insulin treatment in streptozotocin-diabetic male mice.

Neumann UH, Kwon MM, Baker RK, Kieffer TJ.

Am J Physiol Endocrinol Metab. 2018 Dec 1;315(6):E1264-E1273. doi: 10.1152/ajpendo.00159.2018. Epub 2018 Oct 9.


Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

Vogel A, Cervantes A, Chau I, Daniele B, Llovet J, Meyer T, Nault JC, Neumann U, Ricke J, Sangro B, Schirmacher P, Verslype C, Zech CJ, Arnold D, Martinelli E; ESMO Guidelines Committee.

Ann Oncol. 2018 Oct 1;29(Supplement_4):iv238-iv255. doi: 10.1093/annonc/mdy308. No abstract available.


Validity and Reliability of Three-Dimensional Imaging for Measuring Breast Cancer-Related Lymphedema in the Upper Limb: A Cross-Sectional Study.

Preuß M, Killaars R, Piatkowski de Grzymala A, Binnebösel M, Neumann U.

Lymphat Res Biol. 2018 Oct 3. doi: 10.1089/lrb.2017.0076. [Epub ahead of print]


Incisional Hernia Repair of Medium- and Large-Sized Defects: Laparoscopic IPOM Versus Open SUBLAY Technique.

Alizai PH, Lelaona E, Andert A, Neumann UP, Klink CD, Jansen M.

Acta Chir Belg. 2018 Oct 1:1-5. doi: 10.1080/00015458.2018.1501962. [Epub ahead of print]


Prognostic factors of disease-free and overall survival in patients with hepatocellular carcinoma undergoing partial hepatectomy in curative intent.

Lurje G, Bednarsch J, Czigany Z, Amygdalos I, Meister F, Schöning W, Ulmer TF, Foerster M, Dejong C, Neumann UP.

Langenbecks Arch Surg. 2018 Nov;403(7):851-861. doi: 10.1007/s00423-018-1715-9. Epub 2018 Sep 28.


Influence of suture technique on anastomotic leakage rate-a retrospective analyses comparing interrupted-versus continuous-sutures.

Eickhoff R, Eickhoff SB, Katurman S, Klink CD, Heise D, Kroh A, Neumann UP, Binnebösel M.

Int J Colorectal Dis. 2019 Jan;34(1):55-61. doi: 10.1007/s00384-018-3168-6. Epub 2018 Sep 24.


Cross-Species Molecular Imaging of Bile Salts and Lipids in Liver: Identification of Molecular Structural Markers in Health and Disease.

Flinders B, Huizing LRS, van Heerden M, Cuyckens F, Neumann UP, van der Laan LJW, Olde Damink SWM, Heeren RMA, Schaap FG, Vreeken RJ.

Anal Chem. 2018 Oct 16;90(20):11835-11846. doi: 10.1021/acs.analchem.8b01378. Epub 2018 Oct 4.


The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease.

Neumann U, Ufer M, Jacobson LH, Rouzade-Dominguez ML, Huledal G, Kolly C, Lüönd RM, Machauer R, Veenstra SJ, Hurth K, Rueeger H, Tintelnot-Blomley M, Staufenbiel M, Shimshek DR, Perrot L, Frieauff W, Dubost V, Schiller H, Vogg B, Beltz K, Avrameas A, Kretz S, Pezous N, Rondeau JM, Beckmann N, Hartmann A, Vormfelde S, David OJ, Galli B, Ramos R, Graf A, Lopez Lopez C.

EMBO Mol Med. 2018 Nov;10(11). pii: e9316. doi: 10.15252/emmm.201809316.


[Intrahepatic cholangiocarcinoma - current perspectives and treatment algorithm].

Lurje G, Bednarsch J, Roderburg C, Trautwein C, Neumann UP.

Chirurg. 2018 Nov;89(11):858-864. doi: 10.1007/s00104-018-0718-y. Review. German.


Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells.

Engelmann UM, Roeth AA, Eberbeck D, Buhl EM, Neumann UP, Schmitz-Rode T, Slabu I.

Sci Rep. 2018 Sep 4;8(1):13210. doi: 10.1038/s41598-018-31553-9.


Machine perfusion for liver transplantation in the era of marginal organs-New kids on the block.

Czigany Z, Lurje I, Tolba RH, Neumann UP, Tacke F, Lurje G.

Liver Int. 2019 Feb;39(2):228-249. doi: 10.1111/liv.13946. Epub 2018 Sep 29. Review.


Impact of body composition on survival and morbidity after liver resection in hepatocellular carcinoma patients.

Kroh A, Uschner D, Lodewick T, Eickhoff RM, Schöning W, Ulmer FT, Neumann UP, Binnebösel M.

Hepatobiliary Pancreat Dis Int. 2019 Feb;18(1):28-37. doi: 10.1016/j.hbpd.2018.07.008. Epub 2018 Jul 26.


Technical Aspects of Orthotopic Liver Transplantation-a Survey-Based Study Within the Eurotransplant, Swisstransplant, Scandiatransplant, and British Transplantation Society Networks.

Czigany Z, Scherer MN, Pratschke J, Guba M, Nadalin S, Mehrabi A, Berlakovich G, Rogiers X, Pirenne J, Lerut J, Mathe Z, Dutkowski P, Ericzon BG, Malagó M, Heaton N, Schöning W, Bednarsch J, Neumann UP, Lurje G.

J Gastrointest Surg. 2019 Mar;23(3):529-537. doi: 10.1007/s11605-018-3915-6. Epub 2018 Aug 10.


Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 Mice.

Neumann U, Derwenskus F, Gille A, Louis S, Schmid-Staiger U, Briviba K, Bischoff SC.

Nutrients. 2018 Jul 26;10(8). pii: E965. doi: 10.3390/nu10080965.


Differential Roles of Tumor Necrosis Factor Ligand Superfamily Members as Biomarkers in Pancreatic Cancer.

Pombeiro I, Loosen SH, Roy S, Schueller F, Niewenhuisen L, Luedde M, Vucur M, Tacke F, Binnebösel M, Schoening W, Trautwein C, Luedde T, Neumann UP, Roderburg C.

J Clin Med. 2018 Jul 13;7(7). pii: E175. doi: 10.3390/jcm7070175.


Chloroplast Acetyltransferase NSI Is Required for State Transitions in Arabidopsis thaliana.

Koskela MM, Brünje A, Ivanauskaite A, Grabsztunowicz M, Lassowskat I, Neumann U, Dinh TV, Sindlinger J, Schwarzer D, Wirtz M, Tyystjärvi E, Finkemeier I, Mulo P.

Plant Cell. 2018 Aug;30(8):1695-1709. doi: 10.1105/tpc.18.00155. Epub 2018 Jul 2.


[Prophylaxis, diagnosis and therapy of hepatitis-C-virus (HCV) infection: the German guidelines on the management of HCV infection - AWMF-Register-No.: 021/012].

Sarrazin C, Zimmermann T, Berg T, Neumann UP, Schirmacher P, Schmidt H, Spengler U, Timm J, Wedemeyer H, Wirth S, Zeuzem S; Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS); Deutsche Gesellschaft für Pathologie e.V. (DGP); Deutsche Leberstiftung; Gesellschaft für Virologie e.V. (GfV); Gesellschaft für Pädiatrische Gastroenterologie und Ernährung (GPGE); Österreichische Gesellschaft für Gastroenterologie und Hepatologie (ÖGGH); Schweizerische Gesellschaft für Gastroenterologie (SGG); Deutsche Transplantationsgesellschaft e.V. (DTG); Deutsche Leberhilfe e.V; Deutsche Gesellschaft für Infektiologie e.V. (DGI); Deutsche Gesellschaft für Suchtmedizin e.V. (DGS); Deutsche AIDS-Gesellschaft e.V. (DAIG); Deutsche Arbeitsgemeinschaft niedergelassener Ärzte für die Versorgung HIV-Infizierter (DAGNÄ); Robert Koch-Institut.

Z Gastroenterol. 2018 Jul;56(7):756-838. doi: 10.1055/a-0599-1320. Epub 2018 Jun 26. German. No abstract available.


A microfluidics platform for combinatorial drug screening on cancer biopsies.

Eduati F, Utharala R, Madhavan D, Neumann UP, Longerich T, Cramer T, Saez-Rodriguez J, Merten CA.

Nat Commun. 2018 Jun 22;9(1):2434. doi: 10.1038/s41467-018-04919-w.


Serum levels of soluble urokinase plasminogen activator receptor (suPAR) predict outcome after resection of colorectal liver metastases.

Loosen SH, Tacke F, Binnebosel M, Leyh C, Vucur M, Heitkamp F, Schoening W, Ulmer TF, Alizai PH, Trautwein C, Koch A, Longerich T, Roderburg C, Neumann UP, Luedde T.

Oncotarget. 2018 Jun 5;9(43):27027-27038. doi: 10.18632/oncotarget.25471. eCollection 2018 Jun 5.


Lack of liver steatosis in germ-free mice following hypercaloric diets.

Kaden-Volynets V, Basic M, Neumann U, Pretz D, Rings A, Bleich A, Bischoff SC.

Eur J Nutr. 2018 Jun 20. doi: 10.1007/s00394-018-1748-4. [Epub ahead of print]


Influence of Telomere Length in Hepatocytes on Liver Regeneration after Partial Hepatectomy in Rats.

Andert A, Alizai HP, Ulmer TF, Heidenhain C, Ziegler P, Brümmendorf TH, Neumann UP, Beier F, Klink CD.

Eur Surg Res. 2018;59(1-2):83-90. doi: 10.1159/000489090. Epub 2018 Jun 8.


[Oligometastasized colorectal cancer-modern treatment strategies].

Binnebösel M, Lambertz A, Dejong K, Neumann UP.

Chirurg. 2018 Jul;89(7):497-504. doi: 10.1007/s00104-018-0661-y. Review. German.


Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition.

Meier SR, Syvänen S, Hultqvist G, Fang XT, Roshanbin S, Lannfelt L, Neumann U, Sehlin D.

J Nucl Med. 2018 Dec;59(12):1885-1891. doi: 10.2967/jnumed.118.213140. Epub 2018 May 31.


Subcellular Localization Screening of Colletotrichum higginsianum Effector Candidates Identifies Fungal Proteins Targeted to Plant Peroxisomes, Golgi Bodies, and Microtubules.

Robin GP, Kleemann J, Neumann U, Cabre L, Dallery JF, Lapalu N, O'Connell RJ.

Front Plant Sci. 2018 May 2;9:562. doi: 10.3389/fpls.2018.00562. eCollection 2018.


Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors.

Veenstra SJ, Rueeger H, Voegtle M, Lueoend R, Holzer P, Hurth K, Tintelnot-Blomley M, Frederiksen M, Rondeau JM, Jacobson L, Staufenbiel M, Neumann U, Machauer R.

Bioorg Med Chem Lett. 2018 Jul 1;28(12):2195-2200. doi: 10.1016/j.bmcl.2018.05.003. Epub 2018 May 3.


Limb remote ischemic conditioning of the recipient protects the liver in a rat model of arterialized orthotopic liver transplantation.

Czigany Z, Bleilevens C, Beckers C, Stoppe C, Möhring M, Fülöp A, Szijarto A, Lurje G, Neumann UP, Tolba RH.

PLoS One. 2018 Apr 4;13(4):e0195507. doi: 10.1371/journal.pone.0195507. eCollection 2018.


Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation.

Schneider KM, Wirtz TH, Kroy D, Albers S, Neumann UP, Strowig T, Sellge G, Trautwein C.

Case Rep Gastroenterol. 2018 Feb 21;12(1):76-84. doi: 10.1159/000481937. eCollection 2018 Jan-Apr. Review.


Visual quality assessment of the liver graft by the transplanting surgeon predicts postreperfusion syndrome after liver transplantation: a retrospective cohort study.

Kork F, Rimek A, Andert A, Becker NJ, Heidenhain C, Neumann UP, Kroy D, Roehl AB, Rossaint R, Hein M.

BMC Anesthesiol. 2018 Mar 9;18(1):29. doi: 10.1186/s12871-018-0493-9.


Elastic TPU Mesh as Abdominal Wall Inlay Significantly Reduces Defect Size in a Minipig Model.

Heise D, Eickhoff R, Kroh A, Binnebösel M, Klinge U, Klink CD, Neumann UP, Lambertz A.

J Invest Surg. 2018 Feb 22:1-6. doi: 10.1080/08941939.2018.1436207. [Epub ahead of print]


Influence of MMP inhibitor GM6001 loading of fibre coated polypropylene meshes on wound healing: Implications for hernia repair.

Böhm G, Groll J, Heffels KH, Heussen N, Ink P, Alizai HP, Neumann UP, Schnabel R, Mirastschijski U.

J Biomater Appl. 2018 May;32(10):1343-1359. doi: 10.1177/0885328218759043. Epub 2018 Feb 21.


BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology.

Peters F, Salihoglu H, Rodrigues E, Herzog E, Blume T, Filser S, Dorostkar M, Shimshek DR, Brose N, Neumann U, Herms J.

Acta Neuropathol. 2018 May;135(5):695-710. doi: 10.1007/s00401-017-1804-9. Epub 2018 Jan 11.

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