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Synaptic microtubule-associated protein EB3 and SRC phosphorylation mediate structural and behavioral adaptations during withdrawal from cocaine self-administration.

Calipari ES, Godino A, Salery M, Damez-Werno DM, Cahill ME, Werner CT, Gancarz AM, Peck EG, Jlayer Z, Rabkin J, Landry JA, Smith ACW, Defilippi P, Kenny PJ, Hurd YL, Neve RL, Dietz DM, Nestler EJ.

J Neurosci. 2019 May 15. pii: 0024-19. doi: 10.1523/JNEUROSCI.0024-19.2019. [Epub ahead of print]


The critical importance of basic animal research for neuropsychiatric disorders.

Bale TL, Abel T, Akil H, Carlezon WA Jr, Moghaddam B, Nestler EJ, Ressler KJ, Thompson SM.

Neuropsychopharmacology. 2019 May 2. doi: 10.1038/s41386-019-0405-9. [Epub ahead of print] Review. No abstract available.


Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females.

Walker DM, Cunningham AM, Gregory JK, Nestler EJ.

Front Behav Neurosci. 2019 Apr 11;13:66. doi: 10.3389/fnbeh.2019.00066. eCollection 2019.


MiR-218: a molecular switch and potential biomarker of susceptibility to stress.

Torres-Berrío A, Nouel D, Cuesta S, Parise EM, Restrepo-Lozano JM, Larochelle P, Nestler EJ, Flores C.

Mol Psychiatry. 2019 Apr 12. doi: 10.1038/s41380-019-0421-5. [Epub ahead of print]


Fosb Induction in Nucleus Accumbens by Cocaine Is Regulated by E2F3a.

Cates HM, Lardner CK, Bagot RC, Neve RL, Nestler EJ.

eNeuro. 2019 Apr 1;6(2). pii: ENEURO.0325-18.2019. doi: 10.1523/ENEURO.0325-18.2019. eCollection 2019 Mar-Apr.


The Molecular Basis of Drug Addiction: Linking Epigenetic to Synaptic and Circuit Mechanisms.

Nestler EJ, Lüscher C.

Neuron. 2019 Apr 3;102(1):48-59. doi: 10.1016/j.neuron.2019.01.016. Review.


Epigenetic Priming in Drug Addiction.

Mews P, Walker DM, Nestler EJ.

Cold Spring Harb Symp Quant Biol. 2019 Apr 1. pii: 037663. doi: 10.1101/sqb.2018.83.037663. [Epub ahead of print]


Environmental Programming of Susceptibility and Resilience to Stress in Adulthood in Male Mice.

Peña CJ, Nestler EJ, Bagot RC.

Front Behav Neurosci. 2019 Mar 1;13:40. doi: 10.3389/fnbeh.2019.00040. eCollection 2019.


Gadd45b mediates depressive-like role through DNA demethylation.

Labonté B, Jeong YH, Parise E, Issler O, Fatma M, Engmann O, Cho KA, Neve R, Nestler EJ, Koo JW.

Sci Rep. 2019 Mar 15;9(1):4615. doi: 10.1038/s41598-019-40844-8.


Viral labeling of neurons synaptically connected to nucleus accumbens somatostatin interneurons.

Ribeiro EA, Nectow AR, Pomeranz LE, Ekstrand MI, Koo JW, Nestler EJ.

PLoS One. 2019 Mar 7;14(3):e0213476. doi: 10.1371/journal.pone.0213476. eCollection 2019.


Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress.

Föcking M, Sabherwal S, Cates HM, Scaife C, Dicker P, Hryniewiecka M, Wynne K, Rutten BPF, Lewis G, Cannon M, Nestler EJ, Heurich M, Cagney G, Zammit S, Cotter DR.

Mol Psychiatry. 2019 Jan 11. doi: 10.1038/s41380-018-0306-z. [Epub ahead of print]


Knockdown of the histone di-methyltransferase G9a in nucleus accumbens shell decreases cocaine self-administration, stress-induced reinstatement, and anxiety.

Anderson EM, Sun H, Guzman D, Taniguchi M, Cowan CW, Maze I, Nestler EJ, Self DW.

Neuropsychopharmacology. 2018 Dec 26. doi: 10.1038/s41386-018-0305-4. [Epub ahead of print]


A novel role for E2F3b in regulating cocaine action in the prefrontal cortex.

Cates HM, Bagot RC, Heller EA, Purushothaman I, Lardner CK, Walker DM, Peña CJ, Neve RL, Shen L, Nestler EJ.

Neuropsychopharmacology. 2019 Mar;44(4):776-784. doi: 10.1038/s41386-018-0296-1. Epub 2018 Dec 14.


Author Correction: Epigenetic regulation in psychiatric disorders.

Tsankova N, Renthal W, Kumar A, Nestler EJ.

Nat Rev Neurosci. 2019 Mar;20(3):187-188. doi: 10.1038/s41583-018-0089-x.


VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine.

Jiang C, Lin WJ, Labonté B, Tamminga CA, Turecki G, Nestler EJ, Russo SJ, Salton SR.

Neuropsychopharmacology. 2019 Apr;44(5):971-981. doi: 10.1038/s41386-018-0277-4. Epub 2018 Nov 20.


Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder.

Tan A, Costi S, Morris LS, Van Dam NT, Kautz M, Whitton AE, Friedman AK, Collins KA, Ahle G, Chadha N, Do B, Pizzagalli DA, Iosifescu DV, Nestler EJ, Han MH, Murrough JW.

Mol Psychiatry. 2018 Nov 1. doi: 10.1038/s41380-018-0283-2. [Epub ahead of print]


α1- and β3-Adrenergic Receptor-Mediated Mesolimbic Homeostatic Plasticity Confers Resilience to Social Stress in Susceptible Mice.

Zhang H, Chaudhury D, Nectow AR, Friedman AK, Zhang S, Juarez B, Liu H, Pfau ML, Aleyasin H, Jiang C, Crumiller M, Calipari ES, Ku SM, Morel C, Tzavaras N, Montgomery SE, He M, Salton SR, Russo SJ, Nestler EJ, Friedman JM, Cao JL, Han MH.

Biol Psychiatry. 2019 Feb 1;85(3):226-236. doi: 10.1016/j.biopsych.2018.08.020. Epub 2018 Sep 6.


Stereotaxic Surgery and Viral Delivery of Zinc-Finger Epigenetic Editing Tools in Rodent Brain.

Hamilton PJ, Lim CJ, Nestler EJ, Heller EA.

Methods Mol Biol. 2018;1867:229-238. doi: 10.1007/978-1-4939-8799-3_17.


Methylation in OTX2 and related genes, maltreatment, and depression in children.

Kaufman J, Wymbs NF, Montalvo-Ortiz JL, Orr C, Albaugh MD, Althoff R, O'Loughlin K, Holbrook H, Garavan H, Kearney C, Yang BZ, Zhao H, Peña C, Nestler EJ, Lee RS, Mostofsky S, Gelernter J, Hudziak J.

Neuropsychopharmacology. 2018 Oct;43(11):2204-2211. doi: 10.1038/s41386-018-0157-y. Epub 2018 Jul 21.


Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine.

Ribeiro EA, Salery M, Scarpa JR, Calipari ES, Hamilton PJ, Ku SM, Kronman H, Purushothaman I, Juarez B, Heshmati M, Doyle M, Lardner C, Burek D, Strat A, Pirpinias S, Mouzon E, Han MH, Neve RL, Bagot RC, Kasarskis A, Koo JW, Nestler EJ.

Nat Commun. 2018 Aug 8;9(1):3149. doi: 10.1038/s41467-018-05657-9.


Genome-wide transcriptional profiling of central amygdala and orbitofrontal cortex during incubation of methamphetamine craving.

Cates HM, Li X, Purushothaman I, Kennedy PJ, Shen L, Shaham Y, Nestler EJ.

Neuropsychopharmacology. 2018 Nov;43(12):2426-2434. doi: 10.1038/s41386-018-0158-x. Epub 2018 Jul 20.


Withdrawal from repeated morphine administration augments expression of the RhoA network in the nucleus accumbens to control synaptic structure.

Cahill ME, Browne CJ, Wang J, Hamilton PJ, Dong Y, Nestler EJ.

J Neurochem. 2018 Oct;147(1):84-98. doi: 10.1111/jnc.14563. Epub 2018 Sep 26.


Progress in Epigenetics of Depression.

Peña CJ, Nestler EJ.

Prog Mol Biol Transl Sci. 2018;157:41-66. doi: 10.1016/bs.pmbts.2017.12.011. Epub 2018 Apr 10. Review.


Cell-Type-Specific Role of ΔFosB in Nucleus Accumbens In Modulating Intermale Aggression.

Aleyasin H, Flanigan ME, Golden SA, Takahashi A, Menard C, Pfau ML, Multer J, Pina J, McCabe KA, Bhatti N, Hodes GE, Heshmati M, Neve RL, Nestler EJ, Heller EA, Russo SJ.

J Neurosci. 2018 Jun 27;38(26):5913-5924. doi: 10.1523/JNEUROSCI.0296-18.2018. Epub 2018 Jun 11.


Voluntary wheel running promotes resilience to chronic social defeat stress in mice: a role for nucleus accumbens ΔFosB.

Mul JD, Soto M, Cahill ME, Ryan RE, Takahashi H, So K, Zheng J, Croote DE, Hirshman MF, la Fleur SE, Nestler EJ, Goodyear LJ.

Neuropsychopharmacology. 2018 Aug;43(9):1934-1942. doi: 10.1038/s41386-018-0103-z. Epub 2018 May 24.


Cocaine Self-administration Alters Transcriptome-wide Responses in the Brain's Reward Circuitry.

Walker DM, Cates HM, Loh YE, Purushothaman I, Ramakrishnan A, Cahill KM, Lardner CK, Godino A, Kronman HG, Rabkin J, Lorsch ZS, Mews P, Doyle MA, Feng J, Labonté B, Koo JW, Bagot RC, Logan RW, Seney ML, Calipari ES, Shen L, Nestler EJ.

Biol Psychiatry. 2018 Dec 15;84(12):867-880. doi: 10.1016/j.biopsych.2018.04.009. Epub 2018 Apr 25.


Corrigendum: Sex-specific transcriptional signatures in human depression.

Labonté B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, Scarpa JR, Moy G, Loh YE, Cahill M, Lorsch ZS, Hamilton PJ, Calipari ES, Hodes GE, Issler O, Kronman H, Pfau M, Obradovic ALJ, Dong Y, Neve RL, Russo S, Kasarskis A, Tamminga C, Mechawar N, Turecki G, Zhang B, Shen L, Nestler EJ.

Nat Med. 2018 Apr 10;24(4):525. doi: 10.1038/nm0418-525d.


Meeting Report: Can We Make Animal Models of Human Mental Illness?

Monteggia LM, Heimer H, Nestler EJ.

Biol Psychiatry. 2018 Oct 1;84(7):542-545. doi: 10.1016/j.biopsych.2018.02.010. Epub 2018 Feb 22.


Estrogen receptor α drives pro-resilient transcription in mouse models of depression.

Lorsch ZS, Loh YE, Purushothaman I, Walker DM, Parise EM, Salery M, Cahill ME, Hodes GE, Pfau ML, Kronman H, Hamilton PJ, Issler O, Labonté B, Symonds AE, Zucker M, Zhang TY, Meaney MJ, Russo SJ, Shen L, Bagot RC, Nestler EJ.

Nat Commun. 2018 Mar 16;9(1):1116. doi: 10.1038/s41467-018-03567-4.


Viral Expression of Epigenome Editing Tools in Rodent Brain Using Stereotaxic Surgery Techniques.

Hamilton PJ, Lim CJ, Nestler EJ, Heller EA.

Methods Mol Biol. 2018;1767:205-214. doi: 10.1007/978-1-4939-7774-1_10.


Neuroepigenetic Editing.

Hamilton PJ, Lim CJ, Nestler EJ, Heller EA.

Methods Mol Biol. 2018;1767:113-136. doi: 10.1007/978-1-4939-7774-1_5. Review.


Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability.

Hultman R, Ulrich K, Sachs BD, Blount C, Carlson DE, Ndubuizu N, Bagot RC, Parise EM, Vu MT, Gallagher NM, Wang J, Silva AJ, Deisseroth K, Mague SD, Caron MG, Nestler EJ, Carin L, Dzirasa K.

Cell. 2018 Mar 22;173(1):166-180.e14. doi: 10.1016/j.cell.2018.02.012.


Neuroepigenetics and addiction.

Walker DM, Nestler EJ.

Handb Clin Neurol. 2018;148:747-765. doi: 10.1016/B978-0-444-64076-5.00048-X. Review.


Role of Dorsal Striatum Histone Deacetylase 5 in Incubation of Methamphetamine Craving.

Li X, Carreria MB, Witonsky KR, Zeric T, Lofaro OM, Bossert JM, Zhang J, Surjono F, Richie CT, Harvey BK, Son H, Cowan CW, Nestler EJ, Shaham Y.

Biol Psychiatry. 2018 Aug 1;84(3):213-222. doi: 10.1016/j.biopsych.2017.12.008. Epub 2017 Dec 29.


Transcription Factor E2F3a in Nucleus Accumbens Affects Cocaine Action via Transcription and Alternative Splicing.

Cates HM, Heller EA, Lardner CK, Purushothaman I, Peña CJ, Walker DM, Cahill ME, Neve RL, Shen L, Bagot RC, Nestler EJ.

Biol Psychiatry. 2018 Aug 1;84(3):167-179. doi: 10.1016/j.biopsych.2017.11.027. Epub 2017 Dec 5.


Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine.

Calipari ES, Godino A, Peck EG, Salery M, Mervosh NL, Landry JA, Russo SJ, Hurd YL, Nestler EJ, Kiraly DD.

Nat Commun. 2018 Jan 16;9(1):9. doi: 10.1038/s41467-017-01881-x.


Overexpression of the Histone Dimethyltransferase G9a in Nucleus Accumbens Shell Increases Cocaine Self-Administration, Stress-Induced Reinstatement, and Anxiety.

Anderson EM, Larson EB, Guzman D, Wissman AM, Neve RL, Nestler EJ, Self DW.

J Neurosci. 2018 Jan 24;38(4):803-813. doi: 10.1523/JNEUROSCI.1657-17.2017. Epub 2017 Dec 7.


VGF function in depression and antidepressant efficacy.

Jiang C, Lin WJ, Sadahiro M, Labonté B, Menard C, Pfau ML, Tamminga CA, Turecki G, Nestler EJ, Russo SJ, Salton SR.

Mol Psychiatry. 2018 Jul;23(7):1632-1642. doi: 10.1038/mp.2017.233. Epub 2017 Nov 21.


Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits.

You JC, Muralidharan K, Park JW, Petrof I, Pyfer MS, Corbett BF, LaFrancois JJ, Zheng Y, Zhang X, Mohila CA, Yoshor D, Rissman RA, Nestler EJ, Scharfman HE, Chin J.

Nat Med. 2017 Nov;23(11):1377-1383. doi: 10.1038/nm.4413. Epub 2017 Oct 16.


Establishment of a repeated social defeat stress model in female mice.

Takahashi A, Chung JR, Zhang S, Zhang H, Grossman Y, Aleyasin H, Flanigan ME, Pfau ML, Menard C, Dumitriu D, Hodes GE, McEwen BS, Nestler EJ, Han MH, Russo SJ.

Sci Rep. 2017 Oct 9;7(1):12838. doi: 10.1038/s41598-017-12811-8.


Activator Protein-1: redox switch controlling structure and DNA-binding.

Yin Z, Machius M, Nestler EJ, Rudenko G.

Nucleic Acids Res. 2017 Nov 2;45(19):11425-11436. doi: 10.1093/nar/gkx795.


Nucleus accumbens feedforward inhibition circuit promotes cocaine self-administration.

Yu J, Yan Y, Li KL, Wang Y, Huang YH, Urban NN, Nestler EJ, Schlüter OM, Dong Y.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8750-E8759. doi: 10.1073/pnas.1707822114. Epub 2017 Sep 25.


Perinatal Malnutrition Leads to Sexually Dimorphic Behavioral Responses with Associated Epigenetic Changes in the Mouse Brain.

Nätt D, Barchiesi R, Murad J, Feng J, Nestler EJ, Champagne FA, Thorsell A.

Sci Rep. 2017 Sep 11;7(1):11082. doi: 10.1038/s41598-017-10803-2.


Treatment resistant depression: A multi-scale, systems biology approach.

Akil H, Gordon J, Hen R, Javitch J, Mayberg H, McEwen B, Meaney MJ, Nestler EJ.

Neurosci Biobehav Rev. 2018 Jan;84:272-288. doi: 10.1016/j.neubiorev.2017.08.019. Epub 2017 Aug 30. Review.


Poly (ADP-Ribose) Polymerase-1 (PARP-1) Induction by Cocaine Is Post-Transcriptionally Regulated by miR-125b.

Dash S, Balasubramaniam M, Rana T, Godino A, Peck EG, Goodwin JS, Villalta F, Calipari ES, Nestler EJ, Dash C, Pandhare J.

eNeuro. 2017 Aug 18;4(4). pii: ENEURO.0089-17.2017. doi: 10.1523/ENEURO.0089-17.2017. eCollection 2017 Jul-Aug. Erratum in: eNeuro. 2018 Apr 18;5(2):.


Sex-specific transcriptional signatures in human depression.

Labonté B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, Scarpa JR, Moy G, Loh YE, Cahill M, Lorsch ZS, Hamilton PJ, Calipari ES, Hodes GE, Issler O, Kronman H, Pfau M, Obradovic ALJ, Dong Y, Neve RL, Russo S, Kazarskis A, Tamminga C, Mechawar N, Turecki G, Zhang B, Shen L, Nestler EJ.

Nat Med. 2017 Sep;23(9):1102-1111. doi: 10.1038/nm.4386. Epub 2017 Aug 21. Erratum in: Nat Med. 2018 Apr 10;24(4):525.


BDNF-TrkB controls cocaine-induced dendritic spines in rodent nucleus accumbens dissociated from increases in addictive behaviors.

Anderson EM, Wissman AM, Chemplanikal J, Buzin N, Guzman D, Larson EB, Neve RL, Nestler EJ, Cowan CW, Self DW.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9469-9474. doi: 10.1073/pnas.1702441114. Epub 2017 Aug 14.


Gene Network Dysregulation in Dorsolateral Prefrontal Cortex Neurons of Humans with Cocaine Use Disorder.

Ribeiro EA, Scarpa JR, Garamszegi SP, Kasarskis A, Mash DC, Nestler EJ.

Sci Rep. 2017 Jul 14;7(1):5412. doi: 10.1038/s41598-017-05720-3.


ΔFosB Regulates Gene Expression and Cognitive Dysfunction in a Mouse Model of Alzheimer's Disease.

Corbett BF, You JC, Zhang X, Pyfer MS, Tosi U, Iascone DM, Petrof I, Hazra A, Fu CH, Stephens GS, Ashok AA, Aschmies S, Zhao L, Nestler EJ, Chin J.

Cell Rep. 2017 Jul 11;20(2):344-355. doi: 10.1016/j.celrep.2017.06.040.


The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.

Jiang Y, Loh YE, Rajarajan P, Hirayama T, Liao W, Kassim BS, Javidfar B, Hartley BJ, Kleofas L, Park RB, Labonte B, Ho SM, Chandrasekaran S, Do C, Ramirez BR, Peter CJ, C W JT, Safaie BM, Morishita H, Roussos P, Nestler EJ, Schaefer A, Tycko B, Brennand KJ, Yagi T, Shen L, Akbarian S.

Nat Genet. 2017 Aug;49(8):1239-1250. doi: 10.1038/ng.3906. Epub 2017 Jul 3.

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