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Correction: Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform.

Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH.

Biochem J. 2019 Sep 13;476(17):2519. doi: 10.1042/BCJ-2019-0182_COR. No abstract available.


Cutting fuel offers new clues in diabetic mystery.

Neufer PD.

J Biol Chem. 2019 Aug 16;294(33):12328-12329. doi: 10.1074/jbc.H119.010075.


PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training.

Halling JF, Jessen H, Nøhr-Meldgaard J, Buch BT, Christensen NM, Gudiksen A, Ringholm S, Neufer PD, Prats C, Pilegaard H.

Am J Physiol Endocrinol Metab. 2019 Sep 1;317(3):E513-E525. doi: 10.1152/ajpendo.00059.2019. Epub 2019 Jul 2.


Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform.

Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH.

Biochem J. 2019 May 31;476(10):1521-1537. doi: 10.1042/BCJ20190182. Erratum in: Biochem J. 2019 Sep 13;476(17):2519.


Overexpression of Long-Chain Acyl-CoA Synthetase 5 Increases Fatty Acid Oxidation and Free Radical Formation While Attenuating Insulin Signaling in Primary Human Skeletal Myotubes.

Kwak HB, Woodlief TL, Green TD, Cox JH, Hickner RC, Neufer PD, Cortright RN.

Int J Environ Res Public Health. 2019 Mar 31;16(7). pii: E1157. doi: 10.3390/ijerph16071157.


Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants.

Ryan TE, Yamaguchi DJ, Schmidt CA, Zeczycki TN, Shaikh SR, Brophy P, Green TD, Tarpey MD, Karnekar R, Goldberg EJ, Sparagna GC, Torres MJ, Annex BH, Neufer PD, Spangenburg EE, McClung JM.

JCI Insight. 2018 Nov 2;3(21). pii: 123235. doi: 10.1172/jci.insight.123235.


Impact of 17β-estradiol on complex I kinetics and H2O2 production in liver and skeletal muscle mitochondria.

Torres MJ, Ryan TE, Lin CT, Zeczycki TN, Neufer PD.

J Biol Chem. 2018 Oct 26;293(43):16889-16898. doi: 10.1074/jbc.RA118.005148. Epub 2018 Sep 14.


Targeted overexpression of catalase to mitochondria does not prevent cardioskeletal myopathy in Barth syndrome.

Johnson JM, Ferrara PJ, Verkerke ARP, Coleman CB, Wentzler EJ, Neufer PD, Kew KA, de Castro Brás LE, Funai K.

J Mol Cell Cardiol. 2018 Aug;121:94-102. doi: 10.1016/j.yjmcc.2018.07.001. Epub 2018 Jul 2.


Effects of exercise on obesity-induced mitochondrial dysfunction in skeletal muscle.

Heo JW, No MH, Park DH, Kang JH, Seo DY, Han J, Neufer PD, Kwak HB.

Korean J Physiol Pharmacol. 2017 Nov;21(6):567-577. doi: 10.4196/kjpp.2017.21.6.567. Epub 2017 Oct 30. Review.


Docosahexaenoic acid lowers cardiac mitochondrial enzyme activity by replacing linoleic acid in the phospholipidome.

Sullivan EM, Pennington ER, Sparagna GC, Torres MJ, Neufer PD, Harris M, Washington J, Anderson EJ, Zeczycki TN, Brown DA, Shaikh SR.

J Biol Chem. 2018 Jan 12;293(2):466-483. doi: 10.1074/jbc.M117.812834. Epub 2017 Nov 21.


High Incomplete Skeletal Muscle Fatty Acid Oxidation Explains Low Muscle Insulin Sensitivity in Poorly Controlled T2D.

Gavin TP, Ernst JM, Kwak HB, Caudill SE, Reed MA, Garner RT, Nie Y, Weiss JA, Pories WJ, Dar M, Lin CT, Hubal MJ, Neufer PD, Kuang S, Dohm GL.

J Clin Endocrinol Metab. 2018 Mar 1;103(3):882-889. doi: 10.1210/jc.2017-01727.


17β-Estradiol Directly Lowers Mitochondrial Membrane Microviscosity and Improves Bioenergetic Function in Skeletal Muscle.

Torres MJ, Kew KA, Ryan TE, Pennington ER, Lin CT, Buddo KA, Fix AM, Smith CA, Gilliam LA, Karvinen S, Lowe DA, Spangenburg EE, Zeczycki TN, Shaikh SR, Neufer PD.

Cell Metab. 2018 Jan 9;27(1):167-179.e7. doi: 10.1016/j.cmet.2017.10.003. Epub 2017 Nov 2.


Greater Oxidative Capacity in Primary Myotubes from Endurance-trained Women.

Heden TD, Ryan TE, Ferrara PJ, Hickner RC, Brophy PM, Neufer PD, McClung JM, Funai K.

Med Sci Sports Exerc. 2017 Nov;49(11):2151-2157. doi: 10.1249/MSS.0000000000001352.


B Cell Activity Is Impaired in Human and Mouse Obesity and Is Responsive to an Essential Fatty Acid upon Murine Influenza Infection.

Kosaraju R, Guesdon W, Crouch MJ, Teague HL, Sullivan EM, Karlsson EA, Schultz-Cherry S, Gowdy K, Bridges LC, Reese LR, Neufer PD, Armstrong M, Reisdorph N, Milner JJ, Beck M, Shaikh SR.

J Immunol. 2017 Jun 15;198(12):4738-4752. doi: 10.4049/jimmunol.1601031. Epub 2017 May 12.


The Bioenergetics of Exercise.

Neufer PD.

Cold Spring Harb Perspect Med. 2018 May 1;8(5). pii: a029678. doi: 10.1101/cshperspect.a029678. Review.


Long-chain acyl-CoA synthetase 6 regulates lipid synthesis and mitochondrial oxidative capacity in human and rat skeletal muscle.

Teodoro BG, Sampaio IH, Bomfim LH, Queiroz AL, Silveira LR, Souza AO, Fernandes AM, Eberlin MN, Huang TY, Zheng D, Neufer PD, Cortright RN, Alberici LC.

J Physiol. 2017 Feb 1;595(3):677-693. doi: 10.1113/JP272962. Epub 2016 Nov 8.


A Direct Comparison of Metabolic Responses to High-Fat Diet in C57BL/6J and C57BL/6NJ Mice.

Fisher-Wellman KH, Ryan TE, Smith CD, Gilliam LA, Lin CT, Reese LR, Torres MJ, Neufer PD.

Diabetes. 2016 Nov;65(11):3249-3261. Epub 2016 Aug 5.


Looking Beyond Structure: Membrane Phospholipids of Skeletal Muscle Mitochondria.

Heden TD, Neufer PD, Funai K.

Trends Endocrinol Metab. 2016 Aug;27(8):553-562. doi: 10.1016/j.tem.2016.05.007. Epub 2016 Jun 28. Review.


Direct real-time quantification of mitochondrial oxidative phosphorylation efficiency in permeabilized skeletal muscle myofibers.

Lark DS, Torres MJ, Lin CT, Ryan TE, Anderson EJ, Neufer PD.

Am J Physiol Cell Physiol. 2016 Aug 1;311(2):C239-45. doi: 10.1152/ajpcell.00124.2016. Epub 2016 Jun 22.


Targeted overexpression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction.

Gilliam LA, Lark DS, Reese LR, Torres MJ, Ryan TE, Lin CT, Cathey BL, Neufer PD.

Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E293-301. doi: 10.1152/ajpendo.00540.2015. Epub 2016 Jun 21.


Targeted Expression of Catalase to Mitochondria Protects Against Ischemic Myopathy in High-Fat Diet-Fed Mice.

Ryan TE, Schmidt CA, Green TD, Spangenburg EE, Neufer PD, McClung JM.

Diabetes. 2016 Sep;65(9):2553-68. doi: 10.2337/db16-0387. Epub 2016 Jun 9.


Mitochondrial therapy improves limb perfusion and myopathy following hindlimb ischemia.

Ryan TE, Schmidt CA, Alleman RJ, Tsang AM, Green TD, Neufer PD, Brown DA, McClung JM.

J Mol Cell Cardiol. 2016 Aug;97:191-6. doi: 10.1016/j.yjmcc.2016.05.015. Epub 2016 Jun 1.


Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia.

Morad SA, Ryan TE, Neufer PD, Zeczycki TN, Davis TS, MacDougall MR, Fox TE, Tan SF, Feith DJ, Loughran TP Jr, Kester M, Claxton DF, Barth BM, Deering TG, Cabot MC.

J Lipid Res. 2016 Jul;57(7):1231-42. doi: 10.1194/jlr.M067389. Epub 2016 May 2.


Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics.

Alleman RJ, Tsang AM, Ryan TE, Patteson DJ, McClung JM, Spangenburg EE, Shaikh SR, Neufer PD, Brown DA.

Am J Physiol Heart Circ Physiol. 2016 May 15;310(10):H1360-70. doi: 10.1152/ajpheart.00858.2015. Epub 2016 Mar 4.


Mitochondrial Regulation of the Muscle Microenvironment in Critical Limb Ischemia.

Ryan TE, Schmidt CA, Green TD, Brown DA, Neufer PD, McClung JM.

Front Physiol. 2015 Nov 18;6:336. doi: 10.3389/fphys.2015.00336. eCollection 2015. Review.


Protein Kinase A Governs Oxidative Phosphorylation Kinetics and Oxidant Emitting Potential at Complex I.

Lark DS, Reese LR, Ryan TE, Torres MJ, Smith CD, Lin CT, Neufer PD.

Front Physiol. 2015 Nov 17;6:332. doi: 10.3389/fphys.2015.00332. eCollection 2015.


Paternal long-term exercise programs offspring for low energy expenditure and increased risk for obesity in mice.

Murashov AK, Pak ES, Koury M, Ajmera A, Jeyakumar M, Parker M, Williams O, Ding J, Walters D, Neufer PD.

FASEB J. 2016 Feb;30(2):775-84. doi: 10.1096/fj.15-274274. Epub 2015 Oct 27.


Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.

Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET, Newgard CB, MacDonald PE.

J Clin Invest. 2015 Oct 1;125(10):3847-60. doi: 10.1172/JCI82498. Epub 2015 Sep 21.


Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits.

Neufer PD, Bamman MM, Muoio DM, Bouchard C, Cooper DM, Goodpaster BH, Booth FW, Kohrt WM, Gerszten RE, Mattson MP, Hepple RT, Kraus WE, Reid MB, Bodine SC, Jakicic JM, Fleg JL, Williams JP, Joseph L, Evans M, Maruvada P, Rodgers M, Roary M, Boyce AT, Drugan JK, Koenig JI, Ingraham RH, Krotoski D, Garcia-Cazarin M, McGowan JA, Laughlin MR.

Cell Metab. 2015 Jul 7;22(1):4-11. doi: 10.1016/j.cmet.2015.05.011. Epub 2015 Jun 11. Review.


Enhanced mitochondrial superoxide scavenging does not improve muscle insulin action in the high fat-fed mouse.

Lark DS, Kang L, Lustig ME, Bonner JS, James FD, Neufer PD, Wasserman DH.

PLoS One. 2015 May 19;10(5):e0126732. doi: 10.1371/journal.pone.0126732. eCollection 2015.


Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling.

Ludzki A, Paglialunga S, Smith BK, Herbst EA, Allison MK, Heigenhauser GJ, Neufer PD, Holloway GP.

Diabetes. 2015 Aug;64(8):2769-79. doi: 10.2337/db14-1838. Epub 2015 Apr 6.


Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit.

Fisher-Wellman KH, Lin CT, Ryan TE, Reese LR, Gilliam LA, Cathey BL, Lark DS, Smith CD, Muoio DM, Neufer PD.

Biochem J. 2015 Apr 15;467(2):271-80. doi: 10.1042/BJ20141447.


Assessment of in vivo skeletal muscle mitochondrial respiratory capacity in humans by near-infrared spectroscopy: a comparison with in situ measurements.

Ryan TE, Brophy P, Lin CT, Hickner RC, Neufer PD.

J Physiol. 2014 Aug 1;592(15):3231-41. doi: 10.1113/jphysiol.2014.274456. Epub 2014 Jun 20.


Heterozygous SOD2 deletion impairs glucose-stimulated insulin secretion, but not insulin action, in high-fat-fed mice.

Kang L, Dai C, Lustig ME, Bonner JS, Mayes WH, Mokshagundam S, James FD, Thompson CS, Lin CT, Perry CG, Anderson EJ, Neufer PD, Wasserman DH, Powers AC.

Diabetes. 2014 Nov;63(11):3699-710. doi: 10.2337/db13-1845. Epub 2014 Jun 19.


δ-Catenin, a Wnt/β-catenin modulator, reveals inducible mutagenesis promoting cancer cell survival adaptation and metabolic reprogramming.

Nopparat J, Zhang J, Lu JP, Chen YH, Zheng D, Neufer PD, Fan JM, Hong H, Boykin C, Lu Q.

Oncogene. 2015 Mar 19;34(12):1542-52. doi: 10.1038/onc.2014.89. Epub 2014 Apr 14.


BRCA1 is a novel regulator of metabolic function in skeletal muscle.

Jackson KC, Gidlund EK, Norrbom J, Valencia AP, Thomson DM, Schuh RA, Neufer PD, Spangenburg EE.

J Lipid Res. 2014 Apr;55(4):668-80. doi: 10.1194/jlr.M043851. Epub 2014 Feb 24.


Exercise biology and medicine: innovative research to improve global health.

Bamman MM, Cooper DM, Booth FW, Chin ER, Neufer PD, Trappe S, Lightfoot JT, Kraus WE, Joyner MJ.

Mayo Clin Proc. 2014 Feb;89(2):148-53. doi: 10.1016/j.mayocp.2013.11.013. No abstract available.


Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle.

DeBalsi KL, Wong KE, Koves TR, Slentz DH, Seiler SE, Wittmann AH, Ilkayeva OR, Stevens RD, Perry CG, Lark DS, Hui ST, Szweda L, Neufer PD, Muoio DM.

J Biol Chem. 2014 Mar 21;289(12):8106-20. doi: 10.1074/jbc.M113.511535. Epub 2014 Jan 30.


Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia.

Brown DA, Hale SL, Baines CP, del Rio CL, Hamlin RL, Yueyama Y, Kijtawornrat A, Yeh ST, Frasier CR, Stewart LM, Moukdar F, Shaikh SR, Fisher-Wellman KH, Neufer PD, Kloner RA.

J Cardiovasc Pharmacol Ther. 2014 Jan;19(1):121-32. doi: 10.1177/1074248413508003. Epub 2013 Nov 28.


A transient increase in lipid peroxidation primes preadipocytes for delayed mitochondrial inner membrane permeabilization and ATP depletion during prolonged exposure to fatty acids.

Rogers C, Davis B, Neufer PD, Murphy MP, Anderson EJ, Robidoux J.

Free Radic Biol Med. 2014 Feb;67:330-41. doi: 10.1016/j.freeradbiomed.2013.11.012. Epub 2013 Nov 22.


Submaximal ADP-stimulated respiration is impaired in ZDF rats and recovered by resveratrol.

Smith BK, Perry CG, Herbst EA, Ritchie IR, Beaudoin MS, Smith JC, Neufer PD, Wright DC, Holloway GP.

J Physiol. 2013 Dec 1;591(23):6089-101. doi: 10.1113/jphysiol.2013.259226. Epub 2013 Sep 30.


The anticancer agent doxorubicin disrupts mitochondrial energy metabolism and redox balance in skeletal muscle.

Gilliam LAA, Fisher-Wellman KH, Lin CT, Maples JM, Cathey BL, Neufer PD.

Free Radic Biol Med. 2013 Dec;65:988-996. doi: 10.1016/j.freeradbiomed.2013.08.191. Epub 2013 Sep 7.


Mitochondrial respiratory capacity and content are normal in young insulin-resistant obese humans.

Fisher-Wellman KH, Weber TM, Cathey BL, Brophy PM, Gilliam LA, Kane CL, Maples JM, Gavin TP, Houmard JA, Neufer PD.

Diabetes. 2014 Jan;63(1):132-41. doi: 10.2337/db13-0940. Epub 2013 Aug 23.


Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle.

Fisher-Wellman KH, Mattox TA, Thayne K, Katunga LA, La Favor JD, Neufer PD, Hickner RC, Wingard CJ, Anderson EJ.

J Physiol. 2013 Jul 15;591(14):3471-86. doi: 10.1113/jphysiol.2013.254193. Epub 2013 Apr 22.


Methods for assessing mitochondrial function in diabetes.

Perry CG, Kane DA, Lanza IR, Neufer PD.

Diabetes. 2013 Apr;62(4):1041-53. doi: 10.2337/db12-1219. Review.


High-fat load: mechanism(s) of insulin resistance in skeletal muscle.

Lark DS, Fisher-Wellman KH, Neufer PD.

Int J Obes Suppl. 2012 Dec;2(Suppl 2):S31-S36.


Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates.

Smith BK, Perry CG, Koves TR, Wright DC, Smith JC, Neufer PD, Muoio DM, Holloway GP.

Biochem J. 2012 Nov 15;448(1):13-20. doi: 10.1042/BJ20121110.


Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle.

Perry CG, Kane DA, Herbst EA, Mukai K, Lark DS, Wright DC, Heigenhauser GJ, Neufer PD, Spriet LL, Holloway GP.

J Physiol. 2012 Nov 1;590(21):5475-86. doi: 10.1113/jphysiol.2012.234682. Epub 2012 Aug 20.


Transgenic mouse models resistant to diet-induced metabolic disease: is energy balance the key?

Gilliam LA, Neufer PD.

J Pharmacol Exp Ther. 2012 Sep;342(3):631-6. doi: 10.1124/jpet.112.192146. Epub 2012 Jun 13. Review.


Mitochondrial antioxidative capacity regulates muscle glucose uptake in the conscious mouse: effect of exercise and diet.

Kang L, Lustig ME, Bonner JS, Lee-Young RS, Mayes WH, James FD, Lin CT, Perry CG, Anderson EJ, Neufer PD, Wasserman DH.

J Appl Physiol (1985). 2012 Oct 15;113(8):1173-83. doi: 10.1152/japplphysiol.01344.2011. Epub 2012 May 31.

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