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Systematic allelic analysis defines the interplay of key pathways in X chromosome inactivation.

Nesterova TB, Wei G, Coker H, Pintacuda G, Bowness JS, Zhang T, Almeida M, Bloechl B, Moindrot B, Carter EJ, Alvarez Rodrigo I, Pan Q, Bi Y, Song CX, Brockdorff N.

Nat Commun. 2019 Jul 16;10(1):3129. doi: 10.1038/s41467-019-11171-3.


The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome.

Gdula MR, Nesterova TB, Pintacuda G, Godwin J, Zhan Y, Ozadam H, McClellan M, Moralli D, Krueger F, Green CM, Reik W, Kriaucionis S, Heard E, Dekker J, Brockdorff N.

Nat Commun. 2019 Jan 3;10(1):30. doi: 10.1038/s41467-018-07907-2.


hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing.

Pintacuda G, Wei G, Roustan C, Kirmizitas BA, Solcan N, Cerase A, Castello A, Mohammed S, Moindrot B, Nesterova TB, Brockdorff N.

Mol Cell. 2017 Dec 7;68(5):955-969.e10. doi: 10.1016/j.molcel.2017.11.013.


PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation.

Almeida M, Pintacuda G, Masui O, Koseki Y, Gdula M, Cerase A, Brown D, Mould A, Innocent C, Nakayama M, Schermelleh L, Nesterova TB, Koseki H, Brockdorff N.

Science. 2017 Jun 9;356(6342):1081-1084. doi: 10.1126/science.aal2512.


The nuclear matrix protein CIZ1 facilitates localization of Xist RNA to the inactive X-chromosome territory.

Ridings-Figueroa R, Stewart ER, Nesterova TB, Coker H, Pintacuda G, Godwin J, Wilson R, Haslam A, Lilley F, Ruigrok R, Bageghni SA, Albadrani G, Mansfield W, Roulson JA, Brockdorff N, Ainscough JFX, Coverley D.

Genes Dev. 2017 May 1;31(9):876-888. doi: 10.1101/gad.295907.117. Epub 2017 May 25.


Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.

Cooper S, Grijzenhout A, Underwood E, Ancelin K, Zhang T, Nesterova TB, Anil-Kirmizitas B, Bassett A, Kooistra SM, Agger K, Helin K, Heard E, Brockdorff N.

Nat Commun. 2016 Nov 28;7:13661. doi: 10.1038/ncomms13661.


Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells.

von Meyenn F, Iurlaro M, Habibi E, Liu NQ, Salehzadeh-Yazdi A, Santos F, Petrini E, Milagre I, Yu M, Xie Z, Kroeze LI, Nesterova TB, Jansen JH, Xie H, He C, Reik W, Stunnenberg HG.

Mol Cell. 2016 Jun 16;62(6):983. doi: 10.1016/j.molcel.2016.06.005. Epub 2016 Jun 16. No abstract available.


Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells.

von Meyenn F, Iurlaro M, Habibi E, Liu NQ, Salehzadeh-Yazdi A, Santos F, Petrini E, Milagre I, Yu M, Xie Z, Kroeze LI, Nesterova TB, Jansen JH, Xie H, He C, Reik W, Stunnenberg HG.

Mol Cell. 2016 Jun 16;62(6):848-861. doi: 10.1016/j.molcel.2016.04.025. Epub 2016 May 26. Erratum in: Mol Cell. 2016 Jun 16;62(6):983.


MicroRNAs of the miR-290-295 Family Maintain Bivalency in Mouse Embryonic Stem Cells.

Graham B, Marcais A, Dharmalingam G, Carroll T, Kanellopoulou C, Graumann J, Nesterova TB, Bermange A, Brazauskas P, Xella B, Kriaucionis S, Higgs DR, Brockdorff N, Mann M, Fisher AG, Merkenschlager M.

Stem Cell Reports. 2016 May 10;6(5):635-642. doi: 10.1016/j.stemcr.2016.03.005. Epub 2016 Apr 14.


Independent Mechanisms Target SMCHD1 to Trimethylated Histone H3 Lysine 9-Modified Chromatin and the Inactive X Chromosome.

Brideau NJ, Coker H, Gendrel AV, Siebert CA, Bezstarosti K, Demmers J, Poot RA, Nesterova TB, Brockdorff N.

Mol Cell Biol. 2015 Dec;35(23):4053-68. doi: 10.1128/MCB.00432-15. Epub 2015 Sep 21.


A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing.

Moindrot B, Cerase A, Coker H, Masui O, Grijzenhout A, Pintacuda G, Schermelleh L, Nesterova TB, Brockdorff N.

Cell Rep. 2015 Jul 28;12(4):562-72. doi: 10.1016/j.celrep.2015.06.053. Epub 2015 Jul 16.


Spatial separation of Xist RNA and polycomb proteins revealed by superresolution microscopy.

Cerase A, Smeets D, Tang YA, Gdula M, Kraus F, Spivakov M, Moindrot B, Leleu M, Tattermusch A, Demmerle J, Nesterova TB, Green C, Otte AP, Schermelleh L, Brockdorff N.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2235-40. doi: 10.1073/pnas.1312951111. Epub 2014 Jan 27.


Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes.

Gendrel AV, Tang YA, Suzuki M, Godwin J, Nesterova TB, Greally JM, Heard E, Brockdorff N.

Mol Cell Biol. 2013 Aug;33(16):3150-65. doi: 10.1128/MCB.00145-13. Epub 2013 Jun 10.


Pluripotency factor binding and Tsix expression act synergistically to repress Xist in undifferentiated embryonic stem cells.

Nesterova TB, Senner CE, Schneider J, Alcayna-Stevens T, Tattermusch A, Hemberger M, Brockdorff N.

Epigenetics Chromatin. 2011 Oct 7;4(1):17. doi: 10.1186/1756-8935-4-17.


Variability of sequence surrounding the Xist gene in rodents suggests taxon-specific regulation of X chromosome inactivation.

Shevchenko AI, Malakhova AA, Elisaphenko EA, Mazurok NA, Nesterova TB, Brockdorff N, Zakian SM.

PLoS One. 2011;6(8):e22771. doi: 10.1371/journal.pone.0022771. Epub 2011 Aug 3.


Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X-linked gene silencing during random and imprinted X chromosome inactivation.

Senner CE, Nesterova TB, Norton S, Dewchand H, Godwin J, Mak W, Brockdorff N.

Development. 2011 Apr;138(8):1541-50. doi: 10.1242/dev.056812. Epub 2011 Mar 9.


Histone H3 trimethylation at lysine 9 marks the inactive metaphase X chromosome in the marsupial Monodelphis domestica.

Zakharova IS, Shevchenko AI, Shilov AG, Nesterova TB, Vandeberg JL, Zakian SM.

Chromosoma. 2011 Apr;120(2):177-83. doi: 10.1007/s00412-010-0300-y. Epub 2010 Nov 26.


Difference between random and imprinted X inactivation in common voles.

Dementyeva EV, Shevchenko AI, Anopriyenko OV, Mazurok NA, Elisaphenko EA, Nesterova TB, Brockdorff N, Zakian SM.

Chromosoma. 2010 Oct;119(5):541-52. doi: 10.1007/s00412-010-0277-6. Epub 2010 May 15.


Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation.

Tang YA, Huntley D, Montana G, Cerase A, Nesterova TB, Brockdorff N.

Epigenetics Chromatin. 2010 May 7;3(1):10. doi: 10.1186/1756-8935-3-10.


FGF4 independent derivation of trophoblast stem cells from the common vole.

Grigor'eva EV, Shevchenko AI, Mazurok NA, Elisaphenko EA, Zhelezova AI, Shilov AG, Dyban PA, Dyban AP, Noniashvili EM, Slobodyanyuk SY, Nesterova TB, Brockdorff N, Zakian SM.

PLoS One. 2009 Sep 24;4(9):e7161. doi: 10.1371/journal.pone.0007161.


Genome Environment Browser (GEB): a dynamic browser for visualising high-throughput experimental data in the context of genome features.

Huntley D, Tang YA, Nesterova TB, Butcher S, Brockdorff N.

BMC Bioinformatics. 2008 Nov 27;9:501. doi: 10.1186/1471-2105-9-501.


Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a.

Nesterova TB, Popova BC, Cobb BS, Norton S, Senner CE, Tang YA, Spruce T, Rodriguez TA, Sado T, Merkenschlager M, Brockdorff N.

Epigenetics Chromatin. 2008 Oct 27;1(1):2. doi: 10.1186/1756-8935-1-2.


A dual origin of the Xist gene from a protein-coding gene and a set of transposable elements.

Elisaphenko EA, Kolesnikov NN, Shevchenko AI, Rogozin IB, Nesterova TB, Brockdorff N, Zakian SM.

PLoS One. 2008 Jun 25;3(6):e2521. doi: 10.1371/journal.pone.0002521.


Structure and expression pattern of Oct4 gene are conserved in vole Microtus rossiaemeridionalis.

Medvedev SP, Shevchenko AI, Elisaphenko EA, Nesterova TB, Brockdorff N, Zakian SM.

BMC Genomics. 2008 Apr 11;9:162. doi: 10.1186/1471-2164-9-162.


Genes flanking Xist in mouse and human are separated on the X chromosome in American marsupials.

Shevchenko AI, Zakharova IS, Elisaphenko EA, Kolesnikov NN, Whitehead S, Bird C, Ross M, Weidman JR, Jirtle RL, Karamysheva TV, Rubtsov NB, VandeBerg JL, Mazurok NA, Nesterova TB, Brockdorff N, Zakian SM.

Chromosome Res. 2007;15(2):127-36. Epub 2007 Mar 5.


Attenuated spread of X-inactivation in an X;autosome translocation.

Popova BC, Tada T, Takagi N, Brockdorff N, Nesterova TB.

Proc Natl Acad Sci U S A. 2006 May 16;103(20):7706-11. Epub 2006 May 5.


T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer.

Cobb BS, Nesterova TB, Thompson E, Hertweck A, O'Connor E, Godwin J, Wilson CB, Brockdorff N, Fisher AG, Smale ST, Merkenschlager M.

J Exp Med. 2005 May 2;201(9):1367-73.


Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation.

de Napoles M, Mermoud JE, Wakao R, Tang YA, Endoh M, Appanah R, Nesterova TB, Silva J, Otte AP, Vidal M, Koseki H, Brockdorff N.

Dev Cell. 2004 Nov;7(5):663-76.


Reactivation of the paternal X chromosome in early mouse embryos.

Mak W, Nesterova TB, de Napoles M, Appanah R, Yamanaka S, Otte AP, Brockdorff N.

Science. 2004 Jan 30;303(5658):666-9.


Skewing X chromosome choice by modulating sense transcription across the Xist locus.

Nesterova TB, Johnston CM, Appanah R, Newall AE, Godwin J, Alexiou M, Brockdorff N.

Genes Dev. 2003 Sep 1;17(17):2177-90.


Reorganization of the X chromosome in voles of the genus Microtus.

Rubtsov NB, Rubtsova NV, Anopriyenko OV, Karamysheva TV, Shevchenko AI, Mazurok NA, Nesterova TB, Zakian SM.

Cytogenet Genome Res. 2002;99(1-4):323-9.


Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes.

Silva J, Mak W, Zvetkova I, Appanah R, Nesterova TB, Webster Z, Peters AH, Jenuwein T, Otte AP, Brockdorff N.

Dev Cell. 2003 Apr;4(4):481-95.


Enox, a novel gene that maps 10 kb upstream of Xist and partially escapes X inactivation.

Johnston CM, Newall AE, Brockdorff N, Nesterova TB.

Genomics. 2002 Aug;80(2):236-44.


Xist expression and macroH2A1.2 localisation in mouse primordial and pluripotent embryonic germ cells.

Nesterova TB, Mermoud JE, Hilton K, Pehrson J, Surani MA, McLaren A, Brockdorff N.

Differentiation. 2002 Jan;69(4-5):216-25.


The Vole Gene Map.

Nesterova TB, Mazurok NA, Rubtsova NV, Isaenko AA, Zakian SM.

ILAR J. 1998;39(2-3):138-144. No abstract available.


[Gene for structural proteins of the SMC family in the common vole Microtus arvalis].

Pavlova SV, Nesterova TB, Zakiian SM.

Mol Biol (Mosk). 2001 May-Jun;35(3):383-90. Russian.


Loss of Xist imprinting in diploid parthenogenetic preimplantation embryos.

Nesterova TB, Barton SC, Surani MA, Brockdorff N.

Dev Biol. 2001 Jul 15;235(2):343-50.


Characterization of the genomic Xist locus in rodents reveals conservation of overall gene structure and tandem repeats but rapid evolution of unique sequence.

Nesterova TB, Slobodyanyuk SY, Elisaphenko EA, Shevchenko AI, Johnston C, Pavlova ME, Rogozin IB, Kolesnikov NN, Brockdorff N, Zakian SM.

Genome Res. 2001 May;11(5):833-49.


Comparative chromosome and mitochondrial DNA analyses and phylogenetic relationships within common voles (Microtus, Arvicolidae).

Mazurok NA, Rubtsova NV, Isaenko AA, Pavlova ME, Slobodyanyuk SY, Nesterova TB, Zakian SM.

Chromosome Res. 2001;9(2):107-20.


Xist RNA exhibits a banded localization on the inactive X chromosome and is excluded from autosomal material in cis.

Duthie SM, Nesterova TB, Formstone EJ, Keohane AM, Turner BM, Zakian SM, Brockdorff N.

Hum Mol Genet. 1999 Feb;8(2):195-204.


[High-resolution GTG-banding and nucleolar organizer regions of chromosomes of two vole species: Microtus rossiaemeridonionalis and M. transcaspicus (Rodentia, Arvicolidae)].

Mazurok NA, Rubtsova NV, Isaenko AA, Nesterova TB, Meń≠er MN, Zakiian SM.

Genetika. 1998 Aug;34(8):1073-80. Russian.


Developmentally regulated Xist promoter switch mediates initiation of X inactivation.

Johnston CM, Nesterova TB, Formstone EJ, Newall AE, Duthie SM, Sheardown SA, Brockdorff N.

Cell. 1998 Sep 18;94(6):809-17.


Comparative mapping of X chromosomes in vole species of the genus Microtus.

Nesterova TB, Duthie SM, Mazurok NA, Isaenko AA, Rubtsova NV, Zakian SM, Brockdorff N.

Chromosome Res. 1998 Jan;6(1):41-8.


Stabilization of Xist RNA mediates initiation of X chromosome inactivation.

Sheardown SA, Duthie SM, Johnston CM, Newall AE, Formstone EJ, Arkell RM, Nesterova TB, Alghisi GC, Rastan S, Brockdorff N.

Cell. 1997 Oct 3;91(1):99-107.


Novel strategies for eutherian x marsupial somatic cell hybrids: mapping the genome of Monodelphis domestica.

Nesterova TB, Isaenko AA, Matveeva NM, Shilov AG, Rubtsov NB, Vorobieva NV, Rubtsova NV, VandeBerg JL, Zakian SM.

Cytogenet Cell Genet. 1997;76(3-4):115-22.


Organization and chromosomal localization of a B1-like containing repeat of Microtus subarvalis.

Mayorov VI, Adkison LR, Vorobyeva NV, Khrapov EA, Kholodhov NG, Rogozin IB, Nesterova TB, Protopopov AI, Sablina OV, Graphodatsky AS, Zakian SM.

Mamm Genome. 1996 Aug;7(8):593-7.


High-resolution G-banding of chromosones in the common vole Microtus arvalis (Rodentia, Arvicolidae)

Mazurok NA, Isaenko AA, Nesterova TB, Zakian SM.

Hereditas. 1996;124(3):229-32.


[High resolution GTG banding and nucleolus organizer regions of chromosomes from the vole Microtus kirgisorum].

Mazurok NA, Rubtsov NB, Ovechkina IuIu, Nesterova TB, Zakiian SM.

Genetika. 1995 Aug;31(8):1132-8. Russian.


Editorial comment on the nomenclature of the East European vole.

Mazurok NA, Nesterova TB, Zakian SM.

Hereditas. 1995;123(1):95. No abstract available.

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