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Items: 1 to 50 of 564

1.

Progress in Epigenetics of Depression.

Peña CJ, Nestler EJ.

Prog Mol Biol Transl Sci. 2018;157:41-66. doi: 10.1016/bs.pmbts.2017.12.011. Epub 2018 Apr 10.

PMID:
29933956
2.

Cell-Type-Specific Role of ΔFosB in Nucleus Accumbens In Modulating Intermale Aggression.

Aleyasin H, Flanigan ME, Golden SA, Takahashi A, Menard C, Pfau ML, Multer J, Pina J, McCabe KA, Bhatti N, Hodes GE, Heshmati M, Neve RL, Nestler EJ, Heller EA, Russo SJ.

J Neurosci. 2018 Jun 27;38(26):5913-5924. doi: 10.1523/JNEUROSCI.0296-18.2018. Epub 2018 Jun 11.

PMID:
29891732
3.

Voluntary wheel running promotes resilience to chronic social defeat stress in mice: a role for nucleus accumbens ΔFosB.

Mul JD, Soto M, Cahill ME, Ryan RE, Takahashi H, So K, Zheng J, Croote DE, Hirshman MF, la Fleur SE, Nestler EJ, Goodyear LJ.

Neuropsychopharmacology. 2018 May 24. doi: 10.1038/s41386-018-0103-z. [Epub ahead of print]

PMID:
29875450
4.

Cocaine Self-administration Alters Transcriptome-wide Responses in the Brain's Reward Circuitry.

Walker DM, Cates HM, Loh YE, Purushothaman I, Ramakrishnan A, Cahill KM, Lardner CK, Godino A, Kronman HG, Rabkin J, Lorsch ZS, Mews P, Doyle MA, Feng J, Labonté B, Koo JW, Bagot RC, Logan RW, Seney ML, Calipari ES, Shen L, Nestler EJ.

Biol Psychiatry. 2018 Apr 25. pii: S0006-3223(18)31447-1. doi: 10.1016/j.biopsych.2018.04.009. [Epub ahead of print]

PMID:
29861096
5.

Corrigendum: Sex-specific transcriptional signatures in human depression.

Labonté B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, Scarpa JR, Moy G, Loh YE, Cahill M, Lorsch ZS, Hamilton PJ, Calipari ES, Hodes GE, Issler O, Kronman H, Pfau M, Obradovic ALJ, Dong Y, Neve RL, Russo S, Kasarskis A, Tamminga C, Mechawar N, Turecki G, Zhang B, Shen L, Nestler EJ.

Nat Med. 2018 Apr 10;24(4):525. doi: 10.1038/nm0418-525d.

PMID:
29634684
6.

Meeting Report: Can We Make Animal Models of Human Mental Illness?

Monteggia LM, Heimer H, Nestler EJ.

Biol Psychiatry. 2018 Feb 22. pii: S0006-3223(18)30111-2. doi: 10.1016/j.biopsych.2018.02.010. [Epub ahead of print]

PMID:
29606372
7.

Estrogen receptor α drives pro-resilient transcription in mouse models of depression.

Lorsch ZS, Loh YE, Purushothaman I, Walker DM, Parise EM, Salery M, Cahill ME, Hodes GE, Pfau ML, Kronman H, Hamilton PJ, Issler O, Labonté B, Symonds AE, Zucker M, Zhang TY, Meaney MJ, Russo SJ, Shen L, Bagot RC, Nestler EJ.

Nat Commun. 2018 Mar 16;9(1):1116. doi: 10.1038/s41467-018-03567-4.

8.

Viral Expression of Epigenome Editing Tools in Rodent Brain Using Stereotaxic Surgery Techniques.

Hamilton PJ, Lim CJ, Nestler EJ, Heller EA.

Methods Mol Biol. 2018;1767:205-214. doi: 10.1007/978-1-4939-7774-1_10.

PMID:
29524136
9.

Neuroepigenetic Editing.

Hamilton PJ, Lim CJ, Nestler EJ, Heller EA.

Methods Mol Biol. 2018;1767:113-136. doi: 10.1007/978-1-4939-7774-1_5.

PMID:
29524131
10.

Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability.

Hultman R, Ulrich K, Sachs BD, Blount C, Carlson DE, Ndubuizu N, Bagot RC, Parise EM, Vu MT, Gallagher NM, Wang J, Silva AJ, Deisseroth K, Mague SD, Caron MG, Nestler EJ, Carin L, Dzirasa K.

Cell. 2018 Mar 22;173(1):166-180.e14. doi: 10.1016/j.cell.2018.02.012.

PMID:
29502969
11.

Neuroepigenetics and addiction.

Walker DM, Nestler EJ.

Handb Clin Neurol. 2018;148:747-765. doi: 10.1016/B978-0-444-64076-5.00048-X.

PMID:
29478612
12.

Role of Dorsal Striatum Histone Deacetylase 5 in Incubation of Methamphetamine Craving.

Li X, Carreria MB, Witonsky KR, Zeric T, Lofaro OM, Bossert JM, Zhang J, Surjono F, Richie CT, Harvey BK, Son H, Cowan CW, Nestler EJ, Shaham Y.

Biol Psychiatry. 2017 Dec 29. pii: S0006-3223(17)32314-4. doi: 10.1016/j.biopsych.2017.12.008. [Epub ahead of print]

PMID:
29397902
13.

Transcription Factor E2F3a in Nucleus Accumbens Affects Cocaine Action via Transcription and Alternative Splicing.

Cates HM, Heller EA, Lardner CK, Purushothaman I, Peña CJ, Walker DM, Cahill ME, Neve RL, Shen L, Bagot RC, Nestler EJ.

Biol Psychiatry. 2017 Dec 5. pii: S0006-3223(17)32246-1. doi: 10.1016/j.biopsych.2017.11.027. [Epub ahead of print]

PMID:
29397901
14.

Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine.

Calipari ES, Godino A, Peck EG, Salery M, Mervosh NL, Landry JA, Russo SJ, Hurd YL, Nestler EJ, Kiraly DD.

Nat Commun. 2018 Jan 16;9(1):9. doi: 10.1038/s41467-017-01881-x.

15.

Overexpression of the Histone Dimethyltransferase G9a in Nucleus Accumbens Shell Increases Cocaine Self-Administration, Stress-Induced Reinstatement, and Anxiety.

Anderson EM, Larson EB, Guzman D, Wissman AM, Neve RL, Nestler EJ, Self DW.

J Neurosci. 2018 Jan 24;38(4):803-813. doi: 10.1523/JNEUROSCI.1657-17.2017. Epub 2017 Dec 7.

PMID:
29217682
16.

VGF function in depression and antidepressant efficacy.

Jiang C, Lin WJ, Sadahiro M, Labonté B, Menard C, Pfau ML, Tamminga CA, Turecki G, Nestler EJ, Russo SJ, Salton SR.

Mol Psychiatry. 2017 Nov 21. doi: 10.1038/mp.2017.233. [Epub ahead of print]

17.

Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits.

You JC, Muralidharan K, Park JW, Petrof I, Pyfer MS, Corbett BF, LaFrancois JJ, Zheng Y, Zhang X, Mohila CA, Yoshor D, Rissman RA, Nestler EJ, Scharfman HE, Chin J.

Nat Med. 2017 Nov;23(11):1377-1383. doi: 10.1038/nm.4413. Epub 2017 Oct 16.

18.

Establishment of a repeated social defeat stress model in female mice.

Takahashi A, Chung JR, Zhang S, Zhang H, Grossman Y, Aleyasin H, Flanigan ME, Pfau ML, Menard C, Dumitriu D, Hodes GE, McEwen BS, Nestler EJ, Han MH, Russo SJ.

Sci Rep. 2017 Oct 9;7(1):12838. doi: 10.1038/s41598-017-12811-8.

19.

Activator Protein-1: redox switch controlling structure and DNA-binding.

Yin Z, Machius M, Nestler EJ, Rudenko G.

Nucleic Acids Res. 2017 Nov 2;45(19):11425-11436. doi: 10.1093/nar/gkx795.

20.

Nucleus accumbens feedforward inhibition circuit promotes cocaine self-administration.

Yu J, Yan Y, Li KL, Wang Y, Huang YH, Urban NN, Nestler EJ, Schlüter OM, Dong Y.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8750-E8759. doi: 10.1073/pnas.1707822114. Epub 2017 Sep 25.

21.

Perinatal Malnutrition Leads to Sexually Dimorphic Behavioral Responses with Associated Epigenetic Changes in the Mouse Brain.

Nätt D, Barchiesi R, Murad J, Feng J, Nestler EJ, Champagne FA, Thorsell A.

Sci Rep. 2017 Sep 11;7(1):11082. doi: 10.1038/s41598-017-10803-2.

22.

Treatment resistant depression: A multi-scale, systems biology approach.

Akil H, Gordon J, Hen R, Javitch J, Mayberg H, McEwen B, Meaney MJ, Nestler EJ.

Neurosci Biobehav Rev. 2018 Jan;84:272-288. doi: 10.1016/j.neubiorev.2017.08.019. Epub 2017 Aug 30. Review.

PMID:
28859997
23.

Poly (ADP-Ribose) Polymerase-1 (PARP-1) Induction by Cocaine Is Post-Transcriptionally Regulated by miR-125b.

Dash S, Balasubramaniam M, Rana T, Godino A, Peck EG, Goodwin JS, Villalta F, Calipari ES, Nestler EJ, Dash C, Pandhare J.

eNeuro. 2017 Aug 18;4(4). pii: ENEURO.0089-17.2017. doi: 10.1523/ENEURO.0089-17.2017. eCollection 2017 Jul-Aug. Erratum in: eNeuro. 2018 Apr 18;5(2):.

24.

Sex-specific transcriptional signatures in human depression.

Labonté B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, Scarpa JR, Moy G, Loh YE, Cahill M, Lorsch ZS, Hamilton PJ, Calipari ES, Hodes GE, Issler O, Kronman H, Pfau M, Obradovic ALJ, Dong Y, Neve RL, Russo S, Kazarskis A, Tamminga C, Mechawar N, Turecki G, Zhang B, Shen L, Nestler EJ.

Nat Med. 2017 Sep;23(9):1102-1111. doi: 10.1038/nm.4386. Epub 2017 Aug 21. Erratum in: Nat Med. 2018 Apr 10;24(4):525.

PMID:
28825715
25.

BDNF-TrkB controls cocaine-induced dendritic spines in rodent nucleus accumbens dissociated from increases in addictive behaviors.

Anderson EM, Wissman AM, Chemplanikal J, Buzin N, Guzman D, Larson EB, Neve RL, Nestler EJ, Cowan CW, Self DW.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9469-9474. doi: 10.1073/pnas.1702441114. Epub 2017 Aug 14.

26.

Gene Network Dysregulation in Dorsolateral Prefrontal Cortex Neurons of Humans with Cocaine Use Disorder.

Ribeiro EA, Scarpa JR, Garamszegi SP, Kasarskis A, Mash DC, Nestler EJ.

Sci Rep. 2017 Jul 14;7(1):5412. doi: 10.1038/s41598-017-05720-3.

27.

ΔFosB Regulates Gene Expression and Cognitive Dysfunction in a Mouse Model of Alzheimer's Disease.

Corbett BF, You JC, Zhang X, Pyfer MS, Tosi U, Iascone DM, Petrof I, Hazra A, Fu CH, Stephens GS, Ashok AA, Aschmies S, Zhao L, Nestler EJ, Chin J.

Cell Rep. 2017 Jul 11;20(2):344-355. doi: 10.1016/j.celrep.2017.06.040.

28.

The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.

Jiang Y, Loh YE, Rajarajan P, Hirayama T, Liao W, Kassim BS, Javidfar B, Hartley BJ, Kleofas L, Park RB, Labonte B, Ho SM, Chandrasekaran S, Do C, Ramirez BR, Peter CJ, C W JT, Safaie BM, Morishita H, Roussos P, Nestler EJ, Schaefer A, Tycko B, Brennand KJ, Yagi T, Shen L, Akbarian S.

Nat Genet. 2017 Aug;49(8):1239-1250. doi: 10.1038/ng.3906. Epub 2017 Jul 3.

29.

Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2.

Peña CJ, Kronman HG, Walker DM, Cates HM, Bagot RC, Purushothaman I, Issler O, Loh YE, Leong T, Kiraly DD, Goodman E, Neve RL, Shen L, Nestler EJ.

Science. 2017 Jun 16;356(6343):1185-1188. doi: 10.1126/science.aan4491.

30.

In Vivo Fiber Photometry Reveals Signature of Future Stress Susceptibility in Nucleus Accumbens.

Muir J, Lorsch ZS, Ramakrishnan C, Deisseroth K, Nestler EJ, Calipari ES, Bagot RC.

Neuropsychopharmacology. 2018 Jan;43(2):255-263. doi: 10.1038/npp.2017.122. Epub 2017 Jun 7.

PMID:
28589967
31.

Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2.

Engmann O, Labonté B, Mitchell A, Bashtrykov P, Calipari ES, Rosenbluh C, Loh YE, Walker DM, Burek D, Hamilton PJ, Issler O, Neve RL, Turecki G, Hurd Y, Chess A, Shen L, Mansuy I, Jeltsch A, Akbarian S, Nestler EJ.

Biol Psychiatry. 2017 Dec 1;82(11):794-805. doi: 10.1016/j.biopsych.2017.04.013. Epub 2017 May 5.

PMID:
28577753
32.

The dendritic spine morphogenic effects of repeated cocaine use occur through the regulation of serum response factor signaling.

Cahill ME, Walker DM, Gancarz AM, Wang ZJ, Lardner CK, Bagot RC, Neve RL, Dietz DM, Nestler EJ.

Mol Psychiatry. 2018 Jun;23(6):1474-1486. doi: 10.1038/mp.2017.116. Epub 2017 May 30.

PMID:
28555077
33.

MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes.

Lopez JP, Fiori LM, Cruceanu C, Lin R, Labonte B, Cates HM, Heller EA, Vialou V, Ku SM, Gerald C, Han MH, Foster J, Frey BN, Soares CN, Müller DJ, Farzan F, Leri F, MacQueen GM, Feilotter H, Tyryshkin K, Evans KR, Giacobbe P, Blier P, Lam RW, Milev R, Parikh SV, Rotzinger S, Strother SC, Lewis CM, Aitchison KJ, Wittenberg GM, Mechawar N, Nestler EJ, Uher R, Kennedy SH, Turecki G.

Nat Commun. 2017 May 22;8:15497. doi: 10.1038/ncomms15497.

34.

Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice.

Walsh RM, Shen EY, Bagot RC, Anselmo A, Jiang Y, Javidfar B, Wojtkiewicz GJ, Cloutier J, Chen JW, Sadreyev R, Nestler EJ, Akbarian S, Hochedlinger K.

Nat Commun. 2017 May 9;8:15142. doi: 10.1038/ncomms15142.

35.

Cell-Type-Specific Epigenetic Editing at the Fosb Gene Controls Susceptibility to Social Defeat Stress.

Hamilton PJ, Burek DJ, Lombroso SI, Neve RL, Robison AJ, Nestler EJ, Heller EA.

Neuropsychopharmacology. 2018 Jan;43(2):272-284. doi: 10.1038/npp.2017.88. Epub 2017 May 2.

PMID:
28462942
36.

Regulation of BAZ1A and nucleosome positioning in the nucleus accumbens in response to cocaine.

Sun H, Damez-Werno DM, Scobie KN, Shao NY, Dias C, Rabkin J, Wright KN, Mouzon E, Kabbaj M, Neve R, Turecki G, Shen L, Nestler EJ.

Neuroscience. 2017 Jun 14;353:1-6. doi: 10.1016/j.neuroscience.2017.04.007. Epub 2017 Apr 12.

37.

Neural Substrates of Depression and Resilience.

Han MH, Nestler EJ.

Neurotherapeutics. 2017 Jul;14(3):677-686. doi: 10.1007/s13311-017-0527-x. Review.

38.

Brain-Derived Neurotrophic Factor in the Mesolimbic Reward Circuitry Mediates Nociception in Chronic Neuropathic Pain.

Zhang H, Qian YL, Li C, Liu D, Wang L, Wang XY, Liu MJ, Liu H, Zhang S, Guo XY, Yang JX, Ding HL, Koo JW, Mouzon E, Deisseroth K, Nestler EJ, Zachariou V, Han MH, Cao JL.

Biol Psychiatry. 2017 Oct 15;82(8):608-618. doi: 10.1016/j.biopsych.2017.02.1180. Epub 2017 Mar 1.

PMID:
28390647
39.

DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons.

Zhao JY, Liang L, Gu X, Li Z, Wu S, Sun L, Atianjoh FE, Feng J, Mo K, Jia S, Lutz BM, Bekker A, Nestler EJ, Tao YX.

Nat Commun. 2017 Mar 8;8:14712. doi: 10.1038/ncomms14712.

40.

Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons.

Sun L, Zhao JY, Gu X, Liang L, Wu S, Mo K, Feng J, Guo W, Zhang J, Bekker A, Zhao X, Nestler EJ, Tao YX.

Pain. 2017 Jun;158(6):1153-1165. doi: 10.1097/j.pain.0000000000000894.

41.

WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine.

Ceglia I, Lee KW, Cahill ME, Graves SM, Dietz D, Surmeier DJ, Nestler EJ, Nairn AC, Greengard P, Kim Y.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1395-1400. doi: 10.1073/pnas.1621185114. Epub 2017 Jan 23.

42.

Susceptibility to chronic social stress increases plaque progression, vulnerability and platelet activation.

Giannarelli C, Rodriguez DT, Zafar MU, Christoffel D, Vialou V, Peña C, Badimon A, Hodes GF, Mury P, Rabkin J, Alique M, Villa G, Argmann C, Nestler EJ, Russo SJ, Badimon JJ.

Thromb Haemost. 2017 Apr 3;117(4):816-818. doi: 10.1160/TH16-10-0817. Epub 2017 Jan 12. No abstract available.

43.

Tet1 in Nucleus Accumbens Opposes Depression- and Anxiety-Like Behaviors.

Feng J, Pena CJ, Purushothaman I, Engmann O, Walker D, Brown AN, Issler O, Doyle M, Harrigan E, Mouzon E, Vialou V, Shen L, Dawlaty MM, Jaenisch R, Nestler EJ.

Neuropsychopharmacology. 2017 Jul;42(8):1657-1669. doi: 10.1038/npp.2017.6. Epub 2017 Jan 11.

44.

Dopaminergic dynamics underlying sex-specific cocaine reward.

Calipari ES, Juarez B, Morel C, Walker DM, Cahill ME, Ribeiro E, Roman-Ortiz C, Ramakrishnan C, Deisseroth K, Han MH, Nestler EJ.

Nat Commun. 2017 Jan 10;8:13877. doi: 10.1038/ncomms13877.

45.

Understanding the epigenetic basis of sex differences in depression.

Hodes GE, Walker DM, Labonté B, Nestler EJ, Russo SJ.

J Neurosci Res. 2017 Jan 2;95(1-2):692-702. doi: 10.1002/jnr.23876. Review.

46.

Aberrant H3.3 dynamics in NAc promote vulnerability to depressive-like behavior.

Lepack AE, Bagot RC, Peña CJ, Loh YE, Farrelly LA, Lu Y, Powell SK, Lorsch ZS, Issler O, Cates HM, Tamminga CA, Molina H, Shen L, Nestler EJ, Allis CD, Maze I.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12562-12567. Epub 2016 Oct 18.

47.

DCC Confers Susceptibility to Depression-like Behaviors in Humans and Mice and Is Regulated by miR-218.

Torres-Berrío A, Lopez JP, Bagot RC, Nouel D, Dal Bo G, Cuesta S, Zhu L, Manitt C, Eng C, Cooper HM, Storch KF, Turecki G, Nestler EJ, Flores C.

Biol Psychiatry. 2017 Feb 15;81(4):306-315. doi: 10.1016/j.biopsych.2016.08.017. Epub 2016 Aug 18.

48.

Alterations of the Host Microbiome Affect Behavioral Responses to Cocaine.

Kiraly DD, Walker DM, Calipari ES, Labonte B, Issler O, Pena CJ, Ribeiro EA, Russo SJ, Nestler EJ.

Sci Rep. 2016 Oct 18;6:35455. doi: 10.1038/srep35455.

49.

The role of ΔfosB in the medial preoptic area: Differential effects of mating and cocaine history.

McHenry JA, Robison CL, Bell GA, Vialou VV, Bolaños-Guzmán CA, Nestler EJ, Hull EM.

Behav Neurosci. 2016 Oct;130(5):469-78. doi: 10.1037/bne0000160.

50.

Ketamine and Imipramine Reverse Transcriptional Signatures of Susceptibility and Induce Resilience-Specific Gene Expression Profiles.

Bagot RC, Cates HM, Purushothaman I, Vialou V, Heller EA, Yieh L, LaBonté B, Peña CJ, Shen L, Wittenberg GM, Nestler EJ.

Biol Psychiatry. 2017 Feb 15;81(4):285-295. doi: 10.1016/j.biopsych.2016.06.012. Epub 2016 Jun 18.

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