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Items: 33

1.

Mechanism of a Standalone β-Lactone Synthetase: New Continuous Assay for a Widespread ANL Superfamily Enzyme.

Robinson SL, Christenson JK, Richman JE, Jenkins DJ, Neres J, Fonseca DR, Aldrich CC, Wackett LP.

Chembiochem. 2019 Mar 11. doi: 10.1002/cbic.201800821. [Epub ahead of print]

PMID:
30856684
2.

Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria.

Sommer R, Neres J, Piton J, Dhar N, van der Sar A, Mukherjee R, Laroche T, Dyson PJ, McKinney JD, Bitter W, Makarov V, Cole ST.

ACS Chem Biol. 2018 Nov 16;13(11):3184-3192. doi: 10.1021/acschembio.8b00790. Epub 2018 Oct 25.

PMID:
30289689
3.

Characterization of DprE1-Mediated Benzothiazinone Resistance in Mycobacterium tuberculosis.

Foo CS, Lechartier B, Kolly GS, Boy-Röttger S, Neres J, Rybniker J, Lupien A, Sala C, Piton J, Cole ST.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6451-6459. doi: 10.1128/AAC.01523-16. Print 2016 Nov.

4.

Nitroarenes as Antitubercular Agents: Stereoelectronic Modulation to Mitigate Mutagenicity.

Landge S, Ramachandran V, Kumar A, Neres J, Murugan K, Sadler C, Fellows MD, Humnabadkar V, Vachaspati P, Raichurkar A, Sharma S, Ravishankar S, Guptha S, Sambandamurthy VK, Balganesh TS, Ugarkar BG, Balasubramanian V, Bandodkar BS, Panda M.

ChemMedChem. 2016 Feb 4;11(3):331-9. doi: 10.1002/cmdc.201500462. Epub 2016 Jan 11.

PMID:
26751718
5.

Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure-activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-β-D-ribose 2'-oxidase.

Landge S, Mullick AB, Nagalapur K, Neres J, Subbulakshmi V, Murugan K, Ghosh A, Sadler C, Fellows MD, Humnabadkar V, Mahadevaswamy J, Vachaspati P, Sharma S, Kaur P, Mallya M, Rudrapatna S, Awasthy D, Sambandamurthy VK, Pojer F, Cole ST, Balganesh TS, Ugarkar BG, Balasubramanian V, Bandodkar BS, Panda M, Ramachandran V.

Bioorg Med Chem. 2015 Dec 15;23(24):7694-710. doi: 10.1016/j.bmc.2015.11.017. Epub 2015 Nov 18.

PMID:
26643218
6.

The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis.

Makarov V, Neres J, Hartkoorn RC, Ryabova OB, Kazakova E, Šarkan M, Huszár S, Piton J, Kolly GS, Vocat A, Conroy TM, Mikušová K, Cole ST.

Antimicrob Agents Chemother. 2015 Aug;59(8):4446-52. doi: 10.1128/AAC.00778-15. Epub 2015 May 18.

7.

DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization.

Brecik M, Centárová I, Mukherjee R, Kolly GS, Huszár S, Bobovská A, Kilacsková E, Mokošová V, Svetlíková Z, Šarkan M, Neres J, Korduláková J, Cole ST, Mikušová K.

ACS Chem Biol. 2015 Jul 17;10(7):1631-6. doi: 10.1021/acschembio.5b00237. Epub 2015 Apr 29.

PMID:
25906160
8.

2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1.

Neres J, Hartkoorn RC, Chiarelli LR, Gadupudi R, Pasca MR, Mori G, Venturelli A, Savina S, Makarov V, Kolly GS, Molteni E, Binda C, Dhar N, Ferrari S, Brodin P, Delorme V, Landry V, de Jesus Lopes Ribeiro AL, Farina D, Saxena P, Pojer F, Carta A, Luciani R, Porta A, Zanoni G, De Rossi E, Costi MP, Riccardi G, Cole ST.

ACS Chem Biol. 2015 Mar 20;10(3):705-14. doi: 10.1021/cb5007163. Epub 2014 Dec 9.

PMID:
25427196
9.

4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity.

Naik M, Humnabadkar V, Tantry SJ, Panda M, Narayan A, Guptha S, Panduga V, Manjrekar P, Jena LK, Koushik K, Shanbhag G, Jatheendranath S, Manjunatha MR, Gorai G, Bathula C, Rudrapatna S, Achar V, Sharma S, Ambady A, Hegde N, Mahadevaswamy J, Kaur P, Sambandamurthy VK, Awasthy D, Narayan C, Ravishankar S, Madhavapeddi P, Reddy J, Prabhakar K, Saralaya R, Chatterji M, Whiteaker J, McLaughlin B, Chiarelli LR, Riccardi G, Pasca MR, Binda C, Neres J, Dhar N, Signorino-Gelo F, McKinney JD, Ramachandran V, Shandil R, Tommasi R, Iyer PS, Narayanan S, Hosagrahara V, Kavanagh S, Dinesh N, Ghorpade SR.

J Med Chem. 2014 Jun 26;57(12):5419-34. doi: 10.1021/jm5005978. Epub 2014 Jun 11.

PMID:
24871036
10.

Selective detection of epimeric pentose saccharides at physiological pH using a fluorescent receptor.

Gibson MI, Neres J, Fullam E.

Carbohydr Res. 2014 Jun 4;391:61-5. doi: 10.1016/j.carres.2014.02.007. Epub 2014 Feb 15.

PMID:
24785389
11.

Towards a new combination therapy for tuberculosis with next generation benzothiazinones.

Makarov V, Lechartier B, Zhang M, Neres J, van der Sar AM, Raadsen SA, Hartkoorn RC, Ryabova OB, Vocat A, Decosterd LA, Widmer N, Buclin T, Bitter W, Andries K, Pojer F, Dyson PJ, Cole ST.

EMBO Mol Med. 2014 Mar;6(3):372-83. doi: 10.1002/emmm.201303575. Epub 2014 Feb 5.

12.

Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA.

Hartkoorn RC, Pojer F, Read JA, Gingell H, Neres J, Horlacher OP, Altmann KH, Cole ST.

Nat Chem Biol. 2014 Feb;10(2):96-8. doi: 10.1038/nchembio.1405. Epub 2013 Dec 1.

PMID:
24292073
13.

DprE1--from the discovery to the promising tuberculosis drug target.

Mikusová K, Makarov V, Neres J.

Curr Pharm Des. 2014;20(27):4379-403. Review.

PMID:
24245764
14.

Insights into the activity and specificity of Trypanosoma cruzi trans-sialidase from molecular dynamics simulations.

Mitchell FL, Neres J, Ramraj A, Raju RK, Hillier IH, Vincent MA, Bryce RA.

Biochemistry. 2013 May 28;52(21):3740-51. doi: 10.1021/bi301112p. Epub 2013 May 14.

15.

Non-nucleoside inhibitors of BasE, an adenylating enzyme in the siderophore biosynthetic pathway of the opportunistic pathogen Acinetobacter baumannii.

Neres J, Engelhart CA, Drake EJ, Wilson DJ, Fu P, Boshoff HI, Barry CE 3rd, Gulick AM, Aldrich CC.

J Med Chem. 2013 Mar 28;56(6):2385-405. doi: 10.1021/jm301709s. Epub 2013 Mar 13.

16.

Towards a new tuberculosis drug: pyridomycin - nature's isoniazid.

Hartkoorn RC, Sala C, Neres J, Pojer F, Magnet S, Mukherjee R, Uplekar S, Boy-Röttger S, Altmann KH, Cole ST.

EMBO Mol Med. 2012 Oct;4(10):1032-42. doi: 10.1002/emmm.201201689. Epub 2012 Sep 17.

17.

Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis.

Neres J, Pojer F, Molteni E, Chiarelli LR, Dhar N, Boy-Röttger S, Buroni S, Fullam E, Degiacomi G, Lucarelli AP, Read RJ, Zanoni G, Edmondson DE, De Rossi E, Pasca MR, McKinney JD, Dyson PJ, Riccardi G, Mattevi A, Cole ST, Binda C.

Sci Transl Med. 2012 Sep 5;4(150):150ra121. doi: 10.1126/scitranslmed.3004395.

18.

Inhibitors of the salicylate synthase (MbtI) from Mycobacterium tuberculosis discovered by high-throughput screening.

Vasan M, Neres J, Williams J, Wilson DJ, Teitelbaum AM, Remmel RP, Aldrich CC.

ChemMedChem. 2010 Dec 3;5(12):2079-87. doi: 10.1002/cmdc.201000275.

19.
20.

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance.

Manina G, Bellinzoni M, Pasca MR, Neres J, Milano A, Ribeiro AL, Buroni S, Skovierová H, Dianišková P, Mikušová K, Marák J, Makarov V, Giganti D, Haouz A, Lucarelli AP, Degiacomi G, Piazza A, Chiarelli LR, De Rossi E, Salina E, Cole ST, Alzari PM, Riccardi G.

Mol Microbiol. 2010 Sep;77(5):1172-85. doi: 10.1111/j.1365-2958.2010.07277.x.

21.

Tryptophan as a molecular shovel in the glycosyl transfer activity of Trypanosoma cruzi trans-sialidase.

Mitchell FL, Miles SM, Neres J, Bichenkova EV, Bryce RA.

Biophys J. 2010 May 19;98(9):L38-40. doi: 10.1016/j.bpj.2010.01.006.

22.

Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes.

Chu ML, Lang Z, Chavas LM, Neres J, Fedorova OS, Tabernero L, Cherry M, Williams DH, Douglas KT, Eyers PA.

Biochemistry. 2010 Mar 2;49(8):1689-701. doi: 10.1021/bi901970c.

PMID:
20099905
23.

The global virulence regulators VsrAD and PhcA control secondary metabolism in the plant pathogen Ralstonia solanacearum.

Schneider P, Jacobs JM, Neres J, Aldrich CC, Allen C, Nett M, Hoffmeister D.

Chembiochem. 2009 Nov 23;10(17):2730-2. doi: 10.1002/cbic.200900510. No abstract available.

PMID:
19830761
24.

Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening.

Neres J, Brewer ML, Ratier L, Botti H, Buschiazzo A, Edwards PN, Mortenson PN, Charlton MH, Alzari PM, Frasch AC, Bryce RA, Douglas KT.

Bioorg Med Chem Lett. 2009 Feb 1;19(3):589-96. doi: 10.1016/j.bmcl.2008.12.065. Epub 2008 Dec 24.

PMID:
19144516
25.

Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: antibacterial nucleosides effective against Mycobacterium tuberculosis.

Gupte A, Boshoff HI, Wilson DJ, Neres J, Labello NP, Somu RV, Xing C, Barry CE, Aldrich CC.

J Med Chem. 2008 Dec 11;51(23):7495-507. doi: 10.1021/jm8008037.

26.
27.

Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine.

Neres J, Labello NP, Somu RV, Boshoff HI, Wilson DJ, Vannada J, Chen L, Barry CE 3rd, Bennett EM, Aldrich CC.

J Med Chem. 2008 Sep 11;51(17):5349-70. doi: 10.1021/jm800567v. Epub 2008 Aug 9.

28.

Rational drug design in parasitology: trans-sialidase as a case study for Chagas disease.

Neres J, Bryce RA, Douglas KT.

Drug Discov Today. 2008 Feb;13(3-4):110-7. doi: 10.1016/j.drudis.2007.12.004. Review.

PMID:
18275908
29.

Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase.

Neres J, Bonnet P, Edwards PN, Kotian PL, Buschiazzo A, Alzari PM, Bryce RA, Douglas KT.

Bioorg Med Chem. 2007 Mar 1;15(5):2106-19. Epub 2006 Dec 15.

PMID:
17218104
30.

Continuous fluorimetric assay for high-throughput screening of inhibitors of trans-sialidase from Trypanosoma cruzi.

Neres J, Buschiazzo A, Alzari PM, Walsh L, Douglas KT.

Anal Biochem. 2006 Oct 15;357(2):302-4. Epub 2006 Aug 10. No abstract available.

PMID:
16930524
31.

Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase.

Moreira R, Santana AB, Iley J, Neres J, Douglas KT, Horton PN, Hursthouse MB.

J Med Chem. 2005 Jul 28;48(15):4861-70.

PMID:
16033266
32.

Synthesis, stability and in vitro dermal evaluation of aminocarbonyloxymethyl esters as prodrugs of carboxylic acid agents.

Mendes E, Furtado T, Neres J, Iley J, Jarvinen T, Rautio J, Moreira R.

Bioorg Med Chem. 2002 Mar;10(3):809-16.

PMID:
11814870
33.

Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors.

Clemente A, Domingos A, Grancho AP, Iley J, Moreira R, Neres J, Palma N, Santana AB, Valente E.

Bioorg Med Chem Lett. 2001 Apr 23;11(8):1065-8.

PMID:
11327591

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