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Maternal genetic features of the Iron Age Tagar population from Southern Siberia (1st millennium BC).

Pilipenko AS, Trapezov RO, Cherdantsev SV, Babenko VN, Nesterova MS, Pozdnyakov DV, Molodin VI, Polosmak NV.

PLoS One. 2018 Sep 20;13(9):e0204062. doi: 10.1371/journal.pone.0204062. eCollection 2018.


Acute vs chronic exposure to high fat diet leads to distinct regulation of PKA.

London E, Nesterova M, Stratakis CA.

J Mol Endocrinol. 2017 Jul;59(1):1-12. doi: 10.1530/JME-16-0188. Epub 2017 Apr 18.


Celecoxib treatment of fibrous dysplasia (FD) in a human FD cell line and FD-like lesions in mice with protein kinase A (PKA) defects.

Saloustros E, Liu S, Mertz EL, Bhattacharyya N, Starost MF, Salpea P, Nesterova M, Collins M, Leikin S, Stratakis CA.

Mol Cell Endocrinol. 2017 Jan 5;439:165-174. doi: 10.1016/j.mce.2016.08.004. Epub 2016 Aug 4.


Bilateral Adrenal Hyperplasia as a Possible Mechanism for Hyperandrogenism in Women With Polycystic Ovary Syndrome.

Gourgari E, Lodish M, Keil M, Sinaii N, Turkbey E, Lyssikatos C, Nesterova M, de la Luz Sierra M, Xekouki P, Khurana D, Ten S, Dobs A, Stratakis CA.

J Clin Endocrinol Metab. 2016 Sep;101(9):3353-60. doi: 10.1210/jc.2015-4019. Epub 2016 Jun 23.


Studies of mice with cyclic AMP-dependent protein kinase (PKA) defects reveal the critical role of PKA's catalytic subunits in anxiety.

Briassoulis G, Keil MF, Naved B, Liu S, Starost MF, Nesterova M, Gokarn N, Batistatos A, Wu TJ, Stratakis CA.

Behav Brain Res. 2016 Jul 1;307:1-10. doi: 10.1016/j.bbr.2016.03.001. Epub 2016 Mar 16.


Haploinsufficiency for either one of the type-II regulatory subunits of protein kinase A improves the bone phenotype of Prkar1a+/- mice.

Liu S, Saloustros E, Mertz EL, Tsang K, Starost MF, Salpea P, Faucz FR, Szarek E, Nesterova M, Leikin S, Stratakis CA.

Hum Mol Genet. 2015 Nov 1;24(21):6080-92. doi: 10.1093/hmg/ddv320. Epub 2015 Aug 5.


Is IGSF1 involved in human pituitary tumor formation?

Faucz FR, Horvath AD, Azevedo MF, Levy I, Bak B, Wang Y, Xekouki P, Szarek E, Gourgari E, Manning AD, de Alexandre RB, Saloustros E, Trivellin G, Lodish M, Hofman P, Anderson YC, Holdaway I, Oldfield E, Chittiboina P, Nesterova M, Biermasz NR, Wit JM, Bernard DJ, Stratakis CA.

Endocr Relat Cancer. 2015 Feb;22(1):47-54. doi: 10.1530/ERC-14-0465. Epub 2014 Dec 19.


Not all glucocorticoid-induced obesity is the same: differences in adiposity among various diagnostic groups of Cushing syndrome.

London E, Lodish M, Keil M, Lyssikatos C, de la Luz Sierra M, Nesterova M, Stratakis CA.

Horm Metab Res. 2014 Nov;46(12):897-903. doi: 10.1055/s-0034-1389956. Epub 2014 Oct 8.


Comparison of the effects of PRKAR1A and PRKAR2B depletion on signaling pathways, cell growth, and cell cycle control of adrenocortical cells.

Basso F, Rocchetti F, Rodriguez S, Nesterova M, Cormier F, Stratakis CA, Ragazzon B, Bertherat J, Rizk-Rabin M.

Horm Metab Res. 2014 Nov;46(12):883-8. doi: 10.1055/s-0034-1389951. Epub 2014 Sep 30.


Differentially regulated protein kinase A (PKA) activity in adipose tissue and liver is associated with resistance to diet-induced obesity and glucose intolerance in mice that lack PKA regulatory subunit type IIα.

London E, Nesterova M, Sinaii N, Szarek E, Chanturiya T, Mastroyannis SA, Gavrilova O, Stratakis CA.

Endocrinology. 2014 Sep;155(9):3397-408. doi: 10.1210/en.2014-1122. Epub 2014 Jun 10.


Does somatostatin have a role in the regulation of cortisol secretion in primary pigmented nodular adrenocortical disease (ppnad)? a clinical and in vitro investigation.

Bram Z, Xekouki P, Louiset E, Keil MF, Avgeropoulos D, Giatzakis C, Nesterova M, Sinaii N, Hofland LJ, Cherqaoui R, Lefebvre H, Stratakis CA.

J Clin Endocrinol Metab. 2014 May;99(5):E891-901. doi: 10.1210/jc.2013-2657. Epub 2014 Feb 10.


Differences in adiposity in Cushing syndrome caused by PRKAR1A mutations: clues for the role of cyclic AMP signaling in obesity and diagnostic implications.

London E, Rothenbuhler A, Lodish M, Gourgari E, Keil M, Lyssikatos C, de la Luz Sierra M, Patronas N, Nesterova M, Stratakis CA.

J Clin Endocrinol Metab. 2014 Feb;99(2):E303-10. doi: 10.1210/jc.2013-1956. Epub 2013 Nov 18.


Cyclic AMP and c-KIT signaling in familial testicular germ cell tumor predisposition.

Azevedo MF, Horvath A, Bornstein ER, Almeida MQ, Xekouki P, Faucz FR, Gourgari E, Nadella K, Remmers EF, Quezado M, de Alexandre RB, Kratz CP, Nesterova M, Greene MH, Stratakis CA.

J Clin Endocrinol Metab. 2013 Aug;98(8):E1393-400. doi: 10.1210/jc.2012-2838. Epub 2013 Jun 14.


Threat bias in mice with inactivating mutations of Prkar1a.

Keil MF, Briassoulis G, Nesterova M, Miraftab N, Gokarn N, Wu TJ, Stratakis CA.

Neuroscience. 2013 Jun 25;241:206-14. doi: 10.1016/j.neuroscience.2013.03.027. Epub 2013 Mar 24.


Comprehensive analysis of LC/MS data using pseudocolor plots.

Crutchfield CA, Olson MT, Gourgari E, Nesterova M, Stratakis CA, Yergey AL.

J Am Soc Mass Spectrom. 2013 Feb;24(2):230-7. doi: 10.1007/s13361-012-0524-6. Epub 2013 Jan 3.


[Efficacy of convalis in the treatment of pain diabetic polyneuropathy and it's influence on biological age].

Galkin VV, Nesterova MV.

Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(1):97-100. Russian. No abstract available.


PRKAR1A gene analysis and protein kinase A activity in endometrial tumors.

Tsigginou A, Bimpaki E, Nesterova M, Horvath A, Boikos S, Lyssikatos C, Papageorgiou C, Dimitrakakis C, Rodolakis A, Stratakis CA, Antsaklis A.

Endocr Relat Cancer. 2012 Jun 18;19(4):457-62. doi: 10.1530/ERC-11-0328. Print 2012 Aug.


Identification of novel genetic variants in phosphodiesterase 8B (PDE8B), a cAMP-specific phosphodiesterase highly expressed in the adrenal cortex, in a cohort of patients with adrenal tumours.

Rothenbuhler A, Horvath A, Libé R, Faucz FR, Fratticci A, Raffin Sanson ML, Vezzosi D, Azevedo M, Levy I, Almeida MQ, Lodish M, Nesterova M, Bertherat J, Stratakis CA.

Clin Endocrinol (Oxf). 2012 Aug;77(2):195-9. doi: 10.1111/j.1365-2265.2012.04366.x. Erratum in: Clin Endocrinol (Oxf). 2012 Dec;77(6):943.


Comparison of aldosterone production among human adrenocortical cell lines.

Wang T, Rowland JG, Parmar J, Nesterova M, Seki T, Rainey WE.

Horm Metab Res. 2012 Mar;44(3):245-50. doi: 10.1055/s-0031-1298019. Epub 2012 Jan 20.


Activation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutations.

Almeida MQ, Azevedo MF, Xekouki P, Bimpaki EI, Horvath A, Collins MT, Karaviti LP, Jeha GS, Bhattacharyya N, Cheadle C, Watkins T, Bourdeau I, Nesterova M, Stratakis CA.

J Clin Endocrinol Metab. 2012 Apr;97(4):E687-93. doi: 10.1210/jc.2011-3000. Epub 2012 Jan 18.


In vitro studies of novel PRKAR1A mutants that extend the predicted RIα protein sequence into the 3'-untranslated open reading frame: proteasomal degradation leads to RIα haploinsufficiency and Carney complex.

Patronas Y, Horvath A, Greene E, Tsang K, Bimpaki E, Haran M, Nesterova M, Stratakis CA.

J Clin Endocrinol Metab. 2012 Mar;97(3):E496-502. doi: 10.1210/jc.2011-2220. Epub 2011 Dec 28.


Succinate dehydrogenase (SDH) D subunit (SDHD) inactivation in a growth-hormone-producing pituitary tumor: a new association for SDH?

Xekouki P, Pacak K, Almeida M, Wassif CA, Rustin P, Nesterova M, de la Luz Sierra M, Matro J, Ball E, Azevedo M, Horvath A, Lyssikatos C, Quezado M, Patronas N, Ferrando B, Pasini B, Lytras A, Tolis G, Stratakis CA.

J Clin Endocrinol Metab. 2012 Mar;97(3):E357-66. doi: 10.1210/jc.2011-1179. Epub 2011 Dec 14.


A large family with Carney complex caused by the S147G PRKAR1A mutation shows a unique spectrum of disease including adrenocortical cancer.

Anselmo J, Medeiros S, Carneiro V, Greene E, Levy I, Nesterova M, Lyssikatos C, Horvath A, Carney JA, Stratakis CA.

J Clin Endocrinol Metab. 2012 Feb;97(2):351-9. doi: 10.1210/jc.2011-2244. Epub 2011 Nov 23.


Anxiety phenotype in mice that overexpress protein kinase A.

Keil MF, Briassoulis G, Gokarn N, Nesterova M, Wu TJ, Stratakis CA.

Psychoneuroendocrinology. 2012 Jun;37(6):836-43. doi: 10.1016/j.psyneuen.2011.09.016. Epub 2011 Oct 22.


[Biological age and the pain syndrome at diabetic polyneuropathy].

Galkin VV, Nesterova MV, Emel'ianov VV.

Adv Gerontol. 2011;24(2):303-7. Russian.


Role of nonselective cation channels in spontaneous and protein kinase A-stimulated calcium signaling in pituitary cells.

Tomić M, Kucka M, Kretschmannova K, Li S, Nesterova M, Stratakis CA, Stojilkovic SS.

Am J Physiol Endocrinol Metab. 2011 Aug;301(2):E370-9. doi: 10.1152/ajpendo.00130.2011. Epub 2011 May 17.


Integrated genomic analysis of nodular tissue in macronodular adrenocortical hyperplasia: progression of tumorigenesis in a disorder associated with multiple benign lesions.

Almeida MQ, Harran M, Bimpaki EI, Hsiao HP, Horvath A, Cheadle C, Watkins T, Nesterova M, Stratakis CA.

J Clin Endocrinol Metab. 2011 Apr;96(4):E728-38. doi: 10.1210/jc.2010-2420. Epub 2011 Jan 20.


Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype.

Libé R, Horvath A, Vezzosi D, Fratticci A, Coste J, Perlemoine K, Ragazzon B, Guillaud-Bataille M, Groussin L, Clauser E, Raffin-Sanson ML, Siegel J, Moran J, Drori-Herishanu L, Faucz FR, Lodish M, Nesterova M, Bertagna X, Bertherat J, Stratakis CA.

J Clin Endocrinol Metab. 2011 Jan;96(1):E208-14. doi: 10.1210/jc.2010-1704. Epub 2010 Nov 3.


Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors.

Almeida MQ, Tsang KM, Cheadle C, Watkins T, Grivel JC, Nesterova M, Goldbach-Mansky R, Stratakis CA.

Hum Mol Genet. 2011 Jan 1;20(1):165-75. doi: 10.1093/hmg/ddq455. Epub 2010 Oct 11.


Phosphodiesterase 11A (PDE11A) genetic variants may increase susceptibility to prostatic cancer.

Faucz FR, Horvath A, Rothenbuhler A, Almeida MQ, Libé R, Raffin-Sanson ML, Bertherat J, Carraro DM, Soares FA, Molina Gde C, Campos AH, Alexandre RB, Bendhack ML, Nesterova M, Stratakis CA.

J Clin Endocrinol Metab. 2011 Jan;96(1):E135-40. doi: 10.1210/jc.2010-1655. Epub 2010 Sep 29.


The role of germline AIP, MEN1, PRKAR1A, CDKN1B and CDKN2C mutations in causing pituitary adenomas in a large cohort of children, adolescents, and patients with genetic syndromes.

Stratakis CA, Tichomirowa MA, Boikos S, Azevedo MF, Lodish M, Martari M, Verma S, Daly AF, Raygada M, Keil MF, Papademetriou J, Drori-Herishanu L, Horvath A, Tsang KM, Nesterova M, Franklin S, Vanbellinghen JF, Bours V, Salvatori R, Beckers A.

Clin Genet. 2010 Nov;78(5):457-63. doi: 10.1111/j.1399-0004.2010.01406.x.


Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone.

Tsang KM, Starost MF, Nesterova M, Boikos SA, Watkins T, Almeida MQ, Harran M, Li A, Collins MT, Cheadle C, Mertz EL, Leikin S, Kirschner LS, Robey P, Stratakis CA.

Proc Natl Acad Sci U S A. 2010 May 11;107(19):8683-8. doi: 10.1073/pnas.1003680107. Epub 2010 Apr 26.


Investigation of a patient with a partial trisomy 16q including the fat mass and obesity associated gene (FTO): fine mapping and FTO gene expression study.

van den Berg L, de Waal HD, Han JC, Ylstra B, Eijk P, Nesterova M, Heutink P, Stratakis CA.

Am J Med Genet A. 2010 Mar;152A(3):630-7. doi: 10.1002/ajmg.a.33229.


Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling.

Almeida MQ, Muchow M, Boikos S, Bauer AJ, Griffin KJ, Tsang KM, Cheadle C, Watkins T, Wen F, Starost MF, Bossis I, Nesterova M, Stratakis CA.

Hum Mol Genet. 2010 Apr 15;19(8):1387-98. doi: 10.1093/hmg/ddq014. Epub 2010 Jan 15.


Association of the M1V PRKAR1A mutation with primary pigmented nodular adrenocortical disease in two large families.

Pereira AM, Hes FJ, Horvath A, Woortman S, Greene E, Bimpaki E, Alatsatianos A, Boikos S, Smit JW, Romijn JA, Nesterova M, Stratakis CA.

J Clin Endocrinol Metab. 2010 Jan;95(1):338-42. doi: 10.1210/jc.2009-0993. Epub 2009 Nov 13.


8-Cl-adenosine inhibits proliferation and causes apoptosis in B-lymphocytes via protein kinase A-dependent and independent effects: implications for treatment of Carney complex-associated tumors.

Robinson-White AJ, Bossis I, Hsiao HP, Nesterova M, Leitner WW, Stratakis CA.

J Clin Endocrinol Metab. 2009 Oct;94(10):4061-9. doi: 10.1210/jc.2009-0759. Epub 2009 Sep 22.


[Effect of cavinton forte on the cerebral hemodynamic and autoregulation mechanisms of cerebral blood flow in patients with chronic cerebral ischemia].

Grigor'eva AN, Nesterova MV.

Zh Nevrol Psikhiatr Im S S Korsakova. 2009;109(7):90-1. Russian. No abstract available.


Functional phosphodiesterase 11A mutations may modify the risk of familial and bilateral testicular germ cell tumors.

Horvath A, Korde L, Greene MH, Libe R, Osorio P, Faucz FR, Raffin-Sanson ML, Tsang KM, Drori-Herishanu L, Patronas Y, Remmers EF, Nikita ME, Moran J, Greene J, Nesterova M, Merino M, Bertherat J, Stratakis CA.

Cancer Res. 2009 Jul 1;69(13):5301-6. doi: 10.1158/0008-5472.CAN-09-0884. Epub 2009 Jun 23.


Clinical and genetic heterogeneity, overlap with other tumor syndromes, and atypical glucocorticoid hormone secretion in adrenocorticotropin-independent macronodular adrenal hyperplasia compared with other adrenocortical tumors.

Hsiao HP, Kirschner LS, Bourdeau I, Keil MF, Boikos SA, Verma S, Robinson-White AJ, Nesterova M, Lacroix A, Stratakis CA.

J Clin Endocrinol Metab. 2009 Aug;94(8):2930-7. doi: 10.1210/jc.2009-0516. Epub 2009 Jun 9.


Abnormalities of cAMP signaling are present in adrenocortical lesions associated with ACTH-independent Cushing syndrome despite the absence of mutations in known genes.

Bimpaki EI, Nesterova M, Stratakis CA.

Eur J Endocrinol. 2009 Jul;161(1):153-61. doi: 10.1530/EJE-09-0027. Epub 2009 May 8.


An Intronic mutation is associated with prolactinoma in a young boy, decreased penetrance in his large family, and variable effects on MEN1 mRNA and protein.

Drori-Herishanu L, Horvath A, Nesterova M, Patronas Y, Lodish M, Bimpaki E, Patronas N, Agarwal S, Salvatori R, Martari M, Mericq V, Stratakis CA.

Horm Metab Res. 2009 Aug;41(8):630-4. doi: 10.1055/s-0029-1216358. Epub 2009 Apr 23.


MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling.

Iliopoulos D, Bimpaki EI, Nesterova M, Stratakis CA.

Cancer Res. 2009 Apr 15;69(8):3278-82. doi: 10.1158/0008-5472.CAN-09-0155. Epub 2009 Apr 7.


Regulatory subunits of PKA define an axis of cellular proliferation/differentiation in ovarian cancer cells.

Cheadle C, Nesterova M, Watkins T, Barnes KC, Hall JC, Rosen A, Becker KG, Cho-Chung YS.

BMC Med Genomics. 2008 Sep 26;1:43. doi: 10.1186/1755-8794-1-43.


Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors.

Meoli E, Bossis I, Cazabat L, Mavrakis M, Horvath A, Stergiopoulos S, Shiferaw ML, Fumey G, Perlemoine K, Muchow M, Robinson-White A, Weinberg F, Nesterova M, Patronas Y, Groussin L, Bertherat J, Stratakis CA.

Cancer Res. 2008 May 1;68(9):3133-41. doi: 10.1158/0008-5472.CAN-08-0064.


A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex.

Horvath A, Giatzakis C, Tsang K, Greene E, Osorio P, Boikos S, Libè R, Patronas Y, Robinson-White A, Remmers E, Bertherat J, Nesterova M, Stratakis CA.

Eur J Hum Genet. 2008 Oct;16(10):1245-53. doi: 10.1038/ejhg.2008.85. Epub 2008 Apr 23.


In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay.

Greene EL, Horvath AD, Nesterova M, Giatzakis C, Bossis I, Stratakis CA.

Hum Mutat. 2008 May;29(5):633-9. doi: 10.1002/humu.20688.


Large deletions of the PRKAR1A gene in Carney complex.

Horvath A, Bossis I, Giatzakis C, Levine E, Weinberg F, Meoli E, Robinson-White A, Siegel J, Soni P, Groussin L, Matyakhina L, Verma S, Remmers E, Nesterova M, Carney JA, Bertherat J, Stratakis CA.

Clin Cancer Res. 2008 Jan 15;14(2):388-95. doi: 10.1158/1078-0432.CCR-07-1155.


Protein kinase A-independent inhibition of proliferation and induction of apoptosis in human thyroid cancer cells by 8-Cl-adenosine.

Robinson-White AJ, Hsiao HP, Leitner WW, Greene E, Bauer A, Krett NL, Nesterova M, Stratakis CA.

J Clin Endocrinol Metab. 2008 Mar;93(3):1020-9. Epub 2007 Dec 11.


An immortalized human cell line bearing a PRKAR1A-inactivating mutation: effects of overexpression of the wild-type Allele and other protein kinase A subunits.

Nesterova M, Bossis I, Wen F, Horvath A, Matyakhina L, Stratakis CA.

J Clin Endocrinol Metab. 2008 Feb;93(2):565-71. Epub 2007 Dec 4.


cAMP and protein kinase A in endocrine (and other) tumors.

Nesterova M, Stratakis CA.

Expert Rev Endocrinol Metab. 2007 Sep;2(5):667-676. doi: 10.1586/17446651.2.5.667.


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