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Items: 26


Dual function of UPF3B in early and late translation termination.

Neu-Yilik G, Raimondeau E, Eliseev B, Yeramala L, Amthor B, Deniaud A, Huard K, Kerschgens K, Hentze MW, Schaffitzel C, Kulozik AE.

EMBO J. 2017 Oct 16;36(20):2968-2986. doi: 10.15252/embj.201797079. Epub 2017 Sep 12.


The differential expression of alternatively polyadenylated transcripts is a common stress-induced response mechanism that modulates mammalian mRNA expression in a quantitative and qualitative fashion.

Hollerer I, Curk T, Haase B, Benes V, Hauer C, Neu-Yilik G, Bhuvanagiri M, Hentze MW, Kulozik AE.

RNA. 2016 Sep;22(9):1441-53. doi: 10.1261/rna.055657.115. Epub 2016 Jul 12.


Proteomic Analysis Reveals Branch-specific Regulation of the Unfolded Protein Response by Nonsense-mediated mRNA Decay.

Sieber J, Hauer C, Bhuvanagiri M, Leicht S, Krijgsveld J, Neu-Yilik G, Hentze MW, Kulozik AE.

Mol Cell Proteomics. 2016 May;15(5):1584-97. doi: 10.1074/mcp.M115.054056. Epub 2016 Feb 20.


A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation.

Deniaud A, Karuppasamy M, Bock T, Masiulis S, Huard K, Garzoni F, Kerschgens K, Hentze MW, Kulozik AE, Beck M, Neu-Yilik G, Schaffitzel C.

Nucleic Acids Res. 2015 Sep 3;43(15):7600-11. doi: 10.1093/nar/gkv668. Epub 2015 Jun 30.


Mechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exon.

Neu-Yilik G, Amthor B, Gehring NH, Bahri S, Paidassi H, Hentze MW, Kulozik AE.

RNA. 2011 May;17(5):843-54. doi: 10.1261/rna.2401811. Epub 2011 Mar 9.


NMD: multitasking between mRNA surveillance and modulation of gene expression.

Neu-Yilik G, Kulozik AE.

Adv Genet. 2008;62:185-243. doi: 10.1016/S0065-2660(08)00604-4. Review.


The efficiency of nonsense-mediated mRNA decay is an inherent character and varies among different cells.

Linde L, Boelz S, Neu-Yilik G, Kulozik AE, Kerem B.

Eur J Hum Genet. 2007 Nov;15(11):1156-62. Epub 2007 Jul 11.


Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals.

Danckwardt S, Kaufmann I, Gentzel M, Foerstner KU, Gantzert AS, Gehring NH, Neu-Yilik G, Bork P, Keller W, Wilm M, Hentze MW, Kulozik AE.

EMBO J. 2007 Jun 6;26(11):2658-69. Epub 2007 Apr 26.


Nonsense-mediated mRNA decay affects nonsense transcript levels and governs response of cystic fibrosis patients to gentamicin.

Linde L, Boelz S, Nissim-Rafinia M, Oren YS, Wilschanski M, Yaacov Y, Virgilis D, Neu-Yilik G, Kulozik AE, Kerem E, Kerem B.

J Clin Invest. 2007 Mar;117(3):683-92. Epub 2007 Feb 8.


A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay.

Boelz S, Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE.

Biochem Biophys Res Commun. 2006 Oct 13;349(1):186-91. Epub 2006 Aug 11.


Internal ribosome entry sequence-mediated translation initiation triggers nonsense-mediated decay.

Holbrook JA, Neu-Yilik G, Gehring NH, Kulozik AE, Hentze MW.

EMBO Rep. 2006 Jul;7(7):722-6. Epub 2006 Jun 16.


The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD).

Stockklausner C, Breit S, Neu-Yilik G, Echner N, Hentze MW, Kulozik AE, Gehring NH.

Nucleic Acids Res. 2006 May 5;34(8):2355-63. Print 2006.


Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation.

Kunz JB, Neu-Yilik G, Hentze MW, Kulozik AE, Gehring NH.

RNA. 2006 Jun;12(6):1015-22. Epub 2006 Apr 6.


Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements.

Gehring NH, Kunz JB, Neu-Yilik G, Breit S, Viegas MH, Hentze MW, Kulozik AE.

Mol Cell. 2005 Oct 7;20(1):65-75.


mRNA Metabolism and hereditary disorders: a tale of surveillance and escape.

Neu-Yilik G, Kulozik AE.

Klin Padiatr. 2004 Nov-Dec;216(6):304-14. Review.


Nonsense-mediated decay approaches the clinic.

Holbrook JA, Neu-Yilik G, Hentze MW, Kulozik AE.

Nat Genet. 2004 Aug;36(8):801-8. Review.


The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations.

Danckwardt S, Gehring NH, Neu-Yilik G, Hundsdoerfer P, Pforsich M, Frede U, Hentze MW, Kulozik AE.

Blood. 2004 Jul 15;104(2):428-35. Epub 2004 Apr 1.


Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife.

Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE.

Genome Biol. 2004;5(4):218. Epub 2004 Mar 30. Review.


Y14 and hUpf3b form an NMD-activating complex.

Gehring NH, Neu-Yilik G, Schell T, Hentze MW, Kulozik AE.

Mol Cell. 2003 Apr;11(4):939-49.


Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay.

Danckwardt S, Neu-Yilik G, Thermann R, Frede U, Hentze MW, Kulozik AE.

Blood. 2002 Mar 1;99(5):1811-6.


The human intronless melanocortin 4-receptor gene is NMD insensitive.

Brocke KS, Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE.

Hum Mol Genet. 2002 Feb 1;11(3):331-5.


Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia.

Gehring NH, Frede U, Neu-Yilik G, Hundsdoerfer P, Vetter B, Hentze MW, Kulozik AE.

Nat Genet. 2001 Aug;28(4):389-92.


Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs.

Neu-Yilik G, Gehring NH, Thermann R, Frede U, Hentze MW, Kulozik AE.

EMBO J. 2001 Feb 1;20(3):532-40.


Dominant beta-thalassaemia: a highly unstable haemoglobin is caused by a novel 6 bp deletion of the beta-globin gene.

Vetter B, Neu-Yilik G, Kohne E, Arnold R, Sinha P, Gaedicke G, Ivancevic V, Kulozik AE.

Br J Haematol. 2000 Jan;108(1):176-81.


Binary specification of nonsense codons by splicing and cytoplasmic translation.

Thermann R, Neu-Yilik G, Deters A, Frede U, Wehr K, Hagemeier C, Hentze MW, Kulozik AE.

EMBO J. 1998 Jun 15;17(12):3484-94.


Vigilin is a cytoplasmic protein. A study on its expression in primary cells and in established cell lines of different species.

Neu-Yilik G, Zorbas H, Gloe TR, Raabe HM, Hopp-Christensen TA, Müller PK.

Eur J Biochem. 1993 Apr 15;213(2):727-36.

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