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Pillars article: AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature. 2002. 418: 99-103.

Petersen-Mahrt SK, Harris RS, Neuberger MS.

J Immunol. 2015 Mar 1;194(5):2043-7. No abstract available.


Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation.

Dingler FA, Kemmerich K, Neuberger MS, Rada C.

Eur J Immunol. 2014 Jul;44(7):1925-35. doi: 10.1002/eji.201444482. Epub 2014 May 27.


Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α.

Ganesh K, van Maldegem F, Telerman SB, Simpson P, Johnson CM, Williams RL, Neuberger MS, Rada C.

FEBS Lett. 2014 Jan 3;588(1):21-7. doi: 10.1016/j.febslet.2013.11.013. Epub 2013 Nov 20.


DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis.

Taylor BJ, Nik-Zainal S, Wu YL, Stebbings LA, Raine K, Campbell PJ, Rada C, Stratton MR, Neuberger MS.

Elife. 2013 Apr 16;2:e00534. doi: 10.7554/eLife.00534.


Deficiency in spliceosome-associated factor CTNNBL1 does not affect ongoing cell cycling but delays exit from quiescence and results in embryonic lethality in mice.

Chandra A, van Maldegem F, Andrews S, Neuberger MS, Rada C.

Cell Cycle. 2013 Mar 1;12(5):732-42. doi: 10.4161/cc.23594. Epub 2013 Jan 23.


High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region.

Osborn MJ, Ma B, Avis S, Binnie A, Dilley J, Yang X, Lindquist K, Ménoret S, Iscache AL, Ouisse LH, Rajpal A, Anegon I, Neuberger MS, Buelow R, Brüggemann M.

J Immunol. 2013 Feb 15;190(4):1481-90. doi: 10.4049/jimmunol.1203041. Epub 2013 Jan 9. Erratum in: J Immunol. 2013 Jun 15;190(12):6707.


The cytoplasmic AID complex.

Häsler J, Rada C, Neuberger MS.

Semin Immunol. 2012 Aug;24(4):273-80. doi: 10.1016/j.smim.2012.05.004. Epub 2012 Jun 13. Review.


Mutational processes molding the genomes of 21 breast cancers.

Nik-Zainal S, Alexandrov LB, Wedge DC, Van Loo P, Greenman CD, Raine K, Jones D, Hinton J, Marshall J, Stebbings LA, Menzies A, Martin S, Leung K, Chen L, Leroy C, Ramakrishna M, Rance R, Lau KW, Mudie LJ, Varela I, McBride DJ, Bignell GR, Cooke SL, Shlien A, Gamble J, Whitmore I, Maddison M, Tarpey PS, Davies HR, Papaemmanuil E, Stephens PJ, McLaren S, Butler AP, Teague JW, Jönsson G, Garber JE, Silver D, Miron P, Fatima A, Boyault S, Langerød A, Tutt A, Martens JW, Aparicio SA, Borg Å, Salomon AV, Thomas G, Børresen-Dale AL, Richardson AL, Neuberger MS, Futreal PA, Campbell PJ, Stratton MR; Breast Cancer Working Group of the International Cancer Genome Consortium.

Cell. 2012 May 25;149(5):979-93. doi: 10.1016/j.cell.2012.04.024. Epub 2012 May 17.


Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.

Kemmerich K, Dingler FA, Rada C, Neuberger MS.

Nucleic Acids Res. 2012 Jul;40(13):6016-25. doi: 10.1093/nar/gks259. Epub 2012 Mar 24.


REG-γ associates with and modulates the abundance of nuclear activation-induced deaminase.

Uchimura Y, Barton LF, Rada C, Neuberger MS.

J Exp Med. 2011 Nov 21;208(12):2385-91. doi: 10.1084/jem.20110856. Epub 2011 Oct 31.


Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A).

Häsler J, Rada C, Neuberger MS.

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18366-71. doi: 10.1073/pnas.1106729108. Epub 2011 Oct 31.


Human monoclonal antibodies to HIV-1 gp140 from mice bearing YAC-based human immunoglobulin transloci.

Pruzina S, Williams GT, Kaneva G, Davies SL, Martín-López A, Brüggemann M, Vieira SM, Jeffs SA, Sattentau QJ, Neuberger MS.

Protein Eng Des Sel. 2011 Oct;24(10):791-9. doi: 10.1093/protein/gzr038. Epub 2011 Aug 2.


The relationship between hypothesis and experiment in unveiling the mechanisms of antibody gene diversification.

Ganesh K, Neuberger MS.

FASEB J. 2011 Apr;25(4):1123-32. doi: 10.1096/fj.11-0402ufm. Review.


A high-throughput assay for DNA deaminases.

Wang M, Rada C, Neuberger MS.

Methods Mol Biol. 2011;718:171-84. doi: 10.1007/978-1-61779-018-8_11.


The dependence of Ig class-switching on the nuclear export sequence of AID likely reflects interaction with factors additional to Crm1 exportin.

Ellyard JI, Benk AS, Taylor B, Rada C, Neuberger MS.

Eur J Immunol. 2011 Feb;41(2):485-90. doi: 10.1002/eji.201041011. Epub 2010 Dec 23.


Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID.

Wang M, Rada C, Neuberger MS.

J Exp Med. 2010 Jan 18;207(1):141-53. doi: 10.1084/jem.20092238. Epub 2010 Jan 4.


Deficiency in APOBEC2 leads to a shift in muscle fiber type, diminished body mass, and myopathy.

Sato Y, Probst HC, Tatsumi R, Ikeuchi Y, Neuberger MS, Rada C.

J Biol Chem. 2010 Mar 5;285(10):7111-8. doi: 10.1074/jbc.M109.052977. Epub 2009 Dec 17.


The AKV murine leukemia virus is restricted and hypermutated by mouse APOBEC3.

Langlois MA, Kemmerich K, Rada C, Neuberger MS.

J Virol. 2009 Nov;83(22):11550-9. doi: 10.1128/JVI.01430-09. Epub 2009 Sep 2.


AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity.

Wang M, Yang Z, Rada C, Neuberger MS.

Nat Struct Mol Biol. 2009 Jul;16(7):769-76. doi: 10.1038/nsmb.1623. Epub 2009 Jun 21.


The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence.

Geisberger R, Rada C, Neuberger MS.

Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6736-41. doi: 10.1073/pnas.0810808106. Epub 2009 Apr 7.



Gearhart PJ, Lindahl T, Neuberger MS.

Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):561-2. doi: 10.1098/rstb.2008.0236. No abstract available.


Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo.

Takeda E, Tsuji-Kawahara S, Sakamoto M, Langlois MA, Neuberger MS, Rada C, Miyazawa M.

J Virol. 2008 Nov;82(22):10998-1008. doi: 10.1128/JVI.01311-08. Epub 2008 Sep 10.


Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1.

Conticello SG, Ganesh K, Xue K, Lu M, Rada C, Neuberger MS.

Mol Cell. 2008 Aug 22;31(4):474-84. doi: 10.1016/j.molcel.2008.07.009.


Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants.

Larsen E, Kleppa L, Meza TJ, Meza-Zepeda LA, Rada C, Castellanos CG, Lien GF, Nesse GJ, Neuberger MS, Laerdahl JK, William Doughty R, Klungland A.

Cancer Res. 2008 Jun 15;68(12):4571-9. doi: 10.1158/0008-5472.CAN-08-0168.


Human APOBEC3G can restrict retroviral infection in avian cells and acts independently of both UNG and SMUG1.

Langlois MA, Neuberger MS.

J Virol. 2008 May;82(9):4660-4. doi: 10.1128/JVI.02469-07. Epub 2008 Feb 13.


Antibody diversification by somatic mutation: from Burnet onwards.

Neuberger MS.

Immunol Cell Biol. 2008 Feb;86(2):124-32. doi: 10.1038/sj.icb.7100160. Epub 2008 Jan 8. Review.


Dependence of antibody gene diversification on uracil excision.

Di Noia JM, Williams GT, Chan DT, Buerstedde JM, Baldwin GS, Neuberger MS.

J Exp Med. 2007 Dec 24;204(13):3209-19. Epub 2007 Dec 10.


DNA deamination in immunity: AID in the context of its APOBEC relatives.

Conticello SG, Langlois MA, Yang Z, Neuberger MS.

Adv Immunol. 2007;94:37-73. Review.


Molecular mechanisms of antibody somatic hypermutation.

Di Noia JM, Neuberger MS.

Annu Rev Biochem. 2007;76:1-22. Review.


Insights into DNA deaminases.

Conticello SG, Langlois MA, Neuberger MS.

Nat Struct Mol Biol. 2007 Jan;14(1):7-9. No abstract available.


Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase eta for A/T.

Neuberger MS, Rada C.

J Exp Med. 2007 Jan 22;204(1):7-10. Epub 2006 Dec 26. Review.


SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair.

Di Noia JM, Rada C, Neuberger MS.

EMBO J. 2006 Feb 8;25(3):585-95. Epub 2006 Jan 12.


MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells.

MacDuff DA, Neuberger MS, Harris RS.

Mol Immunol. 2006 Mar;43(8):1099-108. Epub 2005 Aug 24.


Mice deficient in APOBEC2 and APOBEC3.

Mikl MC, Watt IN, Lu M, Reik W, Davies SL, Neuberger MS, Rada C.

Mol Cell Biol. 2005 Aug;25(16):7270-7.


Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation.

Neuberger MS, Di Noia JM, Beale RC, Williams GT, Yang Z, Rada C.

Nat Rev Immunol. 2005 Feb;5(2):171-8. doi: 10.1038/nri1553. Review.


Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases.

Conticello SG, Thomas CJ, Petersen-Mahrt SK, Neuberger MS.

Mol Biol Evol. 2005 Feb;22(2):367-77. Epub 2004 Oct 20.


Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo.

Beale RC, Petersen-Mahrt SK, Watt IN, Harris RS, Rada C, Neuberger MS.

J Mol Biol. 2004 Mar 26;337(3):585-96.


The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G.

Conticello SG, Harris RS, Neuberger MS.

Curr Biol. 2003 Nov 11;13(22):2009-13.


By-products of immunoglobulin somatic hypermutation.

Bemark M, Neuberger MS.

Genes Chromosomes Cancer. 2003 Sep;38(1):32-9.


DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses.

Harris RS, Sheehy AM, Craig HM, Malim MH, Neuberger MS.

Nat Immunol. 2003 Jul;4(7):641-3. No abstract available.


Immunity through DNA deamination.

Neuberger MS, Harris RS, Di Noia J, Petersen-Mahrt SK.

Trends Biochem Sci. 2003 Jun;28(6):305-12. Review.


DNA deamination mediates innate immunity to retroviral infection.

Harris RS, Bishop KN, Sheehy AM, Craig HM, Petersen-Mahrt SK, Watt IN, Neuberger MS, Malim MH.

Cell. 2003 Jun 13;113(6):803-9. Erratum in: Cell. 2004 Feb 20;116(4):629.


In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1).

Petersen-Mahrt SK, Neuberger MS.

J Biol Chem. 2003 May 30;278(22):19583-6. Epub 2003 Apr 14.


RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators.

Harris RS, Petersen-Mahrt SK, Neuberger MS.

Mol Cell. 2002 Nov;10(5):1247-53.


Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice.

Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, Neuberger MS.

Curr Biol. 2002 Oct 15;12(20):1748-55.


Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines.

Cumbers SJ, Williams GT, Davies SL, Grenfell RL, Takeda S, Batista FD, Sale JE, Neuberger MS.

Nat Biotechnol. 2002 Nov;20(11):1129-34. Epub 2002 Oct 15.


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