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Items: 19


Development of Gleevec Analogues for Reducing Production of β-Amyloid Peptides through Shifting β-Cleavage of Amyloid Precursor Proteins.

Sun W, Netzer WJ, Sinha A, Gindinova K, Chang E, Sinha SC.

J Med Chem. 2019 Mar 28;62(6):3122-3134. doi: 10.1021/acs.jmedchem.8b02007. Epub 2019 Mar 15.


Nose-to-brain transport of imatinib mesylate: A pharmacokinetic evaluation.

Hada N, Netzer WJ, Belhassan F, Wennogle LP, Gizurarson S.

Eur J Pharm Sci. 2017 May 1;102:46-54. doi: 10.1016/j.ejps.2017.02.032. Epub 2017 Feb 24.


Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage.

Netzer WJ, Bettayeb K, Sinha SC, Flajolet M, Greengard P, Bustos V.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1389-1394. doi: 10.1073/pnas.1620963114. Epub 2017 Jan 23.


δ-COP modulates Aβ peptide formation via retrograde trafficking of APP.

Bettayeb K, Chang JC, Luo W, Aryal S, Varotsis D, Randolph L, Netzer WJ, Greengard P, Flajolet M.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5412-7. doi: 10.1073/pnas.1604156113. Epub 2016 Apr 25.


Dynamin 1 regulates amyloid generation through modulation of BACE-1.

Zhu L, Su M, Lucast L, Liu L, Netzer WJ, Gandy SE, Cai D.

PLoS One. 2012;7(9):e45033. Epub 2012 Sep 14.


Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.

He G, Luo W, Li P, Remmers C, Netzer WJ, Hendrick J, Bettayeb K, Flajolet M, Gorelick F, Wennogle LP, Greengard P.

Nature. 2010 Sep 2;467(7311):95-8. doi: 10.1038/nature09325.


Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model.

Netzer WJ, Powell C, Nong Y, Blundell J, Wong L, Duff K, Flajolet M, Greengard P.

PLoS One. 2010 Jun 3;5(6):e10943. doi: 10.1371/journal.pone.0010943.


A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation.

Zhang YW, Liu S, Zhang X, Li WB, Chen Y, Huang X, Sun L, Luo W, Netzer WJ, Threadgill R, Wiegand G, Wang R, Cohen SN, Greengard P, Liao FF, Li L, Xu H.

Neuron. 2009 Nov 12;64(3):328-40. doi: 10.1016/j.neuron.2009.08.036.


Beta-amyloid modulation of synaptic transmission and plasticity.

Venkitaramani DV, Chin J, Netzer WJ, Gouras GK, Lesne S, Malinow R, Lombroso PJ.

J Neurosci. 2007 Oct 31;27(44):11832-7. Review. No abstract available.


Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.

Cai D, Netzer WJ, Zhong M, Lin Y, Du G, Frohman M, Foster DA, Sisodia SS, Xu H, Gorelick FS, Greengard P.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1941-6. Epub 2006 Jan 31.


Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.

Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, Greengard P.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1936-40. Epub 2006 Jan 31.


Gleevec inhibits beta-amyloid production but not Notch cleavage.

Netzer WJ, Dou F, Cai D, Veach D, Jean S, Li Y, Bornmann WG, Clarkson B, Xu H, Greengard P.

Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12444-9. Epub 2003 Oct 1.


Chaperones increase association of tau protein with microtubules.

Dou F, Netzer WJ, Tanemura K, Li F, Hartl FU, Takashima A, Gouras GK, Greengard P, Xu H.

Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):721-6. Epub 2003 Jan 9.


Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761.

Luo Y, Smith JV, Paramasivam V, Burdick A, Curry KJ, Buford JP, Khan I, Netzer WJ, Xu H, Butko P.

Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12197-202. Epub 2002 Sep 4.


Does insulin dysfunction play a role in Alzheimer's disease?

Gasparini L, Netzer WJ, Greengard P, Xu H.

Trends Pharmacol Sci. 2002 Jun;23(6):288-93. Review.


Protein folding in the cytosol: chaperonin-dependent and -independent mechanisms.

Netzer WJ, Hartl FU.

Trends Biochem Sci. 1998 Feb;23(2):68-73. Review.


Recombination of protein domains facilitated by co-translational folding in eukaryotes.

Netzer WJ, Hartl FU.

Nature. 1997 Jul 24;388(6640):343-9.


Emerging tools for discovering drugs.

Netzer WJ.

Biotechnology (N Y). 1990 Jul;8(7):618-22. No abstract available.


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