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Items: 1 to 50 of 198

1.

Microbe-host interplay in atopic dermatitis and psoriasis.

Fyhrquist N, Muirhead G, Prast-Nielsen S, Jeanmougin M, Olah P, Skoog T, Jules-Clement G, Feld M, Barrientos-Somarribas M, Sinkko H, van den Bogaard EH, Zeeuwen PLJM, Rikken G, Schalkwijk J, Niehues H, Däubener W, Eller SK, Alexander H, Pennino D, Suomela S, Tessas I, Lybeck E, Baran AM, Darban H, Gangwar RS, Gerstel U, Jahn K, Karisola P, Yan L, Hansmann B, Katayama S, Meller S, Bylesjö M, Hupé P, Levi-Schaffer F, Greco D, Ranki A, Schröder JM, Barker J, Kere J, Tsoka S, Lauerma A, Soumelis V, Nestle FO, Homey B, Andersson B, Alenius H.

Nat Commun. 2019 Oct 16;10(1):4703. doi: 10.1038/s41467-019-12253-y.

2.

Translational drug discovery and development with the use of tissue-relevant biomarkers: Towards more physiological relevance and better prediction of clinical efficacy.

Florian P, Flechsenhar KR, Bartnik E, Ding-Pfennigdorff D, Herrmann M, Bryce PJ, Nestle FO.

Exp Dermatol. 2019 Apr 16. doi: 10.1111/exd.13942. [Epub ahead of print] Review.

PMID:
30991456
3.

Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment.

Georgouli M, Herraiz C, Crosas-Molist E, Fanshawe B, Maiques O, Perdrix A, Pandya P, Rodriguez-Hernandez I, Ilieva KM, Cantelli G, Karagiannis P, Mele S, Lam H, Josephs DH, Matias-Guiu X, Marti RM, Nestle FO, Orgaz JL, Malanchi I, Fruhwirth GO, Karagiannis SN, Sanz-Moreno V.

Cell. 2019 Feb 7;176(4):757-774.e23. doi: 10.1016/j.cell.2018.12.038. Epub 2019 Jan 31.

4.

Anti-Folate Receptor Alpha-Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer.

Cheung A, Opzoomer J, Ilieva KM, Gazinska P, Hoffmann RM, Mirza H, Marlow R, Francesch-Domenech E, Fittall M, Dominguez Rodriguez D, Clifford A, Badder L, Patel N, Mele S, Pellizzari G, Bax HJ, Crescioli S, Petranyi G, Larcombe-Young D, Josephs DH, Canevari S, Figini M, Pinder S, Nestle FO, Gillett C, Spicer JF, Grigoriadis A, Tutt ANJ, Karagiannis SN.

Clin Cancer Res. 2018 Oct 15;24(20):5098-5111. doi: 10.1158/1078-0432.CCR-18-0652. Epub 2018 Aug 1.

5.

Skin resident memory CD8+ T cells are phenotypically and functionally distinct from circulating populations and lack immediate cytotoxic function.

Seidel JA, Vukmanovic-Stejic M, Muller-Durovic B, Patel N, Fuentes-Duculan J, Henson SM, Krueger JG, Rustin MHA, Nestle FO, Lacy KE, Akbar AN.

Clin Exp Immunol. 2018 Oct;194(1):79-92. doi: 10.1111/cei.13189. Epub 2018 Sep 12.

6.

An immunologically relevant rodent model demonstrates safety of therapy using a tumour-specific IgE.

Josephs DH, Nakamura M, Bax HJ, Dodev TS, Muirhead G, Saul L, Karagiannis P, Ilieva KM, Crescioli S, Gazinska P, Woodman N, Lombardelli C, Kareemaghay S, Selkirk C, Lentfer H, Barton C, Canevari S, Figini M, Downes N, Dombrowicz D, Corrigan CJ, Nestle FO, Jones PS, Gould HJ, Blower PJ, Tsoka S, Spicer JF, Karagiannis SN.

Allergy. 2018 Dec;73(12):2328-2341. doi: 10.1111/all.13455. Epub 2018 Oct 8.

7.

Evaluation of Antigen-Conjugated Fluorescent Beads to Identify Antigen-Specific B Cells.

Correa I, Ilieva KM, Crescioli S, Lombardi S, Figini M, Cheung A, Spicer JF, Tutt ANJ, Nestle FO, Karagiannis P, Lacy KE, Karagiannis SN.

Front Immunol. 2018 Mar 23;9:493. doi: 10.3389/fimmu.2018.00493. eCollection 2018.

8.

Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.

Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD.

Cell. 2017 Jun 1;169(6):1119-1129.e11. doi: 10.1016/j.cell.2017.05.002. Epub 2017 May 25.

9.

Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling.

Josephs DH, Bax HJ, Dodev T, Georgouli M, Nakamura M, Pellizzari G, Saul L, Karagiannis P, Cheung A, Herraiz C, Ilieva KM, Correa I, Fittall M, Crescioli S, Gazinska P, Woodman N, Mele S, Chiaruttini G, Gilbert AE, Koers A, Bracher M, Selkirk C, Lentfer H, Barton C, Lever E, Muirhead G, Tsoka S, Canevari S, Figini M, Montes A, Downes N, Dombrowicz D, Corrigan CJ, Beavil AJ, Nestle FO, Jones PS, Gould HJ, Sanz-Moreno V, Blower PJ, Spicer JF, Karagiannis SN.

Cancer Res. 2017 Mar 1;77(5):1127-1141. doi: 10.1158/0008-5472.CAN-16-1829. Epub 2017 Jan 17.

10.

Innate and adaptive immune traits are differentially affected by genetic and environmental factors.

Mangino M, Roederer M, Beddall MH, Nestle FO, Spector TD.

Nat Commun. 2017 Jan 5;8:13850. doi: 10.1038/ncomms13850.

11.

Pathogenesis and immunotherapy in cutaneous psoriasis: what can rheumatologists learn?

Alexander H, Nestle FO.

Curr Opin Rheumatol. 2017 Jan;29(1):71-78. Review.

PMID:
27875351
12.

T Cell-Independent Mechanisms Associated with Neutrophil Extracellular Trap Formation and Selective Autophagy in IL-17A-Mediated Epidermal Hyperplasia.

Suzuki E, Maverakis E, Sarin R, Bouchareychas L, Kuchroo VK, Nestle FO, Adamopoulos IE.

J Immunol. 2016 Dec 1;197(11):4403-4412. Epub 2016 Oct 24.

13.

PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells.

Nicholas NS, Pipili A, Lesjak MS, Ameer-Beg SM, Geh JL, Healy C, MacKenzie Ross AD, Parsons M, Nestle FO, Lacy KE, Wells CM.

Oncotarget. 2016 Oct 25;7(43):70881-70897. doi: 10.18632/oncotarget.12282.

14.

IgG subclass switching and clonal expansion in cutaneous melanoma and normal skin.

Saul L, Ilieva KM, Bax HJ, Karagiannis P, Correa I, Rodriguez-Hernandez I, Josephs DH, Tosi I, Egbuniwe IU, Lombardi S, Crescioli S, Hobbs C, Villanova F, Cheung A, Geh JL, Healy C, Harries M, Sanz-Moreno V, Fear DJ, Spicer JF, Lacy KE, Nestle FO, Karagiannis SN.

Sci Rep. 2016 Jul 14;6:29736. doi: 10.1038/srep29736.

15.

Targeting CD8(+) T cells prevents psoriasis development.

Di Meglio P, Villanova F, Navarini AA, Mylonas A, Tosi I, Nestle FO, Conrad C.

J Allergy Clin Immunol. 2016 Jul;138(1):274-276.e6. doi: 10.1016/j.jaci.2015.10.046. Epub 2016 Jan 9. No abstract available.

16.

IgG4 Characteristics and Functions in Cancer Immunity.

Crescioli S, Correa I, Karagiannis P, Davies AM, Sutton BJ, Nestle FO, Karagiannis SN.

Curr Allergy Asthma Rep. 2016 Jan;16(1):7. doi: 10.1007/s11882-015-0580-7. Review.

17.

Establishing an Academic-Industrial Stratified Medicine Consortium: Psoriasis Stratification to Optimize Relevant Therapy.

Griffiths CEM, Barnes MR, Burden AD, Nestle FO, Reynolds NJ, Smith CH, Warren RB, Barker JNWN, On Behalf Of The Psort Consortium.

J Invest Dermatol. 2015 Dec;135(12):2903-2907. doi: 10.1038/jid.2015.286. No abstract available.

18.

TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination.

Cantelli G, Orgaz JL, Rodriguez-Hernandez I, Karagiannis P, Maiques O, Matias-Guiu X, Nestle FO, Marti RM, Karagiannis SN, Sanz-Moreno V.

Curr Biol. 2015 Nov 16;25(22):2899-914. doi: 10.1016/j.cub.2015.09.054. Epub 2015 Oct 29.

19.

Pathogenesis and treatment of psoriasis: exploiting pathophysiological pathways for precision medicine.

Alwan W, Nestle FO.

Clin Exp Rheumatol. 2015 Sep-Oct;33(5 Suppl 93):S2-6. Epub 2015 Oct 15. Review.

PMID:
26472336
20.

Elevated IgG4 in patient circulation is associated with the risk of disease progression in melanoma.

Karagiannis P, Villanova F, Josephs DH, Correa I, Van Hemelrijck M, Hobbs C, Saul L, Egbuniwe IU, Tosi I, Ilieva KM, Kent E, Calonje E, Harries M, Fentiman I, Taylor-Papadimitriou J, Burchell J, Spicer JF, Lacy KE, Nestle FO, Karagiannis SN.

Oncoimmunology. 2015 Jun 3;4(11):e1032492. eCollection 2015 Nov.

21.

Practical guidance on immunogenicity to biologic agents used in the treatment of psoriasis: What can be learnt from other diseases?

Lambert J, Nast A, Nestle FO, Prinz JC.

J Dermatolog Treat. 2015;26(6):520-7. doi: 10.3109/09546634.2015.1034076. Epub 2015 Jun 25. Review.

PMID:
26108443
22.

The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis.

Roederer M, Quaye L, Mangino M, Beddall MH, Mahnke Y, Chattopadhyay P, Tosi I, Napolitano L, Terranova Barberio M, Menni C, Villanova F, Di Meglio P, Spector TD, Nestle FO.

Cell. 2015 Apr 9;161(2):387-403. doi: 10.1016/j.cell.2015.02.046. Epub 2015 Mar 12.

23.

The Characterization of Varicella Zoster Virus-Specific T Cells in Skin and Blood during Aging.

Vukmanovic-Stejic M, Sandhu D, Seidel JA, Patel N, Sobande TO, Agius E, Jackson SE, Fuentes-Duculan J, Suárez-Fariñas M, Mabbott NA, Lacy KE, Ogg G, Nestle FO, Krueger JG, Rustin MHA, Akbar AN.

J Invest Dermatol. 2015 Jul;135(7):1752-1762. doi: 10.1038/jid.2015.63. Epub 2015 Mar 3.

24.

Revisiting the role of B cells in skin immune surveillance.

Egbuniwe IU, Karagiannis SN, Nestle FO, Lacy KE.

Trends Immunol. 2015 Feb;36(2):102-11. doi: 10.1016/j.it.2014.12.006. Epub 2015 Jan 21. Review.

PMID:
25616715
25.

Effects of BRAF mutations and BRAF inhibition on immune responses to melanoma.

Ilieva KM, Correa I, Josephs DH, Karagiannis P, Egbuniwe IU, Cafferkey MJ, Spicer JF, Harries M, Nestle FO, Lacy KE, Karagiannis SN.

Mol Cancer Ther. 2014 Dec;13(12):2769-83. doi: 10.1158/1535-7163.MCT-14-0290. Epub 2014 Nov 10. Review.

26.

Pathway-level disease data mining through hyper-box principles.

Yang L, Ainali C, Kittas A, Nestle FO, Papageorgiou LG, Tsoka S.

Math Biosci. 2015 Feb;260:25-34. doi: 10.1016/j.mbs.2014.09.005. Epub 2014 Sep 19.

PMID:
25242610
27.

Immunogenicity of biotherapy used in psoriasis: the science behind the scenes.

Jullien D, Prinz JC, Nestle FO.

J Invest Dermatol. 2015 Jan;135(1):31-38. doi: 10.1038/jid.2014.295. Epub 2014 Aug 14. Review.

28.

Psoriasis.

Di Meglio P, Villanova F, Nestle FO.

Cold Spring Harb Perspect Med. 2014 Aug 1;4(8). pii: a015354. doi: 10.1101/cshperspect.a015354. Review.

29.

Diverse matrix metalloproteinase functions regulate cancer amoeboid migration.

Orgaz JL, Pandya P, Dalmeida R, Karagiannis P, Sanchez-Laorden B, Viros A, Albrengues J, Nestle FO, Ridley AJ, Gaggioli C, Marais R, Karagiannis SN, Sanz-Moreno V.

Nat Commun. 2014 Jun 25;5:4255. doi: 10.1038/ncomms5255.

30.

Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions.

Di Meglio P, Duarte JH, Ahlfors H, Owens ND, Li Y, Villanova F, Tosi I, Hirota K, Nestle FO, Mrowietz U, Gilchrist MJ, Stockinger B.

Immunity. 2014 Jun 19;40(6):989-1001. doi: 10.1016/j.immuni.2014.04.019. Epub 2014 Jun 5.

31.

Clinical relevance of immunogenicity of biologics in psoriasis: implications for treatment strategies.

Carrascosa JM, van Doorn MB, Lahfa M, Nestle FO, Jullien D, Prinz JC.

J Eur Acad Dermatol Venereol. 2014 Nov;28(11):1424-30. doi: 10.1111/jdv.12549. Epub 2014 May 20. Review.

PMID:
24841895
32.

Mechanisms regulating skin immunity and inflammation.

Pasparakis M, Haase I, Nestle FO.

Nat Rev Immunol. 2014 May;14(5):289-301. doi: 10.1038/nri3646. Epub 2014 Apr 11. Review.

PMID:
24722477
33.

Early intervention in psoriasis and immune-mediated inflammatory diseases: A hypothesis paper.

Girolomoni G, Griffiths CE, Krueger J, Nestle FO, Nicolas JF, Prinz JC, Puig L, Ståhle M, van de Kerkhof PC, Allez M, Emery P, Paul C.

J Dermatolog Treat. 2015 Apr;26(2):103-12. doi: 10.3109/09546634.2014.880396. Epub 2014 Feb 19. Review.

PMID:
24547907
34.

Integrative biology approach identifies cytokine targeting strategies for psoriasis.

Perera GK, Ainali C, Semenova E, Hundhausen C, Barinaga G, Kassen D, Williams AE, Mirza MM, Balazs M, Wang X, Rodriguez RS, Alendar A, Barker J, Tsoka S, Ouyang W, Nestle FO.

Sci Transl Med. 2014 Feb 12;6(223):223ra22. doi: 10.1126/scitranslmed.3007217.

35.

The IL-23/IL-17 axis in psoriatic arthritis.

Suzuki E, Mellins ED, Gershwin ME, Nestle FO, Adamopoulos IE.

Autoimmun Rev. 2014 Apr-May;13(4-5):496-502. doi: 10.1016/j.autrev.2014.01.050. Epub 2014 Jan 11. Review.

36.

Psoriasis beyond the skin: an expert group consensus on the management of psoriatic arthritis and common co-morbidities in patients with moderate-to-severe psoriasis.

Strohal R, Kirby B, Puig L; Psoriasis Expert Panel, Girolomoni G, Kragballe K, Luger T, Nestle FO, Prinz JC, Ståhle M, Yawalkar N.

J Eur Acad Dermatol Venereol. 2014 Dec;28(12):1661-9. doi: 10.1111/jdv.12350. Epub 2013 Dec 24.

37.

Characterization of innate lymphoid cells in human skin and blood demonstrates increase of NKp44+ ILC3 in psoriasis.

Villanova F, Flutter B, Tosi I, Grys K, Sreeneebus H, Perera GK, Chapman A, Smith CH, Di Meglio P, Nestle FO.

J Invest Dermatol. 2014 Apr;134(4):984-991. doi: 10.1038/jid.2013.477. Epub 2013 Nov 11.

38.

TLRs to cytokines: mechanistic insights from the imiquimod mouse model of psoriasis.

Flutter B, Nestle FO.

Eur J Immunol. 2013 Dec;43(12):3138-46. doi: 10.1002/eji.201343801. Epub 2013 Nov 20.

39.
40.

IgG4 antibodies and cancer-associated inflammation: Insights into a novel mechanism of immune escape.

Karagiannis P, Gilbert AE, Nestle FO, Karagiannis SN.

Oncoimmunology. 2013 Jul 1;2(7):e24889. Epub 2013 May 7.

41.

An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element.

Clop A, Bertoni A, Spain SL, Simpson MA, Pullabhatla V, Tonda R, Hundhausen C, Di Meglio P, De Jong P, Hayday AC, Nestle FO, Barker JN, Bell RJ, Capon F, Trembath RC.

PLoS One. 2013 Aug 19;8(8):e71690. doi: 10.1371/journal.pone.0071690. eCollection 2013.

42.

The mechanistic basis for psoriasis immunopathogenesis: translating genotype to phenotype. Report of a workshop, Venice, 2012.

Bachelez H, Viguier M, Tebbey PW, Lowes M, Suárez-Fariñas M, Costanzo A, Nestle FO.

Br J Dermatol. 2013 Aug;169(2):283-6. doi: 10.1111/bjd.12347.

PMID:
23941252
43.

Gene expression changes with age in skin, adipose tissue, blood and brain.

Glass D, Viñuela A, Davies MN, Ramasamy A, Parts L, Knowles D, Brown AA, Hedman AK, Small KS, Buil A, Grundberg E, Nica AC, Di Meglio P, Nestle FO, Ryten M; UK Brain Expression consortium; MuTHER consortium, Durbin R, McCarthy MI, Deloukas P, Dermitzakis ET, Weale ME, Bataille V, Spector TD.

Genome Biol. 2013 Jul 26;14(7):R75. doi: 10.1186/gb-2013-14-7-r75.

44.

Integration of lyoplate based flow cytometry and computational analysis for standardized immunological biomarker discovery.

Villanova F, Di Meglio P, Inokuma M, Aghaeepour N, Perucha E, Mollon J, Nomura L, Hernandez-Fuentes M, Cope A, Prevost AT, Heck S, Maino V, Lord G, Brinkman RR, Nestle FO.

PLoS One. 2013 Jul 3;8(7):e65485. doi: 10.1371/journal.pone.0065485. Print 2013.

45.

The IL23R A/Gln381 allele promotes IL-23 unresponsiveness in human memory T-helper 17 cells and impairs Th17 responses in psoriasis patients.

Di Meglio P, Villanova F, Napolitano L, Tosi I, Terranova Barberio M, Mak RK, Nutland S, Smith CH, Barker JNWN, Todd JA, Nestle FO.

J Invest Dermatol. 2013 Oct;133(10):2381-2389. doi: 10.1038/jid.2013.170. Epub 2013 Apr 5. Erratum in: J Invest Dermatol. 2014 Jun;134(6):1779. Barberio, Manuela Terranova [corrected to Terranova Barberio, Manuela].

46.

Biomarkers in psoriasis and psoriatic arthritis.

Villanova F, Di Meglio P, Nestle FO.

Ann Rheum Dis. 2013 Apr;72 Suppl 2:ii104-10. doi: 10.1136/annrheumdis-2012-203037. Review.

PMID:
23532439
47.

IgG4 subclass antibodies impair antitumor immunity in melanoma.

Karagiannis P, Gilbert AE, Josephs DH, Ali N, Dodev T, Saul L, Correa I, Roberts L, Beddowes E, Koers A, Hobbs C, Ferreira S, Geh JL, Healy C, Harries M, Acland KM, Blower PJ, Mitchell T, Fear DJ, Spicer JF, Lacy KE, Nestle FO, Karagiannis SN.

J Clin Invest. 2013 Apr;123(4):1457-74.

48.

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.

Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, Kang HM, Allen MH, McManus R, Novelli G, Samuelsson L, Schalkwijk J, Ståhle M, Burden AD, Smith CH, Cork MJ, Estivill X, Bowcock AM, Krueger GG, Weger W, Worthington J, Tazi-Ahnini R, Nestle FO, Hayday A, Hoffmann P, Winkelmann J, Wijmenga C, Langford C, Edkins S, Andrews R, Blackburn H, Strange A, Band G, Pearson RD, Vukcevic D, Spencer CC, Deloukas P, Mrowietz U, Schreiber S, Weidinger S, Koks S, Kingo K, Esko T, Metspalu A, Lim HW, Voorhees JJ, Weichenthal M, Wichmann HE, Chandran V, Rosen CF, Rahman P, Gladman DD, Griffiths CE, Reis A, Kere J; Collaborative Association Study of Psoriasis (CASP); Genetic Analysis of Psoriasis Consortium; Psoriasis Association Genetics Extension; Wellcome Trust Case Control Consortium 2, Nair RP, Franke A, Barker JN, Abecasis GR, Elder JT, Trembath RC.

Nat Genet. 2012 Dec;44(12):1341-8. doi: 10.1038/ng.2467. Epub 2012 Nov 11.

49.

Toward prediction of immune mechanisms and design of immunotherapies in melanoma.

Tsoka S, Ainali C, Karagiannis P, Josephs DH, Saul L, Nestle FO, Karagiannis SN.

Crit Rev Biomed Eng. 2012;40(4):279-94. Review.

PMID:
23140120
50.

Transcriptome classification reveals molecular subtypes in psoriasis.

Ainali C, Valeyev N, Perera G, Williams A, Gudjonsson JE, Ouzounis CA, Nestle FO, Tsoka S.

BMC Genomics. 2012 Sep 12;13:472. doi: 10.1186/1471-2164-13-472.

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