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Shared Transcriptional Signatures in Major Depressive Disorder and Mouse Chronic Stress Models.

Scarpa JR, Fatma M, Loh YE, Traore SR, Stefan T, Chen TH, Nestler EJ, Labonté B.

Biol Psychiatry. 2020 Jan 22. pii: S0006-3223(20)30011-1. doi: 10.1016/j.biopsych.2019.12.029. [Epub ahead of print]


Cooperative synaptic and intrinsic plasticity in a disynaptic limbic circuit drive stress-induced anhedonia and passive coping in mice.

Pignatelli M, Tejeda HA, Barker DJ, Bontempi L, Wu J, Lopez A, Palma Ribeiro S, Lucantonio F, Parise EM, Torres-Berrio A, Alvarez-Bagnarol Y, Marino RAM, Cai ZL, Xue M, Morales M, Tamminga CA, Nestler EJ, Bonci A.

Mol Psychiatry. 2020 Mar 11. doi: 10.1038/s41380-020-0686-8. [Epub ahead of print]


Ronald S. Duman, Ph.D. (1954-2020).

Krystal JH, Nestler EJ, Picciotto MR.

Neuropsychopharmacology. 2020 Feb 19. doi: 10.1038/s41386-020-0642-y. [Epub ahead of print] No abstract available.


Unraveling the epigenetic landscape of depression: focus on early life stress

Torres-Berrío A, Issler O, Parise EM, Nestler EJ.

Dialogues Clin Neurosci. 2019 Dec;21(4):341-357. doi: 10.31887/DCNS.2019.21.4/enestler.


Cognition and Related Neural Findings on Methamphetamine Use Disorder: Insights and Treatment Implications From Schizophrenia Research.

Guerin AA, Bonomo Y, Lawrence AJ, Baune BT, Nestler EJ, Rossell SL, Kim JH.

Front Psychiatry. 2019 Dec 17;10:880. doi: 10.3389/fpsyt.2019.00880. eCollection 2019. Review.


Regulation of impulsive and aggressive behaviours by a novel lncRNA.

Labonté B, Abdallah K, Maussion G, Yerko V, Yang J, Bittar T, Quessy F, Golden SA, Navarro L, Checknita D, Gigek C, Lopez JP, Neve RL, Russo SJ, Tremblay RE, Côté G, Meaney MJ, Mechawar N, Nestler EJ, Turecki G.

Mol Psychiatry. 2020 Jan 6. doi: 10.1038/s41380-019-0637-4. [Epub ahead of print]


Silent synapses dictate cocaine memory destabilization and reconsolidation.

Wright WJ, Graziane NM, Neumann PA, Hamilton PJ, Cates HM, Fuerst L, Spenceley A, MacKinnon-Booth N, Iyer K, Huang YH, Shaham Y, Schlüter OM, Nestler EJ, Dong Y.

Nat Neurosci. 2020 Jan;23(1):32-46. doi: 10.1038/s41593-019-0537-6. Epub 2019 Dec 2.


Early life stress alters transcriptomic patterning across reward circuitry in male and female mice.

Peña CJ, Smith M, Ramakrishnan A, Cates HM, Bagot RC, Kronman HG, Patel B, Chang AB, Purushothaman I, Dudley J, Morishita H, Shen L, Nestler EJ.

Nat Commun. 2019 Nov 8;10(1):5098. doi: 10.1038/s41467-019-13085-6.


Alcohol metabolism contributes to brain histone acetylation.

Mews P, Egervari G, Nativio R, Sidoli S, Donahue G, Lombroso SI, Alexander DC, Riesche SL, Heller EA, Nestler EJ, Garcia BA, Berger SL.

Nature. 2019 Oct;574(7780):717-721. doi: 10.1038/s41586-019-1700-7. Epub 2019 Oct 23.


Paternal transgenerational epigenetic mechanisms mediating stress phenotypes of offspring.

Cunningham AM, Walker DM, Nestler EJ.

Eur J Neurosci. 2019 Sep 23. doi: 10.1111/ejn.14582. [Epub ahead of print] Review.


Epigenetic Mechanisms of Opioid Addiction.

Browne CJ, Godino A, Salery M, Nestler EJ.

Biol Psychiatry. 2020 Jan 1;87(1):22-33. doi: 10.1016/j.biopsych.2019.06.027. Epub 2019 Jul 8. Review.


Multidimensional Predictors of Susceptibility and Resilience to Social Defeat Stress.

Nasca C, Menard C, Hodes G, Bigio B, Pena C, Lorsch Z, Zelli D, Ferris A, Kana V, Purushothaman I, Dobbin J, Nassim M, DeAngelis P, Merad M, Rasgon N, Meaney M, Nestler EJ, McEwen BS, Russo SJ.

Biol Psychiatry. 2019 Sep 15;86(6):483-491. doi: 10.1016/j.biopsych.2019.06.030. Epub 2019 Jul 29.


Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex.

Lorsch ZS, Hamilton PJ, Ramakrishnan A, Parise EM, Salery M, Wright WJ, Lepack AE, Mews P, Issler O, McKenzie A, Zhou X, Parise LF, Pirpinias ST, Ortiz Torres I, Kronman HG, Montgomery SE, Loh YE, Labonté B, Conkey A, Symonds AE, Neve RL, Turecki G, Maze I, Dong Y, Zhang B, Shen L, Bagot RC, Nestler EJ.

Nat Neurosci. 2019 Sep;22(9):1413-1423. doi: 10.1038/s41593-019-0462-8. Epub 2019 Aug 19.


Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression.

Koo JW, Chaudhury D, Han MH, Nestler EJ.

Biol Psychiatry. 2019 Nov 15;86(10):738-748. doi: 10.1016/j.biopsych.2019.05.020. Epub 2019 Jun 4. Review.


Epigenetics and addiction.

Hamilton PJ, Nestler EJ.

Curr Opin Neurobiol. 2019 Dec;59:128-136. doi: 10.1016/j.conb.2019.05.005. Epub 2019 Jun 27. Review.


Exercise Modalities Improve Aversive Memory and Survival Rate in Aged Rats: Role of Hippocampal Epigenetic Modifications.

de Meireles LCF, Galvão F Jr, Walker DM, Cechinel LR, de Souza Grefenhagen ÁI, Andrade G, Palazzo RP, Lovatel GA, Basso CG, Nestler EJ, Siqueira IR.

Mol Neurobiol. 2019 Dec;56(12):8408-8419. doi: 10.1007/s12035-019-01675-w. Epub 2019 Jun 27.


Personal reflections on a mentor extraordinaire: Paul Greengard, Ph.D. (1925-2019).

Nestler EJ.

Neuropsychopharmacology. 2019 Sep;44(10):1837-1838. doi: 10.1038/s41386-019-0433-5. Epub 2019 Jun 13. No abstract available.


Neurobiology of Resilience: Interface Between Mind and Body.

Cathomas F, Murrough JW, Nestler EJ, Han MH, Russo SJ.

Biol Psychiatry. 2019 Sep 15;86(6):410-420. doi: 10.1016/j.biopsych.2019.04.011. Epub 2019 Apr 17. Review.


Biology and Bias in Cell Type-Specific RNAseq of Nucleus Accumbens Medium Spiny Neurons.

Kronman H, Richter F, Labonté B, Chandra R, Zhao S, Hoffman G, Lobo MK, Schadt EE, Nestler EJ.

Sci Rep. 2019 Jun 6;9(1):8350. doi: 10.1038/s41598-019-44798-9.


Synaptic Microtubule-Associated Protein EB3 and SRC Phosphorylation Mediate Structural and Behavioral Adaptations During Withdrawal From Cocaine Self-Administration.

Calipari ES, Godino A, Salery M, Damez-Werno DM, Cahill ME, Werner CT, Gancarz AM, Peck EG, Jlayer Z, Rabkin J, Landry JA, Smith ACW, Defilippi P, Kenny PJ, Hurd YL, Neve RL, Dietz DM, Nestler EJ.

J Neurosci. 2019 Jul 17;39(29):5634-5646. doi: 10.1523/JNEUROSCI.0024-19.2019. Epub 2019 May 15.


The critical importance of basic animal research for neuropsychiatric disorders.

Bale TL, Abel T, Akil H, Carlezon WA Jr, Moghaddam B, Nestler EJ, Ressler KJ, Thompson SM.

Neuropsychopharmacology. 2019 Jul;44(8):1349-1353. doi: 10.1038/s41386-019-0405-9. Epub 2019 May 2. No abstract available.


Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females.

Walker DM, Cunningham AM, Gregory JK, Nestler EJ.

Front Behav Neurosci. 2019 Apr 11;13:66. doi: 10.3389/fnbeh.2019.00066. eCollection 2019.


MiR-218: a molecular switch and potential biomarker of susceptibility to stress.

Torres-Berrío A, Nouel D, Cuesta S, Parise EM, Restrepo-Lozano JM, Larochelle P, Nestler EJ, Flores C.

Mol Psychiatry. 2019 Apr 12. doi: 10.1038/s41380-019-0421-5. [Epub ahead of print]


Fosb Induction in Nucleus Accumbens by Cocaine Is Regulated by E2F3a.

Cates HM, Lardner CK, Bagot RC, Neve RL, Nestler EJ.

eNeuro. 2019 Apr 1;6(2). pii: ENEURO.0325-18.2019. doi: 10.1523/ENEURO.0325-18.2019. eCollection 2019 Mar-Apr.


The Molecular Basis of Drug Addiction: Linking Epigenetic to Synaptic and Circuit Mechanisms.

Nestler EJ, Lüscher C.

Neuron. 2019 Apr 3;102(1):48-59. doi: 10.1016/j.neuron.2019.01.016. Review.


Epigenetic Priming in Drug Addiction.

Mews P, Walker DM, Nestler EJ.

Cold Spring Harb Symp Quant Biol. 2018;83:131-139. doi: 10.1101/sqb.2018.83.037663. Epub 2019 Apr 1.


Environmental Programming of Susceptibility and Resilience to Stress in Adulthood in Male Mice.

Peña CJ, Nestler EJ, Bagot RC.

Front Behav Neurosci. 2019 Mar 1;13:40. doi: 10.3389/fnbeh.2019.00040. eCollection 2019.


Gadd45b mediates depressive-like role through DNA demethylation.

Labonté B, Jeong YH, Parise E, Issler O, Fatma M, Engmann O, Cho KA, Neve R, Nestler EJ, Koo JW.

Sci Rep. 2019 Mar 15;9(1):4615. doi: 10.1038/s41598-019-40844-8.


Viral labeling of neurons synaptically connected to nucleus accumbens somatostatin interneurons.

Ribeiro EA, Nectow AR, Pomeranz LE, Ekstrand MI, Koo JW, Nestler EJ.

PLoS One. 2019 Mar 7;14(3):e0213476. doi: 10.1371/journal.pone.0213476. eCollection 2019.


Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress.

Föcking M, Sabherwal S, Cates HM, Scaife C, Dicker P, Hryniewiecka M, Wynne K, Rutten BPF, Lewis G, Cannon M, Nestler EJ, Heurich M, Cagney G, Zammit S, Cotter DR.

Mol Psychiatry. 2019 Jan 11. doi: 10.1038/s41380-018-0306-z. [Epub ahead of print]


Knockdown of the histone di-methyltransferase G9a in nucleus accumbens shell decreases cocaine self-administration, stress-induced reinstatement, and anxiety.

Anderson EM, Sun H, Guzman D, Taniguchi M, Cowan CW, Maze I, Nestler EJ, Self DW.

Neuropsychopharmacology. 2019 Jul;44(8):1370-1376. doi: 10.1038/s41386-018-0305-4. Epub 2018 Dec 26.


A novel role for E2F3b in regulating cocaine action in the prefrontal cortex.

Cates HM, Bagot RC, Heller EA, Purushothaman I, Lardner CK, Walker DM, Peña CJ, Neve RL, Shen L, Nestler EJ.

Neuropsychopharmacology. 2019 Mar;44(4):776-784. doi: 10.1038/s41386-018-0296-1. Epub 2018 Dec 14.


Author Correction: Epigenetic regulation in psychiatric disorders.

Tsankova N, Renthal W, Kumar A, Nestler EJ.

Nat Rev Neurosci. 2019 Mar;20(3):187-188. doi: 10.1038/s41583-018-0089-x.


VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine.

Jiang C, Lin WJ, Labonté B, Tamminga CA, Turecki G, Nestler EJ, Russo SJ, Salton SR.

Neuropsychopharmacology. 2019 Apr;44(5):971-981. doi: 10.1038/s41386-018-0277-4. Epub 2018 Nov 20.


Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder.

Tan A, Costi S, Morris LS, Van Dam NT, Kautz M, Whitton AE, Friedman AK, Collins KA, Ahle G, Chadha N, Do B, Pizzagalli DA, Iosifescu DV, Nestler EJ, Han MH, Murrough JW.

Mol Psychiatry. 2018 Nov 1. doi: 10.1038/s41380-018-0283-2. [Epub ahead of print]


α1- and β3-Adrenergic Receptor-Mediated Mesolimbic Homeostatic Plasticity Confers Resilience to Social Stress in Susceptible Mice.

Zhang H, Chaudhury D, Nectow AR, Friedman AK, Zhang S, Juarez B, Liu H, Pfau ML, Aleyasin H, Jiang C, Crumiller M, Calipari ES, Ku SM, Morel C, Tzavaras N, Montgomery SE, He M, Salton SR, Russo SJ, Nestler EJ, Friedman JM, Cao JL, Han MH.

Biol Psychiatry. 2019 Feb 1;85(3):226-236. doi: 10.1016/j.biopsych.2018.08.020. Epub 2018 Sep 6.


Stereotaxic Surgery and Viral Delivery of Zinc-Finger Epigenetic Editing Tools in Rodent Brain.

Hamilton PJ, Lim CJ, Nestler EJ, Heller EA.

Methods Mol Biol. 2018;1867:229-238. doi: 10.1007/978-1-4939-8799-3_17.


Methylation in OTX2 and related genes, maltreatment, and depression in children.

Kaufman J, Wymbs NF, Montalvo-Ortiz JL, Orr C, Albaugh MD, Althoff R, O'Loughlin K, Holbrook H, Garavan H, Kearney C, Yang BZ, Zhao H, Peña C, Nestler EJ, Lee RS, Mostofsky S, Gelernter J, Hudziak J.

Neuropsychopharmacology. 2018 Oct;43(11):2204-2211. doi: 10.1038/s41386-018-0157-y. Epub 2018 Jul 21.


Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine.

Ribeiro EA, Salery M, Scarpa JR, Calipari ES, Hamilton PJ, Ku SM, Kronman H, Purushothaman I, Juarez B, Heshmati M, Doyle M, Lardner C, Burek D, Strat A, Pirpinias S, Mouzon E, Han MH, Neve RL, Bagot RC, Kasarskis A, Koo JW, Nestler EJ.

Nat Commun. 2018 Aug 8;9(1):3149. doi: 10.1038/s41467-018-05657-9.


Genome-wide transcriptional profiling of central amygdala and orbitofrontal cortex during incubation of methamphetamine craving.

Cates HM, Li X, Purushothaman I, Kennedy PJ, Shen L, Shaham Y, Nestler EJ.

Neuropsychopharmacology. 2018 Nov;43(12):2426-2434. doi: 10.1038/s41386-018-0158-x. Epub 2018 Jul 20.


Withdrawal from repeated morphine administration augments expression of the RhoA network in the nucleus accumbens to control synaptic structure.

Cahill ME, Browne CJ, Wang J, Hamilton PJ, Dong Y, Nestler EJ.

J Neurochem. 2018 Oct;147(1):84-98. doi: 10.1111/jnc.14563. Epub 2018 Sep 26.


Progress in Epigenetics of Depression.

Peña CJ, Nestler EJ.

Prog Mol Biol Transl Sci. 2018;157:41-66. doi: 10.1016/bs.pmbts.2017.12.011. Epub 2018 Apr 10. Review.


Cell-Type-Specific Role of ΔFosB in Nucleus Accumbens In Modulating Intermale Aggression.

Aleyasin H, Flanigan ME, Golden SA, Takahashi A, Menard C, Pfau ML, Multer J, Pina J, McCabe KA, Bhatti N, Hodes GE, Heshmati M, Neve RL, Nestler EJ, Heller EA, Russo SJ.

J Neurosci. 2018 Jun 27;38(26):5913-5924. doi: 10.1523/JNEUROSCI.0296-18.2018. Epub 2018 Jun 11.


Voluntary wheel running promotes resilience to chronic social defeat stress in mice: a role for nucleus accumbens ΔFosB.

Mul JD, Soto M, Cahill ME, Ryan RE, Takahashi H, So K, Zheng J, Croote DE, Hirshman MF, la Fleur SE, Nestler EJ, Goodyear LJ.

Neuropsychopharmacology. 2018 Aug;43(9):1934-1942. doi: 10.1038/s41386-018-0103-z. Epub 2018 May 24.


Cocaine Self-administration Alters Transcriptome-wide Responses in the Brain's Reward Circuitry.

Walker DM, Cates HM, Loh YE, Purushothaman I, Ramakrishnan A, Cahill KM, Lardner CK, Godino A, Kronman HG, Rabkin J, Lorsch ZS, Mews P, Doyle MA, Feng J, Labonté B, Koo JW, Bagot RC, Logan RW, Seney ML, Calipari ES, Shen L, Nestler EJ.

Biol Psychiatry. 2018 Dec 15;84(12):867-880. doi: 10.1016/j.biopsych.2018.04.009. Epub 2018 Apr 25.


Corrigendum: Sex-specific transcriptional signatures in human depression.

Labonté B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, Scarpa JR, Moy G, Loh YE, Cahill M, Lorsch ZS, Hamilton PJ, Calipari ES, Hodes GE, Issler O, Kronman H, Pfau M, Obradovic ALJ, Dong Y, Neve RL, Russo S, Kasarskis A, Tamminga C, Mechawar N, Turecki G, Zhang B, Shen L, Nestler EJ.

Nat Med. 2018 Apr 10;24(4):525. doi: 10.1038/nm0418-525d.


Meeting Report: Can We Make Animal Models of Human Mental Illness?

Monteggia LM, Heimer H, Nestler EJ.

Biol Psychiatry. 2018 Oct 1;84(7):542-545. doi: 10.1016/j.biopsych.2018.02.010. Epub 2018 Feb 22.


Estrogen receptor α drives pro-resilient transcription in mouse models of depression.

Lorsch ZS, Loh YE, Purushothaman I, Walker DM, Parise EM, Salery M, Cahill ME, Hodes GE, Pfau ML, Kronman H, Hamilton PJ, Issler O, Labonté B, Symonds AE, Zucker M, Zhang TY, Meaney MJ, Russo SJ, Shen L, Bagot RC, Nestler EJ.

Nat Commun. 2018 Mar 16;9(1):1116. doi: 10.1038/s41467-018-03567-4.


Viral Expression of Epigenome Editing Tools in Rodent Brain Using Stereotaxic Surgery Techniques.

Hamilton PJ, Lim CJ, Nestler EJ, Heller EA.

Methods Mol Biol. 2018;1767:205-214. doi: 10.1007/978-1-4939-7774-1_10.


Neuroepigenetic Editing.

Hamilton PJ, Lim CJ, Nestler EJ, Heller EA.

Methods Mol Biol. 2018;1767:113-136. doi: 10.1007/978-1-4939-7774-1_5. Review.

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