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Items: 1 to 50 of 78

1.

Measuring the Turnover Rate of Clinically Important Plasma Proteins using an Automated SISCAPA Workflow.

Razavi M, Farrokhi V, Yip R, Anderson NL, Pearson TW, Neubert H.

Clin Chem. 2019 Mar;65(3):492-494. doi: 10.1373/clinchem.2018.294892. Epub 2019 Jan 9. No abstract available.

PMID:
30626630
2.

Report of a TREAT-NMD/World Duchenne Organisation Meeting on Dystrophin Quantification Methodology.

Aartsma-Rus A, Morgan J, Lonkar P, Neubert H, Owens J, Binks M, Montolio M, Phadke R, Datson N, Van Deutekom J, Morris GE, Rao VA, Hoffman EP, Muntoni F, Arechavala-Gomeza V; workshop participants.

J Neuromuscul Dis. 2019;6(1):147-159. doi: 10.3233/JND-180357.

3.

2018 White Paper on Recent Issues in Bioanalysis: focus on immunogenicity assays by hybrid LBA/LCMS and regulatory feedback (Part 2 - PK, PD & ADA assays by hybrid LBA/LCMS & regulatory agencies' inputs on bioanalysis, biomarkers and immunogenicity).

Neubert H, Olah T, Lee A, Fraser S, Dodge R, Laterza O, Szapacs M, Alley SC, Saad OM, Amur S, Chen L, Cherry E, Cho SJ, Cludts I, Donato LD, Edmison A, Ferrari L, Garofolo F, Haidar S, Hopper S, Hottenstein S, Ishii-Watabe A, Kassim S, Kurki P, Lima Santos GM, Miscoria G, Palandra J, Pedras-Vasconcelos J, Piccoli S, Rogstad S, Saito Y, Savoie N, Sikorski T, Spitz S, Staelens L, Verthelyi D, Vinter S, Wadhwa M, Wang YM, Welink J, Weng N, Whale E, Woolf E, Wu J, Yan H, Yu H, Zhou S.

Bioanalysis. 2018 Nov 29. doi: 10.4155/bio-2018-0285. [Epub ahead of print]

PMID:
30488729
4.

New opportunities with quantification of protein therapeutics by LC-MS.

Neubert H, Xu K.

Bioanalysis. 2018 Jul 1;10(13):971-973. doi: 10.4155/bio-2018-0151. No abstract available.

5.

Assessing the Feasibility of Neutralizing Osteopontin with Various Therapeutic Antibody Modalities.

Farrokhi V, Chabot JR, Neubert H, Yang Z.

Sci Rep. 2018 May 17;8(1):7781. doi: 10.1038/s41598-018-26187-w.

6.

2017 White Paper: rise of hybrid LBA/LCMS immunogenicity assays (Part 2: hybrid LBA/LCMS biotherapeutics, biomarkers & immunogenicity assays and regulatory agencies' inputs).

Neubert H, Song A, Lee A, Wei C, Duggan J, Xu K, Woolf E, Evans C, Palandra J, Laterza O, Amur S, Berger I, Bustard M, Cancilla M, Chen SC, Cho SJ, Ciccimaro E, Cludts I, Cocea L, D'Arienzo C, Danan-Leon L, Donato LD, Garofolo F, Haidar S, Ishii-Watabe A, Jiang H, Kadavil J, Kassim S, Kurki P, Blaye OL, Liu K, Mathews R, Lima Santos GM, Niwa M, Pedras-Vasconcelos J, Qian M, Rago B, Saad O, Saito Y, Savoie N, Su D, Szapacs M, Tampal N, Vinter S, Wang J, Welink J, Whale E, Wilson A, Xue YJ.

Bioanalysis. 2017 Dec;9(23):1895-1912. doi: 10.4155/bio-2017-4973. Epub 2017 Dec 5.

7.

Biomeasures and mechanistic modeling highlight PK/PD risks for a monoclonal antibody targeting Fn14 in kidney disease.

Chen X, Farrokhi V, Singh P, Ocana MF, Patel J, Lin LL, Neubert H, Brodfuehrer J.

MAbs. 2018 Jan;10(1):62-70. doi: 10.1080/19420862.2017.1398873. Epub 2017 Nov 30.

8.

Protein Turnover Measurements in Human Serum by Serial Immunoaffinity LC-MS/MS.

Farrokhi V, Chen X, Neubert H.

Clin Chem. 2018 Feb;64(2):279-288. doi: 10.1373/clinchem.2017.272922. Epub 2017 Oct 20.

9.

Anti-MAdCAM Antibody Increases ß7+ T Cells and CCR9 Gene Expression in the Peripheral Blood of Patients With Crohn's Disease.

Hassan-Zahraee M, Banerjee A, Cheng JB, Zhang W, Ahmad A, Page K, von Schack D, Zhang B, Martin SW, Nayak S, Reddy P, Xi L, Neubert H, Fernandez Ocana M, Gorelick K, Clare R, Vincent M, Cataldi F, Hung K.

J Crohns Colitis. 2018 Jan 5;12(1):77-86. doi: 10.1093/ecco-jcc/jjx121.

10.

Clinical chemoproteomics-Opportunities and obstacles.

Jones LH, Neubert H.

Sci Transl Med. 2017 Apr 19;9(386). pii: eaaf7951. doi: 10.1126/scitranslmed.aaf7951. Review.

PMID:
28424333
11.

New Guidelines for Publication of Manuscripts Describing Development and Application of Targeted Mass Spectrometry Measurements of Peptides and Proteins.

Abbatiello S, Ackermann BL, Borchers C, Bradshaw RA, Carr SA, Chalkley R, Choi M, Deutsch E, Domon B, Hoofnagle AN, Keshishian H, Kuhn E, Liebler DC, MacCoss M, MacLean B, Mani DR, Neubert H, Smith D, Vitek O, Zimmerman L.

Mol Cell Proteomics. 2017 Mar;16(3):327-328. doi: 10.1074/mcp.E117.067801. Epub 2017 Feb 9. No abstract available.

12.

Reduced serum myostatin concentrations associated with genetic muscle disease progression.

Burch PM, Pogoryelova O, Palandra J, Goldstein R, Bennett D, Fitz L, Guglieri M, Bettolo CM, Straub V, Evangelista T, Neubert H, Lochmüller H, Morris C.

J Neurol. 2017 Mar;264(3):541-553. doi: 10.1007/s00415-016-8379-6. Epub 2017 Jan 10.

PMID:
28074267
13.

The breadth of biomarkers and their assays: part 2.

Arnold ME, Neubert H, Stevenson LF.

Bioanalysis. 2016 Dec;8(23):2381-2382. No abstract available.

14.

The breadth of biomarkers and their assays.

Arnold ME, Neubert H, Stevenson LF, Garofolo F.

Bioanalysis. 2016 Nov;8(22):2283-2285. No abstract available.

15.

Quantification of protein biomarkers in tissues: new capabilities with pellet digestion peptide immunoaffinity LC-MS/MS.

Neubert H, Fan YY, Fernandez Ocaña M.

Bioanalysis. 2016 Aug;8(15):1551-1555. Epub 2016 Jul 11. No abstract available.

PMID:
27396720
16.

Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies.

Avery LB, Wang M, Kavosi MS, Joyce A, Kurz JC, Fan YY, Dowty ME, Zhang M, Zhang Y, Cheng A, Hua F, Jones HM, Neubert H, Polzer RJ, O'Hara DM.

MAbs. 2016 Aug-Sep;8(6):1064-78. doi: 10.1080/19420862.2016.1193660. Epub 2016 May 27.

17.

Soluble Fn14 Is Detected and Elevated in Mouse and Human Kidney Disease.

Sharif MN, Campanholle G, Nagiec EE, Wang J, Syed J, O'Neil SP, Zhan Y, Brenneman K, Homer B, Neubert H, Karim R, Pullen N, Evans SM, Fleming M, Chockalingam P, Lin LL.

PLoS One. 2016 May 12;11(5):e0155368. doi: 10.1371/journal.pone.0155368. eCollection 2016.

18.

Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice.

Fan YY, Avery LB, Wang M, O'Hara DM, Leung S, Neubert H.

MAbs. 2016 Jul;8(5):848-53. doi: 10.1080/19420862.2016.1178436. Epub 2016 Apr 22.

19.

Quantitative Analysis of Human Neonatal Fc Receptor (FcRn) Tissue Expression in Transgenic Mice by Online Peptide Immuno-Affinity LC-HRMS.

Fan YY, Neubert H.

Anal Chem. 2016 Apr 19;88(8):4239-47. doi: 10.1021/acs.analchem.5b03900. Epub 2016 Apr 4.

PMID:
27012525
20.

Large-scale implementation of sequential protein and peptide immunoaffinity enrichment LC/nanoLC-MS/MS for human β-nerve growth factor.

Schultz GA, McCardle K, Neubert H.

Bioanalysis. 2016 Apr;8(8):753-64. doi: 10.4155/bio-2015-0022. Epub 2016 Mar 23.

PMID:
27005855
21.

Quantitative measurements of GDF-8 using immunoaffinity LC-MS/MS.

Palandra J, Quazi A, Fitz L, Rong H, Morris C, Neubert H.

Proteomics Clin Appl. 2016 May;10(5):597-604. doi: 10.1002/prca.201500112. Epub 2016 Apr 13.

PMID:
26846723
22.

Recommendations for the Generation, Quantification, Storage, and Handling of Peptides Used for Mass Spectrometry-Based Assays.

Hoofnagle AN, Whiteaker JR, Carr SA, Kuhn E, Liu T, Massoni SA, Thomas SN, Townsend RR, Zimmerman LJ, Boja E, Chen J, Crimmins DL, Davies SR, Gao Y, Hiltke TR, Ketchum KA, Kinsinger CR, Mesri M, Meyer MR, Qian WJ, Schoenherr RM, Scott MG, Shi T, Whiteley GR, Wrobel JA, Wu C, Ackermann BL, Aebersold R, Barnidge DR, Bunk DM, Clarke N, Fishman JB, Grant RP, Kusebauch U, Kushnir MM, Lowenthal MS, Moritz RL, Neubert H, Patterson SD, Rockwood AL, Rogers J, Singh RJ, Van Eyk JE, Wong SH, Zhang S, Chan DW, Chen X, Ellis MJ, Liebler DC, Rodland KD, Rodriguez H, Smith RD, Zhang Z, Zhang H, Paulovich AG.

Clin Chem. 2016 Jan;62(1):48-69. doi: 10.1373/clinchem.2015.250563.

23.

2015 White Paper on recent issues in bioanalysis: focus on new technologies and biomarkers (Part 2 - hybrid LBA/LCMS and input from regulatory agencies).

Ackermann B, Neubert H, Hughes N, Garofolo F, Abberley L, Alley SC, Brown-Augsburger P, Bustard M, Chen LZ, Heinrich J, Katori N, Kaur S, Kirkovsky L, Laterza OF, Le Blaye O, Lévesque A, Santos GM, Olah T, Savoie N, Skelly M, Spitz S, Szapacs M, Tampal N, Wang J, Welink J, Wieling J, Haidar S, Vinter S, Whale E, Witte B.

Bioanalysis. 2015 Dec;7(23):3019-34. doi: 10.4155/bio.15.214. Epub 2015 Dec 2.

24.

2014 White Paper on recent issues in bioanalysis: a full immersion in bioanalysis (Part 2 - hybrid LBA/LCMS, ELN & regulatory agencies' input).

Dufield D, Neubert H, Garofolo F, Kirkovsky L, Stevenson L, Dumont I, Kaur S, Xu K, Alley SC, Szapacs M, Arnold M, Bansal S, Haidar S, Welink J, Le Blaye O, Wakelin-Smith J, Whale E, Ishii-Watabe A, Bustard M, Katori N, Amaravadi L, Aubry AF, Beaver C, Bergeron A, Cai XY, Cojocaru L, DeSilva B, Duggan J, Fluhler E, Gorovits B, Gupta S, Hayes R, Ho S, Ingelse B, King L, Lévesque A, Lowes S, Ma M, Musuku A, Myler H, Olah T, Patel S, Rose M, Schultz G, Smeraglia J, Swanson S, Torri A, Vazvaei F, Wilson A, Woolf E, Xue L, Yang TY.

Bioanalysis. 2014;6(23):3237-49. doi: 10.4155/bio.14.279.

25.

Mass cytometry: a highly multiplexed single-cell technology for advancing drug development.

Atkuri KR, Stevens JC, Neubert H.

Drug Metab Dispos. 2015 Feb;43(2):227-33. doi: 10.1124/dmd.114.060798. Epub 2014 Oct 27. Review.

PMID:
25349123
26.

Quantification of biotherapeutic targets: new opportunities with immunoaffinity LC-MS/MS.

Neubert H, Palandra J, Fernández Ocaña M.

Bioanalysis. 2014;6(13):1731-3. doi: 10.4155/bio.14.138. No abstract available.

PMID:
25157479
27.

Serum β-nerve growth factor concentrations in pregnant female, nonpregnant female, and male cynomolgus monkeys.

Neubert H, Clark TH, Deng S, Hurst SI.

Neuroreport. 2014 Aug 6;25(11):829-832. doi: 10.1097/WNR.0000000000000187.

PMID:
24848615
28.

Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach.

Carr SA, Abbatiello SE, Ackermann BL, Borchers C, Domon B, Deutsch EW, Grant RP, Hoofnagle AN, Hüttenhain R, Koomen JM, Liebler DC, Liu T, MacLean B, Mani DR, Mansfield E, Neubert H, Paulovich AG, Reiter L, Vitek O, Aebersold R, Anderson L, Bethem R, Blonder J, Boja E, Botelho J, Boyne M, Bradshaw RA, Burlingame AL, Chan D, Keshishian H, Kuhn E, Kinsinger C, Lee JS, Lee SW, Moritz R, Oses-Prieto J, Rifai N, Ritchie J, Rodriguez H, Srinivas PR, Townsend RR, Van Eyk J, Whiteley G, Wiita A, Weintraub S.

Mol Cell Proteomics. 2014 Mar;13(3):907-17. doi: 10.1074/mcp.M113.036095. Epub 2014 Jan 17.

30.

Targeted quantitative proteomics for the analysis of 14 UGT1As and -2Bs in human liver using NanoUPLC-MS/MS with selected reaction monitoring.

Fallon JK, Neubert H, Hyland R, Goosen TC, Smith PC.

J Proteome Res. 2013 Oct 4;12(10):4402-13. doi: 10.1021/pr4004213. Epub 2013 Sep 26.

PMID:
23977844
31.

Highly specific and sensitive measurements of human and monkey interleukin 21 using sequential protein and tryptic peptide immunoaffinity LC-MS/MS.

Palandra J, Finelli A, Zhu M, Masferrer J, Neubert H.

Anal Chem. 2013 Jun 4;85(11):5522-9. doi: 10.1021/ac4006765. Epub 2013 May 16.

PMID:
23638938
32.

Sequential protein and peptide immunoaffinity capture for mass spectrometry-based quantification of total human β-nerve growth factor.

Neubert H, Muirhead D, Kabir M, Grace C, Cleton A, Arends R.

Anal Chem. 2013 Feb 5;85(3):1719-26. doi: 10.1021/ac303031q. Epub 2013 Jan 7.

PMID:
23249404
33.

Tissue bioanalysis of biotherapeutics and drug targets to support PK/PD.

Neubert H, Fountain S, King L, Clark T, Weng Y, O'Hara DM, Li W, Leung S, Ray C, Palandra J, Ocaña MF, Chen J, Ji C, Wang M, Long K, Gorovits B, Fluhler E.

Bioanalysis. 2012 Nov;4(21):2589-604. doi: 10.4155/bio.12.234. Review.

PMID:
23173794
34.

Synergistic effect of defined artificial extracellular matrices and pulsed electric fields on osteogenic differentiation of human MSCs.

Hess R, Jaeschke A, Neubert H, Hintze V, Moeller S, Schnabelrauch M, Wiesmann HP, Hart DA, Scharnweber D.

Biomaterials. 2012 Dec;33(35):8975-85. doi: 10.1016/j.biomaterials.2012.08.056. Epub 2012 Sep 17.

PMID:
22995709
35.

Clinical pharmacokinetic assessment of an anti-MAdCAM monoclonal antibody therapeutic by LC-MS/MS.

Fernández Ocaña M, James IT, Kabir M, Grace C, Yuan G, Martin SW, Neubert H.

Anal Chem. 2012 Jul 17;84(14):5959-67. doi: 10.1021/ac300600f. Epub 2012 Jul 5.

PMID:
22816779
36.

A novel approach for in vitro studies applying electrical fields to cell cultures by transformer-like coupling.

Hess R, Neubert H, Seifert A, Bierbaum S, Hart DA, Scharnweber D.

Cell Biochem Biophys. 2012 Dec;64(3):223-32. doi: 10.1007/s12013-012-9388-4.

PMID:
22798202
37.

Visualisation tool for peptide fractionation data in proteomics: application to OFFGEL isoelectric focussing.

Azulay DO, Neubert H, Ocaña MF.

BMC Bioinformatics. 2010 Jul 5;11:371. doi: 10.1186/1471-2105-11-371.

38.

Online high-flow peptide immunoaffinity enrichment and nanoflow LC-MS/MS: assay development for total salivary pepsin/pepsinogen.

Neubert H, Gale J, Muirhead D.

Clin Chem. 2010 Sep;56(9):1413-23. doi: 10.1373/clinchem.2010.144576. Epub 2010 May 14.

39.

An immunoaffinity liquid chromatography-tandem mass spectrometry assay for the quantitation of matrix metalloproteinase 9 in mouse serum.

Ocaña MF, Neubert H.

Anal Biochem. 2010 Apr 15;399(2):202-10. doi: 10.1016/j.ab.2010.01.002. Epub 2010 Jan 11.

PMID:
20060801
40.

Online capillary weak cation exchange enrichment hyphenated to nanospray mass spectrometry for quantitation of a basic pegvisomant derived peptide.

Neubert H, James I.

J Chromatogr A. 2009 Aug 14;1216(33):6151-4. doi: 10.1016/j.chroma.2009.06.072. Epub 2009 Jul 1.

PMID:
19608189
41.

Assessing immunogenicity in the presence of excess protein therapeutic using immunoprecipitation and quantitative mass spectrometry.

Neubert H, Grace C, Rumpel K, James I.

Anal Chem. 2008 Sep 15;80(18):6907-14. doi: 10.1021/ac8005439. Epub 2008 Aug 15.

PMID:
18702532
42.

Label-free detection of differential protein expression by LC/MALDI mass spectrometry.

Neubert H, Bonnert TP, Rumpel K, Hunt BT, Henle ES, James IT.

J Proteome Res. 2008 Jun;7(6):2270-9. doi: 10.1021/pr700705u. Epub 2008 Apr 16.

PMID:
18412385
43.

MALDI mass spectrometric determination of dendritic iron chelation stoichiometries and conditional affinity constants.

Kong X, Neubert H, Zhou T, Liu ZD, Hider RC.

J Mass Spectrom. 2008 May;43(5):617-22. doi: 10.1002/jms.1357.

PMID:
18286664
44.

The fenton activity of iron(III) in the presence of deferiprone.

Devanur LD, Neubert H, Hider RC.

J Pharm Sci. 2008 Apr;97(4):1454-67.

PMID:
17724662
45.

Iron binding dendrimers: a novel approach for the treatment of haemochromatosis.

Zhou T, Neubert H, Liu DY, Liu ZD, Ma YM, Kong XL, Luo W, Mark S, Hider RC.

J Med Chem. 2006 Jul 13;49(14):4171-82.

PMID:
16821777
46.

3-Hydroxy-2-(5-hydroxypentyl)-4H-chromen-4-one: a bidentate or tridentate iron(III) ligand?

Kong X, Zhou T, Neubert H, Liu Z, Hider RC.

J Med Chem. 2006 May 18;49(10):3028-31.

PMID:
16686545
47.

Alpha tocopherol supplementation elevates plasma apolipoprotein A1 isoforms in normal healthy subjects.

Aldred S, Sozzi T, Mudway I, Grant MM, Neubert H, Kelly FJ, Griffiths HR.

Proteomics. 2006 Mar;6(5):1695-703.

PMID:
16429457
48.

High affinity iron(III) scavenging by a novel hexadentate 3-hydroxypyridin-4-one-based dendrimer: synthesis and characterization.

Zhou T, Liu ZD, Neubert H, Kong XL, Ma YM, Hider RC.

Bioorg Med Chem Lett. 2005 Nov 15;15(22):5007-11.

PMID:
16153843
49.

Structural characterization of chelator-terminated dendrimers and their synthetic intermediates by mass spectrometry.

Berndt UE, Zhou T, Hider RC, Liu ZD, Neubert H.

J Mass Spectrom. 2005 Sep;40(9):1203-14.

PMID:
16127663

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