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Induction of innate immune memory: the role of cellular metabolism.

Domínguez-Andrés J, Joosten LA, Netea MG.

Curr Opin Immunol. 2018 Sep 18;56:10-16. doi: 10.1016/j.coi.2018.09.001. [Epub ahead of print] Review.


Getting to the marrow of trained immunity.

Groh L, Netea MG, Riksen NP, Keating ST.

Epigenomics. 2018 Sep;10(9):1151-1154. doi: 10.2217/epi-2018-0098. No abstract available.


Genetic variant in IL-32 is associated with the ex vivo cytokine production of anti-TNF treated PBMCs from rheumatoid arthritis patients.

Damen MSMA, Schraa K, Tweehuysen L, den Broeder AA, Netea MG, Popa CD, Joosten LAB.

Sci Rep. 2018 Sep 19;8(1):14050. doi: 10.1038/s41598-018-32485-0.


Be aware, innate immune cells remember.

Riksen NP, Netea MG.

Aging (Albany NY). 2018 Sep 12. doi: 10.18632/aging.101552. [Epub ahead of print] No abstract available.


The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis.

Truax AD, Chen L, Tam JW, Cheng N, Guo H, Koblansky AA, Chou WC, Wilson JE, Brickey WJ, Petrucelli A, Liu R, Cooper DE, Koenigsknecht MJ, Young VB, Netea MG, Stienstra R, Sartor RB, Montgomery SA, Coleman RA, Ting JP.

Cell Host Microbe. 2018 Sep 12;24(3):364-378.e6. doi: 10.1016/j.chom.2018.08.009.


T Cell Metabolism Has Evolved to Tolerate Tuberculosis.

Koeken VACM, van Crevel R, Netea MG.

Cell Metab. 2018 Sep 4;28(3):332-333. doi: 10.1016/j.cmet.2018.08.015.


The impact of sex hormones on BCG-induced trained immunity.

de Bree CLCJ, Janssen R, Aaby P, van Crevel R, Joosten LAB, Benn CS, Netea MG.

J Leukoc Biol. 2018 Sep;104(3):573-578. doi: 10.1002/JLB.5MA0118-027R.


Role of gut microbiota in chronic low-grade inflammation as potential driver for atherosclerotic cardiovascular disease: a systematic review of human studies.

van den Munckhof ICL, Kurilshikov A, Ter Horst R, Riksen NP, Joosten LAB, Zhernakova A, Fu J, Keating ST, Netea MG, de Graaf J, Rutten JHW.

Obes Rev. 2018 Aug 24. doi: 10.1111/obr.12750. [Epub ahead of print] Review.


HDAC inhibitors modulate innate immune responses to micro-organisms relevant to chronic mucocutaneous candidiasis.

Rösler B, Wang X, Keating ST, Joosten LAB, Netea MG, van de Veerdonk FL.

Clin Exp Immunol. 2018 Aug 1. doi: 10.1111/cei.13192. [Epub ahead of print]


Host Genetic Signatures of Susceptibility to Fungal Disease.

Campos CF, van de Veerdonk FL, Gonçalves SM, Cunha C, Netea MG, Carvalho A.

Curr Top Microbiol Immunol. 2018 Jul 25. doi: 10.1007/82_2018_113. [Epub ahead of print]


Non-specific effects of vaccines: Current evidence and potential implications.

de Bree LCJ, Koeken VACM, Joosten LAB, Aaby P, Benn CS, van Crevel R, Netea MG.

Semin Immunol. 2018 Jul 11. pii: S1044-5323(18)30011-3. doi: 10.1016/j.smim.2018.06.002. [Epub ahead of print] Review.


Long-term reprogramming of the innate immune system.

Dominguez-Andres J, Netea MG.

J Leukoc Biol. 2018 Jul 12. doi: 10.1002/JLB.MR0318-104R. [Epub ahead of print] Review.


Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation.

Kiers D, Wielockx B, Peters E, van Eijk LT, Gerretsen J, John A, Janssen E, Groeneveld R, Peters M, Damen L, Meneses AM, Krüger A, Langereis JD, Zomer AL, Blackburn MR, Joosten LA, Netea MG, Riksen NP, van der Hoeven JG, Scheffer GJ, Eltzschig HK, Pickkers P, Kox M.

EBioMedicine. 2018 Jul;33:144-156. doi: 10.1016/j.ebiom.2018.06.021. Epub 2018 Jul 4.


The causes and consequences of variation in human cytokine production in health.

Schirmer M, Kumar V, Netea MG, Xavier RJ.

Curr Opin Immunol. 2018 Jun 15;54:50-58. doi: 10.1016/j.coi.2018.05.012. [Epub ahead of print] Review.


Interferon-γ and CXCL10 responses related to complaints in patients with Q fever fatigue syndrome.

Raijmakers RPH, Jansen AFM, Keijmel SP, Schoffelen T, Scholzen A, van der Meer JWM, Joosten LAB, Netea MG, van Deuren M, Bleeker-Rovers CP.

Eur J Clin Microbiol Infect Dis. 2018 Jul;37(7):1385-1391. doi: 10.1007/s10096-018-3265-z. Epub 2018 May 26.


Antifungal immune responses: emerging host-pathogen interactions and translational implications.

Kumar V, van de Veerdonk FL, Netea MG.

Genome Med. 2018 May 25;10(1):39. doi: 10.1186/s13073-018-0553-2.


Environmental Signals Influencing Myeloid Cell Metabolism and Function in Diabetes.

Ratter JM, Tack CJ, Netea MG, Stienstra R.

Trends Endocrinol Metab. 2018 Jul;29(7):468-480. doi: 10.1016/j.tem.2018.04.008. Epub 2018 May 19. Review.


Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses.

Bakker OB, Aguirre-Gamboa R, Sanna S, Oosting M, Smeekens SP, Jaeger M, Zorro M, Võsa U, Withoff S, Netea-Maier RT, Koenen HJPM, Joosten I, Xavier RJ, Franke L, Joosten LAB, Kumar V, Wijmenga C, Netea MG, Li Y.

Nat Immunol. 2018 Jul;19(7):776-786. doi: 10.1038/s41590-018-0121-3. Epub 2018 May 21.


Bacillus Calmette-Guérin-Induced Trained Immunity Is Not Protective for Experimental Influenza A/Anhui/1/2013 (H7N9) Infection in Mice.

de Bree CLCJ, Marijnissen RJ, Kel JM, Rosendahl Huber SK, Aaby P, Benn CS, Wijnands MVW, Diavatopoulos DA, van Crevel R, Joosten LAB, Netea MG, Dulos J.

Front Immunol. 2018 Apr 30;9:869. doi: 10.3389/fimmu.2018.00869. eCollection 2018.


A novel mutation in the TG gene (G2322S) causing congenital hypothyroidism in a Sudanese family: a case report.

Watanabe Y, Sharwood E, Goodwin B, Creech MK, Hassan HY, Netea MG, Jaeger M, Dumitrescu A, Refetoff S, Huynh T, Weiss RE.

BMC Med Genet. 2018 May 2;19(1):69. doi: 10.1186/s12881-018-0588-7.


Remembering Pathogen Dose: Long-Term Adaptation in Innate Immunity.

Bauer M, Weis S, Netea MG, Wetzker R.

Trends Immunol. 2018 Jun;39(6):438-445. doi: 10.1016/ Epub 2018 Apr 30. Review.


Trained immunity as a novel therapeutic strategy.

Mourits VP, Wijkmans JC, Joosten LA, Netea MG.

Curr Opin Pharmacol. 2018 Aug;41:52-58. doi: 10.1016/j.coph.2018.04.007. Epub 2018 Apr 24. Review.


A role for TLR10 in obesity and adipose tissue morphology.

Boutens L, Mirea AM, van den Munckhof I, Doppenberg-Oosting M, Jaeger M, Hijmans A, Netea MG, Joosten LAB, Stienstra R.

Cytokine. 2018 Aug;108:205-212. doi: 10.1016/j.cyto.2018.03.021. Epub 2018 Apr 23.


Physiological and Genetic Adaptations to Diving in Sea Nomads.

Ilardo MA, Moltke I, Korneliussen TS, Cheng J, Stern AJ, Racimo F, de Barros Damgaard P, Sikora M, Seguin-Orlando A, Rasmussen S, van den Munckhof ICL, Ter Horst R, Joosten LAB, Netea MG, Salingkat S, Nielsen R, Willerslev E.

Cell. 2018 Apr 19;173(3):569-580.e15. doi: 10.1016/j.cell.2018.03.054.


The mineralocorticoid receptor as a modulator of innate immunity and atherosclerosis.

van der Heijden CDCC, Deinum J, Joosten LAB, Netea MG, Riksen NP.

Cardiovasc Res. 2018 Jun 1;114(7):944-953. doi: 10.1093/cvr/cvy092.


Innate immune memory: An evolutionary perspective.

Gourbal B, Pinaud S, Beckers GJM, Van Der Meer JWM, Conrath U, Netea MG.

Immunol Rev. 2018 May;283(1):21-40. doi: 10.1111/imr.12647. Review.


Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity.

Alsina-Beauchamp D, Escós A, Fajardo P, González-Romero D, Díaz-Mora E, Risco A, Martín-Serrano MA, Del Fresno C, Dominguez-Andrés J, Aparicio N, Zur R, Shpiro N, Brown GD, Ardavín C, Netea MG, Alemany S, Sanz-Ezquerro JJ, Cuenda A.

EMBO Mol Med. 2018 May;10(5). pii: e8485. doi: 10.15252/emmm.201708485.


Female-Specific Association Between Variants on Chromosome 9 and Self-Reported Diagnosis of Irritable Bowel Syndrome.

Bonfiglio F, Zheng T, Garcia-Etxebarria K, Hadizadeh F, Bujanda L, Bresso F, Agreus L, Andreasson A, Dlugosz A, Lindberg G, Schmidt PT, Karling P, Ohlsson B, Simren M, Walter S, Nardone G, Cuomo R, Usai-Satta P, Galeazzi F, Neri M, Portincasa P, Bellini M, Barbara G, Latiano A, Hübenthal M, Thijs V, Netea MG, Jonkers D, Chang L, Mayer EA, Wouters MM, Boeckxstaens G, Camilleri M, Franke A, Zhernakova A, D'Amato M.

Gastroenterology. 2018 Jul;155(1):168-179. doi: 10.1053/j.gastro.2018.03.064. Epub 2018 Apr 5.


Tissue Metabolic Changes Drive Cytokine Responses to Mycobacterium tuberculosis.

Lachmandas E, Rios-Miguel AB, Koeken VACM, van der Pasch E, Kumar V, Matzaraki V, Li Y, Oosting M, Joosten LAB, Notebaart RA, Noursadeghi M, Netea MG, van Crevel R, Pollara G.

J Infect Dis. 2018 Jun 5;218(1):165-170. doi: 10.1093/infdis/jiy173.


High-Mobility Group Nucleosome-Binding Protein 1 as Endogenous Ligand Induces Innate Immune Tolerance in a TLR4-Sirtuin-1 Dependent Manner in Human Blood Peripheral Mononuclear Cells.

Arts RJW, Huang PK, Yang, Joosten LAB, van der Meer JWM, Oppenheim JJ, Netea MG, Cheng SC.

Front Immunol. 2018 Mar 14;9:526. doi: 10.3389/fimmu.2018.00526. eCollection 2018.


Effect of Vegan Fecal Microbiota Transplantation on Carnitine- and Choline-Derived Trimethylamine-N-Oxide Production and Vascular Inflammation in Patients With Metabolic Syndrome.

Smits LP, Kootte RS, Levin E, Prodan A, Fuentes S, Zoetendal EG, Wang Z, Levison BS, Cleophas MCP, Kemper EM, Dallinga-Thie GM, Groen AK, Joosten LAB, Netea MG, Stroes ESG, de Vos WM, Hazen SL, Nieuwdorp M.

J Am Heart Assoc. 2018 Mar 26;7(7). pii: e008342. doi: 10.1161/JAHA.117.008342.


Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases.

Rello J, van Engelen TSR, Alp E, Calandra T, Cattoir V, Kern WV, Netea MG, Nseir S, Opal SM, van de Veerdonk FL, Wilcox MH, Wiersinga WJ.

Clin Microbiol Infect. 2018 Mar 24. pii: S1198-743X(18)30221-0. doi: 10.1016/j.cmi.2018.03.011. [Epub ahead of print]


Identification of Discriminating Metabolic Pathways and Metabolites in Human PBMCs Stimulated by Various Pathogenic Agents.

Zhang X, Mardinoglu A, Joosten LAB, Kuivenhoven JA, Li Y, Netea MG, Groen AK.

Front Physiol. 2018 Feb 27;9:139. doi: 10.3389/fphys.2018.00139. eCollection 2018.


Interleukin-32 upregulates the expression of ABCA1 and ABCG1 resulting in reduced intracellular lipid concentrations in primary human hepatocytes.

Damen MSMA, Dos Santos JC, Hermsen R, Adam van der Vliet J, Netea MG, Riksen NP, Dinarello CA, Joosten LAB, Heinhuis B.

Atherosclerosis. 2018 Apr;271:193-202. doi: 10.1016/j.atherosclerosis.2018.02.027. Epub 2018 Mar 2.


The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory Disorders.

Arts RJW, Joosten LAB, Netea MG.

Front Immunol. 2018 Feb 20;9:298. doi: 10.3389/fimmu.2018.00298. eCollection 2018. Review.


DNA methylation in childhood asthma: an epigenome-wide meta-analysis.

Xu CJ, Söderhäll C, Bustamante M, Baïz N, Gruzieva O, Gehring U, Mason D, Chatzi L, Basterrechea M, Llop S, Torrent M, Forastiere F, Fantini MP, Carlsen KCL, Haahtela T, Morin A, Kerkhof M, Merid SK, van Rijkom B, Jankipersadsing SA, Bonder MJ, Ballereau S, Vermeulen CJ, Aguirre-Gamboa R, de Jongste JC, Smit HA, Kumar A, Pershagen G, Guerra S, Garcia-Aymerich J, Greco D, Reinius L, McEachan RRC, Azad R, Hovland V, Mowinckel P, Alenius H, Fyhrquist N, Lemonnier N, Pellet J, Auffray C; BIOS Consortium, van der Vlies P, van Diemen CC, Li Y, Wijmenga C, Netea MG, Moffatt MF, Cookson WOCM, Anto JM, Bousquet J, Laatikainen T, Laprise C, Carlsen KH, Gori D, Porta D, Iñiguez C, Bilbao JR, Kogevinas M, Wright J, Brunekreef B, Kere J, Nawijn MC, Annesi-Maesano I, Sunyer J, Melén E, Koppelman GH.

Lancet Respir Med. 2018 May;6(5):379-388. doi: 10.1016/S2213-2600(18)30052-3. Epub 2018 Feb 26.


Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus.

Stappers MHT, Clark AE, Aimanianda V, Bidula S, Reid DM, Asamaphan P, Hardison SE, Dambuza IM, Valsecchi I, Kerscher B, Plato A, Wallace CA, Yuecel R, Hebecker B, da Glória Teixeira Sousa M, Cunha C, Liu Y, Feizi T, Brakhage AA, Kwon-Chung KJ, Gow NAR, Zanda M, Piras M, Zanato C, Jaeger M, Netea MG, van de Veerdonk FL, Lacerda JF, Campos A, Carvalho A, Willment JA, Latgé JP, Brown GD.

Nature. 2018 Mar 15;555(7696):382-386. doi: 10.1038/nature25974. Epub 2018 Feb 28.


Is non-response to fluconazole maintenance therapy for recurrent Candida vaginitis related to sensitization to atopic reactions?

Donders GGG, Grinceviciene S, Bellen G, Jaeger M, Ten Oever J, Netea MG.

Am J Reprod Immunol. 2018 Apr;79(4):e12811. doi: 10.1111/aji.12811. Epub 2018 Feb 22.


Mycobacterial growth inhibition is associated with trained innate immunity.

Joosten SA, van Meijgaarden KE, Arend SM, Prins C, Oftung F, Korsvold GE, Kik SV, Arts RJ, van Crevel R, Netea MG, Ottenhoff TH.

J Clin Invest. 2018 May 1;128(5):1837-1851. doi: 10.1172/JCI97508. Epub 2018 Apr 3.


Role of glutathione metabolism in host defense against Borrelia burgdorferi infection.

Kerstholt M, Vrijmoeth H, Lachmandas E, Oosting M, Lupse M, Flonta M, Dinarello CA, Netea MG, Joosten LAB.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2320-E2328. doi: 10.1073/pnas.1720833115. Epub 2018 Feb 14.


Neonatal BCG Vaccination Influences Cytokine Responses to Toll-like Receptor Ligands and Heterologous Antigens.

Freyne B, Donath S, Germano S, Gardiner K, Casalaz D, Robins-Browne RM, Amenyogbe N, Messina NL, Netea MG, Flanagan KL, Kollmann T, Curtis N.

J Infect Dis. 2018 May 5;217(11):1798-1808. doi: 10.1093/infdis/jiy069.


Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study.

van Laarhoven A, Dian S, Aguirre-Gamboa R, Avila-Pacheco J, Ricaño-Ponce I, Ruesen C, Annisa J, Koeken VACM, Chaidir L, Li Y, Achmad TH, Joosten LAB, Notebaart RA, Ruslami R, Netea MG, Verbeek MM, Alisjahbana B, Kumar V, Clish CB, Ganiem AR, van Crevel R.

Lancet Infect Dis. 2018 May;18(5):526-535. doi: 10.1016/S1473-3099(18)30053-7. Epub 2018 Feb 3.


Patient Susceptibility to Candidiasis-A Potential for Adjunctive Immunotherapy.

Davidson L, Netea MG, Kullberg BJ.

J Fungi (Basel). 2018 Jan 9;4(1). pii: E9. doi: 10.3390/jof4010009. Review.


Trained Innate Immunity as a Novel Mechanism Linking Infection and the Development of Atherosclerosis.

Leentjens J, Bekkering S, Joosten LAB, Netea MG, Burgner DP, Riksen NP.

Circ Res. 2018 Mar 2;122(5):664-669. doi: 10.1161/CIRCRESAHA.117.312465. Epub 2018 Jan 24. Review.


Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses.

Boutens L, Hooiveld GJ, Dhingra S, Cramer RA, Netea MG, Stienstra R.

Diabetologia. 2018 Apr;61(4):942-953. doi: 10.1007/s00125-017-4526-6. Epub 2018 Jan 14.


Cutting Edge: Plasmodium falciparum Induces Trained Innate Immunity.

Schrum JE, Crabtree JN, Dobbs KR, Kiritsy MC, Reed GW, Gazzinelli RT, Netea MG, Kazura JW, Dent AE, Fitzgerald KA, Golenbock DT.

J Immunol. 2018 Feb 15;200(4):1243-1248. doi: 10.4049/jimmunol.1701010. Epub 2018 Jan 12.


Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.

Christ A, Günther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, Scholz CJ, Oosting M, Haendler K, Baßler K, Klee K, Schulte-Schrepping J, Ulas T, Moorlag SJCFM, Kumar V, Park MH, Joosten LAB, Groh LA, Riksen NP, Espevik T, Schlitzer A, Li Y, Fitzgerald ML, Netea MG, Schultze JL, Latz E.

Cell. 2018 Jan 11;172(1-2):162-175.e14. doi: 10.1016/j.cell.2017.12.013.


Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.

Mitroulis I, Ruppova K, Wang B, Chen LS, Grzybek M, Grinenko T, Eugster A, Troullinaki M, Palladini A, Kourtzelis I, Chatzigeorgiou A, Schlitzer A, Beyer M, Joosten LAB, Isermann B, Lesche M, Petzold A, Simons K, Henry I, Dahl A, Schultze JL, Wielockx B, Zamboni N, Mirtschink P, Coskun Ü, Hajishengallis G, Netea MG, Chavakis T.

Cell. 2018 Jan 11;172(1-2):147-161.e12. doi: 10.1016/j.cell.2017.11.034.


Metabolic Induction of Trained Immunity through the Mevalonate Pathway.

Bekkering S, Arts RJW, Novakovic B, Kourtzelis I, van der Heijden CDCC, Li Y, Popa CD, Ter Horst R, van Tuijl J, Netea-Maier RT, van de Veerdonk FL, Chavakis T, Joosten LAB, van der Meer JWM, Stunnenberg H, Riksen NP, Netea MG.

Cell. 2018 Jan 11;172(1-2):135-146.e9. doi: 10.1016/j.cell.2017.11.025.


BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity.

Arts RJW, Moorlag SJCFM, Novakovic B, Li Y, Wang SY, Oosting M, Kumar V, Xavier RJ, Wijmenga C, Joosten LAB, Reusken CBEM, Benn CS, Aaby P, Koopmans MP, Stunnenberg HG, van Crevel R, Netea MG.

Cell Host Microbe. 2018 Jan 10;23(1):89-100.e5. doi: 10.1016/j.chom.2017.12.010.


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